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mouse-1llip

Mus musculus (C57 Black/6X CBA) LAL mRNA for lysosomal acid lipase

Comment

Q8C2G7 from Okazaki differs by 4 aa || Q6PDR1 Q9Z0M5 some differences

Relationship

Family : Acidic_Lipase

Block : X

Position in NCBI Life Tree : Mus musculus

Molecular evidence

No mutation

No structure

No kinetic

No disease

No substrate

No inhibitor

Database

Sequence

Peptide

MQLQGLVFVF TIGILLSRVP TGTVSAVDPE VNMNVTEIIM RWGYPGEEHS VLTGDGYILS IHRIPRGWKN HFGKGPRPVV YLQHGLLADS SNWVTNIDNS SLGFLLADRG FDVWMGNSRG NTWSLKHKTL SVSQDEFWAF SFDEMAKYDL PASINYILNK TGQEQIYYVG HSQGCTIGFI AFSQMPELAK KIKMFLVLAP VLSLNFASGP LLQLGRLPDP LLKDMFGQKQ FLPQSAMLKW LSIHVCTHVI MKELCANVFF LLCGFNEKNL NMSRVDVYTT HCPAELLVQN MLHWGQVFKY RKLQAFDWGS SEKNYFHYNQ SFPPSYNIKN MRLPTALWSG GRDWLADIND ITILLTQIPK LVYHKNIPEW DHLDFIWGLD APWKLYDEII SLMKKYQ

References

Title : Metabolic changes and propensity for inflammation, fibrosis, and cancer in livers of mice lacking lysosomal acid lipase - Bradic_2023_J.Lipid.Res__100427
Author(s) : Bradic I , Liesinger L , Kuentzel KB , Vujic N , Trauner M , Birner-Gruenberger R , Kratky D
Ref : J Lipid Res , :100427 , 2023
Abstract : Bradic_2023_J.Lipid.Res__100427
ESTHER : Bradic_2023_J.Lipid.Res__100427
PubMedSearch : Bradic_2023_J.Lipid.Res__100427
PubMedID: 37595802
Gene_locus related to this paper: human-LIPA , mouse-1llip

Title : JLR-D-23-00401-R1 Dissecting cell type-specific impact in lysosomal acid lipase deficiency-associated disorders -
Author(s) : Westerterp M , Li F , Zhang H
Ref : J Lipid Res , :100474 , 2023
PubMedID: 37972729
Gene_locus related to this paper: human-LIPA , mouse-1llip

Title : LAL deficiency induced myeloid-derived suppressor cells as targets and biomarkers for lung cancer - Zhao_2023_J.Immunother.Cancer_11_
Author(s) : Zhao T , Liu S , Hanna NH , Jalal S , Ding X , Wan J , Yan C , Du H
Ref : J Immunother Cancer , 11 : , 2023
Abstract : Zhao_2023_J.Immunother.Cancer_11_
ESTHER : Zhao_2023_J.Immunother.Cancer_11_
PubMedSearch : Zhao_2023_J.Immunother.Cancer_11_
PubMedID: 36914206
Gene_locus related to this paper: mouse-1llip

Title : Loss of lysosomal acid lipase results in mitochondrial dysfunction and fiber switch in skeletal muscles of mice - Akhmetshina_2023_Mol.Metab__101869
Author(s) : Akhmetshina A , Bianco V , Bradic I , Korbelius M , Pirchheim A , Kuentzel KB , Eichmann TO , Hinteregger H , Kolb D , Habisch H , Liesinger L , Madl T , Sattler W , Radovic B , Sedej S , Birner-Gruenberger R , Vujic N , Kratky D
Ref : Mol Metab , :101869 , 2023
Abstract : Akhmetshina_2023_Mol.Metab__101869
ESTHER : Akhmetshina_2023_Mol.Metab__101869
PubMedSearch : Akhmetshina_2023_Mol.Metab__101869
PubMedID: 38160938
Gene_locus related to this paper: human-LIPA , mouse-1llip

Title : Therapeutic efficacy of rscAAVrh74.miniCMV.LIPA gene therapy in a mouse model of lysosomal acid lipase deficiency - Lam_2022_Mol.Ther.Methods.Clin.Dev_26_413
Author(s) : Lam P , Ashbrook A , Zygmunt DA , Yan C , Du H , Martin PT
Ref : Mol Ther Methods Clin Dev , 26 :413 , 2022
Abstract : Lam_2022_Mol.Ther.Methods.Clin.Dev_26_413
ESTHER : Lam_2022_Mol.Ther.Methods.Clin.Dev_26_413
PubMedSearch : Lam_2022_Mol.Ther.Methods.Clin.Dev_26_413
PubMedID: 36092360
Gene_locus related to this paper: mouse-1llip , human-LIPA

Title : Loss of Function of Lysosomal Acid Lipase (LAL) Profoundly Impacts Osteoblastogenesis and Increases Fracture Risk in Humans - Helderman_2021_Bone__115946
Author(s) : Helderman RC , Whitney DG , Duta-Mare M , Akhmetshina A , Vujic N , Jayapalan S , Nyman JS , Misra BB , Rosen CJ , Czech MP , Kratky D , Rendina-Ruedy E
Ref : Bone , :115946 , 2021
Abstract : Helderman_2021_Bone__115946
ESTHER : Helderman_2021_Bone__115946
PubMedSearch : Helderman_2021_Bone__115946
PubMedID: 33838322
Gene_locus related to this paper: human-LIPA , mouse-1llip

Title : Hepatocyte-specific lysosomal acid lipase deficiency protects mice from diet-induced obesity but promotes hepatic inflammation - Leopold_2019_Biochim.Biophys.Acta.Mol.Cell.Biol.Lipids_1864_500
Author(s) : Leopold C , Duta-Mare M , Sachdev V , Goeritzer M , Maresch LK , Kolb D , Reicher H , Wagner B , Stojakovic T , Ruelicke T , Haemmerle G , Hoefler G , Sattler W , Kratky D
Ref : Biochimica & Biophysica Acta Molecular & Cellular Biology Lipids , 1864 :500 , 2019
Abstract : Leopold_2019_Biochim.Biophys.Acta.Mol.Cell.Biol.Lipids_1864_500
ESTHER : Leopold_2019_Biochim.Biophys.Acta.Mol.Cell.Biol.Lipids_1864_500
PubMedSearch : Leopold_2019_Biochim.Biophys.Acta.Mol.Cell.Biol.Lipids_1864_500
PubMedID: 30639734
Gene_locus related to this paper: mouse-1llip

Title : Lysosomal acid lipase regulates fatty acid channeling in brown adipose tissue to maintain thermogenesis - Duta-Mare_2018_Biochim.Biophys.Acta_1863_467
Author(s) : Duta-Mare M , Sachdev V , Leopold C , Kolb D , Vujic N , Korbelius M , Hofer DC , Xia W , Huber K , Auer M , Gottschalk B , Magnes C , Graier WF , Prokesch A , Radovic B , Bogner-Strauss JG , Kratky D
Ref : Biochimica & Biophysica Acta , 1863 :467 , 2018
Abstract : Duta-Mare_2018_Biochim.Biophys.Acta_1863_467
ESTHER : Duta-Mare_2018_Biochim.Biophys.Acta_1863_467
PubMedSearch : Duta-Mare_2018_Biochim.Biophys.Acta_1863_467
PubMedID: 29374543
Gene_locus related to this paper: mouse-1llip

Title : Lysosomal lipid hydrolysis provides substrates for lipid mediator synthesis in murine macrophages - Schlager_2017_Oncotarget_8_40037
Author(s) : Schlager S , Vujic N , Korbelius M , Duta-Mare M , Dorow J , Leopold C , Rainer S , Wegscheider M , Reicher H , Ceglarek U , Sattler W , Radovic B , Kratky D
Ref : Oncotarget , 8 :40037 , 2017
Abstract : Schlager_2017_Oncotarget_8_40037
ESTHER : Schlager_2017_Oncotarget_8_40037
PubMedSearch : Schlager_2017_Oncotarget_8_40037
PubMedID: 28402950
Gene_locus related to this paper: mouse-1llip

Title : Endothelial Rab7 GTPase mediates tumor growth and metastasis in lysosomal acid lipase-deficient mice - Zhao_2017_J.Biol.Chem_292_19198
Author(s) : Zhao T , Ding X , Yan C , Du H
Ref : Journal of Biological Chemistry , 292 :19198 , 2017
Abstract : Zhao_2017_J.Biol.Chem_292_19198
ESTHER : Zhao_2017_J.Biol.Chem_292_19198
PubMedSearch : Zhao_2017_J.Biol.Chem_292_19198
PubMedID: 28924047
Gene_locus related to this paper: mouse-1llip

Title : Lysosomal Acid Lipase Hydrolyzes Retinyl Ester and Affects Retinoid Turnover - Grumet_2016_J.Biol.Chem_291_17977
Author(s) : Grumet L , Eichmann TO , Taschler U , Zierler KA , Leopold C , Moustafa T , Radovic B , Romauch M , Yan C , Du H , Haemmerle G , Zechner R , Fickert P , Kratky D , Zimmermann R , Lass A
Ref : Journal of Biological Chemistry , 291 :17977 , 2016
Abstract : Grumet_2016_J.Biol.Chem_291_17977
ESTHER : Grumet_2016_J.Biol.Chem_291_17977
PubMedSearch : Grumet_2016_J.Biol.Chem_291_17977
PubMedID: 27354281
Gene_locus related to this paper: human-LIPA , mouse-1llip

Title : Hepatocyte-Specific Expression of Human Lysosome Acid Lipase Corrects Liver Inflammation and Tumor Metastasis in lal(-\/-) Mice - Du_2015_Am.J.Pathol_185_2379
Author(s) : Du H , Zhao T , Ding X , Yan C
Ref : American Journal of Pathology , 185 :2379 , 2015
Abstract : Du_2015_Am.J.Pathol_185_2379
ESTHER : Du_2015_Am.J.Pathol_185_2379
PubMedSearch : Du_2015_Am.J.Pathol_185_2379
PubMedID: 26212911
Gene_locus related to this paper: mouse-1llip

Title : Reversal of advanced disease in lysosomal acid lipase deficient mice: a model for lysosomal acid lipase deficiency disease - Sun_2014_Mol.Genet.Metab_112_229
Author(s) : Sun Y , Xu YH , Du H , Quinn B , Liou B , Stanton L , Inskeep V , Ran H , Jakubowitz P , Grilliot N , Grabowski GA
Ref : Mol Genet Metab , 112 :229 , 2014
Abstract : Sun_2014_Mol.Genet.Metab_112_229
ESTHER : Sun_2014_Mol.Genet.Metab_112_229
PubMedSearch : Sun_2014_Mol.Genet.Metab_112_229
PubMedID: 24837159
Gene_locus related to this paper: mouse-1llip

Title : Quantitative role of LAL, NPC2, and NPC1 in lysosomal cholesterol processing defined by genetic and pharmacological manipulations - Ramirez_2011_J.Lipid.Res_52_688
Author(s) : Ramirez CM , Liu B , Aqul A , Taylor AM , Repa JJ , Turley SD , Dietschy JM
Ref : J Lipid Res , 52 :688 , 2011
Abstract : Ramirez_2011_J.Lipid.Res_52_688
ESTHER : Ramirez_2011_J.Lipid.Res_52_688
PubMedSearch : Ramirez_2011_J.Lipid.Res_52_688
PubMedID: 21289032
Gene_locus related to this paper: mouse-1llip

Title : Critical roles of lysosomal acid lipase in myelopoiesis - Qu_2010_Am.J.Pathol_176_2394
Author(s) : Qu P , Shelley WC , Yoder MC , Wu L , Du H , Yan C
Ref : American Journal of Pathology , 176 :2394 , 2010
Abstract : Qu_2010_Am.J.Pathol_176_2394
ESTHER : Qu_2010_Am.J.Pathol_176_2394
PubMedSearch : Qu_2010_Am.J.Pathol_176_2394
PubMedID: 20348241
Gene_locus related to this paper: mouse-1llip

Title : Critical roles of lysosomal acid lipase in T cell development and function - Qu_2009_Am.J.Pathol_174_944
Author(s) : Qu P , Du H , Wilkes DS , Yan C
Ref : American Journal of Pathology , 174 :944 , 2009
Abstract : Qu_2009_Am.J.Pathol_174_944
ESTHER : Qu_2009_Am.J.Pathol_174_944
PubMedSearch : Qu_2009_Am.J.Pathol_174_944
PubMedID: 19179613
Gene_locus related to this paper: mouse-1llip

Title : Wolman disease\/cholesteryl ester storage disease: efficacy of plant-produced human lysosomal acid lipase in mice - Du_2008_J.Lipid.Res_49_1646
Author(s) : Du H , Cameron TL , Garger SJ , Pogue GP , Hamm LA , White E , Hanley KM , Grabowski GA
Ref : J Lipid Res , 49 :1646 , 2008
Abstract : Du_2008_J.Lipid.Res_49_1646
ESTHER : Du_2008_J.Lipid.Res_49_1646
PubMedSearch : Du_2008_J.Lipid.Res_49_1646
PubMedID: 18413899
Gene_locus related to this paper: mouse-1llip

Title : Lysosomal acid lipase over-expression disrupts lamellar body genesis and alveolar structure in the lung - Li_2007_Int.J.Exp.Pathol_88_427
Author(s) : Li Y , Qin Y , Li H , Wu R , Yan C , Du H
Ref : International Journal of Experimental Pathology , 88 :427 , 2007
Abstract : Li_2007_Int.J.Exp.Pathol_88_427
ESTHER : Li_2007_Int.J.Exp.Pathol_88_427
PubMedSearch : Li_2007_Int.J.Exp.Pathol_88_427
PubMedID: 18039279
Gene_locus related to this paper: mouse-1llip

Title : Neutral lipids and peroxisome proliferator-activated receptor-{gamma} control pulmonary gene expression and inflammation-triggered pathogenesis in lysosomal acid lipase knockout mice - Lian_2005_Am.J.Pathol_167_813
Author(s) : Lian X , Yan C , Qin Y , Knox L , Li T , Du H
Ref : American Journal of Pathology , 167 :813 , 2005
Abstract : Lian_2005_Am.J.Pathol_167_813
ESTHER : Lian_2005_Am.J.Pathol_167_813
PubMedSearch : Lian_2005_Am.J.Pathol_167_813
PubMedID: 16127159
Gene_locus related to this paper: mouse-1llip

Title : Lysosomal acid lipase deficiency causes respiratory inflammation and destruction in the lung - Lian_2004_Am.J.Physiol.Lung.Cell.Mol.Physiol_286_L801
Author(s) : Lian X , Yan C , Yang L , Xu Y , Du H
Ref : American Journal of Physiology Lung Cell Mol Physiol , 286 :L801 , 2004
Abstract : Lian_2004_Am.J.Physiol.Lung.Cell.Mol.Physiol_286_L801
ESTHER : Lian_2004_Am.J.Physiol.Lung.Cell.Mol.Physiol_286_L801
PubMedSearch : Lian_2004_Am.J.Physiol.Lung.Cell.Mol.Physiol_286_L801
PubMedID: 14644759
Gene_locus related to this paper: mouse-1llip

Title : Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs - Okazaki_2002_Nature_420_563
Author(s) : Okazaki Y , Furuno M , Kasukawa T , Adachi J , Bono H , Kondo S , Nikaido I , Osato N , Saito R , Suzuki H , Yamanaka I , Kiyosawa H , Yagi K , Tomaru Y , Hasegawa Y , Nogami A , Schonbach C , Gojobori T , Baldarelli R , Hill DP , Bult C , Hume DA , Quackenbush J , Schriml LM , Kanapin A , Matsuda H , Batalov S , Beisel KW , Blake JA , Bradt D , Brusic V , Chothia C , Corbani LE , Cousins S , Dalla E , Dragani TA , Fletcher CF , Forrest A , Frazer KS , Gaasterland T , Gariboldi M , Gissi C , Godzik A , Gough J , Grimmond S , Gustincich S , Hirokawa N , Jackson IJ , Jarvis ED , Kanai A , Kawaji H , Kawasawa Y , Kedzierski RM , King BL , Konagaya A , Kurochkin IV , Lee Y , Lenhard B , Lyons PA , Maglott DR , Maltais L , Marchionni L , McKenzie L , Miki H , Nagashima T , Numata K , Okido T , Pavan WJ , Pertea G , Pesole G , Petrovsky N , Pillai R , Pontius JU , Qi D , Ramachandran S , Ravasi T , Reed JC , Reed DJ , Reid J , Ring BZ , Ringwald M , Sandelin A , Schneider C , Semple CA , Setou M , Shimada K , Sultana R , Takenaka Y , Taylor MS , Teasdale RD , Tomita M , Verardo R , Wagner L , Wahlestedt C , Wang Y , Watanabe Y , Wells C , Wilming LG , Wynshaw-Boris A , Yanagisawa M , Yang I , Yang L , Yuan Z , Zavolan M , Zhu Y , Zimmer A , Carninci P , Hayatsu N , Hirozane-Kishikawa T , Konno H , Nakamura M , Sakazume N , Sato K , Shiraki T , Waki K , Kawai J , Aizawa K , Arakawa T , Fukuda S , Hara A , Hashizume W , Imotani K , Ishii Y , Itoh M , Kagawa I , Miyazaki A , Sakai K , Sasaki D , Shibata K , Shinagawa A , Yasunishi A , Yoshino M , Waterston R , Lander ES , Rogers J , Birney E , Hayashizaki Y
Ref : Nature , 420 :563 , 2002
Abstract : Okazaki_2002_Nature_420_563
ESTHER : Okazaki_2002_Nature_420_563
PubMedSearch : Okazaki_2002_Nature_420_563
PubMedID: 12466851
Gene_locus related to this paper: mouse-1lipg , mouse-1llip , mouse-1plrp , mouse-3neur , mouse-ABH15 , mouse-abhd4 , mouse-abhd5 , mouse-Abhd8 , mouse-Abhd11 , mouse-abhda , mouse-acot4 , mouse-adcl4 , mouse-AI607300 , mouse-BAAT , mouse-bphl , mouse-C87498 , mouse-Ldah , mouse-Ces1d , mouse-Ces2e , mouse-CMBL , mouse-DGLB , mouse-dpp9 , mouse-ES10 , mouse-F135A , mouse-FASN , mouse-hslip , mouse-hyes , mouse-Kansl3 , mouse-LIPH , mouse-LIPK , mouse-lipli , mouse-LIPM , mouse-lypla1 , mouse-lypla2 , mouse-MEST , mouse-MGLL , mouse-ndr4 , mouse-OVCA2 , mouse-pafa , mouse-pcp , mouse-ppce , mouse-Ppgb , mouse-PPME1 , mouse-q3uuq7 , mouse-Q8BLF1 , mouse-ACOT6 , mouse-Q8C1A9 , mouse-Q9DAI6 , mouse-Q80UX8 , mouse-Q8BGG9 , mouse-Q8C167 , mouse-rbbp9 , mouse-SERHL , mouse-tssp

Title : Lysosomal Acid lipase deficiency: correction of lipid storage by adenovirus-mediated gene transfer in mice - Du_2002_Hum.Gene.Ther_13_1361
Author(s) : Du H , Heur M , Witte DP , Ameis D , Grabowski GA
Ref : Hum Gene Therapy , 13 :1361 , 2002
Abstract : Du_2002_Hum.Gene.Ther_13_1361
ESTHER : Du_2002_Hum.Gene.Ther_13_1361
PubMedSearch : Du_2002_Hum.Gene.Ther_13_1361
PubMedID: 12162818
Gene_locus related to this paper: mouse-1llip

Title : Enzyme therapy for lysosomal acid lipase deficiency in the mouse - Du_2001_Hum.Mol.Genet_10_1639
Author(s) : Du H , Schiavi S , Levine M , Mishra J , Heur M , Grabowski GA
Ref : Hum Mol Genet , 10 :1639 , 2001
Abstract : Du_2001_Hum.Mol.Genet_10_1639
ESTHER : Du_2001_Hum.Mol.Genet_10_1639
PubMedSearch : Du_2001_Hum.Mol.Genet_10_1639
PubMedID: 11487567
Gene_locus related to this paper: mouse-1llip

Title : Targeted disruption of the mouse lysosomal acid lipase gene: long-term survival with massive cholesteryl ester and triglyceride storage - Du_1998_Hum.Mol.Genet_7_1347
Author(s) : Du H , Duanmu M , Witte D , Grabowski GA
Ref : Hum Mol Genet , 7 :1347 , 1998
Abstract : Du_1998_Hum.Mol.Genet_7_1347
ESTHER : Du_1998_Hum.Mol.Genet_7_1347
PubMedSearch : Du_1998_Hum.Mol.Genet_7_1347
PubMedID: 9700186
Gene_locus related to this paper: mouse-1llip

Title : Tissue and cellular specific expression of murine lysosomal acid lipase mRNA and protein - Du_1996_J.Lipid.Res_37_937
Author(s) : Du H , Witte DP , Grabowski GA
Ref : J Lipid Res , 37 :937 , 1996
Abstract : Du_1996_J.Lipid.Res_37_937
ESTHER : Du_1996_J.Lipid.Res_37_937
PubMedSearch : Du_1996_J.Lipid.Res_37_937
PubMedID: 8725147
Gene_locus related to this paper: human-LIPA , mouse-1llip