mycle-ML0314

 
Mycobacterium leprae ML0314c LipU Secreted carboxyl esterase

Comment
ML0314c showed preference for short carbon chain substrates with maximum activity for pNP-acetate. Secreted carboxyl esterase that could modulate the immune response in leprosy patients. Inhibited by Eserine, DEPC and Orlistat


Relationship
Block H
Mycobacterium leprae position in NCBI Life Tree :
N link to NCBI taxonomic web page and E link to ESTHER gene locus found in this strain.
> cellular organisms: N E > Bacteria: N E > Terrabacteria group: N E > Actinobacteria [phylum]: N E > Actinobacteria [class]: N E > Corynebacteriales: N E > Mycobacteriaceae: N E > Mycobacterium: N E > Mycobacterium leprae: N E
Warning: This entry is a compilation of different species or line or strain with more than 90% amino acide identity. You can retrieve all strain data


Molecular evidence
Database
No mutation
No structure
No kinetic



2 Genbank : AL035159, AL583918
2 UniProtTrembl : Q9ZBM4, Q7AQJ7
2 Interpro : Q9ZBM4, Q7AQJ7
2 Prodom : Q9ZBM4, Q7AQJ7
2 Pfam : Q9ZBM4, Q7AQJ7
2 PIRSF : Q9ZBM4, Q7AQJ7
2 SUPERFAM : Q9ZBM4, Q7AQJ7
2 QuickSwissBlast : Q9ZBM4, Q7AQJ7
 
Sequence
Graphical view for this peptide sequence: mycle-ML0314
Colored MSA for Hormone-sensitive_lipase_like (raw)
MAISAGAPVEIVESGPSIAARLASLTSRLTIRPILAVGSYVPQLPWPFGL
IDHAARVLLPVTNAARAEVNLSNTSAQLVRAAGVRPADGSGRIVLYLHGG
AFLGCGANSHRRLVETLSKLADSPILVVNYRLLPKHSIGMALDDCHDGYQ
WLRRLGYDPEQIVLAGDSAGGYLALALAQRLQDVGEEPAALVAISPLLQL
AKKGKQAHPNAKTDAMFPPKAFDALGRLVASSAAKNKVDDKPEELYEPLD
HIAPGLPRTLIHVSGSEVLLHDAQLAATKLAAVGVPAEIRVWPGQVHVFQ
AAAPMVPEATLSLRQISQYIREATASKASRDRQSL
Legend This sequence has been compared to family alignement (MSA)
red => minority aminoacid
blue => majority aminoacid
color intensity => conservation rate
title => sequence position(MSA position)aminoacid rate
Catalytic site
Catalytic site in the MSA

MAISAGAPVEIVESGPSIAARLASLTSRLTIRPILAVGSYVPQLPWPFGL
IDHAARVLLPVTNAARAEVNLSNTSAQLVRAAGVRPADGSGRIVLYLHGG
AFLGCGANSHRRLVETLSKLADSPILVVNYRLLPKHSIGMALDDCHDGYQ
WLRRLGYDPEQIVLAGDSAGGYLALALAQRLQDVGEEPAALVAISPLLQL
AKKGKQAHPNAKTDAMFPPKAFDALGRLVASSAAKNKVDDKPEELYEPLD
HIAPGLPRTLIHVSGSEVLLHDAQLAATKLAAVGVPAEIRVWPGQVHVFQ
AAAPMVPEATLSLRQISQYIREATASKASRDRQSL

no DNA




References
    Title: Characterization of ML0314c of Mycobacterium leprae and deciphering its role in the immune response in leprosy patients
    Kaur G, Sharma A, Narang T, Dogra S, Kaur J
    Ref: Gene, 643:26, 2018 : PubMed

            

    Title: Massive gene decay in the leprosy bacillus
    Cole ST, Eiglmeier K, Parkhill J, James KD, Thomson NR, Wheeler PR, Honore N, Garnier T, Churcher C and Barrell BG <34 more author(s)>
    Ref: Nature, 409:1007, 2001 : PubMed

            


Other Papers


Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
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