human-PLA1A

 
Homo sapiens (Human) Phospholipase A1 member A, phosphatidylserine-specific phospholipase A1 deltaC

Comment
Hydrolyzes the ester bond at the sn-1 position of glycerophospholipids and produces 2-acyl lysophospholipids. Hydrolyzes phosphatidylserine (PS) in the form of liposomes and 1-acyl-2 lysophosphatidylserine (lyso-PS), but not triolein, phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidic acid (PA) or phosphatidylinositol (PI). alternative splicing Q86WX6. old human-psplip


Relationship
Block L
Homo sapiens position in NCBI Life Tree :
N link to NCBI taxonomic web page and E link to ESTHER gene locus found in this strain.
> cellular organisms: N E > Eukaryota: N E > Opisthokonta: N E > Metazoa: N E > Eumetazoa: N E > Bilateria: N E > Deuterostomia: N E > Chordata: N E > Craniata: N E > Vertebrata: N E > Gnathostomata: N E > Teleostomi: N E > Euteleostomi: N E > Sarcopterygii: N E > Dipnotetrapodomorpha: N E > Tetrapoda: N E > Amniota: N E > Mammalia: N E > Theria: N E > Eutheria: N E > Boreoeutheria: N E > Euarchontoglires: N E > Primates: N E > Haplorrhini: N E > Simiiformes: N E > Catarrhini: N E > Hominoidea: N E > Hominidae: N E > Homininae: N E > Homo: N E > Homo sapiens: N E

Molecular evidence
Database
No mutation
No structure
No kinetic

Substrate: Lysophosphatidylserine ,

>3 Genbank links 4 more: NP_056984, AF035269, U37591
2 UniProt : Q53H76, H7C4H1
1 Ncbi-nid : 4090961
1 Ncbi-pid : 4090962
3 UniProtTrembl : G5E9W0, Q53H76, H7C4H1
3 Interpro : G5E9W0, Q53H76, H7C4H1
3 Prodom : G5E9W0, Q53H76, H7C4H1
3 Pfam : G5E9W0, Q53H76, H7C4H1
3 PIRSF : G5E9W0, Q53H76, H7C4H1
3 SUPERFAM : G5E9W0, Q53H76, H7C4H1
3 QuickSwissBlast : G5E9W0, Q53H76, H7C4H1
1 EntrezGene : 51365
1 SNP : 51365
1 UniGene : 437451
1 HUGO HGNC : 17661
1 OMIM : 607460
1 Ensembl : ENSG00000144837
 
Sequence
Graphical view for this peptide sequence: human-PLA1A
Colored MSA for Phospholipase (raw)
MPPGPWESCFWVGGLILWLSVGSSGDAPPTPQPKCADFQSANLFEGTDLK
VQFLLFVPSNPSCGQLVEGSSDLQNSGFNATLGTKLIIHGFRVLGTKPSW
IDTFIRTLLRATNANVIAVDWIYGSTGVYFSAVKNVIKLSLEISLFLNKL
LVLGVSESSIHIIGVSLGAHVGGMVGQLFGGQLGQITGLDPAGPEYTRAS
VEERLDAGDALFTEAIHTDTDNLGIRIPVGHVDYFVNGGQDQPGCPTFFY
AGYSYLICDHMRAVHLYISALENSCPLMAFPCASYKAFLAGRCLDCFNPF
LLSCPRIGLVEQGGVKIEPLPKEVKVYLLTTSSAPYCMHHSLVEFHLKEL
RNKDTNIEVTFLSSNITSSSKITIPKQQRYGKGIIAHATPQCQINQVKFK
FQSSNRVWKKDRTTIIGKFCTALLPVNDREKMVCLPEPVNLQASVTVSCD
LKIACV
Legend This sequence has been compared to family alignement (MSA)
red => minority aminoacid
blue => majority aminoacid
color intensity => conservation rate
title => sequence position(MSA position)aminoacid rate
Catalytic site
Catalytic site in the MSA

MPPGPWESCFWVGGLILWLSVGSSGDAPPTPQPKCADFQSANLFEGTDLK
VQFLLFVPSNPSCGQLVEGSSDLQNSGFNATLGTKLIIHGFRVLGTKPSW
IDTFIRTLLRATNANVIAVDWIYGSTGVYFSAVKNVIKLSLEISLFLNKL
LVLGVSESSIHIIGVSLGAHVGGMVGQLFGGQLGQITGLDPAGPEYTRAS
VEERLDAGDALFTEAIHTDTDNLGIRIPVGHVDYFVNGGQDQPGCPTFFY
AGYSYLICDHMRAVHLYISALENSCPLMAFPCASYKAFLAGRCLDCFNPF
LLSCPRIGLVEQGGVKIEPLPKEVKVYLLTTSSAPYCMHHSLVEFHLKEL
RNKDTNIEVTFLSSNITSSSKITIPKQQRYGKGIIAHATPQCQINQVKFK
FQSSNRVWKKDRTTIIGKFCTALLPVNDREKMVCLPEPVNLQASVTVSCD
LKIACV

Graphical view for this nucleotide DNA sequence (1811 bp): human-PLA1A



References
2 more
    Title: An alternative splicing form of phosphatidylserine-specific phospholipase A1 that exhibits lysophosphatidylserine-specific lysophospholipase activity in humans
    Nagai Y, Aoki J, Sato T, Amano K, Matsuda Y, Arai H and
    Ref: Journal of Biological Chemistry, 274:11053, 1999 : PubMed

            

    Title: Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library
    Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S
    Ref: Gene, 200:149, 1997 : PubMed

            

    Title: Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides
    Maruyama K, Sugano S
    Ref: Gene, 138:171, 1994 : PubMed

            


Other Papers


Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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