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Gene_locus Report for: mychd-k5b926

Mycolicibacterium hassiacum (Mycobacterium hassiacum) MetA Homoserine O-acetyltransferase

Comment
Other strain: Mycolicibacterium hassiacum (strain DSM 44199 / CIP 105218 / JCM 12690 / 3849) (Mycobacterium hassiacum)


Relationship
Family|Homoserine_transacetylase
Block| X
Position in NCBI Life Tree|Mycobacterium hassiacum
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms: N E > Bacteria: N E > Terrabacteria group: N E > Actinobacteria [phylum]: N E > Actinobacteria [class]: N E > Corynebacteriales: N E > Mycobacteriaceae: N E > Mycobacterium: N E > Mycobacterium hassiacum: N E


Molecular evidence
Database
No mutation
1 structure:
5W8O: Homoserine transacetylase MetA from Mycobacterium hassiacum
No kinetic





No Substrate
No inhibitor
2 Genbank : EKF24713, VCT88733
1 UniProt : K5B926
1 Structure : 5W8O
1 UniProt : K5B926
1 Interpro : K5B926
1 Prodom : K5B926
1 Pfam : K5B926
1 PIRSF : K5B926
1 SUPERFAM : K5B926
Sequence
Graphical view for this peptide sequence: mychd-k5b926
Colored MSA for Homoserine_transacetylase (raw)
MTMADAEIARLPAEGELGIVDIGALTLESGAVIDNVQIAVERWGELSPSR
DNVVVVLHALTGDSHVAGPAGPNYPTPGWWDGVVGPGAAIDTRRWCAIAT
NVLGGCRGSTGPGSLHPDGKAWGSRFPAVTVRDQVRADLAALNAMGIHQV
AAVVGGSMGGARALEWVIGHPETVRAGLILAVGARATADQIGTQSTQVAA
IKADPNWQNGDYYGTGLKPDVGLQIARRFAHLTYRGEVELDTRFGNAPQD
DENPLLGGRYAVESYLEYQGRKLVDRFDAGTYVTLTDSLSSHDVGRGRGG
VEAALRSCEVPVVVGGFTSDRLYPLRLQEELAELMPGCRGLNVVESIYGH
DGFLIETEAVGKLIRQTLELASRP
Legend This sequence has been compared to family alignement (MSA)
red => minority aminoacid
blue => majority aminoacid
color intensity => conservation rate
title => sequence position(MSA position)aminoacid rate
Catalytic site
Catalytic site in the MSA

MTMADAEIARLPAEGELGIVDIGALTLESGAVIDNVQIAVERWGELSPSR
DNVVVVLHALTGDSHVAGPAGPNYPTPGWWDGVVGPGAAIDTRRWCAIAT
NVLGGCRGSTGPGSLHPDGKAWGSRFPAVTVRDQVRADLAALNAMGIHQV
AAVVGGSMGGARALEWVIGHPETVRAGLILAVGARATADQIGTQSTQVAA
IKADPNWQNGDYYGTGLKPDVGLQIARRFAHLTYRGEVELDTRFGNAPQD
DENPLLGGRYAVESYLEYQGRKLVDRFDAGTYVTLTDSLSSHDVGRGRGG
VEAALRSCEVPVVVGGFTSDRLYPLRLQEELAELMPGCRGLNVVESIYGH
DGFLIETEAVGKLIRQTLELASRP


Reference
    Title: Structural analysis of mycobacterial homoserine transacetylases central to methionine biosynthesis reveals druggable active site
    Chaton CT, Rodriguez ES, Reed RW, Li J, Kenner CW, Korotkov KV
    Ref: Sci Rep, 9:20267, 2019 : PubMed

            


Other Papers


Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page and ACEDB Home Page
AcePerl Lincoln Stein Home Page
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