Homo sapiens (Human) Monoacylglycerol lipase ABHD2 LABH2 LBH2 protein phps1-2
Monoacylglycerol lipase ABHD2 Enhanced neointimal hyperplasia was observed in Abhd2-deficient mice, using an experimental vascular cuff placement injury model. Abhd2 is expressed in vascular smooth muscle cells (SMCs). An association between the human ABHD2 gene and colorectal cancer and with Risks for Chronic Obstructive Pulmonary Disease is reported. ABHD2 is a steroid-activated (progesterone P4) enzyme that hydrolyzes 2-arachidonoylglycerol. ABHD2 is expressed in sperm and in ovaries
MNAMLETPEL PAVFDGVKLA AVAAVLYVIV RCLNLKSPTA PPDLYFQDSG LSRFLLKSCP LLTKEYIPPL IWGKSGHIQT ALYGKMGRVR SPHPYGHRKF ITMSDGATST FDLFEPLAEH CVGDDITMVI CPGIANHSEK QYIRTFVDYA QKNGYRCAVL NHLGALPNIE LTSPRMFTYG CTWEFGAMVN YIKKTYPLTQ LVVVGFSLGG NIVCKYLGET QANQEKVLCC VSVCQGYSAL RAQETFMQWD QCRRFYNFLM ADNMKKIILS HRQALFGDHV KKPQSLEDTD LSRLYTATSL MQIDDNVMRK FHGYNSLKEY YEEESCMRYL HRIYVPLMLV NAADDPLVHE SLLTIPKSLS EKRENVMFVL PLHGGHLGFF EGSVLFPEPL TWMDKLVVEY ANAICQWERN KLQCSDTEQV EADLE
| Title : Abhd2, a Candidate Gene Regulating Airway Remodeling in COPD via TGF-beta - Lv_2024_Int.J.Chron.Obstruct.Pulmon.Dis_19_33 |
| Author(s) : Lv MY , Jin LL , Sang XQ , Shi WC , Qiang LX , Lin QY , Jin SD |
| Ref : Int J Chron Obstruct Pulmon Dis , 19 :33 , 2024 |
| Abstract : Lv_2024_Int.J.Chron.Obstruct.Pulmon.Dis_19_33 |
| ESTHER : Lv_2024_Int.J.Chron.Obstruct.Pulmon.Dis_19_33 |
| PubMedSearch : Lv_2024_Int.J.Chron.Obstruct.Pulmon.Dis_19_33 |
| PubMedID: 38197032 |
| Gene_locus related to this paper: human-ABHD2 |
| Title : Progesterone induces meiosis through two obligate co-receptors with PLA2 activity - Nader_2023_bioRxiv__ |
| Author(s) : Nader N , Zarif L , Halama A , Yadav S , Dib M , Attarwala N , Chen Q , Suhre K , Gross SS , Machaca K |
| Ref : Biorxiv , : , 2023 |
| Abstract : Nader_2023_bioRxiv__ |
| ESTHER : Nader_2023_bioRxiv__ |
| PubMedSearch : Nader_2023_bioRxiv__ |
| PubMedID: 37905030 |
| Gene_locus related to this paper: human-ABHD2 |
| Title : Lipidomic QTL in Diversity Outbred mice identifies a novel function for alpha\/beta hydrolase domain 2 (Abhd2) as an enzyme that metabolizes phosphatidylcholine and cardiolipin - Price_2023_PLoS.Genet_19_e1010713 |
| Author(s) : Price TR , Stapleton DS , Schueler KL , Norris MK , Parks BW , Yandell BS , Churchill GA , Holland WL , Keller MP , Attie AD |
| Ref : PLoS Genet , 19 :e1010713 , 2023 |
| Abstract : Price_2023_PLoS.Genet_19_e1010713 |
| ESTHER : Price_2023_PLoS.Genet_19_e1010713 |
| PubMedSearch : Price_2023_PLoS.Genet_19_e1010713 |
| PubMedID: 37523383 |
| Gene_locus related to this paper: human-ABHD2 , mouse-ABHD2 |
| Title : Lipidomic QTL in Diversity Outbred mice identifies a novel function for alpha\/beta hydrolase domain 2 (Abhd2) as an enzyme that metabolizes phosphatidylcholine and cardiolipin - Price_2023_bioRxiv__ |
| Author(s) : Price TR , Stapleton DS , Schueler KL , Norris MK , Parks BW , Yandell BS , Churchill GA , Holland WL , Keller MP , Attie AD |
| Ref : Biorxiv , : , 2023 |
| Abstract : Price_2023_bioRxiv__ |
| ESTHER : Price_2023_bioRxiv__ |
| PubMedSearch : Price_2023_bioRxiv__ |
| PubMedID: 36993241 |
| Gene_locus related to this paper: human-ABHD2 , mouse-ABHD2 |
| Title : Radiometric Assay of ABHD2 Activity - Fazio_2023_Methods.Mol.Biol_2576_299 |
| Author(s) : Fazio D , Criscuolo E , Maccarrone M |
| Ref : Methods Mol Biol , 2576 :299 , 2023 |
| Abstract : Fazio_2023_Methods.Mol.Biol_2576_299 |
| ESTHER : Fazio_2023_Methods.Mol.Biol_2576_299 |
| PubMedSearch : Fazio_2023_Methods.Mol.Biol_2576_299 |
| PubMedID: 36152197 |
| Gene_locus related to this paper: human-ABHD2 |
| Title : Progesterone activates the cyclic AMP-protein kinase A signalling pathway by upregulating ABHD2 in fertile men - Jiang_2021_J.Int.Med.Res_49_300060521999527 |
| Author(s) : Jiang F , Zhu Y , Chen Y , Tang X , Liu L , Chen G , Liu Y , Sun X |
| Ref : J Internal Medicine Res , 49 :300060521999527 , 2021 |
| Abstract : Jiang_2021_J.Int.Med.Res_49_300060521999527 |
| ESTHER : Jiang_2021_J.Int.Med.Res_49_300060521999527 |
| PubMedSearch : Jiang_2021_J.Int.Med.Res_49_300060521999527 |
| PubMedID: 33752482 |
| Gene_locus related to this paper: human-ABHD2 |
| Title : Alpha\/Beta Hydrolase Domain-Containing Protein 2 regulates the rhythm of follicular maturation and estrous stages of the female reproductive cycle - Bjorkgren_2021_Front.Cell.Dev.Biol_9_710864 |
| Author(s) : Bjorkgren I , Chung DH , Mendoza S , Gabelev-Khasin L , Modzelewski A , He L , Lishko PV |
| Ref : Front Cell Developmental Biology , 9 :710864 , 2021 |
| Abstract : Bjorkgren_2021_Front.Cell.Dev.Biol_9_710864 |
| ESTHER : Bjorkgren_2021_Front.Cell.Dev.Biol_9_710864 |
| PubMedSearch : Bjorkgren_2021_Front.Cell.Dev.Biol_9_710864 |
| PubMedID: 34568325 |
| Gene_locus related to this paper: human-ABHD2 , mouse-ABHD2 |
| Title : miR-140-3p Inhibits Cutaneous Melanoma Progression by Disrupting AKT\/p70S6K and JNK Pathways through ABHD2 - He_2020_Mol.Ther.Oncolytics_17_83 |
| Author(s) : He Y , Yang Y , Liao Y , Xu J , Liu L , Li C , Xiong X |
| Ref : Mol Ther Oncolytics , 17 :83 , 2020 |
| Abstract : He_2020_Mol.Ther.Oncolytics_17_83 |
| ESTHER : He_2020_Mol.Ther.Oncolytics_17_83 |
| PubMedSearch : He_2020_Mol.Ther.Oncolytics_17_83 |
| PubMedID: 32322665 |
| Gene_locus related to this paper: human-ABHD2 |
| Title : Retinoic Acid Induces Differentiation of Mouse F9 Embryonic Carcinoma Cell by Modulating the miR-485 Targeting of Abhd2 - Yu_2019_Int.J.Mol.Sci_20_ |
| Author(s) : Yu M , Zhang L , Liu Y , Liu D , Guo Z |
| Ref : Int J Mol Sci , 20 : , 2019 |
| Abstract : Yu_2019_Int.J.Mol.Sci_20_ |
| ESTHER : Yu_2019_Int.J.Mol.Sci_20_ |
| PubMedSearch : Yu_2019_Int.J.Mol.Sci_20_ |
| PubMedID: 31035455 |
| Gene_locus related to this paper: human-ABHD2 |
| Title : ABHD2 Inhibitor Identified by Activity-Based Protein Profiling Reduces Acrosome Reaction - Baggelaar_2019_ACS.Chem.Biol_14_2295 |
| Author(s) : Baggelaar MP , den Dulk H , Florea BI , Fazio D , Perruzza D , Bernabo N , Raspa M , Janssen APA , Scavizzi F , Barboni B , Overkleeft HS , Maccarrone M , van der Stelt M |
| Ref : ACS Chemical Biology , 14 :2295 , 2019 |
| Abstract : Baggelaar_2019_ACS.Chem.Biol_14_2295 |
| ESTHER : Baggelaar_2019_ACS.Chem.Biol_14_2295 |
| PubMedSearch : Baggelaar_2019_ACS.Chem.Biol_14_2295 |
| PubMedID: 31525885 |
| Gene_locus related to this paper: human-ABHD2 , human-ABHD3 |
| Title : Characterisation and localisation of the endocannabinoid system components in the adult human testis - Nielsen_2019_Sci.Rep_9_12866 |
| Author(s) : Nielsen JE , Rolland AD , Rajpert-De Meyts E , Janfelt C , Jorgensen A , Winge SB , Kristensen DM , Juul A , Chalmel F , Jegou B , Skakkebaek NE |
| Ref : Sci Rep , 9 :12866 , 2019 |
| Abstract : Nielsen_2019_Sci.Rep_9_12866 |
| ESTHER : Nielsen_2019_Sci.Rep_9_12866 |
| PubMedSearch : Nielsen_2019_Sci.Rep_9_12866 |
| PubMedID: 31537814 |
| Gene_locus related to this paper: human-ABHD2 , human-MGLL |
| Title : Asymmetrically Positioned Flagellar Control Units Regulate Human Sperm Rotation - Miller_2018_Cell.Rep_24_2606 |
| Author(s) : Miller MR , Kenny SJ , Mannowetz N , Mansell SA , Wojcik M , Mendoza S , Zucker RS , Xu K , Lishko PV |
| Ref : Cell Rep , 24 :2606 , 2018 |
| Abstract : Miller_2018_Cell.Rep_24_2606 |
| ESTHER : Miller_2018_Cell.Rep_24_2606 |
| PubMedSearch : Miller_2018_Cell.Rep_24_2606 |
| PubMedID: 30184496 |
| Gene_locus related to this paper: human-ABHD2 |
| Title : Regulation of the sperm calcium channel CatSper by endogenous steroids and plant triterpenoids - Mannowetz_2017_Proc.Natl.Acad.Sci.U.S.A_114_5743 |
| Author(s) : Mannowetz N , Miller MR , Lishko PV |
| Ref : Proc Natl Acad Sci U S A , 114 :5743 , 2017 |
| Abstract : Mannowetz_2017_Proc.Natl.Acad.Sci.U.S.A_114_5743 |
| ESTHER : Mannowetz_2017_Proc.Natl.Acad.Sci.U.S.A_114_5743 |
| PubMedSearch : Mannowetz_2017_Proc.Natl.Acad.Sci.U.S.A_114_5743 |
| PubMedID: 28507119 |
| Gene_locus related to this paper: human-ABHD2 |
| Title : Regulation of calcium release from the endoplasmic reticulum by the serine hydrolase ABHD2 - Yun_2017_Biochem.Biophys.Res.Commun_490_1226 |
| Author(s) : Yun B , Lee H , Powell R , Reisdorph N , Ewing H , Gelb MH , Hsu KL , Cravatt BF , Leslie CC |
| Ref : Biochemical & Biophysical Research Communications , 490 :1226 , 2017 |
| Abstract : Yun_2017_Biochem.Biophys.Res.Commun_490_1226 |
| ESTHER : Yun_2017_Biochem.Biophys.Res.Commun_490_1226 |
| PubMedSearch : Yun_2017_Biochem.Biophys.Res.Commun_490_1226 |
| PubMedID: 28684316 |
| Gene_locus related to this paper: human-ABHD2 |
| Title : Unconventional endocannabinoid signaling governs sperm activation via the sex hormone progesterone - Miller_2016_Science_352_555 |
| Author(s) : Miller MR , Mannowetz N , Iavarone AT , Safavi R , Gracheva EO , Smith JF , Hill RZ , Bautista DM , Kirichok Y , Lishko PV |
| Ref : Science , 352 :555 , 2016 |
| Abstract : Miller_2016_Science_352_555 |
| ESTHER : Miller_2016_Science_352_555 |
| PubMedSearch : Miller_2016_Science_352_555 |
| PubMedID: 26989199 |
| Gene_locus related to this paper: human-ABHD2 |
| Title : Abhydrolase domain containing 2, an androgen target gene, promotes prostate cancer cell proliferation and migration - Obinata_2016_Eur.J.Cancer_57_39 |
| Author(s) : Obinata D , Takada S , Takayama K , Urano T , Ito A , Ashikari D , Fujiwara K , Yamada Y , Murata T , Kumagai J , Fujimura T , Ikeda K , Horie-Inoue K , Homma Y , Takahashi S , Inoue S |
| Ref : Eur J Cancer , 57 :39 , 2016 |
| Abstract : Obinata_2016_Eur.J.Cancer_57_39 |
| ESTHER : Obinata_2016_Eur.J.Cancer_57_39 |
| PubMedSearch : Obinata_2016_Eur.J.Cancer_57_39 |
| PubMedID: 26854828 |
| Gene_locus related to this paper: human-ABHD2 |
| Title : Molecular characterization of human ABHD2 as TAG lipase and ester hydrolase - Manda_2016_Biosci.Rep_36_ |
| Author(s) : Manda NK , Thunuguntla VBSC , Veeramachaneni GK , Bokka CS , Guntupalli S , Bondili JS |
| Ref : Bioscience Reports , 36 : , 2016 |
| Abstract : Manda_2016_Biosci.Rep_36_ |
| ESTHER : Manda_2016_Biosci.Rep_36_ |
| PubMedSearch : Manda_2016_Biosci.Rep_36_ |
| PubMedID: 27247428 |
| Gene_locus related to this paper: human-ABHD2 |
| Title : Associations of ABHD2 Genetic Variations with Risks for Chronic Obstructive Pulmonary Disease in a Chinese Han Population - Liu_2015_PLoS.One_10_e0123929 |
| Author(s) : Liu L , Li X , Yuan R , Zhang H , Qiang L , Shen J , Jin S |
| Ref : PLoS ONE , 10 :e0123929 , 2015 |
| Abstract : Liu_2015_PLoS.One_10_e0123929 |
| ESTHER : Liu_2015_PLoS.One_10_e0123929 |
| PubMedSearch : Liu_2015_PLoS.One_10_e0123929 |
| PubMedID: 25880496 |
| Gene_locus related to this paper: human-ABHD2 |
| Title : Age-related pulmonary emphysema in mice lacking alpha\/beta hydrolase domain containing 2 gene - Jin_2009_Biochem.Biophys.Res.Commun_380_419 |
| Author(s) : Jin S , Zhao G , Li Z , Nishimoto Y , Isohama Y , Shen J , Ito T , Takeya M , Araki K , He P , Yamamura K |
| Ref : Biochemical & Biophysical Research Communications , 380 :419 , 2009 |
| Abstract : Jin_2009_Biochem.Biophys.Res.Commun_380_419 |
| ESTHER : Jin_2009_Biochem.Biophys.Res.Commun_380_419 |
| PubMedSearch : Jin_2009_Biochem.Biophys.Res.Commun_380_419 |
| PubMedID: 19250629 |
| Gene_locus related to this paper: human-ABHD2 , mouse-ABHD2 |
| Title : Elevated mature macrophage expression of human ABHD2 gene in vulnerable plaque - Miyata_2008_Biochem.Biophys.Res.Commun_365_207 |
| Author(s) : Miyata K , Nakayama M , Mizuta S , Hokimoto S , Sugamura K , Oshima S , Oike Y , Sugiyama S , Ogawa H , Yamamura K |
| Ref : Biochemical & Biophysical Research Communications , 365 :207 , 2008 |
| Abstract : Miyata_2008_Biochem.Biophys.Res.Commun_365_207 |
| ESTHER : Miyata_2008_Biochem.Biophys.Res.Commun_365_207 |
| PubMedSearch : Miyata_2008_Biochem.Biophys.Res.Commun_365_207 |
| PubMedID: 17980156 |
| Gene_locus related to this paper: human-ABHD2 , mouse-ABHD2 |
| Title : Increase of smooth muscle cell migration and of intimal hyperplasia in mice lacking the alpha\/beta hydrolase domain containing 2 gene - Miyata_2005_Biochem.Biophys.Res.Commun_329_296 |
| Author(s) : Miyata K , Oike Y , Hoshii T , Maekawa H , Ogawa H , Suda T , Araki K , Yamamura K |
| Ref : Biochemical & Biophysical Research Communications , 329 :296 , 2005 |
| Abstract : Miyata_2005_Biochem.Biophys.Res.Commun_329_296 |
| ESTHER : Miyata_2005_Biochem.Biophys.Res.Commun_329_296 |
| PubMedSearch : Miyata_2005_Biochem.Biophys.Res.Commun_329_296 |
| PubMedID: 15721306 |
| Gene_locus related to this paper: human-ABHD2 , mouse-ABHD2 |
| Title : Primary structure of a human protein which bears structural similarities to members of the rhodopsin\/beta-adrenergic receptor family - |
| Author(s) : Rapiejko PJ , George ST , Malbon CC |
| Ref : Nucleic Acids Research , 16 :8721 , 1988 |
| PubMedID: 2843827 |
| Gene_locus related to this paper: human-ABHD2 |