human-PNLIPRP2

 
Homo sapiens (Human) pancreatic lipase related protein 2

Comment
human-PNLIPRP2 adopt in solution an open lid conformation which creates a large cavity capable of accommodating the galactose polar head of galactolipids (Eydoux 2008). q5jyh9 (old) protein (fragment) a dead processed gene (incomplete) nothing close in the genome to complete, RP6149D17.1-001, ENSG00000189372


Relationship
Block L
Homo sapiens position in NCBI Life Tree :
N link to NCBI taxonomic web page and E link to ESTHER gene locus found in this strain.
> cellular organisms: N E > Eukaryota: N E > Opisthokonta: N E > Metazoa: N E > Eumetazoa: N E > Bilateria: N E > Deuterostomia: N E > Chordata: N E > Craniata: N E > Vertebrata: N E > Gnathostomata: N E > Teleostomi: N E > Euteleostomi: N E > Sarcopterygii: N E > Dipnotetrapodomorpha: N E > Tetrapoda: N E > Amniota: N E > Mammalia: N E > Theria: N E > Eutheria: N E > Boreoeutheria: N E > Euarchontoglires: N E > Primates: N E > Haplorrhini: N E > Simiiformes: N E > Catarrhini: N E > Hominoidea: N E > Hominidae: N E > Homininae: N E > Homo: N E > Homo sapiens: N E

Molecular evidence
Database
No mutation
2 structures: 2PVS, 2OXE
Kinetic: human-PNLIPRP2

Substrate: Retinol-palmitate , Retinol-oleate , KM043 , DGDG , LMGL05010021 , C8-DGDG , C8-MGDG , MGDG , Tributyrin , Egg-Lecithin ,
Inhibitor: Paraoxon , Orlistat ,
>3 Genbank links 2 more: CR456949, M93284, BC005989
2 UniProt : P54317, A0A087WX88
1 Ncbi-nid : 187231
2 Structure : 2PVS, 2OXE
2 UniProtTrembl : P54317, A0A087WX88
2 Interpro : P54317, A0A087WX88
2 Prodom : P54317, A0A087WX88
2 Pfam : P54317, A0A087WX88
2 PIRSF : P54317, A0A087WX88
2 SUPERFAM : P54317, A0A087WX88
2 QuickSwissBlast : P54317, A0A087WX88
1 EntrezGene : 5408
1 SNP : 5408
1 UniGene : 423598
1 HUGO HGNC : 9157
1 OMIM : 604423
1 Ensembl : ENSG00000266200
 
Sequence
Graphical view for this peptide sequence: human-PNLIPRP2
Colored MSA for Pancreatic_lipase (raw)
MLPPWTLGLLLLATVRGKEVCYGQLGCFSDEKPWAGTLQRPVKLLPWSPE
DIDTRFLLYTNENPNNFQLITGTEPDTIEASNFQLDRKTRFIIHGFLDKA
EDSWPSDMCKKMFEVEKVNCICVDWRHGSRAMYTQAVQNIRVVGAETAFL
IQALSTQLGYSLEDVHVIGHSLGAHTAAEAGRRLGGRVGRITGLDPAGPC
FQDEPEEVRLDPSDAVFVDVIHTDSSPIVPSLGFGMSQKVGHLDFFPNGG
KEMPGCKKNVLSTITDIDGIWEGIGGFVSCNHLRSFEYYSSSVLNPDGFL
GYPCASYDEFQESKCFPCPAEGCPKMGHYADQFKGKTSAVEQTFFLNTGE
SGNFTSWRYKVSVTLSGKEKVNGYIRIALYGSNENSKQYEIFKGSLKPDA
SHTCAIDVDFNVGKIQKVKFLWNKRGINLSEPKLGASQITVQSGEDGTEY
NFCSSDTVEENVLQSLYPC
Legend This sequence has been compared to family alignement (MSA)
red => minority aminoacid
blue => majority aminoacid
color intensity => conservation rate
title => sequence position(MSA position)aminoacid rate
Catalytic site
Catalytic site in the MSA

MLPPWTLGLLLLATVRGKEVCYGQLGCFSDEKPWAGTLQRPVKLLPWSPE
DIDTRFLLYTNENPNNFQLITGTEPDTIEASNFQLDRKTRFIIHGFLDKA
EDSWPSDMCKKMFEVEKVNCICVDWRHGSRAMYTQAVQNIRVVGAETAFL
IQALSTQLGYSLEDVHVIGHSLGAHTAAEAGRRLGGRVGRITGLDPAGPC
FQDEPEEVRLDPSDAVFVDVIHTDSSPIVPSLGFGMSQKVGHLDFFPNGG
KEMPGCKKNVLSTITDIDGIWEGIGGFVSCNHLRSFEYYSSSVLNPDGFL
GYPCASYDEFQESKCFPCPAEGCPKMGHYADQFKGKTSAVEQTFFLNTGE
SGNFTSWRYKVSVTLSGKEKVNGYIRIALYGSNENSKQYEIFKGSLKPDA
SHTCAIDVDFNVGKIQKVKFLWNKRGINLSEPKLGASQITVQSGEDGTEY
NFCSSDTVEENVLQSLYPC

Graphical view for this nucleotide DNA sequence (1495 bp): human-PNLIPRP2



References
12 more
    Title: The beta5-Loop and Lid Domain Contribute to the Substrate Specificity of Pancreatic Lipase-related Protein 2 (PNLIPRP2)
    Xiao X, Lowe ME
    Ref: Journal of Biological Chemistry, 290:28847, 2015 : PubMed

            

    Title: Pancreatic lipase and pancreatic lipase-related protein 2, but not pancreatic lipase-related protein 1, hydrolyze retinyl palmitate in physiological conditions
    Reboul E, Berton A, Moussa M, Kreuzer C, Crenon I, Borel P
    Ref: Biochimica & Biophysica Acta, 1761:4, 2006 : PubMed

            

    Title: Two novel human pancreatic lipase related proteins, hPLRP1 and hPLRP2. Differences in colipase dependence and in lipase activity
    Giller T, Buchwald P, Blum-Kaelin D, Hunziker W
    Ref: Journal of Biological Chemistry, 267:16509, 1992 : PubMed

            


Other Papers


Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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