Gene_Locus Report

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Gene_locus Report for: mycle-mpt5

Mycobacterium leprae (and strain Br4923) mpt51 antigen precursor

Relationship
Family|A85-Mycolyl-transferase
Block| X
Position in NCBI Life Tree|Mycobacterium leprae
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms: N E > Bacteria: N E > Terrabacteria group: N E > Actinobacteria [phylum]: N E > Actinobacteria [class]: N E > Corynebacteriales: N E > Mycobacteriaceae: N E > Mycobacterium: N E > Mycobacterium leprae: N E
Warning: This entry is a compilation of different species or line or strain with more than 90% amino acide identity. You can retrieve all strain data


Molecular evidence
Database
No mutation
No structure
No kinetic





No Substrate
No inhibitor
>3 Genbank links 1 more: D50488, AL583917, Z21949
1 UniProt : Q05868
1 UniProt : Q05868
1 Interpro : Q05868
1 Prodom : Q05868
1 Pfam : Q05868
1 PIRSF : Q05868
1 SUPERFAM : Q05868
Sequence
Graphical view for this peptide sequence: mycle-mpt5
Colored MSA for A85-Mycolyl-transferase (raw)
MRGLSAVVRVLCVAALAVGVFAAAVLLAGTAGNAKAAGYESLMVPSNAMG
RDIPVAFMAGGPHAVYLLDAFNAALDVSNWVTAGNAMTTLGGRGISVVAP
AGGAYSMYTNWENDGSKQWDTFLSSELPDWLATKRGLAPDGHAAVGASQG
GYAALALAAFHPDRFGFAGSLSGFVYPSSTNYNGAILAGLQQFGGIDGNG
MWGAPQLGRWKWHDPYVHASLLAQNNTRVWVYSPMTMGGDIDAMIGQAVA
SMGSSREFYQQYRSVGGHNGHFDFSGGGDNGWGAWAPQLAAMSGDIVGAI
R
Legend This sequence has been compared to family alignement (MSA)
red => minority aminoacid
blue => majority aminoacid
color intensity => conservation rate
title => sequence position(MSA position)aminoacid rate
Catalytic site
Catalytic site in the MSA

MRGLSAVVRVLCVAALAVGVFAAAVLLAGTAGNAKAAGYESLMVPSNAMG
RDIPVAFMAGGPHAVYLLDAFNAALDVSNWVTAGNAMTTLGGRGISVVAP
AGGAYSMYTNWENDGSKQWDTFLSSELPDWLATKRGLAPDGHAAVGASQG
GYAALALAAFHPDRFGFAGSLSGFVYPSSTNYNGAILAGLQQFGGIDGNG
MWGAPQLGRWKWHDPYVHASLLAQNNTRVWVYSPMTMGGDIDAMIGQAVA
SMGSSREFYQQYRSVGGHNGHFDFSGGGDNGWGAWAPQLAAMSGDIVGAI
R


References
    Title: Comparative genomic and phylogeographic analysis of Mycobacterium leprae
    Monot M, Honore N, Garnier T, Zidane N, Sherafi D, Paniz-Mondolfi A, Matsuoka M, Taylor GM, Donoghue HD and Cole ST <21 more author(s)>
    Ref: Nat Genet, 41:1282, 2009 : PubMed

            

    Title: Massive gene decay in the leprosy bacillus
    Cole ST, Eiglmeier K, Parkhill J, James KD, Thomson NR, Wheeler PR, Honore N, Garnier T, Churcher C and Barrell BG <34 more author(s)>
    Ref: Nature, 409:1007, 2001 : PubMed

            

    Title: The Mycobacterium leprae antigen 85 complex gene family: identification of the genes for the 85A, 85C, and related MPT51 proteins
    Rinke de Wit TF, Bekelie S, Osland A, Wieles B, Janson AA, Thole JE
    Ref: Infect Immun, 61:3642, 1993 : PubMed

            


Other Papers


Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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