Homo sapiens (Human) DAGLA Sn1-specific diacylglycerol lipase alpha DGL-alpha, neural stem cell-derived dendrite regulator KIAA0659
DAGLA is a diacylglycerol (DAG) lipase (EC 3.1.1.34) that catalyzes the hydrolysis of DAG to 2-arachidonoyl-glycerol, the most abundant endocannabinoid in tissues. The endocannabinoid 2-arachidonoylglycerol produced by diacylglycerol lipase alpha mediates retrograde suppression of synaptic transmission. Only central part Pfam A Lipase_3 394 534. Autoantibodies to DAGLA were detected in the sera of 17 patients with cerebellitis, epilepsy and hippocampal sclerosis, or brain stem encephalitis. A duplication of 20 genes, including DAGLA, resulted in adult onset spinocerebellar ataxia (Knight et al. 2004 2008)
MPGIVVFRRR WSVGSDDLVL PAIFLFLLHT TWFVILSVVL FGLVYNPHEA CSLNLVDHGR GYLGILLSCM IAEMAIIWLS MRGGILYTEP RDSMQYVLYV RLAILVIEFI YAIVGIVWLT QYYTSCNDLT AKNVTLGMVV CNWVVILSVC ITVLCVFDPT GRTFVKLRAT KRRQRNLRTY NLRHRLEEGQ ATSWSRRLKV FLCCTRTKDS QSDAYSEIAY LFAEFFRDLD IVPSDIIAGL VLLRQRQRAK RNAVLDEANN DILAFLSGMP VTRNTKYLDL KNSQEMLRYK EVCYYMLFAL AAYGWPMYLM RKPACGLCQL ARSCSCCLCP ARPRFAPGVT IEEDNCCGCN AIAIRRHFLD ENMTAVDIVY TSCHDAVYET PFYVAVDHDK KKVVISIRGT LSPKDALTDL TGDAERLPVE GHHGTWLGHK GMVLSAEYIK KKLEQEMVLS QAFGRDLGRG TKHYGLIVVG HSLGAGTAAI LSFLLRPQYP TLKCFAYSPP GGLLSEDAME YSKEFVTAVV LGKDLVPRIG LSQLEGFRRQ LLDVLQRSTK PKWRIIVGAT KCIPKSELPE EVEVTTLAST RLWTHPSDLT IALSASTPLY PPGRIIHVVH NHPAEQCCCC EQEEPTYFAI WGDNKAFNEV IISPAMLHEH LPYVVMEGLN KVLENYNKGK TALLSAAKVM VSPTEV
| Title : Pharmacological diacylglycerol lipase inhibition impairs contextual fear extinction in mice - Ramos-Medina_2024_Psychopharmacology.(Berl)__ |
| Author(s) : Ramos-Medina L , Rosas-Vidal LE , Patel S |
| Ref : Psychopharmacology (Berl) , : , 2024 |
| Abstract : Ramos-Medina_2024_Psychopharmacology.(Berl)__ |
| ESTHER : Ramos-Medina_2024_Psychopharmacology.(Berl)__ |
| PubMedSearch : Ramos-Medina_2024_Psychopharmacology.(Berl)__ |
| PubMedID: 38182791 |
| Gene_locus related to this paper: human-DAGLA , human-DAGLB |
| Title : Endocannabinoid 2-Arachidonoylglycerol Synthesis and Metabolism at Neuronal Nuclear Matrix Fractions Derived from Adult Rat Brain Cortex - Aretxabala_2023_Int.J.Mol.Sci_24_3165 |
| Author(s) : Aretxabala X , Garcia Del Cano G , Barrondo S , Lopez De Jesus M , Gonzalez-Burguera I , Saumell-Esnaola M , Goicolea MA , Salles J |
| Ref : Int J Mol Sci , 24 : , 2023 |
| Abstract : Aretxabala_2023_Int.J.Mol.Sci_24_3165 |
| ESTHER : Aretxabala_2023_Int.J.Mol.Sci_24_3165 |
| PubMedSearch : Aretxabala_2023_Int.J.Mol.Sci_24_3165 |
| PubMedID: 36834575 |
| Gene_locus related to this paper: human-ABHD12 , human-DAGLA , ratno-q5ylm1 , ratno-q6ayt7 |
| Title : Diacylglycerol lipase alpha promotes hepatocellular carcinoma progression and induces lenvatinib resistance by enhancing YAP activity - Yan_2023_Cell.Death.Dis_14_404 |
| Author(s) : Yan YC , Meng GX , Yang CC , Yang YF , Tan SY , Yan LJ , Ding ZN , Ma YL , Dong ZR , Li T |
| Ref : Cell Death Dis , 14 :404 , 2023 |
| Abstract : Yan_2023_Cell.Death.Dis_14_404 |
| ESTHER : Yan_2023_Cell.Death.Dis_14_404 |
| PubMedSearch : Yan_2023_Cell.Death.Dis_14_404 |
| PubMedID: 37414748 |
| Gene_locus related to this paper: human-DAGLA |
| Title : Inhibition of diacylglycerol lipase beta modulates lipid and endocannabinoid levels in the ex vivo human placenta - Berger_2023_Front.Endocrinol.(Lausanne)_14_1092024 |
| Author(s) : Berger N , van der Wel T , Hirschmugl B , Baernthaler T , Gindlhuber J , Fawzy N , Eichmann T , Birner-Gruenberger R , Zimmermann R , van der Stelt M , Wadsack C |
| Ref : Front Endocrinol (Lausanne) , 14 :1092024 , 2023 |
| Abstract : Berger_2023_Front.Endocrinol.(Lausanne)_14_1092024 |
| ESTHER : Berger_2023_Front.Endocrinol.(Lausanne)_14_1092024 |
| PubMedSearch : Berger_2023_Front.Endocrinol.(Lausanne)_14_1092024 |
| PubMedID: 36864832 |
| Gene_locus related to this paper: human-DAGLA , human-DAGLB |
| Title : Ventral hippocampal diacylglycerol lipase-alpha deletion decreases avoidance behaviors and alters excitation-inhibition balance - Kondev_2023_Neurobiol.Stress_22_100510 |
| Author(s) : Kondev V , Bluett R , Najeed M , Rosas-Vidal LE , Grueter BA , Patel S |
| Ref : Neurobiol Stress , 22 :100510 , 2023 |
| Abstract : Kondev_2023_Neurobiol.Stress_22_100510 |
| ESTHER : Kondev_2023_Neurobiol.Stress_22_100510 |
| PubMedSearch : Kondev_2023_Neurobiol.Stress_22_100510 |
| PubMedID: 36594052 |
| Gene_locus related to this paper: human-DAGLA , mouse-q6wqj1 |
| Title : Endocannabinoid dysfunction in neurological disease: neuro-ocular DAGLA-related syndrome (NODRS) - Bainbridge_2022_Brain__ |
| Author(s) : Bainbridge MN , Mazumder A , Ogasawara D , Abou Jamra R , Bernard G , Bertini E , Burglen L , Cope H , Crawford A , Derksen A , Dure L , Gantz E , Koch-Hogrebe M , Hurst ACE , Mahida S , Marshall P , Micalizzi A , Novelli A , Peng H , Rodriguez D , Robbins SL , Rutledge SL , Scalise R , Schliesske S , Shashi V , Srivastava S , Thiffault I , Topol S , Qebibo L , Wieczorek D , Cravatt B , Haricharan S , Torkamani A , Friedman J |
| Ref : Brain , : , 2022 |
| Abstract : Bainbridge_2022_Brain__ |
| ESTHER : Bainbridge_2022_Brain__ |
| PubMedSearch : Bainbridge_2022_Brain__ |
| PubMedID: 35737950 |
| Gene_locus related to this paper: human-DAGLA |
| Title : Regulation of adult neurogenesis by the endocannabinoid-producing enzyme diacylglycerol lipase alpha (DAGLa) - Schuele_2022_Sci.Rep_12_633 |
| Author(s) : Schuele LL , Schuermann B , Bilkei-Gorzo A , Gorgzadeh S , Zimmer A , Leidmaa E |
| Ref : Sci Rep , 12 :633 , 2022 |
| Abstract : Schuele_2022_Sci.Rep_12_633 |
| ESTHER : Schuele_2022_Sci.Rep_12_633 |
| PubMedSearch : Schuele_2022_Sci.Rep_12_633 |
| PubMedID: 35022487 |
| Gene_locus related to this paper: human-DAGLA , mouse-q6wqj1 |
| Title : In situ localization of diacylglycerol lipase alpha and beta producing an endocannabinoid 2-arachidonoylglycerol and of cannabinoid receptor 1 in the primary oocytes of postnatal mice - Kamnate_2021_J.Anat__ |
| Author(s) : Kamnate A , Sirisin J , Polsan Y , Chomphoo S , Watanabe M , Kondo H , Hipkaeo W |
| Ref : Journal of Anatomy , : , 2021 |
| Abstract : Kamnate_2021_J.Anat__ |
| ESTHER : Kamnate_2021_J.Anat__ |
| PubMedSearch : Kamnate_2021_J.Anat__ |
| PubMedID: 33398893 |
| Gene_locus related to this paper: human-DAGLA , human-DAGLB , mouse-DGLB , mouse-q6wqj1 |
| Title : Diacylglycerol lipase alpha promotes tumorigenesis in oral cancer by cell-cycle progression - Okubo_2018_Exp.Cell.Res_367_112 |
| Author(s) : Okubo Y , Kasamatsu A , Yamatoji M , Fushimi K , Ishigami T , Shimizu T , Kasama H , Shiiba M , Tanzawa H , Uzawa K |
| Ref : Experimental Cell Research , 367 :112 , 2018 |
| Abstract : Okubo_2018_Exp.Cell.Res_367_112 |
| ESTHER : Okubo_2018_Exp.Cell.Res_367_112 |
| PubMedSearch : Okubo_2018_Exp.Cell.Res_367_112 |
| PubMedID: 29614312 |
| Gene_locus related to this paper: human-DAGLA |
| Title : Chemical Proteomics Maps Brain Region Specific Activity of Endocannabinoid Hydrolases - Baggelaar_2017_ACS.Chem.Biol_12_852 |
| Author(s) : Baggelaar MP , van Esbroeck AC , van Rooden EJ , Florea BI , Overkleeft HS , Marsicano G , Chaouloff F , van der Stelt M |
| Ref : ACS Chemical Biology , 12 :852 , 2017 |
| Abstract : Baggelaar_2017_ACS.Chem.Biol_12_852 |
| ESTHER : Baggelaar_2017_ACS.Chem.Biol_12_852 |
| PubMedSearch : Baggelaar_2017_ACS.Chem.Biol_12_852 |
| PubMedID: 28106377 |
| Gene_locus related to this paper: human-ABHD4 , human-ABHD6 , human-ABHD12 , human-DAGLA , human-MGLL |
| Title : A novel live cell assay to measure diacylglycerol lipase alpha activity - Singh_2016_Biosci.Rep_36_ |
| Author(s) : Singh PK , Markwick R , Howell FV , Williams G , Doherty P |
| Ref : Bioscience Reports , 36 : , 2016 |
| Abstract : Singh_2016_Biosci.Rep_36_ |
| ESTHER : Singh_2016_Biosci.Rep_36_ |
| PubMedSearch : Singh_2016_Biosci.Rep_36_ |
| PubMedID: 27013337 |
| Gene_locus related to this paper: human-DAGLA |
| Title : Rapid and profound rewiring of brain lipid signaling networks by acute diacylglycerol lipase inhibition - Ogasawara_2016_Proc.Natl.Acad.Sci.U.S.A_113_26 |
| Author(s) : Ogasawara D , Deng H , Viader A , Baggelaar MP , Breman A , den Dulk H , van den Nieuwendijk AM , Soethoudt M , van der Wel T , Zhou J , Overkleeft HS , Sanchez-Alavez M , Mori S , Nguyen W , Conti B , Liu X , Chen Y , Liu QS , Cravatt BF , van der Stelt M |
| Ref : Proc Natl Acad Sci U S A , 113 :26 , 2016 |
| Abstract : Ogasawara_2016_Proc.Natl.Acad.Sci.U.S.A_113_26 |
| ESTHER : Ogasawara_2016_Proc.Natl.Acad.Sci.U.S.A_113_26 |
| PubMedSearch : Ogasawara_2016_Proc.Natl.Acad.Sci.U.S.A_113_26 |
| PubMedID: 26668358 |
| Gene_locus related to this paper: human-DAGLA , human-DAGLB |
| Title : Highly Selective, Reversible Inhibitor Identified by Comparative Chemoproteomics Modulates Diacylglycerol Lipase Activity in Neurons - Baggelaar_2015_J.Am.Chem.Soc_137_8851 |
| Author(s) : Baggelaar MP , Chameau PJ , Kantae V , Hummel J , Hsu KL , Janssen F , van der Wel T , Soethoudt M , Deng H , den Dulk H , Allara M , Florea BI , Di Marzo V , Wadman WJ , Kruse CG , Overkleeft HS , Hankemeier T , Werkman TR , Cravatt BF , van der Stelt M |
| Ref : Journal of the American Chemical Society , 137 :8851 , 2015 |
| Abstract : Baggelaar_2015_J.Am.Chem.Soc_137_8851 |
| ESTHER : Baggelaar_2015_J.Am.Chem.Soc_137_8851 |
| PubMedSearch : Baggelaar_2015_J.Am.Chem.Soc_137_8851 |
| PubMedID: 26083464 |
| Gene_locus related to this paper: human-DAGLA , human-DAGLB |
| Title : Development of an activity-based probe and in silico design reveal highly selective inhibitors for diacylglycerol lipase-alpha in brain - |
| Author(s) : Baggelaar MP , Janssen FJ , van Esbroeck AC , den Dulk H , Allara M , Hoogendoorn S , McGuire R , Florea BI , Meeuwenoord N , van den Elst H , van der Marel GA , Brouwer J , Di Marzo V , Overkleeft HS , van der Stelt M |
| Ref : Angew Chem Int Ed Engl , 52 :12081 , 2013 |
| PubMedID: 24173880 |
| Gene_locus related to this paper: human-DAGLA |
| Title : Acute inhibition of diacylglycerol lipase blocks endocannabinoid-mediated retrograde signalling: evidence for on-demand biosynthesis of 2-arachidonoylglycerol - Hashimotodani_2013_J.Physiol_591_4765 |
| Author(s) : Hashimotodani Y , Ohno-Shosaku T , Tanimura A , Kita Y , Sano Y , Shimizu T , Di Marzo V , Kano M |
| Ref : The Journal of Physiology , 591 :4765 , 2013 |
| Abstract : Hashimotodani_2013_J.Physiol_591_4765 |
| ESTHER : Hashimotodani_2013_J.Physiol_591_4765 |
| PubMedSearch : Hashimotodani_2013_J.Physiol_591_4765 |
| PubMedID: 23858009 |
| Gene_locus related to this paper: human-DAGLA |
| Title : A novel fluorophosphonate inhibitor of the biosynthesis of the endocannabinoid 2-arachidonoylglycerol with potential anti-obesity effects - Bisogno_2013_Br.J.Pharmacol_169_784 |
| Author(s) : Bisogno T , Mahadevan A , Coccurello R , Chang JW , Allara M , Chen Y , Giacovazzo G , Lichtman A , Cravatt BF , Moles A , Di Marzo V |
| Ref : British Journal of Pharmacology , 169 :784 , 2013 |
| Abstract : Bisogno_2013_Br.J.Pharmacol_169_784 |
| ESTHER : Bisogno_2013_Br.J.Pharmacol_169_784 |
| PubMedSearch : Bisogno_2013_Br.J.Pharmacol_169_784 |
| PubMedID: 23072382 |
| Gene_locus related to this paper: human-DAGLA , human-DAGLB |
| Title : DAGLbeta inhibition perturbs a lipid network involved in macrophage inflammatory responses - Hsu_2012_Nat.Chem.Biol_8_999 |
| Author(s) : Hsu KL , Tsuboi K , Adibekian A , Pugh H , Masuda K , Cravatt BF |
| Ref : Nat Chemical Biology , 8 :999 , 2012 |
| Abstract : Hsu_2012_Nat.Chem.Biol_8_999 |
| ESTHER : Hsu_2012_Nat.Chem.Biol_8_999 |
| PubMedSearch : Hsu_2012_Nat.Chem.Biol_8_999 |
| PubMedID: 23103940 |
| Gene_locus related to this paper: human-DAGLA , human-DAGLB |
| Title : Activation of type 5 metabotropic glutamate receptors and diacylglycerol lipase-alpha initiates 2-arachidonoylglycerol formation and endocannabinoid-mediated analgesia - Gregg_2012_J.Neurosci_32_9457 |
| Author(s) : Gregg LC , Jung KM , Spradley JM , Nyilas R , Suplita RL, 2nd , Zimmer A , Watanabe M , Mackie K , Katona I , Piomelli D , Hohmann AG |
| Ref : Journal of Neuroscience , 32 :9457 , 2012 |
| Abstract : Gregg_2012_J.Neurosci_32_9457 |
| ESTHER : Gregg_2012_J.Neurosci_32_9457 |
| PubMedSearch : Gregg_2012_J.Neurosci_32_9457 |
| PubMedID: 22787031 |
| Gene_locus related to this paper: human-DAGLA |
| Title : DAGL-dependent endocannabinoid signalling: roles in axonal pathfinding, synaptic plasticity and adult neurogenesis - Oudin_2011_Eur.J.Neurosci_34_1634 |
| Author(s) : Oudin MJ , Hobbs C , Doherty P |
| Ref : European Journal of Neuroscience , 34 :1634 , 2011 |
| Abstract : Oudin_2011_Eur.J.Neurosci_34_1634 |
| ESTHER : Oudin_2011_Eur.J.Neurosci_34_1634 |
| PubMedSearch : Oudin_2011_Eur.J.Neurosci_34_1634 |
| PubMedID: 22103420 |
| Gene_locus related to this paper: human-DAGLA , human-DAGLB , mouse-DGLB , mouse-q6wqj1 |
| Title : The endocannabinoid 2-arachidonoylglycerol produced by diacylglycerol lipase alpha mediates retrograde suppression of synaptic transmission - Tanimura_2010_Neuron_65_320 |
| Author(s) : Tanimura A , Yamazaki M , Hashimotodani Y , Uchigashima M , Kawata S , Abe M , Kita Y , Hashimoto K , Shimizu T , Watanabe M , Sakimura K , Kano M |
| Ref : Neuron , 65 :320 , 2010 |
| Abstract : Tanimura_2010_Neuron_65_320 |
| ESTHER : Tanimura_2010_Neuron_65_320 |
| PubMedSearch : Tanimura_2010_Neuron_65_320 |
| PubMedID: 20159446 |
| Gene_locus related to this paper: human-DAGLA |
| Title : Development of a potent inhibitor of 2-arachidonoylglycerol hydrolysis with antinociceptive activity in vivo - Bisogno_2009_Biochim.Biophys.Acta_1791_53 |
| Author(s) : Bisogno T , Ortar G , Petrosino S , Morera E , Palazzo E , Nalli M , Maione S , Di Marzo V |
| Ref : Biochimica & Biophysica Acta , 1791 :53 , 2009 |
| Abstract : Bisogno_2009_Biochim.Biophys.Acta_1791_53 |
| ESTHER : Bisogno_2009_Biochim.Biophys.Acta_1791_53 |
| PubMedSearch : Bisogno_2009_Biochim.Biophys.Acta_1791_53 |
| PubMedID: 19027877 |
| Gene_locus related to this paper: human-DAGLA , human-DAGLB |
| Title : A duplication at chromosome 11q12.2-11q12.3 is associated with spinocerebellar ataxia type 20 - Knight_2008_Hum.Mol.Genet_17_3847 |
| Author(s) : Knight MA , Hernandez D , Diede SJ , Dauwerse HG , Rafferty I , van de Leemput J , Forrest SM , Gardner RJ , Storey E , van Ommen GJ , Tapscott SJ , Fischbeck KH , Singleton AB |
| Ref : Hum Mol Genet , 17 :3847 , 2008 |
| Abstract : Knight_2008_Hum.Mol.Genet_17_3847 |
| ESTHER : Knight_2008_Hum.Mol.Genet_17_3847 |
| PubMedSearch : Knight_2008_Hum.Mol.Genet_17_3847 |
| PubMedID: 18801880 |
| Gene_locus related to this paper: human-DAGLA |
| Title : Development of the first potent and specific inhibitors of endocannabinoid biosynthesis - Bisogno_2006_Biochim.Biophys.Acta_1761_205 |
| Author(s) : Bisogno T , Cascio MG , Saha B , Mahadevan A , Urbani P , Minassi A , Appendino G , Saturnino C , Martin B , Razdan R , Di Marzo V |
| Ref : Biochimica & Biophysica Acta , 1761 :205 , 2006 |
| Abstract : Bisogno_2006_Biochim.Biophys.Acta_1761_205 |
| ESTHER : Bisogno_2006_Biochim.Biophys.Acta_1761_205 |
| PubMedSearch : Bisogno_2006_Biochim.Biophys.Acta_1761_205 |
| PubMedID: 16466961 |
| Gene_locus related to this paper: human-DAGLA , human-DAGLB |
| Title : Dominantly inherited ataxia and dysphonia with dentate calcification: spinocerebellar ataxia type 20 - Knight_2004_Brain_127_1172 |
| Author(s) : Knight MA , Gardner RJ , Bahlo M , Matsuura T , Dixon JA , Forrest SM , Storey E |
| Ref : Brain , 127 :1172 , 2004 |
| Abstract : Knight_2004_Brain_127_1172 |
| ESTHER : Knight_2004_Brain_127_1172 |
| PubMedSearch : Knight_2004_Brain_127_1172 |
| PubMedID: 14998916 |
| Gene_locus related to this paper: human-DAGLA |
| Title : Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain - Bisogno_2003_J.Cell.Biol_163_463 |
| Author(s) : Bisogno T , Howell F , Williams G , Minassi A , Cascio MG , Ligresti A , Matias I , Schiano-Moriello A , Paul P , Williams EJ , Gangadharan U , Hobbs C , Di Marzo V , Doherty P |
| Ref : Journal of Cell Biology , 163 :463 , 2003 |
| Abstract : Bisogno_2003_J.Cell.Biol_163_463 |
| ESTHER : Bisogno_2003_J.Cell.Biol_163_463 |
| PubMedSearch : Bisogno_2003_J.Cell.Biol_163_463 |
| PubMedID: 14610053 |
| Gene_locus related to this paper: human-DAGLA , human-DAGLB , mouse-DGLB , mouse-q6wqj1 |
| Title : Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro - Ishikawa_1998_DNA.Res_5_169 |
| Author(s) : Ishikawa K , Nagase T , Suyama M , Miyajima N , Tanaka A , Kotani H , Nomura N , Ohara O |
| Ref : DNA Research , 5 :169 , 1998 |
| Abstract : Ishikawa_1998_DNA.Res_5_169 |
| ESTHER : Ishikawa_1998_DNA.Res_5_169 |
| PubMedSearch : Ishikawa_1998_DNA.Res_5_169 |
| PubMedID: 9734811 |
| Gene_locus related to this paper: human-DAGLA |