Gene_locus Report for: macfa-CES1v1 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey); Macaca nemestrina (Pig-tailed macaque). Carboxylic ester hydrolase
Comment
Other strains: Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey); Macaca nemestrina (Pig-tailed macaque) Relationship
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) cellular organisms: N E > Eukaryota: N E > Opisthokonta: N E > Metazoa: N E > Eumetazoa: N E > Bilateria: N E > Deuterostomia: N E > Chordata: N E > Craniata: N E > Vertebrata: N E > Gnathostomata: N E > Teleostomi: N E > Euteleostomi: N E > Sarcopterygii: N E > Dipnotetrapodomorpha: N E > Tetrapoda: N E > Amniota: N E > Mammalia: N E > Theria: N E > Eutheria: N E > Boreoeutheria: N E > Euarchontoglires: N E > Primates: N E > Haplorrhini: N E > Simiiformes: N E > Catarrhini: N E > Cercopithecoidea: N E > Cercopithecidae: N E > Cercopithecinae: N E > Macaca: N E > Macaca fascicularis: N E ABHD6-Lip :
macfa-g7nzc0 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) ABHD6 .
ABHD8 :
macfa-q4r584 Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey) Abhydrolase domain containing 8 (abhd8) .
ABHD10 :
macfa-a0a2k5wkd0 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey). Abhydrolase domain containing 10 .
ABHD11-Acetyl_transferase :
macfa-a0a2k5vx54 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey). AB hydrolase-1 domain-containing protein .
ABHD12-PHARC :
macfa-g7pa87 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Putative uncharacterized protein ,
macfa-q4r766 Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey) reading frame 22 (c20orf22) .
ABHD13-BEM46 :
macfa-a0a2k5uyw5 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey). Abhydrolase domain containing 13 .
ABHD16 :
macfa-q4r8p0 Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey) BAT5 (HLA-B-associated transcript 5) (NG26 protein) (G5) (PP199) ,
macfa-a0a2k5vu07 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey). Abhydrolase domain containing 16B .
ABHD18 :
macfa-g8f4f7 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey). Putative uncharacterized protein .
abh_upf0017 :
macfa-abhd2 Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey) Abhydrolase containing 2 (abhd2), transcriptvariant 2 ,
macfa-a0a2k5v623 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey). Hydrolase_4 domain-containing protein .
ACHE :
macfa-g8f585 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey); Macaca nemestrina (Pig-tailed macaque) Putative uncharacterized protein .
Acidic_Lipase :
macfa-q4r4s5 Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey) acid, cholesterol esterase (wolmandisease) (lipa) .
Acyl-CoA_Thioesterase :
macfa-q4r4j8 Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey) Acyl-CoA thioesterase (zap128),mrna, refseq: nm_006821.3 .
Arb2_FAM172A :
macfa-g7p7y3 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey). Protein FAM172A .
Arylacetamide_deacetylase :
macfa-g8f3k0 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey). Putative uncharacterized protein .
BCHE :
macfa-BCHE Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey); Macaca nemestrina Butyrylcholinesterase .
Carboxypeptidase_S10 :
macfa-g7pv26 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Carboxypeptidase .
Carb_B_Chordata :
macfa-cxest Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey); Macaca nemestrina (Pig-tailed macaque) liver carboxylesterase 1 precursor (EC 3.1.1.1) ,
macfa-CES1v2 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey). Carboxylic ester hydrolase ,
macfa-CES5 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey); Macaca nemestrina (Pig-tailed macaque). Carboxylic ester hydrolase ,
macfa-CES2v3 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey); Macaca nemestrina (Pig-tailed macaque). mfCES2Av1 CES2v3 Carboxylic ester hydrolase ,
macfa-a0a2k5uar1 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) mfCES2C. Carboxylic ester hydrolase ,
macfa-a0a2k5uy76 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey); Macaca nemestrina (Pig-tailed macaque). Carboxylic ester hydrolase ,
macfa-a0a2k5wym0 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey); Macaca nemestrina (Pig-tailed macaque). Carboxylic ester hydrolase .
Cholesterol_esterase :
macfa-a0a2k5vz29 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey); Macaca nemestrina (Pig-tailed macaque). Carboxyl ester lipase .
CIB-CCG1-interacting-factor-B :
macfa-g7nzx2 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey). Putative uncharacterized protein .
CMBL :
macfa-a0a2k5tui1 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey). Carboxymethylenebutenolidase-like protein .
DPP4N_Peptidase_S9 :
macfa-q4r3b2 Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey) (dpp6), transcript variant 1 .
Duf_676 :
macfa-q4r8v0 Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey) loc51059 (loc51059) .
Epoxide_hydrolase :
macfa-q4r3z0 Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey) microsomal (xenobiotic) (ephx1) .
FSH1 :
macfa-g8f5i1 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey); Macaca nemestrina (Pig-tailed macaque); Macaca mulatta (Rhesus macaque). Ovarian cancer-associated gene 2 protein .
Hepatic_Lipase :
macfa-g7pbk1 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey). Hepatic triacylglycerol lipase .
Hydrolase_RBBP9_YdeN :
macfa-q4r5r1 Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey) binding protein 9 (rbbp9), transcriptvariant 2 .
Kynurenine-formamidase :
macfa-g7psx7 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey). N-formylkynurenine formamidase .
Lipase_3 :
macfa-a0a2k5uqq3 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey); Macaca nemestrina (Pig-tailed macaque). Uncharacterized protein .
Lipoprotein_Lipase :
macfa-lipli Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey) lipoprotein lipase (EC 3.1.1.34) ,
macfa-g8f3e1 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey). Lipase G, endothelial type ,
macfa-i7gcw6 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey). Lipoprotein lipase .
Maspardin-ACP33-SPG21_like :
macfa-SPG21 Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey)acid cluster protein 33 ACP33 (autosomal recessive, mastsyndrome) (spg21) Maspardin .
MEST-like :
macfa-q4r3p4 Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey) transcript homolog (mouse) (mest),transcript variant 1 .
Ndr_family :
macfa-ndrg2 Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey) (ndrg2), transcript variant 8 ,
macfa-q4r4q3 Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey) regulated gene 1 (ndrg1) ,
macfa-g7pgg6 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Putative uncharacterized protein .
Neuroligin :
macfa-g7nze2 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey); Macaca nemestrina (Pig-tailed macaque) Putative uncharacterized protein ,
macfa-g7q259 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Putative uncharacterized protein ,
macfa-3neur Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey); Macaca nemestrina (Pig-tailed macaque) hypothetical protein ,
macfa-a0a2k5w1n7 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey); Macaca nemestrina (Pig-tailed macaque). Neuroligin 2 ,
macfa-a0a2k5wkf3 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey); Macaca nemestrina (Pig-tailed macaque). Neuroligin .
NLS3-Tex30 :
macfa-KANSL3 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Putative uncharacterized protein ,
macfa-TEX30 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) testis expressed 30 .
Palmitoyl-protein_thioesterase :
macfa-PPT1 Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey) palmitoyl-protein thioesterase .
Pancreatic_lipase :
macfa-a0a2k5urk5 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey); Macaca nemestrina (Pig-tailed macaque). Pancreatic lipase ,
macfa-a0a2k5wye4 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey). Pancreatic lipase ,
macfa-g7pe14 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey); Macaca nemestrina (Pig-tailed macaque) Pancreatic lipase ,
macfa-a0a2k5x9b0 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey); Macaca nemestrina (Pig-tailed macaque) Pancreatic lipase .
Phospholipase :
macfa-g7nxn9 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey). Uncharacterized protein ,
macfa-a0a2k5u0a0 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey). Lipase H ,
macfa-a0a2k5tze4 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey). Lipase I .
S9N_PREPL_Peptidase_S9 :
macfa-ppcel Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Prolylendopeptidase-like .
SERHL :
macfa-a0a2k5v7v4 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey). Uncharacterized protein .
Thyroglobulin :
macfa-g7pd01 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey); Macaca nemestrina (Pig-tailed macaque) Thyroglobulin .
Valacyclovir-hydrolase :
macfa-g7p4b9 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Valacyclovir hydrolase Warning: This entry is a compilation of different species or line or strain with more than 90% amino acide identity. You can
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(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) Macaca nemestrina:
N ,
E .
Molecular evidence
Database
No mutation No structure No kinetic No Substrate No inhibitor
Sequence
Graphical view for this peptide sequence: macfa-CES1v1 Colored MSA for Carb_B_Chordata (raw)
MWLRALVLATLAAFTAWAGHPSSPPVVDTVHGKVLGKFVSLEGFAQPVAV
FLGIPFAKPPLGPLRFTPPQPAEPWSFVKNATSYPPMCSQDAVAGQVLSE
LFTNRKENIPLKLSEDCLYLNIYTPADLTKKNRLPVMVWIHGGGLMVGAA
STYDGLALAAHENVVVVTIQYRLGIWGFFSTGDEHSRGNWGHLDQLAALR
WVQDNIASFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLFHRAISESGV
ALTAVLVKKGDVKPLAEQIAIAAGCQTTTSAVMVHCLRQKTEEELLETTL
KMKFFSLDLHGDPRESHPFLGTVIDGLLLPKTPEELQAERKFNTVPYMVG
FNKQEFGWIIPMLMGYPLSEGKLDQKTAMSLLWKSYPLVYIAKELIPEAT
EKYLGGTNDPVKKKDLFLDLLADVMFSVPSVIVARHHRDAGVPTYMYEFQ
YRPSFSSDMKPKTVIGDHGDELFSVFGAPFLKEGASEEEIRLSKMVMKFW
ANFARNGNPNGEGLPRWPEYNQEEGYLQIGANTQAAQKLKDKEVAFWTTL
FAKKAVEKPPQTEHIEL
Legend
This sequence has been compared to family alignement (MSA) red => minority aminoacid blue => majority aminoacid color intensity => conservation rate title => sequence position(MSA position)aminoacid rate Catalytic site Catalytic site in the MSA
M W L R A L V L A T L A A F T A W A G H P S S P P V V D T V H G K V L G K F V S L E G F A Q P V A V F L G I P F A K P P L G P L R F T P P Q P A E P W S F V K N A T S Y P P M C S Q D A V A G Q V L S E L F T N R K E N I P L K L S E D C L Y L N I Y T P A D L T K K N R L P V M V W I H G G G L M V G A A S T Y D G L A L A A H E N V V V V T I Q Y R L G I W G F F S T G D E H S R G N W G H L D Q L A A L R W V Q D N I A S F G G N P G S V T I F G E S A G G E S V S V L V L S P L A K N L F H R A I S E S G V A L T A V L V K K G D V K P L A E Q I A I A A G C Q T T T S A V M V H C L R Q K T E E E L L E T T L K M K F F S L D L H G D P R E S H P F L G T V I D G L L L P K T P E E L Q A E R K F N T V P Y M V G F N K Q E F G W I I P M L M G Y P L S E G K L D Q K T A M S L L W K S Y P L V Y I A K E L I P E A T E K Y L G G T N D P V K K K D L F L D L L A D V M F S V P S V I V A R H H R D A G V P T Y M Y E F Q Y R P S F S S D M K P K T V I G D H G D E L F S V F G A P F L K E G A S E E E I R L S K M V M K F W A N F A R N G N P N G E G L P R W P E Y N Q E E G Y L Q I G A N T Q A A Q K L K D K E V A F W T T L F A K K A V E K P P Q T E H I E L
Reference
Title: Systematic identification and characterization of carboxylesterases in cynomolgus macaquesUno Y , Uehara S , Hosokawa M , Imai T Ref: Drug Metabolism & Disposition: The Biological Fate of Chemicals, 42 :2002, 2014 : PubMed Abstract ESTHER: Uno_2014_Drug.Metab.Dispos_42_2002 PubMedSearch: Uno 2014 Drug.Metab.Dispos 42 2002 PubMedID: 25256558 Gene_locus related to this paper: macfa-CES1v2 ,
macfa-CES1v1 ,
macfa-CES5 ,
macfa-CES2v3 Abstract
Carboxylesterase (CES) is important for detoxification of a wide range of drugs and xenobiotics and catalyzes cholesterol and fatty acid metabolism. Cynomolgus macaques are widely used in drug metabolism studies; however, cynomolgus CES has not been fully investigated at molecular levels, partly due to the lack of gene information. In this study, we isolated and characterized cDNAs for CES homologous to human CES1, CES2, and CES5A in cynomolgus macaques. By genome analysis, in the cynomolgus macaque genome, three gene sequences were found for CES1(v1-3) and CES2(v1-3), whereas one gene sequence was found for CES5A. Cynomolgus CES1, CES2, and CES5A genes were located in the genomic regions corresponding to the human genes. We successfully identified CES1v1, CES1v2, CES2v1, CES2v3, and CES5A cDNAs from cynomolgus liver. Sequence analysis showed that amino acid sequences of each CES were highly homologous to that of the human homolog. All five CESs had sequences characteristic for CES enzymes, including the catalytic triad and oxyanion hole loop. By quantitative polymerase chain reaction, the most abundant expression of CES mRNAs among the 10 tissue types analyzed was observed in liver (CES1v1 and CES2v3 mRNAs), jejunum (CES2v1 mRNAs), and kidney (CES1v2 and CES5A mRNA), the organs important for drug metabolism and excretion. The results indicated that cynomolgus macaques express at least five CES genes, which potentially encode intact CES proteins.
Other Papers
