(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) > cellular organisms: NE > Bacteria: NE > Terrabacteria group: NE > Actinobacteria [phylum]: NE > Actinobacteria [class]: NE > Corynebacteriales: NE > Mycobacteriaceae: NE > Mycobacterium: NE > Mycobacterium leprae: NE
Warning: This entry is a compilation of different species or line or strain with more than 90% amino acide identity. You can retrieve all strain data
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) Mycobacterium leprae Br4923: N, E.
Mycobacterium leprae TN: N, E.
Mycobacterium leprae 3125609: N, E.
LegendThis sequence has been compared to family alignement (MSA) red => minority aminoacid blue => majority aminoacid color intensity => conservation rate title => sequence position(MSA position)aminoacid rate Catalytic site Catalytic site in the MSA MTKTSRGTPVPPIAKRVETRRERHGDVFFDPYEWLRDNNNPEVVAYLDAE NDYVNQMTAHLEPLQQKIFNEIKARTKENDLSVPTRQANWWYYSRTFEGK QYRVQCRCPVASPDDWTPPALYENTEISGEQVLLDSNAEAEGHAFFALGT FMVSLDSNLLAYSVDFVGDERYTLRFKDLRTGERYPDEIVGIGAGATWAA DNRTVYYLTLDESRRPDTVWRCRLGSGQPSEQVYHEADERFWLAVGLSRS EAYIFIAAGSAITSEWRYADSTNPDAQFTVVLPRRDGIEYSVEHAPSGLV GGQDRFLILHNDGAVNFTLVESPVSNPEQQRTLIPHRDDVRLDSADAFAG YLVVSYRREALPRVQLWPIDPDGSYGEPEEISFESELMWVSLEANSNWVS PKLRIRAGSFVTPVRVYDVDLATGERTLLREQPVLGGYKHEDYVERREWA QADDGTWIPVSIVHRAAIRFPAPAVLYGYGAYEICVDPSFSIPRLSLLDR GMMFVIAHVRGGGEMGRLWYEHGKLLEKKNTFTDFISVAKHLVDSGQTRS QELVALGGSAGGLLMGVVANIAPDLFTGILAQVPFVDPLTTMLDPSLPLT VTEWDEWGNPLIDSDFYSYIKSYSPYENVEAKQYPAILAMTSLHDTRVHY VEPAKWIAALRHTKSDGNPVLLKTQMAAGHAGISGRYKAWQETAFQYAWL LAAVDVDQYGTATEVDDLGGGAQG
Leprosy, a chronic human neurological disease, results from infection with the obligate intracellular pathogen Mycobacterium leprae, a close relative of the tubercle bacillus. Mycobacterium leprae has the longest doubling time of all known bacteria and has thwarted every effort at culture in the laboratory. Comparing the 3.27-megabase (Mb) genome sequence of an armadillo-derived Indian isolate of the leprosy bacillus with that of Mycobacterium tuberculosis (4.41 Mb) provides clear explanations for these properties and reveals an extreme case of reductive evolution. Less than half of the genome contains functional genes but pseudogenes, with intact counterparts in M. tuberculosis, abound. Genome downsizing and the current mosaic arrangement appear to have resulted from extensive recombination events between dispersed repetitive sequences. Gene deletion and decay have eliminated many important metabolic activities including siderophore production, part of the oxidative and most of the microaerophilic and anaerobic respiratory chains, and numerous catabolic systems and their regulatory circuits.
Title: Use of an ordered cosmid library to deduce the genomic organization of Mycobacterium leprae Eiglmeier K, Honore N, Woods SA, Caudron B, Cole ST Ref: Molecular Microbiology, 7:197, 1993 : PubMed
In an attempt to unify the genetic and biological research on Mycobacterium leprae, the aetiological agent of leprosy, a cosmid library was constructed and then ordered by a combination of fingerprinting and hybridization techniques. The genome of M. leprae is represented by four contigs of overlapping clones which, together, account for nearly 2.8Mb of DNA. Several arguments suggest that the gaps between the contigs are small in size and that virtually complete coverage of the chromosome has been obtained. All of the cloned M. leprae genes have been positioned on the contig maps together with the 29 copies of the dispersed repetitive element, RLEP. These have been classified into four groups on the basis of differences in their organization. Several key housekeeping genes were identified and mapped by hybridization with heterologous probes, and the current genome map of this uncultivable pathogen comprises 72 loci.
Mycobacterium leprae ML2603 similar to myctu-rv0183