Gene_Locus Report

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Gene_locus Report for: drome-aes02

Drosophila melanogaster (Fruit fly) alpha esterase (aE2),CG2505 gh15053p

Comment
Nucleotide sequence of the Celera sequence differs from the published sequence for this transcript GH15053p CG2505-PA


Relationship
Family|Carb_B_Arthropoda
Block| C
Position in NCBI Life Tree|Drosophila melanogaster
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms: N E > Eukaryota: N E > Opisthokonta: N E > Metazoa: N E > Eumetazoa: N E > Bilateria: N E > Protostomia: N E > Ecdysozoa: N E > Panarthropoda: N E > Arthropoda: N E > Mandibulata: N E > Pancrustacea: N E > Hexapoda: N E > Insecta: N E > Dicondylia: N E > Pterygota: N E > Neoptera: N E > Holometabola: N E > Diptera: N E > Brachycera: N E > Muscomorpha: N E > Eremoneura: N E > Cyclorrhapha: N E > Schizophora: N E > Acalyptratae: N E > Ephydroidea: N E > Drosophilidae: N E > Drosophilinae: N E > Drosophilini: N E > Drosophila [fruit fly, genus]: N E > Sophophora: N E > melanogaster group: N E > melanogaster subgroup: N E > Drosophila melanogaster: N E


Molecular evidence
Database
No mutation
No structure
No kinetic





No Substrate
1 inhbitor:
NBD-HE-HP
>3 Genbank links 5 more: U51044, AE003671, AY051497
1 Ncbi-nid : 1272301
3 Ncbi-pid : 7298794, 28381148, 15291305
2 UniProt : Q24195, Q961N0
2 Interpro : Q24195, Q961N0
2 Prodom : Q24195, Q961N0
2 Pfam : Q24195, Q961N0
2 PIRSF : Q24195, Q961N0
2 SUPERFAM : Q24195, Q961N0
1 FlyBase : 0015570
Sequence
Graphical view for this peptide sequence: drome-aes02
Colored MSA for Carb_B_Arthropoda (raw)
MGAQLVGHKVQQYRLSTGHTVILDTKYGQVRGLQRKTVYDKEPYFAFEGI
PYAKPPVGDLRFRAPQPPEPWQGVLNCTTNRSKPMQRNMLLGIVEGSEDC
LHLNVYVKALKSEKPLPVIVWIYGGGFQKGEASRDIYSPDYFMKKPVVFV
AINYRLAALGFLSLKDPKLDVPGNAGLKDQVMALRWISQNIAQFNGDPNN
ITLMGESAGSASVHVMMTTEQTRGLFHKAIMQSGCALSEWVESPDNNWAF
RLAQNLGYMGDEKDADVLSFLSKVSARQIAAIDQDVINLDEVRSFLLFAF
GPVIEPYETDHCVWPKRPKDLLSEAWGNDIPVIVGGNSFEGLFSYQLVRK
DPWALKNFHNILPREVRETSSLEGQDLLVRRLKQLYFNNEMQESMEMFEA
LNIFSHRQIWHDTHRFILARQSYAPKTPTYLYRFDFDSPHFNQXRRLVCG
DRIRGVAHADELSYLFYNIIASKLDKSSMEYKTIERMVGMWTSFASSGNP
NCPELGSAKWEAVQLKENAVEKCFNISHDLEMRDLPESDCLAVWDTFYPR
ESLF
Legend This sequence has been compared to family alignement (MSA)
red => minority aminoacid
blue => majority aminoacid
color intensity => conservation rate
title => sequence position(MSA position)aminoacid rate
Catalytic site
Catalytic site in the MSA

MGAQLVGHKVQQYRLSTGHTVILDTKYGQVRGLQRKTVYDKEPYFAFEGI
PYAKPPVGDLRFRAPQPPEPWQGVLNCTTNRSKPMQRNMLLGIVEGSEDC
LHLNVYVKALKSEKPLPVIVWIYGGGFQKGEASRDIYSPDYFMKKPVVFV
AINYRLAALGFLSLKDPKLDVPGNAGLKDQVMALRWISQNIAQFNGDPNN
ITLMGESAGSASVHVMMTTEQTRGLFHKAIMQSGCALSEWVESPDNNWAF
RLAQNLGYMGDEKDADVLSFLSKVSARQIAAIDQDVINLDEVRSFLLFAF
GPVIEPYETDHCVWPKRPKDLLSEAWGNDIPVIVGGNSFEGLFSYQLVRK
DPWALKNFHNILPREVRETSSLEGQDLLVRRLKQLYFNNEMQESMEMFEA
LNIFSHRQIWHDTHRFILARQSYAPKTPTYLYRFDFDSPHFNQXRRLVCG
DRIRGVAHADELSYLFYNIIASKLDKSSMEYKTIERMVGMWTSFASSGNP
NCPELGSAKWEAVQLKENAVEKCFNISHDLEMRDLPESDCLAVWDTFYPR
ESLF


References
    Title: Functional fat body proteomics and gene targeting reveal in vivo functions of Drosophila melanogaster a-Esterase-7
    Birner-Gruenberger R, Bickmeyer I, Lange J, Hehlert P, Hermetter A, Kollroser M, Rechberger GN, Kuhnlein RP
    Ref: Insect Biochemistry & Molecular Biology, 42:220, 2012 : PubMed

            

    Title: Duplication and divergence of the genes of the alpha-esterase cluster of Drosophila melanogaster
    Robin C, Russell RJ, Medveczky KM, Oakeshott JG
    Ref: Journal of Molecular Evolution, 43:241, 1996 : PubMed

            


Other Papers


Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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