Gene_Locus Report

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Gene_locus Report for: human-MGLL

Homo sapiens (Human) Monoglyceride lipase (MAGL) lysophospholipase homolog

Comment
Human monoacylglycerol lipase (hMAGL Monoglyceride lipase MGLL) converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain. Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth


Relationship
Family|Monoglyceridelipase_lysophospholip
Block| X
Position in NCBI Life Tree|Homo sapiens
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms: N E > Eukaryota: N E > Opisthokonta: N E > Metazoa: N E > Eumetazoa: N E > Bilateria: N E > Deuterostomia: N E > Chordata: N E > Craniata: N E > Vertebrata: N E > Gnathostomata: N E > Teleostomi: N E > Euteleostomi: N E > Sarcopterygii: N E > Dipnotetrapodomorpha: N E > Tetrapoda: N E > Amniota: N E > Mammalia: N E > Theria: N E > Eutheria: N E > Boreoeutheria: N E > Euarchontoglires: N E > Primates: N E > Haplorrhini: N E > Simiiformes: N E > Catarrhini: N E > Hominoidea: N E > Hominidae: N E > Homininae: N E > Homo: N E > Homo sapiens: N E


Molecular evidence
Database
No mutation
16 structures (e.g. : 3HJU, 3JW8, 3JWE... more)
No kinetic





5 substrates (e.g. : 2-Arachidonylglycerol, AHMMCE, Arachidonoyl-1-thioglycerol... more)
49 inhibitors (e.g. : (R)-3t, 1-(2-Morpholine-acetamido)-tanshinone-IIA, 2-methyl-pentane-2,4-diol... more)
>3 Genbank links 12 more: U67963, CR456835, AJ270950
>3 UniProt links 1 more: Q99685, Q2VYF8, B2ZGL7
>3 Structure links 13 more: 8PTC, 8AQF, 7L4W
>3 UniProt links 4 more: Q99685, Q2VYF8, B2ZGL7
>3 Interpro links 4 more: Q99685, Q2VYF8, B2ZGL7
>3 Pfam links 4 more: Q99685, Q2VYF8, B2ZGL7
>3 PIRSF links 4 more: Q99685, Q2VYF8, B2ZGL7
>3 SUPERFAM links 4 more: Q99685, Q2VYF8, B2ZGL7
1 EntrezGene : 11343
1 SNP : 11343
1 HUGO HGNC : 17038
1 IUPHAR : 1399
1 OMIM : 609699
1 Ensembl : ENSG00000074416
Sequence
Graphical view for this peptide sequence: human-MGLL
Colored MSA for Monoglyceridelipase_lysophospholip (raw)
MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHG
AGEHSGRYEELARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDV
LQHVDSMQKDYPGLPVFLLGHSMGGAIAILTAAERPGHFAGMVLISPLVL
ANPESATTFKVLAAKVLNLVLPNLSLGPIDSSVLSRNKTEVDIYNSDPLI
CRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADRLCDSKGAYLL
MELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTA
SPP
Legend This sequence has been compared to family alignement (MSA)
red => minority aminoacid
blue => majority aminoacid
color intensity => conservation rate
title => sequence position(MSA position)aminoacid rate
Catalytic site
Catalytic site in the MSA

MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHG
AGEHSGRYEELARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDV
LQHVDSMQKDYPGLPVFLLGHSMGGAIAILTAAERPGHFAGMVLISPLVL
ANPESATTFKVLAAKVLNLVLPNLSLGPIDSSVLSRNKTEVDIYNSDPLI
CRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADRLCDSKGAYLL
MELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTA
SPP


References
76 more
    Title: MAGL inhibition relieves synovial inflammation and pain via regulating NOX4-Nrf2 redox balance in osteoarthritis
    Li X, Tao H, Zhou J, Zhang L, Shi Y, Zhang C, Sun W, Chu M, Chen K and Hao Y <3 more author(s)>
    Ref: Free Radic Biol Med, 208:13, 2023 : PubMed

            

    Title: ABHD6 and MAGL control 2-AG levels in the PAG and allodynia in a CSD-induced periorbital model of headache
    Liktor-Busa E, Levine AA, Palomino SM, Singh S, Wahl J, Vanderah TW, Stella N, Largent-Milnes TM
    Ref: Front Pain Res (Lausanne), 4:1171188, 2023 : PubMed

            

    Title: IL-8-induced CXCR2 down-regulation in circulating monocytes in hepatocellular carcinoma is partially dependent on MAGL
    Liu CZ, Liu XB, Sun J, Yu CQ, Yao JC, Liu Z, Hao JC
    Ref: BMC Cancer, 23:626, 2023 : PubMed

            


Other Papers


Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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