Gene_locus Report for: drops-q291e8 Drosophila pseudoobscura (Fruit fly) ga22078-pa (fragment)
Relationship
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) cellular organisms: N E > Eukaryota: N E > Opisthokonta: N E > Metazoa: N E > Eumetazoa: N E > Bilateria: N E > Protostomia: N E > Ecdysozoa: N E > Panarthropoda: N E > Arthropoda: N E > Mandibulata: N E > Pancrustacea: N E > Hexapoda: N E > Insecta: N E > Dicondylia: N E > Pterygota: N E > Neoptera: N E > Holometabola: N E > Diptera: N E > Brachycera: N E > Muscomorpha: N E > Eremoneura: N E > Cyclorrhapha: N E > Schizophora: N E > Acalyptratae: N E > Ephydroidea: N E > Drosophilidae: N E > Drosophilinae: N E > Drosophilini: N E > Drosophila [fruit fly, genus]: N E > Sophophora: N E > obscura group: N E > pseudoobscura subgroup: N E > Drosophila pseudoobscura: N E A85-EsteraseD-FGH :
drops-CG4390 Drosophila pseudoobscura (Fruit fly) cg4390-pa .
ABHD11-Acetyl_transferase :
drops-q29gb0 Drosophila pseudoobscura (Fruit fly) ga15213-pa (fragment) .
ABHD12-PHARC :
drops-q28wj5 Drosophila pseudoobscura (Fruit fly) ga13500-pa (fragment) .
ABHD16 :
drops-q29d59 Drosophila pseudoobscura (Fruit fly) ga12040-pa (fragment) .
abh_upf0017 :
drops-q29l31 Drosophila pseudoobscura (Fruit fly) ga17475-pa (fragment) .
ACHE :
drops-ACHE Drosophila pseudoobscura (Fruit fly) ga14718-pa .
Acidic_Lipase :
drops-q28wt8 Drosophila pseudoobscura (Fruit fly) ga10982-pa (fragment) ,
drops-q29a22 Drosophila pseudoobscura (Fruit fly) ga21347-pa (fragment) ,
drops-q29ay7 Drosophila pseudoobscura (Fruit fly) ga14975-pa (fragment) ,
drops-q29ay8 Drosophila pseudoobscura (Fruit fly) ga11091-pa (fragment) ,
drops-q29ay9 Drosophila pseudoobscura (Fruit fly) ga19835-pa (fragment) ,
drops-q29dc9 Drosophila pseudoobscura (Fruit fly) ga19240-pa (fragment) ,
drops-q29kr3 Drosophila pseudoobscura (Fruit fly) ga16540-pa (fragment) ,
drops-q29kr5 Drosophila pseudoobscura (Fruit fly) ga20265-pa (fragment) ,
drops-q29kr8 Drosophila pseudoobscura (Fruit fly) ga14881-pa (fragment) ,
drops-q29kr9 Drosophila pseudoobscura (Fruit fly) ga19361-pa (fragment) ,
drops-q29m66 Drosophila pseudoobscura (Fruit fly) ga15458-pa (fragment) ,
drops-q290z8 Drosophila pseudoobscura (Fruit fly) ga20819-pa (fragment) ,
drops-q296x1 Drosophila pseudoobscura (Fruit fly) ga15999-pa (fragment) ,
drops-q296x2 Drosophila pseudoobscura (Fruit fly) ga16001-pa (fragment) .
Carboxypeptidase_S10 :
drops-q29dw3 Drosophila pseudoobscura (Fruit fly) ga17392-pa (fragment) ,
drops-q29dw4 Drosophila pseudoobscura (Fruit fly) ga16937-pa (fragment) ,
drops-q29kd5 Drosophila pseudoobscura (Fruit fly) ga16504-pa (fragment) ,
drops-q29kd6 Drosophila pseudoobscura (Fruit fly) ga16505-pa (fragment) .
Carb_B_Arthropoda :
drops-est5a Drosophila pseudoobscura (Fruit fly) gene for esterase 5A ,
drops-est5b Drosophila pseudoobscura (Fruit fly) esterase 5B and esterase 5C ,
drops-est5c Drosophila pseudoobscura protein for esterase C (Fruit fly) (hydrolase 5c) (carboxylesterase-5c) ,
drops-q29bq2 Drosophila pseudoobscura (Fruit fly) ga10132-pa ,
drops-q29dd7 Drosophila pseudoobscura (Fruit fly) ga20417-pa ,
drops-q29g93 Drosophila pseudoobscura (Fruit fly) ga19574-pa (fragment) ,
drops-q29na5 Drosophila pseudoobscura (Fruit fly) ga17724-pa (fragment) ,
drops-q290i1 Drosophila pseudoobscura (Fruit fly) ga19300-pa (fragment) ,
drops-q293y7 Drosophila pseudoobscura (Fruit fly) ga18409-pa (fragment) ,
drops-q294n6 Drosophila pseudoobscura (Fruit fly) ga11698-pa ,
drops-q294n7 Drosophila pseudoobscura (Fruit fly) ga10578-pa (fragment) ,
drops-q294n9 Drosophila pseudoobscura (Fruit fly) ga10746-pa (fragment) ,
drops-q294p0 Drosophila pseudoobscura (Fruit fly) ga10768-pa (fragment) ,
drops-q294p1 Drosophila pseudoobscura (Fruit fly) ga10843-pa (fragment) ,
drops-q294p3 Drosophila pseudoobscura (Fruit fly) ga10886-pa (fragment) ,
drops-q294p4 Drosophila pseudoobscura (Fruit fly) ga10907-pa .
CGI-58_ABHD5_ABHD4 :
drops-q292g6 Drosophila pseudoobscura (Fruit fly) ga15096-pa (fragment) .
DPP4N_Peptidase_S9 :
drops-q2m169 Drosophila pseudoobscura (Fruit fly) ga16711-pa (fragment) ,
drops-q29js9 Drosophila pseudoobscura (Fruit fly) ga10914-pa (fragment) ,
drops-q29pk4 Drosophila pseudoobscura (Fruit fly) ga10719-pa (fragment) ,
drops-q295h3 Drosophila pseudoobscura (Fruit fly) ga17656-pa (fragment) .
Duf_829 :
drops-q29k25 Drosophila pseudoobscura (Fruit fly) GA20925-PA ,
drops-q291y3 Drosophila pseudoobscura (Fruit fly) GA15913-PA .
Epoxide_hydrolase :
drops-q290v8 Drosophila pseudoobscura (Fruit fly) ga13496-pa (fragment) ,
drops-q290v9 Drosophila pseudoobscura (Fruit fly) ga13493-pa (fragment) ,
drops-q290w0 Drosophila pseudoobscura (Fruit fly) ga13492-pa (fragment) .
FSH1 :
drops-q29br3 Drosophila pseudoobscura (Fruit fly) ga18864-pa (fragment) LOVG .
Gliotactin :
drops-q29ke5 Drosophila pseudoobscura (Fruit fly) ga17762-pa (fragment) .
Glutactin :
drops-q29jt5 Drosophila pseudoobscura (Fruit fly) ga21671-pa (fragment) ,
drops-q29jt6 Drosophila pseudoobscura (Fruit fly) ga21673-pa (fragment) .
Hormone-sensitive_lipase_like :
drops-q28zi3 Drosophila pseudoobscura (Fruit fly) ga10731-pa (fragment) .
Insect_lipase :
drops-q2m0u9 Drosophila pseudoobscura (Fruit fly) ga19044-pa (fragment) ,
drops-q29ad8 Drosophila pseudoobscura (Fruit fly) ga19482-pa (fragment) ,
drops-q29ad9 Drosophila pseudoobscura (Fruit fly) ga19487-pa (fragment) ,
drops-q29ae0 Drosophila pseudoobscura (Fruit fly) ga19495-pa (fragment) ,
drops-q29ae1 Drosophila pseudoobscura (Fruit fly) ga19496-pa (fragment) ,
drops-q29dp4 Drosophila pseudoobscura (Fruit fly) ga10269-pa (fragment) ,
drops-q29e16 Drosophila pseudoobscura (Fruit fly) ga10083-pa (fragment) ,
drops-q29fi0 Drosophila pseudoobscura (Fruit fly) ga10123-pa (fragment) ,
drops-q29fw9 Drosophila pseudoobscura (Fruit fly) ga15172-pa (fragment) ,
drops-q29hd2 Drosophila pseudoobscura (Fruit fly) ga14861-pa (fragment) ,
drops-q29hu2 Drosophila pseudoobscura (Fruit fly) ga18700-pa (fragment) ,
drops-q29hu3 Drosophila pseudoobscura (Fruit fly) ga14858-pa (fragment) ,
drops-q29kq9 Drosophila pseudoobscura (Fruit fly) ga19587-pa (fragment) ,
drops-q29kz0 Drosophila pseudoobscura (Fruit fly) ga16393-pa (fragment) ,
drops-q29kz1 Drosophila pseudoobscura (Fruit fly) ga15027-pa (fragment) ,
drops-q29lv0 Drosophila pseudoobscura (Fruit fly) ga20301-pa (fragment) ,
drops-q29mj7 Drosophila pseudoobscura (Fruit fly) ga18069-pa (fragment) ,
drops-q29mv2 Drosophila pseudoobscura (Fruit fly) ga12169-pa (fragment) ,
drops-q29n87 Drosophila pseudoobscura (Fruit fly) ga14444-pa (fragment) ,
drops-q29pe4 Drosophila pseudoobscura (Fruit fly) ga19771-pa (fragment) ,
drops-q290k3 Drosophila pseudoobscura (Fruit fly) ga19620-pa (fragment) ,
drops-q294u9 Drosophila pseudoobscura (Fruit fly) ga18570-pa (fragment) ,
drops-q296h2 Drosophila pseudoobscura (Fruit fly) ga18274-pa (fragment) .
Juvenile_hormone_esterase :
drops-q28wt2 Drosophila pseudoobscura (Fruit fly) ga21068-pa (fragment) .
Lipase_3 :
drops-b5dmp7 Drosophila pseudoobscura (Fruit fly) ga17341-pa (fragment) .
LYsophospholipase_carboxylesterase :
drops-q2lz68 Drosophila pseudoobscura (Fruit fly) ga15093-pa (fragment) ,
drops-q297h5 Drosophila pseudoobscura (Fruit fly) ga19689-pa (fragment) .
Neuroligin :
drops-q29jy5 Drosophila pseudoobscura (Fruit fly) ga12514-pa (fragment) ,
drops-q294n3 Drosophila pseudoobscura (Fruit fly) ga16044-pa (fragment) .
Neurotactin :
drops-nrtac Drosophila pseudoobscura (Fruit fly) ga21977-pa (fragment) .
OtherNon-catalytic_C :
drops-q28zz1 Drosophila pseudoobscura (Fruit fly) ga10254-pa (fragment) ,
drops-q29lf8 Drosophila pseudoobscura (Fruit fly) ga18850-pa (fragment) ,
drops-q29na6 Drosophila pseudoobscura (Fruit fly) ga18147-pa (fragment) ,
drops-q291d5 Drosophila pseudoobscura (Fruit fly) ga11870-pa .
Palmitoyl-protein_thioesterase :
drops-q29gs6 Drosophila pseudoobscura (Fruit fly) ga11401-pa (fragment) ,
drops-q29m27 Drosophila pseudoobscura (Fruit fly) ga18478-pa (fragment) .
Pancreatic_lipase :
drops-q29h54 Drosophila pseudoobscura (Fruit fly) ga19265-pa (fragment) .
PC-sterol_acyltransferase :
drops-q29ks6 Drosophila pseudoobscura (Fruit fly) ga15103-pa (fragment) .
PGAP1 :
drops-q29i09 Drosophila pseudoobscura (Fruit fly) ga16331-pa (fragment) .
PPase_methylesterase_euk :
drops-q29f66 Drosophila pseudoobscura (Fruit fly) ga18635-pa (fragment) .
Prolylcarboxypeptidase :
drops-q29f35 Drosophila pseudoobscura (Fruit fly) ga22150-pa (fragment) ,
drops-q29mx0 Drosophila pseudoobscura (Fruit fly) ga15377-pa (fragment) ,
drops-q293n1 Drosophila pseudoobscura Drosophila persimilis (Fruit fly) ga11106-pa (fragment) ,
drops-q293n4 Drosophila pseudoobscura, Drosophila persimilis, (Fruit fly) ga17653-pa (fragment) ,
drops-q293n5 Drosophila pseudoobscura Drosophila persimilis (Fruit fly) ga14959-pa (fragment) ,
drops-q293n6 Drosophila pseudoobscura Drosophila persimilis (Fruit fly) ga17650-pa (fragment) .
SERHL :
drops-q2lyp3 Drosophila pseudoobscura (Fruit fly) ga20494-pa (fragment) ,
drops-q2lyp4 Drosophila pseudoobscura (Fruit fly) ga10906-pa (fragment) ,
drops-q2lyu3 Drosophila pseudoobscura (Fruit fly) ga19073-pa (fragment) ,
drops-q29m81 Drosophila pseudoobscura (Fruit fly) ga17793-pa (kraken protein)(fragment) .
Thioesterase :
drops-q29m07 Drosophila pseudoobscura (Fruit fly) ga17498-pa (fragment) ,
drops-q29m08 Drosophila pseudoobscura (Fruit fly) ga17497-pa (fragment) .
Valacyclovir-hydrolase :
drops-q298u8 Drosophila pseudoobscura (Fruit fly) ga18833-pa (fragment) .
Yolk-Protein_dipter :
drops-q29fw0 Drosophila pseudoobscura (Fruit fly) ga15558-pa (fragment) ,
drops-q29hv0 Drosophila pseudoobscura (Fruit fly) ga10778-pa (fragment) Warning: This entry is a compilation of different species or line or strain with more than 90% amino acid identity. You can
retrieve all strain data
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) Drosophila pseudoobscura pseudoobscura:
N ,
E .
Molecular evidence
Database
No mutation No structure No kinetic No Substrate No inhibitor
Sequence
Graphical view for this peptide sequence: drops-q291e8 Colored MSA for Carb_B_Arthropoda (raw)
MTVLDDGPGGTENCDKSAAASTAQSFFEEQEQSWCPKERSERKRVVSGLQ
QFKISDKSAAALAAQNFFEERERSWCPKERSERKRVIVGLSNRAGYVIWG
SKMQRTGGKSILVRLYSSMKVKIPVKQGIVVGQQQKLPSGLEYNSFLGVP
YAEPPVGNLRFRSPVPQERFEEHELDCSKERDVSHQRDPFTTEVAGSENC
LFLNVYAPKGKRSSSPLPVMVWIHGGGFFFGNGNSDFHFPAKLMEQDVIV
VTLNYRLGALGFLTLPEEGIHGNMGLKDQRMALQWLQDNIASFNGDPNNV
TLFGESAGGASVHLHTYARHANKLFHKAIMQSGTGNMEWVFQPDAAFKTR
RLAELLGGGDFGSNTKALLEFLQSEKVKPIGILANTMKVLTADERRRHLP
FAFKPVVEEASSPDSFIDQNILDLMHKRDHVGKMPMIMGYNSAEGLAMIV
RAKTKLEEYEQDLARTVPRNLVPDPQAPEAQEAAADIRNFYFDGQALTKK
HLDSMVDLFSDYHFSMDLQIAAEIHANCQTQSPLYFYRLDYVGGRNLYKT
IFQNENLRGVAHADDICYLFQMAGDDSPMQKDDALVSERICQMWANFARH
GIPSDSWKPVQKALPGQAMQLDCLLIDRECKMQKNPDGDRMDFWRSMYRR
YSPQCSVRAKL
Legend
This sequence has been compared to family alignement (MSA) red => minority aminoacid blue => majority aminoacid color intensity => conservation rate title => sequence position(MSA position)aminoacid rate Catalytic site Catalytic site in the MSA
M T V L D D G P G G T E N C D K S A A A S T A Q S F F E E Q E Q S W C P K E R S E R K R V V S G L Q Q F K I S D K S A A A L A A Q N F F E E R E R S W C P K E R S E R K R V I V G L S N R A G Y V I W G S K M Q R T G G K S I L V R L Y S S M K V K I P V K Q G I V V G Q Q Q K L P S G L E Y N S F L G V P Y A E P P V G N L R F R S P V P Q E R F E E H E L D C S K E R D V S H Q R D P F T T E V A G S E N C L F L N V Y A P K G K R S S S P L P V M V W I H G G G F F F G N G N S D F H F P A K L M E Q D V I V V T L N Y R L G A L G F L T L P E E G I H G N M G L K D Q R M A L Q W L Q D N I A S F N G D P N N V T L F G E S A G G A S V H L H T Y A R H A N K L F H K A I M Q S G T G N M E W V F Q P D A A F K T R R L A E L L G G G D F G S N T K A L L E F L Q S E K V K P I G I L A N T M K V L T A D E R R R H L P F A F K P V V E E A S S P D S F I D Q N I L D L M H K R D H V G K M P M I M G Y N S A E G L A M I V R A K T K L E E Y E Q D L A R T V P R N L V P D P Q A P E A Q E A A A D I R N F Y F D G Q A L T K K H L D S M V D L F S D Y H F S M D L Q I A A E I H A N C Q T Q S P L Y F Y R L D Y V G G R N L Y K T I F Q N E N L R G V A H A D D I C Y L F Q M A G D D S P M Q K D D A L V S E R I C Q M W A N F A R H G I P S D S W K P V Q K A L P G Q A M Q L D C L L I D R E C K M Q K N P D G D R M D F W R S M Y R R Y S P Q C S V R A K L
References
Title: Evolution of genes and genomes on the Drosophila phylogenyClark AG , Eisen MB , Smith DR , Bergman CM , Oliver B , Markow TA , Kaufman TC , Kellis M , Gelbart W and MacCallum I <405 more author(s)> Clark AG , Eisen MB , Smith DR , Bergman CM , Oliver B , Markow TA , Kaufman TC , Kellis M , Gelbart W , Iyer VN , Pollard DA , Sackton TB , Larracuente AM , Singh ND , Abad JP , Abt DN , Adryan B , Aguade M , Akashi H , Anderson WW , Aquadro CF , Ardell DH , Arguello R , Artieri CG , Barbash DA , Barker D , Barsanti P , Batterham P , Batzoglou S , Begun D , Bhutkar A , Blanco E , Bosak SA , Bradley RK , Brand AD , Brent MR , Brooks AN , Brown RH , Butlin RK , Caggese C , Calvi BR , Bernardo de Carvalho A , Caspi A , Castrezana S , Celniker SE , Chang JL , Chapple C , Chatterji S , Chinwalla A , Civetta A , Clifton SW , Comeron JM , Costello JC , Coyne JA , Daub J , David RG , Delcher AL , Delehaunty K , Do CB , Ebling H , Edwards K , Eickbush T , Evans JD , Filipski A , Findeiss S , Freyhult E , Fulton L , Fulton R , Garcia AC , Gardiner A , Garfield DA , Garvin BE , Gibson G , Gilbert D , Gnerre S , Godfrey J , Good R , Gotea V , Gravely B , Greenberg AJ , Griffiths-Jones S , Gross S , Guigo R , Gustafson EA , Haerty W , Hahn MW , Halligan DL , Halpern AL , Halter GM , Han MV , Heger A , Hillier L , Hinrichs AS , Holmes I , Hoskins RA , Hubisz MJ , Hultmark D , Huntley MA , Jaffe DB , Jagadeeshan S , Jeck WR , Johnson J , Jones CD , Jordan WC , Karpen GH , Kataoka E , Keightley PD , Kheradpour P , Kirkness EF , Koerich LB , Kristiansen K , Kudrna D , Kulathinal RJ , Kumar S , Kwok R , Lander E , Langley CH , Lapoint R , Lazzaro BP , Lee SJ , Levesque L , Li R , Lin CF , Lin MF , Lindblad-Toh K , Llopart A , Long M , Low L , Lozovsky E , Lu J , Luo M , Machado CA , Makalowski W , Marzo M , Matsuda M , Matzkin L , McAllister B , McBride CS , McKernan B , McKernan K , Mendez-Lago M , Minx P , Mollenhauer MU , Montooth K , Mount SM , Mu X , Myers E , Negre B , Newfeld S , Nielsen R , Noor MA , O'Grady P , Pachter L , Papaceit M , Parisi MJ , Parisi M , Parts L , Pedersen JS , Pesole G , Phillippy AM , Ponting CP , Pop M , Porcelli D , Powell JR , Prohaska S , Pruitt K , Puig M , Quesneville H , Ram KR , Rand D , Rasmussen MD , Reed LK , Reenan R , Reily A , Remington KA , Rieger TT , Ritchie MG , Robin C , Rogers YH , Rohde C , Rozas J , Rubenfield MJ , Ruiz A , Russo S , Salzberg SL , Sanchez-Gracia A , Saranga DJ , Sato H , Schaeffer SW , Schatz MC , Schlenke T , Schwartz R , Segarra C , Singh RS , Sirot L , Sirota M , Sisneros NB , Smith CD , Smith TF , Spieth J , Stage DE , Stark A , Stephan W , Strausberg RL , Strempel S , Sturgill D , Sutton G , Sutton GG , Tao W , Teichmann S , Tobari YN , Tomimura Y , Tsolas JM , Valente VL , Venter E , Venter JC , Vicario S , Vieira FG , Vilella AJ , Villasante A , Walenz B , Wang J , Wasserman M , Watts T , Wilson D , Wilson RK , Wing RA , Wolfner MF , Wong A , Wong GK , Wu CI , Wu G , Yamamoto D , Yang HP , Yang SP , Yorke JA , Yoshida K , Zdobnov E , Zhang P , Zhang Y , Zimin AV , Baldwin J , Abdouelleil A , Abdulkadir J , Abebe A , Abera B , Abreu J , Acer SC , Aftuck L , Alexander A , An P , Anderson E , Anderson S , Arachi H , Azer M , Bachantsang P , Barry A , Bayul T , Berlin A , Bessette D , Bloom T , Blye J , Boguslavskiy L , Bonnet C , Boukhgalter B , Bourzgui I , Brown A , Cahill P , Channer S , Cheshatsang Y , Chuda L , Citroen M , Collymore A , Cooke P , Costello M , D'Aco K , Daza R , De Haan G , DeGray S , DeMaso C , Dhargay N , Dooley K , Dooley E , Doricent M , Dorje P , Dorjee K , Dupes A , Elong R , Falk J , Farina A , Faro S , Ferguson D , Fisher S , Foley CD , Franke A , Friedrich D , Gadbois L , Gearin G , Gearin CR , Giannoukos G , Goode T , Graham J , Grandbois E , Grewal S , Gyaltsen K , Hafez N , Hagos B , Hall J , Henson C , Hollinger A , Honan T , Huard MD , Hughes L , Hurhula B , Husby ME , Kamat A , Kanga B , Kashin S , Khazanovich D , Kisner P , Lance K , Lara M , Lee W , Lennon N , Letendre F , LeVine R , Lipovsky A , Liu X , Liu J , Liu S , Lokyitsang T , Lokyitsang Y , Lubonja R , Lui A , Macdonald P , Magnisalis V , Maru K , Matthews C , McCusker W , McDonough S , Mehta T , Meldrim J , Meneus L , Mihai O , Mihalev A , Mihova T , Mittelman R , Mlenga V , Montmayeur A , Mulrain L , Navidi A , Naylor J , Negash T , Nguyen T , Nguyen N , Nicol R , Norbu C , Norbu N , Novod N , O'Neill B , Osman S , Markiewicz E , Oyono OL , Patti C , Phunkhang P , Pierre F , Priest M , Raghuraman S , Rege F , Reyes R , Rise C , Rogov P , Ross K , Ryan E , Settipalli S , Shea T , Sherpa N , Shi L , Shih D , Sparrow T , Spaulding J , Stalker J , Stange-Thomann N , Stavropoulos S , Stone C , Strader C , Tesfaye S , Thomson T , Thoulutsang Y , Thoulutsang D , Topham K , Topping I , Tsamla T , Vassiliev H , Vo A , Wangchuk T , Wangdi T , Weiand M , Wilkinson J , Wilson A , Yadav S , Young G , Yu Q , Zembek L , Zhong D , Zimmer A , Zwirko Z , Alvarez P , Brockman W , Butler J , Chin C , Grabherr M , Kleber M , Mauceli E , MacCallum I (- 405) Ref: Nature, 450 :203, 2007 : PubMed Abstract ESTHER: Clark_2007_Nature_450_203 PubMedSearch: Clark 2007 Nature 450 203 PubMedID: 17994087 Gene_locus related to this paper: droan-ACHE ,
droan-b3lx10 ,
droan-b3lx75 ,
droan-b3lxv7 ,
droan-b3ly87 ,
droan-b3lyh4 ,
droan-b3lyh5 ,
droan-b3lyh7 ,
droan-b3lyh9 ,
droan-b3lyi0 ,
droan-b3lyi2 ,
droan-b3lyi3 ,
droan-b3lyi4 ,
droan-b3lyj8 ,
droan-b3lyj9 ,
droan-b3lyx4 ,
droan-b3lyx5 ,
droan-b3lyx6 ,
droan-b3lyx7 ,
droan-b3lyx9 ,
droan-b3lz72 ,
droan-b3m1x3 ,
droan-b3m2d4 ,
droan-b3m3d9 ,
droan-b3m4e3 ,
droan-b3m5w1 ,
droan-b3m6i7 ,
droan-b3m7v2 ,
droan-b3m9a5 ,
droan-b3m9f4 ,
droan-b3m9p3 ,
droan-b3m254 ,
droan-b3m259 ,
droan-b3m260 ,
droan-b3m262 ,
droan-b3m524 ,
droan-b3m635 ,
droan-b3m845 ,
droan-b3m846 ,
droan-b3md01 ,
droan-b3mdh7 ,
droan-b3mdm6 ,
droan-b3mdw8 ,
droan-b3mee1 ,
droan-b3mf47 ,
droan-b3mf48 ,
droan-b3mg94 ,
droan-b3mgk2 ,
droan-b3mgn6 ,
droan-b3mii3 ,
droan-b3mjk2 ,
droan-b3mjk3 ,
droan-b3mjk4 ,
droan-b3mjk5 ,
droan-b3mjl2 ,
droan-b3mjl4 ,
droan-b3mjl7 ,
droan-b3mjl9 ,
droan-b3mjm8 ,
droan-b3mjm9 ,
droan-b3mjs6 ,
droan-b3mkr0 ,
droan-b3ml20 ,
droan-b3mly4 ,
droan-b3mly5 ,
droan-b3mly6 ,
droan-b3mmm8 ,
droan-b3mnb5 ,
droan-b3mny9 ,
droan-b3mtj5 ,
droan-b3muw4 ,
droan-b3muw8 ,
droan-b3n0e7 ,
droan-b3n2j7 ,
droan-b3n247 ,
droan-c5idb2 ,
droer-ACHE ,
droer-b3n5c7 ,
droer-b3n5d0 ,
droer-b3n5d8 ,
droer-b3n5d9 ,
droer-b3n5t7 ,
droer-b3n5y4 ,
droer-b3n7d2 ,
droer-b3n7d3 ,
droer-b3n7d4 ,
droer-b3n7k8 ,
droer-b3n8e4 ,
droer-b3n8f7 ,
droer-b3n8f8 ,
droer-b3n9e1 ,
droer-b3n319 ,
droer-b3n547 ,
droer-b3n549 ,
droer-b3n558 ,
droer-b3n560 ,
droer-b3n577 ,
droer-b3n612 ,
droer-b3nar5 ,
droer-b3nb91 ,
droer-b3nct9 ,
droer-b3nd53 ,
droer-b3ndh9 ,
droer-b3ndq8 ,
droer-b3ne66 ,
droer-b3ne67 ,
droer-b3ne97 ,
droer-b3nfk3 ,
droer-b3nfq9 ,
droer-b3nim7 ,
droer-b3nkn2 ,
droer-b3nm11 ,
droer-b3nmh4 ,
droer-b3nmy2 ,
droer-b3npx2 ,
droer-b3npx3 ,
droer-b3nq76 ,
droer-b3nqg9 ,
droer-b3nqm8 ,
droer-b3nr28 ,
droer-b3nrd3 ,
droer-b3nst4 ,
droer-b3nwa7 ,
droer-b3nyp5.1 ,
droer-b3nyp5.2 ,
droer-b3nyp6 ,
droer-b3nyp7 ,
droer-b3nyp8 ,
droer-b3nyp9 ,
droer-b3nyq3 ,
droer-b3nz06 ,
droer-b3nz14 ,
droer-b3nzj0 ,
droer-b3p0c0 ,
droer-b3p0c1 ,
droer-b3p0c2 ,
droer-b3p2x6 ,
droer-b3p2x7 ,
droer-b3p2x9 ,
droer-b3p2y1 ,
droer-b3p2y2 ,
droer-b3p6d4 ,
droer-b3p6d5 ,
droer-b3p6w3 ,
droer-b3p7b4 ,
droer-b3p7h9 ,
droer-b3p152 ,
droer-b3p486 ,
droer-b3p487 ,
droer-b3p488 ,
droer-b3p489 ,
droer-EST6 ,
droer-q670j5 ,
drogr-ACHE ,
drogr-b4iwp3 ,
drogr-b4iww3 ,
drogr-b4iwy3 ,
drogr-b4ixf7 ,
drogr-b4ixh4 ,
drogr-b4iyz5 ,
drogr-b4j2s2 ,
drogr-b4j2u8 ,
drogr-b4j3u1 ,
drogr-b4j3v3 ,
drogr-b4j4g7 ,
drogr-b4j4x9 ,
drogr-b4j6e6 ,
drogr-b4j9c9 ,
drogr-b4j9y4 ,
drogr-b4j156 ,
drogr-b4j384 ,
drogr-b4j605 ,
drogr-b4j685 ,
drogr-b4ja76 ,
drogr-b4jay5 ,
drogr-b4jcf0 ,
drogr-b4jcf1 ,
drogr-b4jdg6 ,
drogr-b4jdg7 ,
drogr-b4jdh6 ,
drogr-b4jdz1 ,
drogr-b4jdz2 ,
drogr-b4jdz4 ,
drogr-b4je66 ,
drogr-b4je79 ,
drogr-b4je82 ,
drogr-b4je88 ,
drogr-b4je89 ,
drogr-b4je90 ,
drogr-b4je91 ,
drogr-b4jf76 ,
drogr-b4jf79 ,
drogr-b4jf80 ,
drogr-b4jf81 ,
drogr-b4jf82 ,
drogr-b4jf83 ,
drogr-b4jf84 ,
drogr-b4jf85 ,
drogr-b4jf87 ,
drogr-b4jf91 ,
drogr-b4jf92 ,
drogr-b4jg66 ,
drogr-b4jgh0 ,
drogr-b4jgh1 ,
drogr-b4jgr9 ,
drogr-b4ji67 ,
drogr-b4jls2 ,
drogr-b4jnh9 ,
drogr-b4jpc6 ,
drogr-b4jpq3 ,
drogr-b4jpx9 ,
drogr-b4jql2 ,
drogr-b4jrh5 ,
drogr-b4jsb2 ,
drogr-b4jth3 ,
drogr-b4jti1 ,
drogr-b4jul5 ,
drogr-b4jur4 ,
drogr-b4jvh3 ,
drogr-b4jz00 ,
drogr-b4jz03 ,
drogr-b4jz04 ,
drogr-b4jz05 ,
drogr-b4jzh2 ,
drogr-b4k0u2 ,
drogr-b4k2r1 ,
drogr-b4k234 ,
drogr-b4k235 ,
drome-BEM46 ,
drome-CG3734 ,
drome-CG9953 ,
drome-CG11626 ,
drome-GH02439 ,
dromo-ACHE ,
dromo-b4k6a7 ,
dromo-b4k6a8 ,
dromo-b4k6q8 ,
dromo-b4k6q9 ,
dromo-b4k6r1 ,
dromo-b4k6r3 ,
dromo-b4k6r4 ,
dromo-b4k6r5 ,
dromo-b4k6r6 ,
dromo-b4k6r7 ,
dromo-b4k6r8 ,
dromo-b4k6r9 ,
dromo-b4k6s0 ,
dromo-b4k6s1 ,
dromo-b4k6s2 ,
dromo-b4k9c7 ,
dromo-b4k9d3 ,
dromo-b4k571 ,
dromo-b4k721 ,
dromo-b4ka74 ,
dromo-b4ka89 ,
dromo-b4kaj4 ,
dromo-b4kc20 ,
dromo-b4kcl2 ,
dromo-b4kcl3 ,
dromo-b4kd55.1 ,
dromo-b4kd55.2 ,
dromo-b4kd56 ,
dromo-b4kd57 ,
dromo-b4kde1 ,
dromo-b4kdg2 ,
dromo-b4kdh4 ,
dromo-b4kdh5 ,
dromo-b4kdh6 ,
dromo-A0A0Q9XDF2 ,
dromo-b4kdh8.1 ,
dromo-b4kdh8.2 ,
dromo-b4kg04 ,
dromo-b4kg05 ,
dromo-b4kg06 ,
dromo-b4kg16 ,
dromo-b4kg44 ,
dromo-b4kg90 ,
dromo-b4kh20 ,
dromo-b4kh21 ,
dromo-b4kht7 ,
dromo-b4kid3 ,
dromo-b4kik0 ,
dromo-b4kjx0 ,
dromo-b4kki1 ,
dromo-b4kkp6 ,
dromo-b4kkp8 ,
dromo-b4kkq8 ,
dromo-b4kkr0 ,
dromo-b4kkr3 ,
dromo-b4kkr4 ,
dromo-b4kks0 ,
dromo-b4kks1 ,
dromo-b4kks2 ,
dromo-b4kla1 ,
dromo-b4klv8 ,
dromo-b4knt4 ,
dromo-b4kp08 ,
dromo-b4kp16 ,
dromo-b4kqa6 ,
dromo-b4kqa7 ,
dromo-b4kqa8 ,
dromo-b4kqh1 ,
dromo-b4kst4 ,
dromo-b4ksy6 ,
dromo-b4kt84 ,
dromo-b4ktf5 ,
dromo-b4ktf6 ,
dromo-b4kvl3 ,
dromo-b4kvw2 ,
dromo-b4kwv4 ,
dromo-b4kwv5 ,
dromo-b4kxz6 ,
dromo-b4ky12 ,
dromo-b4ky36 ,
dromo-b4ky44 ,
dromo-b4kzu7 ,
dromo-b4l0n8 ,
dromo-b4l4u5 ,
dromo-b4l6l9 ,
dromo-b4l084 ,
drope-ACHE ,
drope-b4g3s6 ,
drope-b4g4p7 ,
drope-b4g6v4 ,
drope-b4g8m0 ,
drope-b4g8n6 ,
drope-b4g8n7 ,
drope-b4g9p2 ,
drope-b4g815 ,
drope-b4g816 ,
drope-b4gat7 ,
drope-b4gav5 ,
drope-b4gb05 ,
drope-b4gc08 ,
drope-b4gcr3 ,
drope-b4gdk2 ,
drope-b4gdl9 ,
drope-b4gdv9 ,
drope-b4gei8 ,
drope-b4gei9 ,
drope-b4gej0 ,
drope-b4ghz9 ,
drope-b4gj62 ,
drope-b4gj64 ,
drope-b4gj74 ,
drope-b4gkf4 ,
drope-b4gkv2 ,
drope-b4gky9 ,
drope-b4gl76 ,
drope-b4glf3 ,
drope-b4gmt3 ,
drope-b4gmt7 ,
drope-b4gmt9 ,
drope-b4gmu2 ,
drope-b4gmu3 ,
drope-b4gmu4 ,
drope-b4gmu5 ,
drope-b4gmu6 ,
drope-b4gmu7 ,
drope-b4gmv1 ,
drope-b4gn08 ,
drope-b4gpa7 ,
drope-b4gq13 ,
drope-b4grh7 ,
drope-b4gsf9 ,
drope-b4gsw4 ,
drope-b4gsw5 ,
drope-b4gsx2 ,
drope-b4gsx7 ,
drope-b4gsy6 ,
drope-b4gsy7 ,
drope-b4guj8 ,
drope-b4gw36 ,
drope-b4gzc2 ,
drope-b4gzc6 ,
drope-b4gzc7 ,
drope-b4h4p9 ,
drope-b4h5l3 ,
drope-b4h6a0 ,
drope-b4h6a8 ,
drope-b4h6a9 ,
drope-b4h6b0 ,
drope-b4h7m7 ,
drope-b4h462 ,
drope-b4h601 ,
drope-b4h602 ,
drope-b4hay1 ,
drope-b4hb18 ,
drope-est5a ,
drope-est5b ,
drope-est5c ,
drops-ACHE ,
drops-b5dhd2 ,
drops-b5dk96 ,
drops-b5dpe3 ,
drops-b5drp9 ,
drops-b5dwa7 ,
drops-b5dwa8 ,
drops-b5dz85 ,
drops-b5dz86 ,
drops-est5a ,
drops-est5b ,
drops-q29bq2 ,
drops-q29dd7 ,
drops-q29ew0 ,
drops-q291d5 ,
drops-q291e8 ,
drops-q293n1 ,
drops-q293n4 ,
drops-q293n5 ,
drops-q293n6 ,
drops-q294n6 ,
drops-q294n7 ,
drops-q294n9 ,
drops-q294p4 ,
drose-b4he97 ,
drose-b4hfu2 ,
drose-b4hg54 ,
drose-b4hga0 ,
drose-b4hgu9 ,
drose-b4hgv0 ,
drose-b4hgv3 ,
drose-b4hgv4 ,
drose-b4hhm8 ,
drose-b4hhs6 ,
drose-b4hie4 ,
drose-b4him9 ,
drose-b4hk63 ,
drose-b4hkj5 ,
drose-b4hr07 ,
drose-b4hr81 ,
drose-b4hre7 ,
drose-b4hs13 ,
drose-b4hsj9 ,
drose-b4hsk0 ,
drose-b4hsm8 ,
drose-b4hvr5 ,
drose-b4hwr7 ,
drose-b4hwr8 ,
drose-b4hwr9 ,
drose-b4hws6 ,
drose-b4hws7 ,
drose-b4hwt0 ,
drose-b4hwt2 ,
drose-b4hwu1 ,
drose-b4hwu2 ,
drose-b4hxs9 ,
drose-b4hxu4 ,
drose-b4hxz1 ,
drose-b4hyp8 ,
drose-b4hyp9 ,
drose-b4hyq0 ,
drose-b4hyz4 ,
drose-b4hyz5 ,
drose-b4i1k8 ,
drose-b4i2f3 ,
drose-b4i2w5 ,
drose-b4i4u3 ,
drose-b4i4u7 ,
drose-b4i4u9 ,
drose-b4i4v0 ,
drose-b4i4v1 ,
drose-b4i4v4 ,
drose-b4i4v5 ,
drose-b4i4v6 ,
drose-b4i4v7 ,
drose-b4i4v8 ,
drose-b4i4w0 ,
drose-b4i7s6 ,
drose-b4i133 ,
drose-b4i857 ,
drose-b4iam7 ,
drose-b4iam9 ,
drose-b4iaq6 ,
drose-b4icf6 ,
drose-b4icf7 ,
drose-b4id80 ,
drose-b4ifc5 ,
drose-b4ihv9 ,
drose-b4iie9 ,
drose-b4ilj8 ,
drose-b4in13 ,
drose-b4inj9 ,
drosi-ACHE ,
drosi-aes04a ,
drosi-b4nsh8 ,
drosi-b4q3d7 ,
drosi-b4q4w5 ,
drosi-b4q4y7 ,
drosi-b4q6h6 ,
drosi-b4q7u2 ,
drosi-b4q7u3 ,
drosi-b4q9c6 ,
drosi-b4q9c7 ,
drosi-b4q9d3 ,
drosi-b4q9d4 ,
drosi-b4q9r0 ,
drosi-b4q9r1 ,
drosi-b4q9r3 ,
drosi-b4q9s2 ,
drosi-b4q9s3 ,
drosi-b4q429 ,
drosi-b4q530 ,
drosi-b4q734 ,
drosi-b4q782 ,
drosi-b4q783 ,
drosi-b4q942 ,
drosi-b4qet1 ,
drosi-b4qfv6 ,
drosi-b4qge5 ,
drosi-b4qgh5 ,
drosi-b4qgs5 ,
drosi-b4qhf3 ,
drosi-b4qhf4 ,
drosi-b4qhi5 ,
drosi-b4qjr2 ,
drosi-b4qjr3 ,
drosi-b4qjv6 ,
drosi-b4qk23 ,
drosi-b4qk51 ,
drosi-b4qlt1 ,
drosi-b4qlz9 ,
drosi-b4qmn9 ,
drosi-b4qrq7 ,
drosi-b4qs01 ,
drosi-b4qs57 ,
drosi-b4qs82 ,
drosi-b4qs83 ,
drosi-b4qs84 ,
drosi-b4qs85 ,
drosi-b4qs86 ,
drosi-b4qsq1 ,
drosi-b4quk6 ,
drosi-b4qvg5 ,
drosi-b4qvg6 ,
drosi-b4qzn2 ,
drosi-b4qzn3 ,
drosi-b4qzn5 ,
drosi-b4qzn7 ,
drosi-b4qzn8 ,
drosi-b4qzp2 ,
drosi-b4qzp3 ,
drosi-b4qzp4 ,
drosi-b4qzp5 ,
drosi-b4qzp6 ,
drosi-b4qzp7 ,
drosi-b4r1a4 ,
drosi-b4r025 ,
drosi-b4r207 ,
drosi-b4r662 ,
drosi-este6 ,
drosi-q670k8 ,
drovi-ACHE ,
drovi-b4lev2 ,
drovi-b4lf33 ,
drovi-b4lf51 ,
drovi-b4lg54 ,
drovi-b4lg72 ,
drovi-b4lgc6 ,
drovi-b4lgd5 ,
drovi-b4lgg0 ,
drovi-b4lgk5 ,
drovi-b4lgn2 ,
drovi-b4lh17 ,
drovi-b4lh18 ,
drovi-b4lk43 ,
drovi-b4ll59 ,
drovi-b4ll60 ,
drovi-b4llm5 ,
drovi-b4lln3 ,
drovi-b4lmk4 ,
drovi-b4lmp0 ,
drovi-b4lnr4 ,
drovi-b4lp47 ,
drovi-b4lpd0 ,
drovi-b4lps0 ,
drovi-b4lqc6 ,
drovi-b4lr00 ,
drovi-b4lrp6 ,
drovi-b4lrw2 ,
drovi-b4lse7 ,
drovi-b4lse9 ,
drovi-b4lsf0 ,
drovi-b4lsn0 ,
drovi-b4lsq5 ,
drovi-b4lt32 ,
drovi-b4ltr1 ,
drovi-b4lui7 ,
drovi-b4lui9 ,
drovi-b4luj8 ,
drovi-b4luk0 ,
drovi-b4luk3 ,
drovi-b4luk8 ,
drovi-b4luk9 ,
drovi-b4lul0 ,
drovi-b4lve2 ,
drovi-b4lxi9 ,
drovi-b4lxj8 ,
drovi-b4lyf3 ,
drovi-b4lyq2 ,
drovi-b4lyq3 ,
drovi-b4lz07 ,
drovi-b4lz13 ,
drovi-b4lz14 ,
drovi-b4lz15 ,
drovi-b4m0j7 ,
drovi-b4m0s0 ,
drovi-b4m2b6 ,
drovi-b4m4h7 ,
drovi-b4m4h8 ,
drovi-b4m4i0 ,
drovi-b4m4i2 ,
drovi-b4m4i3.A ,
drovi-b4m4i3.B ,
drovi-b4m4i4 ,
drovi-b4m4i5 ,
drovi-b4m4i6 ,
drovi-b4m4i7 ,
drovi-b4m4i8 ,
drovi-b4m4i9 ,
drovi-b4m4j2 ,
drovi-b4m5a0 ,
drovi-b4m5a1 ,
drovi-b4m5a2 ,
drovi-b4m6b9 ,
drovi-b4m7k9 ,
drovi-b4m9g9 ,
drovi-b4m9h0 ,
drovi-b4m564 ,
drovi-b4m599 ,
drovi-b4m918 ,
drovi-b4mb87 ,
drovi-b4mc71 ,
drovi-b4mfa4 ,
drowi-ACHE ,
drowi-b4mjb9 ,
drowi-b4mkt7 ,
drowi-b4mlc1 ,
drowi-b4mp68 ,
drowi-b4mqe9 ,
drowi-b4mqf0.2 ,
drowi-b4mqf1 ,
drowi-b4mqf3 ,
drowi-b4mqf4 ,
drowi-b4mqf5 ,
drowi-b4mqq6 ,
drowi-b4mrd1 ,
drowi-b4mrk3 ,
drowi-b4mtl5 ,
drowi-b4mug2 ,
drowi-b4muj8 ,
drowi-b4mv18 ,
drowi-b4mw32 ,
drowi-b4mw85 ,
drowi-b4mwp2 ,
drowi-b4mwp6 ,
drowi-b4mwq5 ,
drowi-b4mwr0 ,
drowi-b4mwr8 ,
drowi-b4mwr9 ,
drowi-b4mwt1 ,
drowi-b4mwz7 ,
drowi-b4mxn5 ,
drowi-b4my54 ,
drowi-b4myg1 ,
drowi-b4myh5 ,
drowi-b4n0d4 ,
drowi-b4n1a7 ,
drowi-b4n1c8 ,
drowi-b4n3s9 ,
drowi-b4n3x7 ,
drowi-b4n4x9 ,
drowi-b4n4y0 ,
drowi-b4n6m1 ,
drowi-b4n6n0 ,
drowi-b4n6n7 ,
drowi-b4n6u6 ,
drowi-b4n7s6 ,
drowi-b4n7s7 ,
drowi-b4n7s8 ,
drowi-b4n899.1 ,
drowi-b4n8a1 ,
drowi-b4n8a2 ,
drowi-b4n8a3 ,
drowi-b4n8a4 ,
drowi-b4n8a9 ,
drowi-b4n023 ,
drowi-b4n075 ,
drowi-b4n543 ,
drowi-b4n888 ,
drowi-b4n889 ,
drowi-b4n891 ,
drowi-b4n893 ,
drowi-b4n895 ,
drowi-b4n897 ,
drowi-b4n898 ,
drowi-b4n899.2 ,
drowi-b4nae3 ,
drowi-b4ner8 ,
drowi-b4ng76 ,
drowi-b4nga7 ,
drowi-b4ngb5 ,
drowi-b4nhz9 ,
drowi-b4nj18 ,
drowi-b4nj19 ,
drowi-b4nja7 ,
drowi-b4nja8 ,
drowi-b4nja9 ,
drowi-b4njk8 ,
drowi-b4nkc8 ,
drowi-b4nky0 ,
drowi-b4nl36 ,
drowi-b4nm27 ,
drowi-b4nn59 ,
drowi-b4nnc1 ,
drowi-b4nng1 ,
drowi-b4nng2 ,
droya-ACHE ,
droya-aes04 ,
droya-b4itg2 ,
droya-b4itg6 ,
droya-b4itu9 ,
droya-b4iuv4 ,
droya-b4iuv5 ,
droya-b4nxe6 ,
droya-b4nxg5 ,
droya-b4nxg6 ,
droya-b4nxg8 ,
droya-b4nxw4 ,
droya-b4ny57 ,
droya-b4ny58 ,
droya-b4ny86 ,
droya-b4nzz8 ,
droya-b4p0b5 ,
droya-b4p0q9 ,
droya-b4p0r0 ,
droya-b4p0r7 ,
droya-b4p0r8 ,
droya-b4p0r9 ,
droya-b4p0s0 ,
droya-b4p0s2 ,
droya-b4p0t0 ,
droya-b4p0t1 ,
droya-b4p3h4 ,
droya-b4p3x8 ,
droya-b4p5g8 ,
droya-b4p6c9 ,
droya-b4p6l9 ,
droya-b4p6r1 ,
droya-b4p6r2 ,
droya-b4p7u4 ,
droya-b4p8w7 ,
droya-b4p023 ,
droya-b4p241 ,
droya-b4p774 ,
droya-b4pat9 ,
droya-b4pbl1 ,
droya-b4pd22 ,
droya-b4pd70 ,
droya-b4pdm8 ,
droya-b4pet9 ,
droya-b4pff9 ,
droya-b4pga7 ,
droya-b4pgu0 ,
droya-b4pig3 ,
droya-b4pjt8 ,
droya-b4pka2 ,
droya-b4plh2 ,
droya-b4pma3 ,
droya-b4pmv3 ,
droya-b4pmv4 ,
droya-b4pmv5 ,
droya-b4pn92 ,
droya-b4pp65 ,
droya-b4ppc5 ,
droya-b4ppc6 ,
droya-b4ppc7 ,
droya-b4ppc8 ,
droya-b4pq03 ,
droya-b4prg6B ,
droya-b4prg9 ,
droya-b4prh3 ,
droya-b4prh4 ,
droya-b4prh6 ,
droya-b4prh7 ,
droya-b4psz8 ,
droya-b4psz9 ,
droya-b4pv22 ,
droya-b4q0g5 ,
droya-b4q246 ,
droya-EST6 ,
droya-q71d76 ,
drowi-b4n7m9 ,
drope-b4gkk1 ,
droer-b3n5s3 ,
drose-b4i1w5 ,
drowi-a0a0q9x0t3 ,
drogr-b4jvm7 ,
dromo-b4ku70 ,
drovi-b4mcn9 ,
drovi-b4lty2 ,
drogr-b4jdu1 ,
drovi-a0a0q9wiq8 ,
dromo-b4kf70 ,
drosi-b2zi86 ,
droya-b4p2y4 ,
drose-b2zic5 ,
droer-b3n895 Abstract
Comparative analysis of multiple genomes in a phylogenetic framework dramatically improves the precision and sensitivity of evolutionary inference, producing more robust results than single-genome analyses can provide. The genomes of 12 Drosophila species, ten of which are presented here for the first time (sechellia, simulans, yakuba, erecta, ananassae, persimilis, willistoni, mojavensis, virilis and grimshawi), illustrate how rates and patterns of sequence divergence across taxa can illuminate evolutionary processes on a genomic scale. These genome sequences augment the formidable genetic tools that have made Drosophila melanogaster a pre-eminent model for animal genetics, and will further catalyse fundamental research on mechanisms of development, cell biology, genetics, disease, neurobiology, behaviour, physiology and evolution. Despite remarkable similarities among these Drosophila species, we identified many putatively non-neutral changes in protein-coding genes, non-coding RNA genes, and cis-regulatory regions. These may prove to underlie differences in the ecology and behaviour of these diverse species.
Title: Comparative genome sequencing of Drosophila pseudoobscura: chromosomal, gene, and cis-element evolutionRichards S , Liu Y , Bettencourt BR , Hradecky P , Letovsky S , Nielsen R , Thornton K , Hubisz MJ , Chen R and Gibbs RA <42 more author(s)> Richards S , Liu Y , Bettencourt BR , Hradecky P , Letovsky S , Nielsen R , Thornton K , Hubisz MJ , Chen R , Meisel RP , Couronne O , Hua S , Smith MA , Zhang P , Liu J , Bussemaker HJ , van Batenburg MF , Howells SL , Scherer SE , Sodergren E , Matthews BB , Crosby MA , Schroeder AJ , Ortiz-Barrientos D , Rives CM , Metzker ML , Muzny DM , Scott G , Steffen D , Wheeler DA , Worley KC , Havlak P , Durbin KJ , Egan A , Gill R , Hume J , Morgan MB , Miner G , Hamilton C , Huang Y , Waldron L , Verduzco D , Clerc-Blankenburg KP , Dubchak I , Noor MA , Anderson W , White KP , Clark AG , Schaeffer SW , Gelbart W , Weinstock GM , Gibbs RA (- 42) Ref: Genome Res, 15 :1, 2005 : PubMed Abstract ESTHER: Richards_2005_Genome.Res_15_1 PubMedSearch: Richards 2005 Genome.Res 15 1 PubMedID: 15632085 Gene_locus related to this paper: drome-BEM46 ,
drome-GH02439 ,
drops-ACHE ,
drops-b5dhd2 ,
drops-b5di70 ,
drops-b5djn7 ,
drops-b5dk96 ,
drops-b5dm12 ,
drops-b5dpe3 ,
drops-b5drp9 ,
drops-b5du62 ,
drops-b5dud8 ,
drops-b5dwa7 ,
drops-b5dwa8 ,
drops-b5dy09 ,
drops-b5dz85 ,
drops-b5dz86 ,
drops-b5e1k7 ,
drops-CG4390 ,
drops-est5a ,
drops-est5b ,
drops-est5c ,
drops-nrtac ,
drops-q2lyp3 ,
drops-q2lyp4 ,
drops-q2lyu3 ,
drops-q2lz68 ,
drops-q2m0u9 ,
drops-q2m169 ,
drops-q28wj5 ,
drops-q28wt2 ,
drops-q28wt8 ,
drops-q28zi3 ,
drops-q28zz1 ,
drops-q29a22 ,
drops-q29ad8 ,
drops-q29ad9 ,
drops-q29ae0 ,
drops-q29ae1 ,
drops-q29ay7 ,
drops-q29ay8 ,
drops-q29ay9 ,
drops-q29bq2 ,
drops-q29br3 ,
drops-q29d59 ,
drops-q29dc9 ,
drops-q29dd7 ,
drops-q29dp4 ,
drops-q29dw3 ,
drops-q29dw4 ,
drops-q29e16 ,
drops-q29ew0 ,
drops-q29f35 ,
drops-q29f66 ,
drops-q29fi0 ,
drops-q29fw0 ,
drops-q29fw9 ,
drops-q29g93 ,
drops-q29gb0 ,
drops-q29gs6 ,
drops-q29h54 ,
drops-b5dmp7 ,
drops-q29hd2 ,
drops-q29hu2 ,
drops-q29hu3 ,
drops-q29hv0 ,
drops-q29i09 ,
drops-q29js9 ,
drops-q29jt5 ,
drops-q29jt6 ,
drops-q29jy5 ,
drops-q29k25 ,
drops-q29kd5 ,
drops-q29kd6 ,
drops-q29ke5 ,
drops-q29kq9 ,
drops-q29kr1 ,
drops-q29kr3 ,
drops-q29kr5 ,
drops-q29kr8 ,
drops-q29kr9 ,
drops-q29ks6 ,
drops-q29kz0 ,
drops-q29kz1 ,
drops-q29l31 ,
drops-q29lf8 ,
drops-q29lv0 ,
drops-q29m07 ,
drops-q29m08 ,
drops-q29m27 ,
drops-q29m66 ,
drops-q29m81 ,
drops-q29mj7 ,
drops-q29mv2 ,
drops-q29mx0 ,
drops-q29n87 ,
drops-q29na5 ,
drops-q29na6 ,
drops-q29pe4 ,
drops-q29pk4 ,
drops-q290i1 ,
drops-q290k3 ,
drops-q290v8 ,
drops-q290v9 ,
drops-q290w0 ,
drops-q290z8 ,
drops-q291d5 ,
drops-q291e8 ,
drops-q291y3 ,
drops-q292f5 ,
drops-q292g6 ,
drops-q293n1 ,
drops-q293n4 ,
drops-q293n5 ,
drops-q293n6 ,
drops-q293y7 ,
drops-q294n3 ,
drops-q294n6 ,
drops-q294n7 ,
drops-q294n9 ,
drops-q294p0 ,
drops-q294p1 ,
drops-q294p3 ,
drops-q294p4 ,
drops-q294u9 ,
drops-q295h3 ,
drops-q296h2 ,
drops-q296x1 ,
drops-q296x2 ,
drops-q297h5 ,
drops-q298u8 ,
drope-b4gkk1 Abstract
We have sequenced the genome of a second Drosophila species, Drosophila pseudoobscura, and compared this to the genome sequence of Drosophila melanogaster, a primary model organism. Throughout evolution the vast majority of Drosophila genes have remained on the same chromosome arm, but within each arm gene order has been extensively reshuffled, leading to a minimum of 921 syntenic blocks shared between the species. A repetitive sequence is found in the D. pseudoobscura genome at many junctions between adjacent syntenic blocks. Analysis of this novel repetitive element family suggests that recombination between offset elements may have given rise to many paracentric inversions, thereby contributing to the shuffling of gene order in the D. pseudoobscura lineage. Based on sequence similarity and synteny, 10,516 putative orthologs have been identified as a core gene set conserved over 25-55 million years (Myr) since the pseudoobscura/melanogaster divergence. Genes expressed in the testes had higher amino acid sequence divergence than the genome-wide average, consistent with the rapid evolution of sex-specific proteins. Cis-regulatory sequences are more conserved than random and nearby sequences between the species--but the difference is slight, suggesting that the evolution of cis-regulatory elements is flexible. Overall, a pattern of repeat-mediated chromosomal rearrangement, and high coadaptation of both male genes and cis-regulatory sequences emerges as important themes of genome divergence between these species of Drosophila.
Other Papers
