(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) > cellular organisms: NE > Eukaryota: NE > Stramenopiles: NE > Oomycetes: NE > Peronosporales: NE > Peronosporaceae: NE > Hyaloperonospora: NE > Hyaloperonospora arabidopsidis: NE
LegendThis sequence has been compared to family alignement (MSA) red => minority aminoacid blue => majority aminoacid color intensity => conservation rate title => sequence position(MSA position)aminoacid rate Catalytic site Catalytic site in the MSA MATSRNKSILSHHNYGNLCAKTLEPMLDSYTPTWWTNSHIQCLLTFIVPQ SSIKYQRQVLALKDGGQACLDWALESSIKMKTPLKPNSPIAVIMHGLVGC SESMRSICAEALLHGYRPVVFNKRGHGGLKLATPKLQQFGCVQDLKEAIA HIESSFPESKLYGIGYSAGSGLLCSYLGERGDKSRLRAGVLVSPGYNAFD LFCGGKINPFYNFLMTFTLKSFLLRHKKELSDVVDVAAALRATSIREFDQ HVYMKMHGYEDLESYWKVNNPMRDVDNIQVPLLCINALDDPVCTKETIPY DLFLDKPEAMLLTTAEGSHCAFFEGIFQLKAWCHTAAMVYLDRVREFDSI ATTSWDAPTAASPA
Many oomycete and fungal plant pathogens are obligate biotrophs, which extract nutrients only from living plant tissue and cannot grow apart from their hosts. Although these pathogens cause substantial crop losses, little is known about the molecular basis or evolution of obligate biotrophy. Here, we report the genome sequence of the oomycete Hyaloperonospora arabidopsidis (Hpa), an obligate biotroph and natural pathogen of Arabidopsis thaliana. In comparison with genomes of related, hemibiotrophic Phytophthora species, the Hpa genome exhibits dramatic reductions in genes encoding (i) RXLR effectors and other secreted pathogenicity proteins, (ii) enzymes for assimilation of inorganic nitrogen and sulfur, and (iii) proteins associated with zoospore formation and motility. These attributes comprise a genomic signature of evolution toward obligate biotrophy.
