(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) > cellular organisms: NE > Eukaryota: NE > Opisthokonta: NE > Fungi: NE > Dikarya: NE > Ascomycota: NE > saccharomyceta: NE > Pezizomycotina: NE > leotiomyceta: NE > sordariomyceta: NE > Sordariomycetes: NE > Hypocreomycetidae: NE > Hypocreales: NE > Nectriaceae: NE > Fusarium: NE > Fusarium oxysporum species complex: NE > Fusarium oxysporum: NE > Fusarium oxysporum Fo47: NE
Warning: This entry is a compilation of different species or line or strain with more than 90% amino acide identity. You can retrieve all strain data
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) Fusarium oxysporum f. sp. lycopersici 4287: N, E.
Fusarium oxysporum f. sp. lycopersici MN25: N, E.
Fusarium oxysporum f. sp. pisi HDV247: N, E.
Fusarium oxysporum f. sp. melonis 26406: N, E.
Fusarium oxysporum f. sp. vasinfectum 25433: N, E.
LegendThis sequence has been compared to family alignement (MSA) red => minority aminoacid blue => majority aminoacid color intensity => conservation rate title => sequence position(MSA position)aminoacid rate Catalytic site Catalytic site in the MSA MQTGPLFGVLGLLATTQTKQFDPFLADLTHQGPRTLHHGWANLTVETNTG TFIGMYNDTYPNVRQFLRIPFAQPPVGDLRWEPPQKLSNSSKVYDSTRFG PACPQYVSSSHVFWNKYAPPNPLLSLGERRDQGAVAWSSDEDCLSLAVWT PSYANKSSQLPVALFATGGGGLTGGITVPSQLPEQWVSRSQEHIVVTINY RVNIFGNPKSRAVQETSLTLLDVRAAVEWVHENIQQFGGDRDNILLWGES QGARLVDMYTTAFWEMPLATKFGLLSNGPDYIINTTEVQDPYADFDVVAK GLGCDYGDDYKAELECMRQVSWVQIEEFINRYDKKPSIAFDNYIPDEKYI FANKSDRYAKHLVARGPAIRSTTSTELQPSPNLTQTAEVARYFDCFALRD IKLRESIGLESFRYFYVGNYSNISPQPWLGAYHWTDLLMIFGTYVKMVGD TPQAEIDTSAAMQDYFVAFLKEGANVTSSVGWPVFKHQGKNNGSIIEFGA RGSPARNITGDYLDASCYNASVPFPILS
Fusarium species are among the most important phytopathogenic and toxigenic fungi. To understand the molecular underpinnings of pathogenicity in the genus Fusarium, we compared the genomes of three phenotypically diverse species: Fusarium graminearum, Fusarium verticillioides and Fusarium oxysporum f. sp. lycopersici. Our analysis revealed lineage-specific (LS) genomic regions in F. oxysporum that include four entire chromosomes and account for more than one-quarter of the genome. LS regions are rich in transposons and genes with distinct evolutionary profiles but related to pathogenicity, indicative of horizontal acquisition. Experimentally, we demonstrate the transfer of two LS chromosomes between strains of F. oxysporum, converting a non-pathogenic strain into a pathogen. Transfer of LS chromosomes between otherwise genetically isolated strains explains the polyphyletic origin of host specificity and the emergence of new pathogenic lineages in F. oxysporum. These findings put the evolution of fungal pathogenicity into a new perspective.
