human-PNLIPRP1

 
Homo sapiens (Human) pancreatic lipase related protein 1

Comment
also clone MGC:12257 BC005233 13528867


Relationship
Block L
Homo sapiens position in NCBI Life Tree :
N link to NCBI taxonomic web page and E link to ESTHER gene locus found in this strain.
> cellular organisms: N E > Eukaryota: N E > Opisthokonta: N E > Metazoa: N E > Eumetazoa: N E > Bilateria: N E > Deuterostomia: N E > Chordata: N E > Craniata: N E > Vertebrata: N E > Gnathostomata: N E > Teleostomi: N E > Euteleostomi: N E > Sarcopterygii: N E > Dipnotetrapodomorpha: N E > Tetrapoda: N E > Amniota: N E > Mammalia: N E > Theria: N E > Eutheria: N E > Boreoeutheria: N E > Euarchontoglires: N E > Primates: N E > Haplorrhini: N E > Simiiformes: N E > Catarrhini: N E > Hominoidea: N E > Hominidae: N E > Homininae: N E > Homo: N E > Homo sapiens: N E

Molecular evidence
Database
No mutation
1 structure:
2PPL: Human Pancreatic lipase-related protein 1
No kinetic



>3 Genbank links 4 more: M93283, BC005233, BC025784
>3 UniProt links 6 more: P54315, E7EX42, E9PJC9
1 Ncbi-nid : 187229
1 Structure : 2PPL
>3 UniProtTrembl links 6 more: P54315, E7EX42, E9PJC9
>3 Interpro links 6 more: P54315, E7EX42, E9PJC9
>3 Prodom links 6 more: P54315, E7EX42, E9PJC9
>3 Pfam links 6 more: P54315, E7EX42, E9PJC9
>3 PIRSF links 6 more: P54315, E7EX42, E9PJC9
>3 SUPERFAM links 6 more: P54315, E7EX42, E9PJC9
>3 QuickSwissBlast links 6 more: P54315, E7EX42, E9PJC9
1 EntrezGene : 5407
1 SNP : 5407
1 UniGene : 73923
1 HUGO HGNC : 9156
1 OMIM : 604422
1 Ensembl : ENSG00000187021
 
Sequence
Graphical view for this peptide sequence: human-PNLIPRP1
Colored MSA for Pancreatic_lipase (raw)
MLIFWTITLFLLGAAKGKEVCYEDLGCFSDTEPWGGTAIRPLKILPWSPE
KIGTRFLLYTNENPNNFQILLLSDPSTIEASNFQMDRKTRFIIHGFIDKG
DESWVTDMCKKLFEVEEVNCICVDWKKGSQATYTQAANNVRVVGAQVAQM
LDILLTEYSYPPSKVHLIGHSLGAHVAGEAGSKTPGLSRITGLDPVEASF
ESTPEEVRLDPSDADFVDVIHTDAAPLIPFLGFGTNQQMGHLDFFPNGGE
SMPGCKKNALSQIVDLDGIWAGTRDFVACNHLRSYKYYLESILNPDGFAA
YPCTSYKSFESDKCFPCPDQGCPQMGHYADKFAGRTSEEQQKFFLNTGEA
SNFARWRYGVSITLSGRTATGQIKVALFGNKGNTHQYSIFRGILKPGSTH
SYEFDAKLDVGTIEKVKFLWNNNVINPTLPKVGATKITVQKGEEKTVYNF
CSEDTVREDTLLTLTPC
Legend This sequence has been compared to family alignement (MSA)
red => minority aminoacid
blue => majority aminoacid
color intensity => conservation rate
title => sequence position(MSA position)aminoacid rate
Catalytic site
Catalytic site in the MSA

MLIFWTITLFLLGAAKGKEVCYEDLGCFSDTEPWGGTAIRPLKILPWSPE
KIGTRFLLYTNENPNNFQILLLSDPSTIEASNFQMDRKTRFIIHGFIDKG
DESWVTDMCKKLFEVEEVNCICVDWKKGSQATYTQAANNVRVVGAQVAQM
LDILLTEYSYPPSKVHLIGHSLGAHVAGEAGSKTPGLSRITGLDPVEASF
ESTPEEVRLDPSDADFVDVIHTDAAPLIPFLGFGTNQQMGHLDFFPNGGE
SMPGCKKNALSQIVDLDGIWAGTRDFVACNHLRSYKYYLESILNPDGFAA
YPCTSYKSFESDKCFPCPDQGCPQMGHYADKFAGRTSEEQQKFFLNTGEA
SNFARWRYGVSITLSGRTATGQIKVALFGNKGNTHQYSIFRGILKPGSTH
SYEFDAKLDVGTIEKVKFLWNNNVINPTLPKVGATKITVQKGEEKTVYNF
CSEDTVREDTLLTLTPC

Graphical view for this nucleotide DNA sequence (1527 bp): human-PNLIPRP1



References
1 more
    Title: The DNA sequence and comparative analysis of human chromosome 10
    Deloukas P, Earthrowl ME, Grafham DV, Rubenfield M, French L, Steward CA, Sims SK, Jones MC, Searle S and Rogers J <126 more author(s)>
    Ref: Nature, 429:375, 2004 : PubMed

            

    Title: Pancreatic lipase-related protein 1 (PLRP1) is present in the pancreatic juice of several species
    De Caro J, Carriere F, Barboni P, Giller T, Verger R, de Caro A
    Ref: Biochimica & Biophysica Acta, 1387:331, 1998 : PubMed

            

    Title: Two novel human pancreatic lipase related proteins, hPLRP1 and hPLRP2. Differences in colipase dependence and in lipase activity
    Giller T, Buchwald P, Blum-Kaelin D, Hunziker W
    Ref: Journal of Biological Chemistry, 267:16509, 1992 : PubMed

            


Other Papers


Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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