Gene_locus Report for: leibr-a4hk72

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms: N E > Eukaryota: N E > Euglenozoa: N E > Kinetoplastida: N E > Trypanosomatidae: N E > Leishmaniinae: N E > Leishmania [genus]: N E > Viannia: N E > Leishmania braziliensis species complex: N E > Leishmania braziliensis: N E

Title: Comparative genomic analysis of three Leishmania species that cause diverse human disease
Peacock CS, Seeger K, Harris D, Murphy L, Ruiz JC, Quail MA, Peters N, Adlem E, Tivey A and Berriman M <32 more author(s)> Peacock CS, Seeger K, Harris D, Murphy L, Ruiz JC, Quail MA, Peters N, Adlem E, Tivey A, Aslett M, Kerhornou A, Ivens A, Fraser A, Rajandream MA, Carver T, Norbertczak H, Chillingworth T, Hance Z, Jagels K, Moule S, Ormond D, Rutter S, Squares R, Whitehead S, Rabbinowitsch E, Arrowsmith C, White B, Thurston S, Bringaud F, Baldauf SL, Faulconbridge A, Jeffares D, Depledge DP, Oyola SO, Hilley JD, Brito LO, Tosi LR, Barrell B, Cruz AK, Mottram JC, Smith DF, Berriman M (- 32)
Ref: Nat Genet, 39:839, 2007 : PubMed
Abstract


ESTHER: Peacock_2007_Nat.Genet_39_839
PubMedSearch: Peacock 2007 Nat.Genet 39 839
PubMedID: 17572675
Gene_locus related to this paper: leibr-a4h6l0, leibr-a4h6l1, leibr-a4h9b6, leibr-a4h908, leibr-a4h956, leibr-a4h959, leibr-a4h960, leibr-a4hen1, leibr-a4hf07, leibr-a4hgl0, leibr-a4hhu6, leibr-a4hj94, leibr-a4hk72, leibr-a4hpa8, leibr-a4hpz5, leiin-a4huz4, leiin-a4hxe0, leiin-a4hxh8, leiin-a4hxi1, leiin-a4hxn7, leiin-a4hyv9, leiin-a4i1v9, leiin-a4i4z6, leiin-a4i6n9, leiin-a4i7q7, leiin-a4idl6, leima-e9ady6, leima-OPB, leima-q4q0t5, leima-q4q8a8, leima-q4q398, leima-q4q942, leima-q4qe85, leima-q4qe86, leima-q4qj45

Abstract

Leishmania parasites cause a broad spectrum of clinical disease. Here we report the sequencing of the genomes of two species of Leishmania: Leishmania infantum and Leishmania braziliensis. The comparison of these sequences with the published genome of Leishmania major reveals marked conservation of synteny and identifies only approximately 200 genes with a differential distribution between the three species. L. braziliensis, contrary to Leishmania species examined so far, possesses components of a putative RNA-mediated interference pathway, telomere-associated transposable elements and spliced leader-associated SLACS retrotransposons. We show that pseudogene formation and gene loss are the principal forces shaping the different genomes. Genes that are differentially distributed between the species encode proteins implicated in host-pathogen interactions and parasite survival in the macrophage.