drome-b6idz4

 
Drosophila melanogaster (Fruit fly) neuroligin 4 (Fruit fly) GH07829p

Comment
dnlg4 Dmnlg4 Nucleotide sequence from Celera only n-term Pfam A COesterase 8 374 Pfam A COesterase 419 541


Relationship
Family Neuroligin
Block C
Drosophila melanogaster position in NCBI Life Tree :
N link to NCBI taxonomic web page and E link to ESTHER gene locus found in this strain.
> cellular organisms: N E > Eukaryota: N E > Opisthokonta: N E > Metazoa: N E > Eumetazoa: N E > Bilateria: N E > Protostomia: N E > Ecdysozoa: N E > Panarthropoda: N E > Arthropoda: N E > Mandibulata: N E > Pancrustacea: N E > Hexapoda: N E > Insecta: N E > Dicondylia: N E > Pterygota: N E > Neoptera: N E > Holometabola: N E > Diptera: N E > Brachycera: N E > Muscomorpha: N E > Eremoneura: N E > Cyclorrhapha: N E > Schizophora: N E > Acalyptratae: N E > Ephydroidea: N E > Drosophilidae: N E > Drosophilinae: N E > Drosophilini: N E > Drosophila [fruit fly, genus]: N E > Sophophora: N E > melanogaster group: N E > melanogaster subgroup: N E > Drosophila melanogaster: N E

Molecular evidence
Database
No mutation
No structure
No kinetic



2 Genbank : BT050584, AE003729
1 UniProt : B6IDZ4
1 Ncbi-pid : 7300594
2 UniProtTrembl : B6IDZ4, Q9VDP5
2 Interpro : B6IDZ4, Q9VDP5
2 Prodom : B6IDZ4, Q9VDP5
2 Pfam : B6IDZ4, Q9VDP5
2 PIRSF : B6IDZ4, Q9VDP5
2 SUPERFAM : B6IDZ4, Q9VDP5
2 QuickSwissBlast : B6IDZ4, Q9VDP5
1 FlyBase : 0038776
 
Sequence
Graphical view for this peptide sequence: drome-b6idz4
Colored MSA for Neuroligin (raw)
MGESQLLLLLRLLLLPTVLISWMHCAGASTADIYKGARLGHRIVQTRYGR
LHGLILPLDSFRFLRSVEVFLGVPYATPPTKQNRFSPTRAPAPWDGIRIS
DKYSPVCPQRLPNIQNETAALEKMPKGRLEYLKRLLPFLENQSEDCLYLN
VFSPVNAGANEKKLPVIVFIHGESFEWSSGNPYDGSVLASYGEVVVVTLN
YRLGILGFLNANPNPHAHARVANYGLMDQMAALHWIQQNIQKFGGDPNSV
TLAGHGTGAACINYLMTSPTMVRGLFHRAILMSGSAYSSWALVEDPVLFA
IKLAKEVNCTIPDDINRHHEQIVDCLRDVPLEDLYLADIQAPNFLTSFGP
SVDGVVIRPGHSNLDIDDLMARNSRRSSADSGFQSSAGGGGGQGGGAGGG
GGGGSGSSFGGGYFGGSGAGTMNMGGHYDVLFGVVTGESIWRFSAHDIQN
GFEGERRDKIIRTYVRNAYNYHLNEIFYTIVNEYTDWDRTSQHPINTRDT
AVAALSDAQFVAPIVRAGDILAANSPPPVSSSSTAGSPGANAAASTSAGS
TQPSGRCYFYVFDYQTKDGDYPQRMGTVHGEDLPYIFGAPLVDGFSHFPQ
NYTKSETALSEAVMIFWTNFARTGNPNEHHRQDSSLPVSKERNRFRSITW
ENYDPLHQKYLEIGMKPRIKNHFRAHQLSIWLRLIPELHRAGMEDVIARH
NLFRNHDDMDLYEGPVKPDPFGISTAAGASGSSSSSSSSSRLLLVDEQLM
MKKGRGLNGSAYLNGILG
Legend This sequence has been compared to family alignement (MSA)
red => minority aminoacid
blue => majority aminoacid
color intensity => conservation rate
title => sequence position(MSA position)aminoacid rate
Catalytic site
Catalytic site in the MSA

MGESQLLLLLRLLLLPTVLISWMHCAGASTADIYKGARLGHRIVQTRYGR
LHGLILPLDSFRFLRSVEVFLGVPYATPPTKQNRFSPTRAPAPWDGIRIS
DKYSPVCPQRLPNIQNETAALEKMPKGRLEYLKRLLPFLENQSEDCLYLN
VFSPVNAGANEKKLPVIVFIHGESFEWSSGNPYDGSVLASYGEVVVVTLN
YRLGILGFLNANPNPHAHARVANYGLMDQMAALHWIQQNIQKFGGDPNSV
TLAGHGTGAACINYLMTSPTMVRGLFHRAILMSGSAYSSWALVEDPVLFA
IKLAKEVNCTIPDDINRHHEQIVDCLRDVPLEDLYLADIQAPNFLTSFGP
SVDGVVIRPGHSNLDIDDLMARNSRRSSADSGFQSSAGGGGGQGGGAGGG
GGGGSGSSFGGGYFGGSGAGTMNMGGHYDVLFGVVTGESIWRFSAHDIQN
GFEGERRDKIIRTYVRNAYNYHLNEIFYTIVNEYTDWDRTSQHPINTRDT
AVAALSDAQFVAPIVRAGDILAANSPPPVSSSSTAGSPGANAAASTSAGS
TQPSGRCYFYVFDYQTKDGDYPQRMGTVHGEDLPYIFGAPLVDGFSHFPQ
NYTKSETALSEAVMIFWTNFARTGNPNEHHRQDSSLPVSKERNRFRSITW
ENYDPLHQKYLEIGMKPRIKNHFRAHQLSIWLRLIPELHRAGMEDVIARH
NLFRNHDDMDLYEGPVKPDPFGISTAAGASGSSSSSSSSSRLLLVDEQLM
MKKGRGLNGSAYLNGILG

no DNA




References
    Title: Drosophila Neuroligin 4 Regulates Sleep through Modulating GABA Transmission
    Li Y, Zhou Z, Zhang X, Tong H, Li P, Zhang ZC, Jia Z, Xie W, Han J
    Ref: Journal of Neuroscience, 33:15545, 2013 : PubMed

            

    Title: The genome sequence of Drosophila melanogaster
    Adams MD, Celniker SE, Holt RA, Evans CA, Gocayne JD, Amanatides PG, Scherer SE, Li PW, Hoskins RA and Venter JC <185 more author(s)>
    Ref: Science, 287:2185, 2000 : PubMed

            


Other Papers


Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
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