(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) > cellular organisms: NE > Eukaryota: NE > Euglenozoa: NE > Kinetoplastida: NE > Trypanosomatidae: NE > Leishmaniinae: NE > Leishmania [genus]: NE > Leishmania [subgenus]: NE > Leishmania donovani species complex: NE > Leishmania infantum: NE
Warning: This entry is a compilation of different species or line or strain with more than 90% amino acide identity. You can retrieve all strain data
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) Leishmania mexicana MHOM/GT/2001/U1103: N, E.
Leishmania donovani BPK282A1: N, E.
LegendThis sequence has been compared to family alignement (MSA) red => minority aminoacid blue => majority aminoacid color intensity => conservation rate title => sequence position(MSA position)aminoacid rate Catalytic site Catalytic site in the MSA MPPSAHAATATNAEAQGDDVDMHVMTYDQRCHGRSTFAGGEDHLSIEVLM RDFLDVLQYAKTELYPTSNVYVLGHSLGGAVVARALSGNKSALERVSGVL LVDVVEGTAQLSLQHMKSFLKNRPNTFPEVKDAEVWFLRMGGMQNPQGAE VSVPPLLQQNDKTGLWQWRTDIRKMESVWDGWFAGLDEAFISLPCAKMLC TANAERLDKTLTVAQMQGKFQFEVIGNGCGHYVMDDATSTVVAKVRRFVK RNEVLTQKLQLMNKNLSGQKNNTTVPPNRM
Leishmania parasites cause a broad spectrum of clinical disease. Here we report the sequencing of the genomes of two species of Leishmania: Leishmania infantum and Leishmania braziliensis. The comparison of these sequences with the published genome of Leishmania major reveals marked conservation of synteny and identifies only approximately 200 genes with a differential distribution between the three species. L. braziliensis, contrary to Leishmania species examined so far, possesses components of a putative RNA-mediated interference pathway, telomere-associated transposable elements and spliced leader-associated SLACS retrotransposons. We show that pseudogene formation and gene loss are the principal forces shaping the different genomes. Genes that are differentially distributed between the species encode proteins implicated in host-pathogen interactions and parasite survival in the macrophage.
