human-ABHD4

 
Homo sapiens (Human) abhydrolase domain-containing protein 4 FLJ12816 similar to 2-hydroxymuconic semialdehyde hydrolase (EC 3.1.1.-)

Comment
selectively hydrolyzes N-acyl phosphatidylethanolamines NAPEs and lysoNAPE to N-Acyl ethanolamines (NAEs) Simon et al .2006


Relationship
Block X
Homo sapiens position in NCBI Life Tree :
N link to NCBI taxonomic web page and E link to ESTHER gene locus found in this strain.
> cellular organisms: N E > Eukaryota: N E > Opisthokonta: N E > Metazoa: N E > Eumetazoa: N E > Bilateria: N E > Deuterostomia: N E > Chordata: N E > Craniata: N E > Vertebrata: N E > Gnathostomata: N E > Teleostomi: N E > Euteleostomi: N E > Sarcopterygii: N E > Dipnotetrapodomorpha: N E > Tetrapoda: N E > Amniota: N E > Mammalia: N E > Theria: N E > Eutheria: N E > Boreoeutheria: N E > Euarchontoglires: N E > Primates: N E > Haplorrhini: N E > Simiiformes: N E > Catarrhini: N E > Hominoidea: N E > Hominidae: N E > Homininae: N E > Homo: N E > Homo sapiens: N E

Molecular evidence
Database
No mutation
No structure
No kinetic

Substrate: NAPE , Dipalmitoylphosphatidylethanolamine ,
Inhibitor: ABC47 , Methyl-arachidonyl-fluorophosphonate ,
>3 Genbank links 2 more: AK022878, BC024779, AK293198
3 UniProt : Q8TB40, B4DNZ5, B4DW04
1 Ncbi-nid : 10434527
1 Ncbi-pid : 10434528
3 UniProtTrembl : Q8TB40, B4DNZ5, B4DW04
3 Interpro : Q8TB40, B4DNZ5, B4DW04
3 Prodom : Q8TB40, B4DNZ5, B4DW04
3 Pfam : Q8TB40, B4DNZ5, B4DW04
3 PIRSF : Q8TB40, B4DNZ5, B4DW04
3 SUPERFAM : Q8TB40, B4DNZ5, B4DW04
3 QuickSwissBlast : Q8TB40, B4DNZ5, B4DW04
1 EntrezGene : 63874
1 SNP : 63874
1 UniGene : 445665
1 HUGO HGNC : 20154
1 Ensembl : ENSG00000100439
 
Sequence
Graphical view for this peptide sequence: human-ABHD4
Colored MSA for CGI-58_ABHD5_ABHD4 (raw)
MADDLEQQSQGWLSSWLPTWRPTSMSQLKNVEARILQCLQNKFLARYVSL
PNQNKIWTVTVSPEQNDRTPLVMVHGFGGGVGLWILNMDSLSARRTLHTF
DLLGFGRSSRPAFPRDPEGAEDEFVTSIETWRETMGIPSMILLGHSLGGF
LATSYSIKYPDRVKHLILVDPWGFPLRPTNPSGICAPPAWVKAVASVLGR
SNPLAVLRVAGPWGPGLVQRFRPDFKRKFADFFEDDTISEYIYHCNAQNP
SGETAFKAMMESFGWARRPMLERIHLIRKDVPITMIYGSDTWIDTSTGKK
VKMQRPDSYVRDMEIKGASHHVYADQPHIFNAVVEEICDSVD
Legend This sequence has been compared to family alignement (MSA)
red => minority aminoacid
blue => majority aminoacid
color intensity => conservation rate
title => sequence position(MSA position)aminoacid rate
Catalytic site
Catalytic site in the MSA

MADDLEQQSQGWLSSWLPTWRPTSMSQLKNVEARILQCLQNKFLARYVSL
PNQNKIWTVTVSPEQNDRTPLVMVHGFGGGVGLWILNMDSLSARRTLHTF
DLLGFGRSSRPAFPRDPEGAEDEFVTSIETWRETMGIPSMILLGHSLGGF
LATSYSIKYPDRVKHLILVDPWGFPLRPTNPSGICAPPAWVKAVASVLGR
SNPLAVLRVAGPWGPGLVQRFRPDFKRKFADFFEDDTISEYIYHCNAQNP
SGETAFKAMMESFGWARRPMLERIHLIRKDVPITMIYGSDTWIDTSTGKK
VKMQRPDSYVRDMEIKGASHHVYADQPHIFNAVVEEICDSVD

Graphical view for this nucleotide DNA sequence (2574 bp): human-ABHD4
>human-ABHD4
gctcccgggtcagctggtgctggcgtcaggcgctgggcgggctcgccagg
acctggcaaggcttgtttactatggccgatgatctggagcagcagtctca
aggctggctgagtagctggctgcccacgtggcgccccacttccatgtctc
agctgaagaatgtggaagccaggatcctccagtgtctccagaataagttc
ctggccagatatgtatccctcccaaaccagaataagatctggacggtgac
tgtgagccccgagcaaaacgaccgcacccccttggtgatggtgcatggtt
ttgggggcggcgtgggtctctggatcctcaacatggactcactgagtgcc
cgccgcacactgcacaccttcgatctgcttggcttcgggcgaagctcaag
gccagcattcccaagggacccggagggggctgaggatgagtttgtgacat
cgatagagacatggcgggagaccatggggatccccagcatgatcctcctg
gggcacagtttgggaggattcctggccacttcttactcaatcaagtaccc
tgatagagttaaacacctcatcctggtggacccatggggctttcccctcc
gaccaactaaccccagtgggatctgtgcacccccagcctgggtcaaagcc
gtggcatctgtcctaggacgttccaatccattggctgttcttcgagtagc
tgggccctgggggcctggtctggtgcagcgattccggccggacttcaaac
gcaagtttgcagacttctttgaagatgataccatatcagagtatatttac
cactgcaacgcacagaatcccagtggtgagacagcattcaaagccatgat
ggagtcctttggctgggcccggcgccctatgctggagcgaattcacttga
ttcgaaaagatgtgcctatcactatgatctacgggtccgacacctggata
gataccagtacgggaaaaaaggtgaagatgcagcggccggattcctatgt
ccgagacatggagattaagggtgcctcccaccatgtctatgctgaccagc
cacacatcttcaatgctgtggtggaggagatctgcgactcagttgattga
gctgctctctgaagaggaagaggagaaagccagagagtcactcttacctc
cctgtctgcttactcacccactctgtcctttcctcaccaactaacatgtg
ccagccaggcagagtcttgtgctgttcccagaacaggacgacagtgaaaa
gaacactcttgaccctacactgaaggctgaaggcagaagccacaagaggc
cttgagtgccacccccagggaagaacataaagggttgcacaatgccaccc
atccactccttgccaagtgttacccagatggtggaggatgtgaagggatt
gcgccaagccacattcactctctctgtggcctttcttcctctgggcaaag
aagggcttccagtggcctttcctcactctgtagtgtttgtggggatagat
tccatgcaagaacaccttcctcctccatcccccacttcaccccatcccat
accagttccatccagggtctgcttaactgccaagagcaggtcctggagtt
cccttcacctgcagagtccttttcatgacctaggaggtcttattcaaagc
cctcattgacagaggaggaaacaggccaaggcaggacatggctggaccat
ggtgatacagctctgtgtgattcaagttctggcagagcttgtaaggctag
agcccaggtctgccgacaccctgtgcttgttgcacacttgatttgctaag
gctggagacaggcaccattgccatggggctggtcctagtcactggccgag
gataagcccgtccctgtcccacattctagccccactatgcgggggtgctg
ttgtcctgcctgtgtctcatccccggctgcctaagctagggacactcaag
tgcttccttccttgccccatcttcctcccaactggaggcctctgagcctc
ccctgtgccttgggccctgaagccccatatgtagtatagagcaaaggtgg
ctcctggtgaagagagggtggaaaggcccttcagccccagggccatgtct
gggttctccatgcccatcagtctctgcagtttctctacctgcccccagag
ctgaggccatctgcaagcccctgcccatggcccaatggggagcctccagc
cacaagttccctgtccttatcagccactgggtggttcccactgcatgacc
ctctatccctgccatctgtccccatggtttccagctcaatccacccctga
cccatctgtcagctttttcccagggagccgtttcaggggttctgggcagt
aggctgggcctggcctcagaacctggtggctcctgcctgctccttcactt
ttgtaaaaccatccccttcaccagaatggtattaactcctggtgctttgt
actactggtccagctgccctgggctccttttctatattaataaagaaacg
agtaaaaatt



References
6 more
    Title: ABHD4-Regulating RNA Panel: Novel Biomarkers in Acute Coronary Syndrome Diagnosis
    Agwa SHA, Elzahwy SS, El Meteini MS, Elghazaly H, Saad M, Abd Elsamee AM, Shamekh R, Matboli M
    Ref: Cells, 10:, 2021 : PubMed

            

    Title: ABHD4-dependent developmental anoikis safeguards the embryonic brain
    Laszlo ZI, Lele Z, Zoldi M, Miczan V, Mogor F, Simon GM, Mackie K, Kacskovics I, Cravatt BF, Katona I
    Ref: Nat Commun, 11:4363, 2020 : PubMed

            

    Title: Complete sequencing and characterization of 21,243 full-length human cDNAs
    Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H and Sugano S <144 more author(s)>
    Ref: Nat Genet, 36:40, 2004 : PubMed

            


Other Papers


Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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