Gene_locus Report for: legpa-q5x3j6

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms: N E > Bacteria: N E > Proteobacteria: N E > Gammaproteobacteria: N E > Legionellales: N E > Legionellaceae: N E > Legionella: N E > Legionella pneumophila: N E

6_AlphaBeta_hydrolase : legpa-q5ws59Legionella pneumophila (strain Paris); Legionella hackeliae hypothetical protein, legpa-q5x2c0Legionella pneumophila (strain Paris) hypothetical protein, legpa-q5x2s1Legionella pneumophila (strain Paris) hypothetical protein, legpa-q5x5b2Legionella pneumophila (strain Paris) Legionella pneumophila subsp. pneumophila (strain Philadelphia 1) (strain Lens) hypothetical protein, legpa-q5x5z2Legionella pneumophila (strain Paris) Legionella pneumophila subsp. pneumophila (strain Philadelphia 1) hypothetical protein, legpa-q5x8e6Legionella pneumophila (strain Paris) Legionella pneumophila subsp. pneumophila (strain Philadelphia 1) (strain Lens) hypothetical protein, legpa-q5x405Legionella pneumophila (strain Paris) (strain Corby) Legionella pneumophila subsp. pneumophila (strain Philadelphia 1) (strain Lens) hypothetical protein, legpc-a5iar0Legionella pneumophila (strains Corby; Lens; Paris; subsp. pneumophila str. Philadelphia 1 ATCC 33152 / DSM 7513) Probable hydrolase, legpl-q5wvw9Legionella pneumophila (strain Lens) (strain Paris) subsp. pneumophila (strain Philadelphia) hypothetical protein, legpn-Q8KU34Legionella pneumophila putative lipase lipa (strain paris philadelphia lens).
A85-IroE-IroD-Fes-Yiel : legpa-q5ws33Legionella pneumophila (strain Paris); Legionella hackeliae hypothetical protein, legpa-q5ws67Legionella pneumophila (strain Paris); Legionella hackeliae hypothetical protein.
abh_upf0017 : legpa-q5x4t1Legionella pneumophila hypothetical protein.
ACPH_Peptidase_S9 : legpa-q5x4r4Legionella pneumophila (strain Paris) (strain Lens) Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 )acylaminoacyl peptidase.
AlphaBeta_hydrolase : legph-q5zv00Legionella pneumophila subsp. pneumophila (strain Philadelphia 1) (strain Lens) sidb putative substrate of the dot/icm system.
BioH : legpa-q5x590Legionella pneumophila (strain Paris) (strain Lens) Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 ) (strain Corby) biotin biosynthesis protein bioh.
CarbLipBact_2 : legpl-q5wsw9Legionella pneumophila complete genome.
Chlorophyllase : legpa-q5ws68Legionella pneumophila (strain Paris); Legionella hackeliae hypothetical protein.
Dienelactone_hydrolase : legpl-q5wtd3Legionella pneumophila (strain Lens) Legionella pneumophila subsp. pneumophila (strain Philadelphia 1) egionella pneumophila (strain Paris) hypothetical protein, legpn-SBPALegionella pneumophila sbpa Legionella pneumophila (strain Paris)Legionella pneumophila subsp. pneumophila (strain Philadelphia).
DLH-S : legpc-a5iew3Legionella pneumophila (strains Corby; serogroup 1 (strain 2300/99 Alcoy)) Putative uncharacterized protein.
Duf_676 : legpa-q5x611Legionella pneumophila (strain Paris) hypothetical protein.
Duf_3141 : legpa-q5x3d6Legionella pneumophila (strain Paris) (strain Corby) (strain Lens) (strain Philadelphia 1 ATCC 33152 / DSM 7513) Putative uncharacterized protein, legpn-Q8RNQ1Legionella pneumophila (and subsp. pneumophila (strain Philadelphia 1 ATCC 33152 / DSM 7513) (strain Paris) (strain Corby) hypothetical protein.
Duf_3530 : legpl-q5wua5Legionella pneumophila Putative uncharacterized protein.
Est-OsmC : legpa-q5x8m4Legionella pneumophila Legionella pneumophila subsp. pneumophila esterase often found in n-term of an OsmC/Ohr family domain but not here.
Fungal-Bact_LIP : legph-q5zwi2 Legionella pneumophila Putative uncharacterized protein.
Hormone-sensitive_lipase_like : legpa-q5x424Legionella pneumophila Lipase.
lpg2422 : legph-q5zsu4 Legionella pneumophila subsp. pneumophila. Uncharacterized protein.
LYsophospholipase_carboxylesterase : legpa-q5x819Legionella pneumophila (strain Paris) (strain Lens) Legionella pneumophila subsp. pneumophila (strain Philadelphia 1) hypothetical protein.
PhaC_cen_dom : legpa-q5x2r4Legionella pneumophila, Polyhydroxyalkanoic synthase phbC, legpa-q5x322Legionella pneumophila PHA synthase.
PHA_synth_I : legpa-q5x7f5Legionella pneumophila (strain Paris) (strain Lens) Legionella pneumophila subsp. pneumophila (strain Philadelphia 1) hypothetical protein.
PlaB : legpn-i7i328 Legionella pneumophila subsp. pneumophila Legionella drancourtii, Phospholipase LpPlaB.
Proline_iminopeptidase : legpa-q5x473Legionella pneumophila hypothetical protein.
Thioesterase : legpa-q5x3a5Legionella pneumophila (strain Paris) Legionella pneumophila subsp. pneumophila (strain Philadelphia 1) hypothetical protein, legpl-q5wur2Legionella pneumophila (strain Lens) hypothetical protein

Title: Evidence in the Legionella pneumophila genome for exploitation of host cell functions and high genome plasticity
Cazalet C, Rusniok C, Bruggemann H, Zidane N, Magnier A, Ma L, Tichit M, Jarraud S, Bouchier C and Buchrieser C <4 more author(s)> Cazalet C, Rusniok C, Bruggemann H, Zidane N, Magnier A, Ma L, Tichit M, Jarraud S, Bouchier C, Vandenesch F, Kunst F, Etienne J, Glaser P, Buchrieser C (- 4)
Ref: Nat Genet, 36:1165, 2004 : PubMed
Abstract


ESTHER: Cazalet_2004_Nat.Genet_36_1165
PubMedSearch: Cazalet 2004 Nat.Genet 36 1165
PubMedID: 15467720
Gene_locus related to this paper: legph-q5zsu4, legpa-q5ws33, legpa-q5ws59, legpa-q5ws67, legpa-q5ws68, legpa-q5x2c0, legpa-q5x2r4, legpa-q5x2s1, legpa-q5x3a5, legpa-q5x3d6, legpa-q5x3j6, legpa-q5x4r4, legpa-q5x4t1, legpa-q5x5b2, legpa-q5x5z2, legpa-q5x7f5, legpa-q5x8e6, legpa-q5x8m4, legpa-q5x322, legpa-q5x405, legpa-q5x424, legpa-q5x473, legpa-q5x590, legpa-q5x611, legpa-q5x819, legpc-a5iar0, legph-q5zv00, legph-q5zwi2, legpl-q5wtd3, legpl-q5wua5, legpl-q5wur2, legpl-q5wvw9, legpn-Q8KU34, legpn-Q8RNQ1, legpn-SBPA, legpn-i7i328, legpl-q5wsw9

Abstract

Legionella pneumophila, the causative agent of Legionnaires' disease, replicates as an intracellular parasite of amoebae and persists in the environment as a free-living microbe. Here we have analyzed the complete genome sequences of L. pneumophila Paris (3,503,610 bp, 3,077 genes), an endemic strain that is predominant in France, and Lens (3,345,687 bp, 2,932 genes), an epidemic strain responsible for a major outbreak of disease in France. The L. pneumophila genomes show marked plasticity, with three different plasmids and with about 13% of the sequence differing between the two strains. Only strain Paris contains a type V secretion system, and its Lvh type IV secretion system is encoded by a 36-kb region that is either carried on a multicopy plasmid or integrated into the chromosome. Genetic mobility may enhance the versatility of L. pneumophila. Numerous genes encode eukaryotic-like proteins or motifs that are predicted to modulate host cell functions to the pathogen's advantage. The genome thus reflects the history and lifestyle of L. pneumophila, a human pathogen of macrophages that coevolved with fresh-water amoebae.