Gene_locus Report for: mycle-MLC1351.21C

only n-term PfamA Abhydrolase_1 157 344

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms: N E > Bacteria: N E > Terrabacteria group: N E > Actinobacteria [phylum]: N E > Actinobacteria [class]: N E > Corynebacteriales: N E > Mycobacteriaceae: N E > Mycobacterium: N E > Mycobacterium leprae: N E

6_AlphaBeta_hydrolase : mycle-ML0376Mycobacterium leprae putative membrane protein, mycle-ML1921Mycobacterium leprae hypothetical protein ml1921, mycle-ML2269Mycobacterium leprae putative hydrolase, mycle-Q49856Mycobacterium leprae b229_c1_169.
A85-Mycolyl-transferase : mycle-a85aMycobacterium leprae (and strain Br4923) Antigen 85A, mycolytransferase, mycle-a85bMycobacterium leprae (strain Br4923; complex B) ag85B fibronectin-binding protein B, mycle-a85cMycobacterium leprae (and strain Br4923) binding protein C ag85C, mycle-mpt5Mycobacterium leprae (and strain Br4923) mpt51 antigen precursor.
Aclacinomycin-methylesterase_RdmC : mycle-lipGMycobacterium leprae (strains TN; Br4923) ML1899 lipG.
AlphaBeta_hydrolase : mycle-ML1339Mycobacterium leprae hypothetical protein (putative secreted protease).
Carbon-carbon_bond_hydrolase : mycle-tpeaMycobacterium leprae tropinesterase ML0685 MLCB1779.02.
Chlorophyllase : mycle-ML0370Mycobacterium leprae hypothetical protein ml0370 b229_f1_20.
Cutinase : mycle-q9cdb3Mycobacterium leprae hypothetical protein ml0099.
Dienelactone_hydrolase : mycle-ML1444Mycobacterium leprae possible dienelactone hydrolase.
Epoxide_hydrolase : mycle-ML2297Mycobacterium leprae (and strain Br4923) putative hydrolase, mycle-MLCB22.16cMycobacterium leprae (and strain Br4923) MLCB22.16c gene.
Esterase_phb : mycle-LPQCMycobacterium leprae putative secreted hydrolaseLPQC.
Homoserine_transacetylase : mycle-metxMycobacterium leprae (and strain Br4923) (homoserine transacetylase) (hta).
Hormone-sensitive_lipase_like : mycle-ML0314Mycobacterium leprae ML0314c LipU Secreted carboxyl esterase.
Monoglyceridelipase_lysophospholip : mycle-ML2603 Mycobacterium leprae ML2603 similar to myctu-rv0183.
PE-PPE : mycle-q9cc62Mycobacterium leprae (and strain Br4923 Lepb1170_F3_112) Putative uncharacterized protein ML1232.
S9N_PREPL_Peptidase_S9 : mycle-PTRBMycobacterium leprae ptrb (protease II).
Thioesterase : mycle-ML2359Mycobacterium leprae putative thioesterase, mycle-PKS13Mycobacterium leprae polyketide synthase.
Tiancimycin-TnmK-Tripeptidase-HIP : mycle-ML1632Mycobacterium leprae possible hydrolase, mycle-ML1633Mycobacterium leprae possible secreted hydrolase

Title: Comparative genomic and phylogeographic analysis of Mycobacterium leprae
Monot M, Honore N, Garnier T, Zidane N, Sherafi D, Paniz-Mondolfi A, Matsuoka M, Taylor GM, Donoghue HD and Cole ST <21 more author(s)> Monot M, Honore N, Garnier T, Zidane N, Sherafi D, Paniz-Mondolfi A, Matsuoka M, Taylor GM, Donoghue HD, Bouwman A, Mays S, Watson C, Lockwood D, Khamesipour A, Dowlati Y, Jianping S, Rea TH, Vera-Cabrera L, Stefani MM, Banu S, MacDonald M, Sapkota BR, Spencer JS, Thomas J, Harshman K, Singh P, Busso P, Gattiker A, Rougemont J, Brennan PJ, Cole ST (- 21)
Ref: Nat Genet, 41:1282, 2009 : PubMed
Abstract


ESTHER: Monot_2009_Nat.Genet_41_1282
PubMedSearch: Monot 2009 Nat.Genet 41 1282
PubMedID: 19881526
Gene_locus related to this paper: mycle-a85a, mycle-a85b, mycle-a85c, mycle-lipG, mycle-metx, mycle-ML1632, mycle-ML2297, mycle-ML2603, mycle-MLC1351.21C, mycle-MLCB22.16c, mycle-mpt5, mycle-q9cc62, mycle-q9cdb3, mycle-tpea

Abstract

Reductive evolution and massive pseudogene formation have shaped the 3.31-Mb genome of Mycobacterium leprae, an unculturable obligate pathogen that causes leprosy in humans. The complete genome sequence of M. leprae strain Br4923 from Brazil was obtained by conventional methods (6x coverage), and Illumina resequencing technology was used to obtain the sequences of strains Thai53 (38x coverage) and NHDP63 (46x coverage) from Thailand and the United States, respectively. Whole-genome comparisons with the previously sequenced TN strain from India revealed that the four strains share 99.995% sequence identity and differ only in 215 polymorphic sites, mainly SNPs, and by 5 pseudogenes. Sixteen interrelated SNP subtypes were defined by genotyping both extant and extinct strains of M. leprae from around the world. The 16 SNP subtypes showed a strong geographical association that reflects the migration patterns of early humans and trade routes, with the Silk Road linking Europe to China having contributed to the spread of leprosy.



        

Title: Use of an ordered cosmid library to deduce the genomic organization of Mycobacterium leprae
Eiglmeier K, Honore N, Woods SA, Caudron B, Cole ST
Ref: Molecular Microbiology, 7:197, 1993 : PubMed
Abstract


ESTHER: Eiglmeier_1993_Mol.Microbiol_7_197
PubMedSearch: Eiglmeier 1993 Mol.Microbiol 7 197
PubMedID: 8446027
Gene_locus related to this paper: mycle-MLC1351.21C, mycle-MLCB22.16c, mycle-PTRB, mycle-tpea

Abstract

In an attempt to unify the genetic and biological research on Mycobacterium leprae, the aetiological agent of leprosy, a cosmid library was constructed and then ordered by a combination of fingerprinting and hybridization techniques. The genome of M. leprae is represented by four contigs of overlapping clones which, together, account for nearly 2.8Mb of DNA. Several arguments suggest that the gaps between the contigs are small in size and that virtually complete coverage of the chromosome has been obtained. All of the cloned M. leprae genes have been positioned on the contig maps together with the 29 copies of the dispersed repetitive element, RLEP. These have been classified into four groups on the basis of differences in their organization. Several key housekeeping genes were identified and mapped by hybridization with heterologous probes, and the current genome map of this uncultivable pathogen comprises 72 loci.