Gene_locus Report for: macfa-SPG21 Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey)acid cluster protein 33 ACP33 (autosomal recessive, mastsyndrome) (spg21) Maspardin
Relationship
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) cellular organisms: N E > Eukaryota: N E > Opisthokonta: N E > Metazoa: N E > Eumetazoa: N E > Bilateria: N E > Deuterostomia: N E > Chordata: N E > Craniata: N E > Vertebrata: N E > Gnathostomata: N E > Teleostomi: N E > Euteleostomi: N E > Sarcopterygii: N E > Dipnotetrapodomorpha: N E > Tetrapoda: N E > Amniota: N E > Mammalia: N E > Theria: N E > Eutheria: N E > Boreoeutheria: N E > Euarchontoglires: N E > Primates: N E > Haplorrhini: N E > Simiiformes: N E > Catarrhini: N E > Cercopithecoidea: N E > Cercopithecidae: N E > Cercopithecinae: N E > Macaca: N E > Macaca fascicularis: N E ABHD6-Lip :
macfa-g7nzc0 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) ABHD6 .
ABHD8 :
macfa-q4r584 Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey) Abhydrolase domain containing 8 (abhd8) .
ABHD10 :
macfa-a0a2k5wkd0 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey). Abhydrolase domain containing 10 .
ABHD11-Acetyl_transferase :
macfa-a0a2k5vx54 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey). AB hydrolase-1 domain-containing protein .
ABHD12-PHARC :
macfa-g7pa87 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Putative uncharacterized protein ,
macfa-q4r766 Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey) reading frame 22 (c20orf22) .
ABHD13-BEM46 :
macfa-a0a2k5uyw5 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey). Abhydrolase domain containing 13 .
ABHD16 :
macfa-q4r8p0 Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey) BAT5 (HLA-B-associated transcript 5) (NG26 protein) (G5) (PP199) ,
macfa-a0a2k5vu07 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey). Abhydrolase domain containing 16B .
ABHD18 :
macfa-g8f4f7 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey). Putative uncharacterized protein .
abh_upf0017 :
macfa-abhd2 Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey) Abhydrolase containing 2 (abhd2), transcriptvariant 2 ,
macfa-a0a2k5v623 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey). Hydrolase_4 domain-containing protein .
ACHE :
macfa-g8f585 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey); Macaca nemestrina (Pig-tailed macaque) Putative uncharacterized protein .
Acidic_Lipase :
macfa-q4r4s5 Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey) acid, cholesterol esterase (wolmandisease) (lipa) .
Acyl-CoA_Thioesterase :
macfa-q4r4j8 Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey) Acyl-CoA thioesterase (zap128),mrna, refseq: nm_006821.3 .
Arb2_FAM172A :
macfa-g7p7y3 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey). Protein FAM172A .
Arylacetamide_deacetylase :
macfa-g8f3k0 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey). Putative uncharacterized protein .
BCHE :
macfa-BCHE Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey); Macaca nemestrina Butyrylcholinesterase .
Carboxypeptidase_S10 :
macfa-g7pv26 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Carboxypeptidase .
Carb_B_Chordata :
macfa-cxest Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey); Macaca nemestrina (Pig-tailed macaque) liver carboxylesterase 1 precursor (EC 3.1.1.1) ,
macfa-CES1v2 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey). Carboxylic ester hydrolase ,
macfa-CES1v1 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey); Macaca nemestrina (Pig-tailed macaque). Carboxylic ester hydrolase ,
macfa-CES5 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey); Macaca nemestrina (Pig-tailed macaque). Carboxylic ester hydrolase ,
macfa-CES2v3 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey); Macaca nemestrina (Pig-tailed macaque). mfCES2Av1 CES2v3 Carboxylic ester hydrolase ,
macfa-a0a2k5uar1 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) mfCES2C. Carboxylic ester hydrolase ,
macfa-a0a2k5uy76 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey); Macaca nemestrina (Pig-tailed macaque). Carboxylic ester hydrolase ,
macfa-a0a2k5wym0 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey); Macaca nemestrina (Pig-tailed macaque). Carboxylic ester hydrolase .
Cholesterol_esterase :
macfa-a0a2k5vz29 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey); Macaca nemestrina (Pig-tailed macaque). Carboxyl ester lipase .
CIB-CCG1-interacting-factor-B :
macfa-g7nzx2 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey). Putative uncharacterized protein .
CMBL :
macfa-a0a2k5tui1 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey). Carboxymethylenebutenolidase-like protein .
DPP4N_Peptidase_S9 :
macfa-q4r3b2 Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey) (dpp6), transcript variant 1 .
Duf_676 :
macfa-q4r8v0 Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey) loc51059 (loc51059) .
Epoxide_hydrolase :
macfa-q4r3z0 Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey) microsomal (xenobiotic) (ephx1) .
FSH1 :
macfa-g8f5i1 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey); Macaca nemestrina (Pig-tailed macaque); Macaca mulatta (Rhesus macaque). Ovarian cancer-associated gene 2 protein .
Hepatic_Lipase :
macfa-g7pbk1 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey). Hepatic triacylglycerol lipase .
Hydrolase_RBBP9_YdeN :
macfa-q4r5r1 Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey) binding protein 9 (rbbp9), transcriptvariant 2 .
Kynurenine-formamidase :
macfa-g7psx7 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey). N-formylkynurenine formamidase .
Lipase_3 :
macfa-a0a2k5uqq3 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey); Macaca nemestrina (Pig-tailed macaque). Uncharacterized protein .
Lipoprotein_Lipase :
macfa-lipli Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey) lipoprotein lipase (EC 3.1.1.34) ,
macfa-g8f3e1 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey). Lipase G, endothelial type ,
macfa-i7gcw6 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey). Lipoprotein lipase .
MEST-like :
macfa-q4r3p4 Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey) transcript homolog (mouse) (mest),transcript variant 1 .
Ndr_family :
macfa-ndrg2 Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey) (ndrg2), transcript variant 8 ,
macfa-q4r4q3 Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey) regulated gene 1 (ndrg1) ,
macfa-g7pgg6 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Putative uncharacterized protein .
Neuroligin :
macfa-g7nze2 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey); Macaca nemestrina (Pig-tailed macaque) Putative uncharacterized protein ,
macfa-g7q259 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Putative uncharacterized protein ,
macfa-3neur Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey); Macaca nemestrina (Pig-tailed macaque) hypothetical protein ,
macfa-a0a2k5w1n7 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey); Macaca nemestrina (Pig-tailed macaque). Neuroligin 2 ,
macfa-a0a2k5wkf3 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey); Macaca nemestrina (Pig-tailed macaque). Neuroligin .
NLS3-Tex30 :
macfa-KANSL3 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Putative uncharacterized protein ,
macfa-TEX30 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) testis expressed 30 .
Palmitoyl-protein_thioesterase :
macfa-PPT1 Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey) palmitoyl-protein thioesterase .
Pancreatic_lipase :
macfa-a0a2k5urk5 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey); Macaca nemestrina (Pig-tailed macaque). Pancreatic lipase ,
macfa-a0a2k5wye4 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey). Pancreatic lipase ,
macfa-g7pe14 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey); Macaca nemestrina (Pig-tailed macaque) Pancreatic lipase ,
macfa-a0a2k5x9b0 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey); Macaca nemestrina (Pig-tailed macaque) Pancreatic lipase .
Phospholipase :
macfa-g7nxn9 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey). Uncharacterized protein ,
macfa-a0a2k5u0a0 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey). Lipase H ,
macfa-a0a2k5tze4 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey). Lipase I .
S9N_PREPL_Peptidase_S9 :
macfa-ppcel Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Prolylendopeptidase-like .
SERHL :
macfa-a0a2k5v7v4 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey). Uncharacterized protein .
Thyroglobulin :
macfa-g7pd01 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey); Macaca nemestrina (Pig-tailed macaque) Thyroglobulin .
Valacyclovir-hydrolase :
macfa-g7p4b9 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Valacyclovir hydrolase Molecular evidence
Database
No mutation No structure No kinetic No Substrate No inhibitor
Sequence
Graphical view for this peptide sequence: macfa-SPG21 Colored MSA for Maspardin-ACP33-SPG21_like (raw)
MGEVKVSPDYNWFRGTVPLKKIIVDDDDSKIWSLYDAGPRSIRCPLIFLP
PVSGTADVFFRQILALTGWGYRVIALQYPVYWDHLEFCDGFRKLLDHLQL
DKVHLFGASLGGFLAQKFAEYTHKSPRVHSLILCNSFSDTSIFNQTWTAN
SFWLMPAFMLKKIVLGNFSSGPVDPMMADAIDFMVDRLESLGQSELASRL
TLNCQNSYVEPHKIRDIPVTIMDVFDQSALSTEAKEEMYKLYPNARRAHL
KTGGNFPYLCRSAEVNLYVQIHLLQFHGTKYAAIDPSMVSAEELEVQKGS
LGINQEEQ
Legend
This sequence has been compared to family alignement (MSA) red => minority aminoacid blue => majority aminoacid color intensity => conservation rate title => sequence position(MSA position)aminoacid rate Catalytic site Catalytic site in the MSA
M G E V K V S P D Y N W F R G T V P L K K I I V D D D D S K I W S L Y D A G P R S I R C P L I F L P P V S G T A D V F F R Q I L A L T G W G Y R V I A L Q Y P V Y W D H L E F C D G F R K L L D H L Q L D K V H L F G A S L G G F L A Q K F A E Y T H K S P R V H S L I L C N S F S D T S I F N Q T W T A N S F W L M P A F M L K K I V L G N F S S G P V D P M M A D A I D F M V D R L E S L G Q S E L A S R L T L N C Q N S Y V E P H K I R D I P V T I M D V F D Q S A L S T E A K E E M Y K L Y P N A R R A H L K T G G N F P Y L C R S A E V N L Y V Q I H L L Q F H G T K Y A A I D P S M V S A E E L E V Q K G S L G I N Q E E Q
References
Title: Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaquesYan G , Zhang G , Fang X , Zhang Y , Li C , Ling F , Cooper DN , Li Q , Li Y and Wang X <32 more author(s)> Yan G , Zhang G , Fang X , Zhang Y , Li C , Ling F , Cooper DN , Li Q , Li Y , van Gool AJ , Du H , Chen J , Chen R , Zhang P , Huang Z , Thompson JR , Meng Y , Bai Y , Wang J , Zhuo M , Wang T , Huang Y , Wei L , Li J , Wang Z , Hu H , Yang P , Le L , Stenson PD , Li B , Liu X , Ball EV , An N , Huang Q , Fan W , Zhang X , Wang W , Katze MG , Su B , Nielsen R , Yang H , Wang X (- 32) Ref: Nat Biotechnol, 29 :1019, 2011 : PubMed Abstract ESTHER: Yan_2011_Nat.Biotechnol_29_1019 PubMedSearch: Yan 2011 Nat.Biotechnol 29 1019 PubMedID: 22002653 Gene_locus related to this paper: macfa-BCHE ,
macfa-g7nzc0 ,
macfa-g7nze2 ,
macfa-g7p4b9 ,
macfa-g7pa87 ,
macfa-g7pd01 ,
macfa-g7q259 ,
macfa-3neur ,
macfa-g8f585 ,
macfa-KANSL3 ,
macfa-q4r8p0 ,
macfa-SPG21 ,
macfa-TEX30 ,
macmu-3neur ,
macmu-ACHE ,
macmu-BCHE ,
macmu-f6sz31 ,
macmu-f6the6 ,
macmu-f6zkq5 ,
macmu-f7buk8 ,
macmu-f7cfi8 ,
macmu-f7flv1 ,
macmu-f7ggk1 ,
macmu-f7hir7 ,
macmu-g7n054 ,
macmu-g7npb8 ,
macmu-g7nq39 ,
macmu-KANSL3 ,
macmu-TEX30 ,
macfa-g7pgg6 ,
macmu-g7n4x3 ,
macfa-g7nzx2 ,
macfa-g8f4f7 ,
macmu-f7ba84 ,
macfa-g7psx7 ,
macmu-h9er02 ,
macfa-g8f3k0 ,
macfa-a0a2k5w1n7 ,
macmu-g7mxj6 ,
macfa-g7pbk1 ,
macfa-a0a2k5urk5 ,
macfa-a0a2k5wye4 ,
macfa-g7pe14 ,
macmu-f7hkw9 ,
macmu-f7hm08 ,
macmu-g7mke4 ,
macfa-g7nxn9 ,
macmu-a0a1d5rh04 ,
macmu-h9fud6 ,
macfa-g8f3e1 ,
macfa-i7gcw6 ,
macmu-f6qwx1 ,
macmu-f7h4t2 ,
macfa-a0a2k5wkd0 ,
macfa-a0a2k5v7v4 ,
macfa-g7p7y3 ,
macfa-a0a2k5uqq3 ,
macmu-i2cu80 ,
macfa-g8f5i1 ,
macmu-f7h550 ,
macmu-f7gkb9 ,
macfa-a0a2k5tui1 Abstract
The nonhuman primates most commonly used in medical research are from the genus Macaca. To better understand the genetic differences between these animal models, we present high-quality draft genome sequences from two macaque species, the cynomolgus/crab-eating macaque and the Chinese rhesus macaque. Comparison with the previously sequenced Indian rhesus macaque reveals that all three macaques maintain abundant genetic heterogeneity, including millions of single-nucleotide substitutions and many insertions, deletions and gross chromosomal rearrangements. By assessing genetic regions with reduced variability, we identify genes in each macaque species that may have experienced positive selection. Genetic divergence patterns suggest that the cynomolgus macaque genome has been shaped by introgression after hybridization with the Chinese rhesus macaque. Macaque genes display a high degree of sequence similarity with human disease gene orthologs and drug targets. However, we identify several putatively dysfunctional genetic differences between the three macaque species, which may explain functional differences between them previously observed in clinical studies.
Title: Substitution rate and structural divergence of 5'UTR evolution: comparative analysis between human and cynomolgus monkey cDNAsOsada N , Hirata M , Tanuma R , Kusuda J , Hida M , Suzuki Y , Sugano S , Gojobori T , Shen CK and Hashimoto K <1 more author(s)> Osada N , Hirata M , Tanuma R , Kusuda J , Hida M , Suzuki Y , Sugano S , Gojobori T , Shen CK , Wu CI , Hashimoto K (- 1) Ref: Molecular Biology Evolution, 22 :1976, 2005 : PubMed Abstract ESTHER: Osada_2005_Mol.Biol.Evol_22_1976 PubMedSearch: Osada 2005 Mol.Biol.Evol 22 1976 PubMedID: 15944441 Gene_locus related to this paper: macfa-abhd2 ,
macfa-ndrg2 ,
macfa-PPT1 ,
macfa-q4r3b2 ,
macfa-q4r3p4 ,
macfa-q4r3z0 ,
macfa-q4r4j8 ,
macfa-q4r4q3 ,
macfa-q4r4s5 ,
macmu-f6rbn1 ,
macfa-q4r5r1 ,
macfa-q4r8p0 ,
macfa-q4r8v0 ,
macfa-q4r584 ,
macfa-q4r766 ,
macfa-SPG21 Abstract
The substitution rate and structural divergence in the 5'-untranslated region (UTR) were investigated by using human and cynomolgus monkey cDNA sequences. Due to the weaker functional constraint in the UTR than in the coding sequence, the divergence between humans and macaques would provide a good estimate of the nucleotide substitution rate and structural divergence in the 5'UTR. We found that the substitution rate in the 5'UTR (K5UTR) averaged approximately 10%-20% lower than the synonymous substitution rate (Ks). However, both the K5UTR and nonsynonymous substitution rate (Ka) were significantly higher in the testicular cDNAs than in the brain cDNAs, whereas the Ks did not differ. Further, an in silico analysis revealed that 27% (169/622) of macaque testicular cDNAs had an altered exon-intron structure in the 5'UTR compared with the human cDNAs. The fraction of cDNAs with an exon alteration was significantly higher in the testicular cDNAs than in the brain cDNAs. We confirmed by using reverse transcriptase-polymerase chain reaction that about one-third (6/16) of in silico "macaque-specific" exons in the 5'UTR were actually macaque specific in the testis. The results imply that positive selection increased K5UTR and structural alteration rate of a certain fraction of genes as well as Ka. We found that both positive and negative selection can act on the 5'UTR sequences.
Other Papers
