Gene_Locus Report

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Gene_locus Report for: human-ABHD12B

Homo sapiens (Human) Abhydrolase domain-containing protein 12B ABHD12B protein c14orf29

Comment
Q8N4D2 fragment Homo sapiens (Human) similar to riken cdna 6330583m11 (c14orf29 variant 4), C14orf29


Relationship
Family|ABHD12-PHARC
Block| X
Position in NCBI Life Tree|Homo sapiens
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms: N E > Eukaryota: N E > Opisthokonta: N E > Metazoa: N E > Eumetazoa: N E > Bilateria: N E > Deuterostomia: N E > Chordata: N E > Craniata: N E > Vertebrata: N E > Gnathostomata: N E > Teleostomi: N E > Euteleostomi: N E > Sarcopterygii: N E > Dipnotetrapodomorpha: N E > Tetrapoda: N E > Amniota: N E > Mammalia: N E > Theria: N E > Eutheria: N E > Boreoeutheria: N E > Euarchontoglires: N E > Primates: N E > Haplorrhini: N E > Simiiformes: N E > Catarrhini: N E > Hominoidea: N E > Hominidae: N E > Homininae: N E > Homo: N E > Homo sapiens: N E


Molecular evidence
Database
No mutation
No structure
No kinetic





No Substrate
No inhibitor
>3 Genbank links 5 more: AY311396, AY311397, AY311398
1 UniProt : Q7Z5M8
1 UniProt : Q7Z5M8
1 Interpro : Q7Z5M8
1 Prodom : Q7Z5M8
1 Pfam : Q7Z5M8
1 PIRSF : Q7Z5M8
1 SUPERFAM : Q7Z5M8
1 EntrezGene : 145447
1 SNP : 145447
1 UniGene : 271896
1 HUGO HGNC : 19837
1 Ensembl : ENSG00000131969
Sequence
Graphical view for this peptide sequence: human-ABHD12B
Colored MSA for ABHD12-PHARC (raw)
MDAQDCQAAASPEPPGPPARSCVAAWWDMVDRNLRYFPHSCSMLGRKIAA
LYDSFTSKSLKEHVFLPLIDMLIYFNFFKAPFLVDLKKPELKIPHTVNFY
LRVEPGVMLGIWHTVPSCRGEDAKGKDCCWYEAALRDGNPIIVYLHGSAE
HRAASHRLKLVKVLSDGGFHVLSVDYRGFGDSTGKPTEEGLTTDAICVYE
WTKARSGITPVCLWGHSLGTGVATNAAKVLEEKGCPVDAIVLEAPFTNMW
VASINYPLLKIYRNIPGFLRTLMDALRKDKIIFPNDENVKFLSSPLLILH
GEDDRTVPLEYGKKLYEIARNAYRNKERVKMVIFPPGFQHNLLCKSPTLL
ITVRDFLSKQWS
Legend This sequence has been compared to family alignement (MSA)
red => minority aminoacid
blue => majority aminoacid
color intensity => conservation rate
title => sequence position(MSA position)aminoacid rate
Catalytic site
Catalytic site in the MSA

MDAQDCQAAASPEPPGPPARSCVAAWWDMVDRNLRYFPHSCSMLGRKIAA
LYDSFTSKSLKEHVFLPLIDMLIYFNFFKAPFLVDLKKPELKIPHTVNFY
LRVEPGVMLGIWHTVPSCRGEDAKGKDCCWYEAALRDGNPIIVYLHGSAE
HRAASHRLKLVKVLSDGGFHVLSVDYRGFGDSTGKPTEEGLTTDAICVYE
WTKARSGITPVCLWGHSLGTGVATNAAKVLEEKGCPVDAIVLEAPFTNMW
VASINYPLLKIYRNIPGFLRTLMDALRKDKIIFPNDENVKFLSSPLLILH
GEDDRTVPLEYGKKLYEIARNAYRNKERVKMVIFPPGFQHNLLCKSPTLL
ITVRDFLSKQWS


Reference
    Title: Increase in Cellular Lysophosphatidylserine Content Exacerbates Inflammatory Responses in LPS-Activated Microglia
    Minamihata T, Takano K, Nakamura Y, Seto R, Moriyama M
    Ref: Neurochem Res, :, 2021 : PubMed

            


Other Papers


Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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