Gene_locus Report for: leima-q4q7v8

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms: N E > Eukaryota: N E > Euglenozoa: N E > Kinetoplastida: N E > Trypanosomatidae: N E > Leishmaniinae: N E > Leishmania [genus]: N E > Leishmania [subgenus]: N E > Leishmania major species complex: N E > Leishmania major: N E

6_AlphaBeta_hydrolase : leima-L2464.12Leishmania major protein p265.36, unknown function, leima-q4q2c9Leishmania major hypothetical protein, leima-q4q942Leishmania major Leishmania infantum Putative uncharacterized protein, leima-q4qe87Leishmania major hydrolase-like protein, leima-q4qec8Leishmania major Putative uncharacterized protein.
ABHD17-depalmitoylase : leima-q4q4j7Leishmania major Putative serine peptidase.
abh_upf0017 : leima-q4qgz4Leishmania major Putative uncharacterized protein, leima-q4qgz5Leishmania major Putative uncharacterized protein.
Aclacinomycin-methylesterase_RdmC : leima-q4q8a8Leishmania major Leishmania infantum hydrolase, alpha/beta fold family, putative, leima-q4qe85Leishmania major Leishmania infantum Leishmania braziliensis hydrolase-like protein (esterase-like protein), leima-q4qe86Leishmania major Leishmania infantum hydrolase-like protein (esterase-like protein), leima-q4qe90Leishmania major hydrolase, alpha/beta fold family-like protein.
Carboxypeptidase_S10 : leima-q4qdz7Leishmania major family s10) (EC 3.4.16.5).
Cocaine_esterase : leima-q4q871Leishmania major putative.
Dienelactone_hydrolase : leima-q4q0a1Leishmania major similarity to endo-1-like protein.
DPP4N_Peptidase_S9 : leima-q4q1h9Leishmania major peptidase, clan sc, family s9b.
Duf_676 : leima-q4q819Leishmania major hypothetical protein, leima-q4qb85Leishmania major hypothetical protein.
Duf_726 : leima-q4qe31Leishmania major Putative uncharacterized protein.
Esterase_phb : leima-q4q0v0Leishmania major hypothetical protein (EC 3.1.1.73).
Fusarinine_C_esterase_sidJ : leima-q4q0t5Leishmania major, Leishmania infantum, Leishmania donovani, hypothetical protein.
LIDHydrolase : leima-q4q9g9Leishmania major Putative uncharacterized protein.
Lipase_3 : leima-L2802.02Leishmania major hypothetical 88.2 kda protein, leima-P883.01Leishmania major hypothetical 13.3 kda protein (fragment), leima-P883.35Leishmania major possible lipase precursor, leima-q4q4t6Leishmania major hypothetical protein, leima-q4q398Leishmania major, Leishmania mexicana, Leishmania infantum, Leishmania donovani, hypothetical protein, leima-q4q615Leishmania major lipase, putative (EC 3.1.1.3), leima-q4qe26Leishmania major hypothetical protein.
LYsophospholipase_carboxylesterase : leima-q4qae7Leishmania major lysophospholipase, putative.
Monoglyceridelipase_lysophospholip : leima-q4q6e9Leishmania major monoglyceride lipase, putative (EC 3.1.1.23).
PC-sterol_acyltransferase : leima-q4qhs0Leishmania major (EC 2.3.1.158).
PPase_methylesterase_euk : leima-q4q5j1Leishmania major Protein phosphatase methylesterase 1.
S9N_PPCE_Peptidase_S9 : leima-q4q080Leishmania major prolyl oligopeptidase (EC 3.4.21.26).
S9N_PREPL_Peptidase_S9 : leima-OPB Leishmania major Leishmania mexicana, Leishmania donovan, L. amazonensis, L. braziliensis, L. infantum, L. donovani, oligopeptidase B (EC 3.4.21.83), leima-q4qj45Leishmania major, Leishmania mexicana, L. donovani, L. amazonensis, L. braziliensis, L. infantum Oligopeptidase B-like protein Serine peptidase, clan sc, family s9a-like protein)

Title: The genome of the kinetoplastid parasite, Leishmania major
Ivens AC, Peacock CS, Worthey EA, Murphy L, Aggarwal G, Berriman M, Sisk E, Rajandream MA, Adlem E and Myler PJ <91 more author(s)> Ivens AC, Peacock CS, Worthey EA, Murphy L, Aggarwal G, Berriman M, Sisk E, Rajandream MA, Adlem E, Aert R, Anupama A, Apostolou Z, Attipoe P, Bason N, Bauser C, Beck A, Beverley SM, Bianchettin G, Borzym K, Bothe G, Bruschi CV, Collins M, Cadag E, Ciarloni L, Clayton C, Coulson RM, Cronin A, Cruz AK, Davies RM, De Gaudenzi J, Dobson DE, Duesterhoeft A, Fazelina G, Fosker N, Frasch AC, Fraser A, Fuchs M, Gabel C, Goble A, Goffeau A, Harris D, Hertz-Fowler C, Hilbert H, Horn D, Huang Y, Klages S, Knights A, Kube M, Larke N, Litvin L, Lord A, Louie T, Marra M, Masuy D, Matthews K, Michaeli S, Mottram JC, Muller-Auer S, Munden H, Nelson S, Norbertczak H, Oliver K, O'Neil S, Pentony M, Pohl TM, Price C, Purnelle B, Quail MA, Rabbinowitsch E, Reinhardt R, Rieger M, Rinta J, Robben J, Robertson L, Ruiz JC, Rutter S, Saunders D, Schafer M, Schein J, Schwartz DC, Seeger K, Seyler A, Sharp S, Shin H, Sivam D, Squares R, Squares S, Tosato V, Vogt C, Volckaert G, Wambutt R, Warren T, Wedler H, Woodward J, Zhou S, Zimmermann W, Smith DF, Blackwell JM, Stuart KD, Barrell B, Myler PJ (- 91)
Ref: Science, 309:436, 2005 : PubMed
Abstract


ESTHER: Ivens_2005_Science_309_436
PubMedSearch: Ivens 2005 Science 309 436
PubMedID: 16020728
Gene_locus related to this paper: leima-e9ady6, leima-L2464.12, leima-L2802.02, leima-OPB, leima-q4fw33, leima-q4fwg8, leima-q4fwj0, leima-q4fya7, leima-q4q0a1, leima-q4q0t5, leima-q4q0v0, leima-q4q1h9, leima-q4q2c9, leima-q4q4j7, leima-q4q4t6, leima-q4q5j1, leima-q4q6e9, leima-q4q7v8, leima-q4q8a8, leima-q4q9g9, leima-q4q080, leima-q4q398, leima-q4q615, leima-q4q819, leima-q4q871, leima-q4q942, leima-q4qae7, leima-q4qb85, leima-q4qdz7, leima-q4qe26, leima-q4qe31, leima-q4qe85, leima-q4qe86, leima-q4qe87, leima-q4qe90, leima-q4qec8, leima-q4qgz4, leima-q4qgz5, leima-q4qhs0, leima-q4qj45

Abstract

Leishmania species cause a spectrum of human diseases in tropical and subtropical regions of the world. We have sequenced the 36 chromosomes of the 32.8-megabase haploid genome of Leishmania major (Friedlin strain) and predict 911 RNA genes, 39 pseudogenes, and 8272 protein-coding genes, of which 36% can be ascribed a putative function. These include genes involved in host-pathogen interactions, such as proteolytic enzymes, and extensive machinery for synthesis of complex surface glycoconjugates. The organization of protein-coding genes into long, strand-specific, polycistronic clusters and lack of general transcription factors in the L. major, Trypanosoma brucei, and Trypanosoma cruzi (Tritryp) genomes suggest that the mechanisms regulating RNA polymerase II-directed transcription are distinct from those operating in other eukaryotes, although the trypanosomatids appear capable of chromatin remodeling. Abundant RNA-binding proteins are encoded in the Tritryp genomes, consistent with active posttranscriptional regulation of gene expression.