Gene_locus Report for: leima-q4q9g9 Leishmania major Putative uncharacterized protein
Relationship
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) cellular organisms: N E > Eukaryota: N E > Euglenozoa: N E > Kinetoplastida: N E > Trypanosomatidae: N E > Leishmaniinae: N E > Leishmania [genus]: N E > Leishmania [subgenus]: N E > Leishmania major species complex: N E > Leishmania major: N E 6_AlphaBeta_hydrolase :
leima-L2464.12 Leishmania major protein p265.36, unknown function ,
leima-q4q2c9 Leishmania major hypothetical protein ,
leima-q4q942 Leishmania major Leishmania infantum Putative uncharacterized protein ,
leima-q4qe87 Leishmania major hydrolase-like protein ,
leima-q4qec8 Leishmania major Putative uncharacterized protein .
ABHD17-depalmitoylase :
leima-q4q4j7 Leishmania major Putative serine peptidase .
abh_upf0017 :
leima-q4q7v8 Leishmania major Putative uncharacterized protein ,
leima-q4qgz4 Leishmania major Putative uncharacterized protein ,
leima-q4qgz5 Leishmania major Putative uncharacterized protein .
Aclacinomycin-methylesterase_RdmC :
leima-q4q8a8 Leishmania major Leishmania infantum hydrolase, alpha/beta fold family, putative ,
leima-q4qe85 Leishmania major Leishmania infantum Leishmania braziliensis hydrolase-like protein (esterase-like protein) ,
leima-q4qe86 Leishmania major Leishmania infantum hydrolase-like protein (esterase-like protein) ,
leima-q4qe90 Leishmania major hydrolase, alpha/beta fold family-like protein .
Carboxypeptidase_S10 :
leima-q4qdz7 Leishmania major family s10) (EC 3.4.16.5) .
Cocaine_esterase :
leima-q4q871 Leishmania major putative .
Dienelactone_hydrolase :
leima-q4q0a1 Leishmania major similarity to endo-1-like protein .
DPP4N_Peptidase_S9 :
leima-q4q1h9 Leishmania major peptidase, clan sc, family s9b .
Duf_676 :
leima-q4q819 Leishmania major hypothetical protein ,
leima-q4qb85 Leishmania major hypothetical protein .
Duf_726 :
leima-q4qe31 Leishmania major Putative uncharacterized protein .
Esterase_phb :
leima-q4q0v0 Leishmania major hypothetical protein (EC 3.1.1.73) .
Fusarinine_C_esterase_sidJ :
leima-q4q0t5 Leishmania major, Leishmania infantum, Leishmania donovani, hypothetical protein .
Lipase_3 :
leima-L2802.02 Leishmania major hypothetical 88.2 kda protein ,
leima-P883.01 Leishmania major hypothetical 13.3 kda protein (fragment) ,
leima-P883.35 Leishmania major possible lipase precursor ,
leima-q4q4t6 Leishmania major hypothetical protein ,
leima-q4q398 Leishmania major, Leishmania mexicana, Leishmania infantum, Leishmania donovani, hypothetical protein ,
leima-q4q615 Leishmania major lipase, putative (EC 3.1.1.3) ,
leima-q4qe26 Leishmania major hypothetical protein .
LYsophospholipase_carboxylesterase :
leima-q4qae7 Leishmania major lysophospholipase, putative .
Monoglyceridelipase_lysophospholip :
leima-q4q6e9 Leishmania major monoglyceride lipase, putative (EC 3.1.1.23) .
PC-sterol_acyltransferase :
leima-q4qhs0 Leishmania major (EC 2.3.1.158) .
PPase_methylesterase_euk :
leima-q4q5j1 Leishmania major Protein phosphatase methylesterase 1 .
S9N_PPCE_Peptidase_S9 :
leima-q4q080 Leishmania major prolyl oligopeptidase (EC 3.4.21.26) .
S9N_PREPL_Peptidase_S9 :
leima-OPB ,
leima-q4qj45 Leishmania major, Leishmania mexicana, L. donovani, L. amazonensis, L. braziliensis, L. infantum Oligopeptidase B-like protein Serine peptidase, clan sc, family s9a-like protein) Warning: This entry is a compilation of different species or line or strain with more than 90% amino acid identity. You can
retrieve all strain data
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) Leishmania major strain Friedlin:
N ,
E .
Molecular evidence
Database
No mutation No structure No kinetic No Substrate No inhibitor
Sequence
Graphical view for this peptide sequence: leima-q4q9g9 Colored MSA for LIDHydrolase (raw)
MSSPNTIVAWRAPVAGGAVVDVLQSSSNLLQYLSTEESSNDGRRLPSSHR
KLLFFFPGNPGLVQFYEPLCAFLETNKFDVLVMGYAGHSLTELNEGRVFS
LADQVDIAESFVATLMNKNTERKYNGNIYAAGHSIGGFVALQMVARYSVI
KKCFGLCPVMSHMRDSPNGRRLFYLSSTFVQCCLAMVAALLGLLPYKLRL
LLITTLEPNLSFALGEALAHHFHRRCLTNSLYMAMTEFRMLLQPDAALLR
CVQERLILYYVKKDGWAPLSFAEEIGGICPRLGACVIEEDAGVPHAWCLN
HSETVARNAILKHC
Legend
This sequence has been compared to family alignement (MSA) red => minority aminoacid blue => majority aminoacid color intensity => conservation rate title => sequence position(MSA position)aminoacid rate Catalytic site Catalytic site in the MSA
M S S P N T I V A W R A P V A G G A V V D V L Q S S S N L L Q Y L S T E E S S N D G R R L P S S H R K L L F F F P G N P G L V Q F Y E P L C A F L E T N K F D V L V M G Y A G H S L T E L N E G R V F S L A D Q V D I A E S F V A T L M N K N T E R K Y N G N I Y A A G H S I G G F V A L Q M V A R Y S V I K K C F G L C P V M S H M R D S P N G R R L F Y L S S T F V Q C C L A M V A A L L G L L P Y K L R L L L I T T L E P N L S F A L G E A L A H H F H R R C L T N S L Y M A M T E F R M L L Q P D A A L L R C V Q E R L I L Y Y V K K D G W A P L S F A E E I G G I C P R L G A C V I E E D A G V P H A W C L N H S E T V A R N A I L K H C
Reference
Title: The genome of the kinetoplastid parasite, Leishmania majorIvens AC , Peacock CS , Worthey EA , Murphy L , Aggarwal G , Berriman M , Sisk E , Rajandream MA , Adlem E and Myler PJ <91 more author(s)> Ivens AC , Peacock CS , Worthey EA , Murphy L , Aggarwal G , Berriman M , Sisk E , Rajandream MA , Adlem E , Aert R , Anupama A , Apostolou Z , Attipoe P , Bason N , Bauser C , Beck A , Beverley SM , Bianchettin G , Borzym K , Bothe G , Bruschi CV , Collins M , Cadag E , Ciarloni L , Clayton C , Coulson RM , Cronin A , Cruz AK , Davies RM , De Gaudenzi J , Dobson DE , Duesterhoeft A , Fazelina G , Fosker N , Frasch AC , Fraser A , Fuchs M , Gabel C , Goble A , Goffeau A , Harris D , Hertz-Fowler C , Hilbert H , Horn D , Huang Y , Klages S , Knights A , Kube M , Larke N , Litvin L , Lord A , Louie T , Marra M , Masuy D , Matthews K , Michaeli S , Mottram JC , Muller-Auer S , Munden H , Nelson S , Norbertczak H , Oliver K , O'Neil S , Pentony M , Pohl TM , Price C , Purnelle B , Quail MA , Rabbinowitsch E , Reinhardt R , Rieger M , Rinta J , Robben J , Robertson L , Ruiz JC , Rutter S , Saunders D , Schafer M , Schein J , Schwartz DC , Seeger K , Seyler A , Sharp S , Shin H , Sivam D , Squares R , Squares S , Tosato V , Vogt C , Volckaert G , Wambutt R , Warren T , Wedler H , Woodward J , Zhou S , Zimmermann W , Smith DF , Blackwell JM , Stuart KD , Barrell B , Myler PJ (- 91) Ref: Science, 309 :436, 2005 : PubMed Abstract ESTHER: Ivens_2005_Science_309_436 PubMedSearch: Ivens 2005 Science 309 436 PubMedID: 16020728 Gene_locus related to this paper: leima-e9ady6 ,
leima-L2464.12 ,
leima-L2802.02 ,
leima-OPB ,
leima-q4fw33 ,
leima-q4fwg8 ,
leima-q4fwj0 ,
leima-q4fya7 ,
leima-q4q0a1 ,
leima-q4q0t5 ,
leima-q4q0v0 ,
leima-q4q1h9 ,
leima-q4q2c9 ,
leima-q4q4j7 ,
leima-q4q4t6 ,
leima-q4q5j1 ,
leima-q4q6e9 ,
leima-q4q7v8 ,
leima-q4q8a8 ,
leima-q4q9g9 ,
leima-q4q080 ,
leima-q4q398 ,
leima-q4q615 ,
leima-q4q819 ,
leima-q4q871 ,
leima-q4q942 ,
leima-q4qae7 ,
leima-q4qb85 ,
leima-q4qdz7 ,
leima-q4qe26 ,
leima-q4qe31 ,
leima-q4qe85 ,
leima-q4qe86 ,
leima-q4qe87 ,
leima-q4qe90 ,
leima-q4qec8 ,
leima-q4qgz4 ,
leima-q4qgz5 ,
leima-q4qhs0 ,
leima-q4qj45 Abstract
Leishmania species cause a spectrum of human diseases in tropical and subtropical regions of the world. We have sequenced the 36 chromosomes of the 32.8-megabase haploid genome of Leishmania major (Friedlin strain) and predict 911 RNA genes, 39 pseudogenes, and 8272 protein-coding genes, of which 36% can be ascribed a putative function. These include genes involved in host-pathogen interactions, such as proteolytic enzymes, and extensive machinery for synthesis of complex surface glycoconjugates. The organization of protein-coding genes into long, strand-specific, polycistronic clusters and lack of general transcription factors in the L. major, Trypanosoma brucei, and Trypanosoma cruzi (Tritryp) genomes suggest that the mechanisms regulating RNA polymerase II-directed transcription are distinct from those operating in other eukaryotes, although the trypanosomatids appear capable of chromatin remodeling. Abundant RNA-binding proteins are encoded in the Tritryp genomes, consistent with active posttranscriptional regulation of gene expression.
Other Papers
Leishmania major Leishmania mexicana, Leishmania donovan, L. amazonensis, L. braziliensis, L. infantum, L. donovani, oligopeptidase B (EC 3.4.21.83)