Gene_locus Report for: mycpa-q73xs5 Mycobacterium paratuberculosis Mycobacterium avium (strain 104) Putative uncharacterized protein
Relationship
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) cellular organisms: N E > Bacteria: N E > Terrabacteria group: N E > Actinobacteria [phylum]: N E > Actinobacteria [class]: N E > Corynebacteriales: N E > Mycobacteriaceae: N E > Mycobacterium: N E > Mycobacterium avium complex (MAC): N E > Mycobacterium avium: N E > Mycobacterium avium subsp. paratuberculosis: N E 6_AlphaBeta_hydrolase :
mycpa-q73ry6 Mycobacterium paratuberculosis Mycobacterium avium (strain 104) hypothetical protein ,
mycpa-q73s17 Mycobacterium paratuberculosis Mycobacterium avium (strain 104), alpha/beta fold family protein ,
mycpa-q73sm2 Mycobacterium paratuberculosis Mycobacterium avium (strain 104) bpoc_2 ,
mycpa-q73tc9 Mycobacterium paratuberculosis, Mycobacterium avium Putative uncharacterized protein ,
mycpa-q73ur3 Mycobacterium paratuberculosis Mycobacterium avium (strain 104) lipv ,
mycpa-q73uy7 Mycobacterium paratuberculosis and Mycobacterium avium (strain 104) hpx ,
mycpa-q73v88 Mycobacterium paratuberculosis Mycobacterium avium (strain 104) hypothetical protein ,
mycpa-q73vm9 Mycobacterium paratuberculosis Mycobacterium avium (strain 104) hypothetical protein ,
mycpa-q73wj1 Mycobacterium paratuberculosis bpob ,
mycpa-q73ws9 Mycobacterium paratuberculosis hypothetical protein ,
mycpa-q73x18 Mycobacterium paratuberculosis Mycobacterium avium (strain 104) hypothetical protein ,
mycpa-q73ya7 Mycobacterium paratuberculosis (and strain 104) hypothetical protein ,
mycpa-q73z93 Mycobacterium paratuberculosis Mycobacterium avium (strain 104), alpha/beta fold family protein, putative ,
mycpa-q742v3 Mycobacterium paratuberculosis Mycobacterium avium (strain 104) hypothetical protein ,
mycpa-q743k3 Mycobacterium paratuberculosis bpoa ,
mycpa-q743x3 Mycobacterium paratuberculosis Mycobacterium avium (strain 104) alpha/beta hydrolase fold family protein ,
mycpa-q744u6 Mycobacterium paratuberculosis Mycobacterium avium (strain 104) hypothetical protein ,
mycpa-q744y3 Mycobacterium paratuberculosis Mycobacterium avium (strain 104)hypothetical protein .
A85-Est-Putative :
mycpa-q73rz3 Mycobacterium paratuberculosis hypothetical protein ,
mycpa-q740k0 Mycobacterium paratuberculosis Mycobacterium avium (strain 104) hypothetical protein ,
mycpa-q742t6 Mycobacterium paratuberculosis Mycobacterium avium (strain 104) hypothetical protein .
A85-Feruloyl-Esterase :
mycpa-q73sr2 Mycobacterium paratuberculosis hypothetical protein ,
mycpa-q743h7 Mycobacterium paratuberculosis hypothetical protein .
A85-Mycolyl-transferase :
mycav-a85a Mycobacterium avium and Mycobacterium paratuberculosis ag85A fibronectin-binding protein A antigen 85-a (mycolyl transferase) (EC 2.3.1.122) (fragment) ,
mycav-a85b Mycobacterium avium (strain 104) complex B ag85B and Mycobacterium paratuberculosis fbpb fibronectin-binding protein B ,
mycpa-Q8KY59 Mycobacterium paratuberculosis antigen 85a complex ,
mycpa-Q8L371 Mycobacterium paratuberculosis 85b protein ,
mycpa-q745l2 Mycobacterium paratuberculosis Mycobacterium avium (strain 104) fbpc1 .
Abhydrolase_9 :
mycpa-q741s1 Mycobacterium paratuberculosis; Mycobacterium avium; Mycobacterium avium subsp.; Mycobacterium sp. Putative uncharacterized protein .
AlphaBeta_hydrolase :
mycpa-q73w68 Mycobacterium paratuberculosis hypothetical protein .
BD-FAE :
mycpa-lipM Mycobacterium paratuberculosis and Mycobacterium avium (strain 104) lipm ,
mycpa-lipO Mycobacterium paratuberculosis and Mycobacterium avium (strain 104) lipo ,
mycpa-lipQ Mycobacterium paratuberculosis and Mycobacterium avium (strain 104) lipq ,
mycpa-q73tr2 Mycobacterium paratuberculosis and Mycobacterium avium (strain 104) lipc ,
mycpa-q73tr3 Mycobacterium paratuberculosis lipw .
Carbon-carbon_bond_hydrolase :
mycpa-q73ub4 Mycobacterium paratuberculosis, Mycobacterium avium, hypothetical protein ,
mycpa-q73zz9 Mycobacterium paratuberculosis Mycobacterium avium (strain 104) 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase ,
mycpa-q742y5 Mycobacterium paratuberculosis Mycobacterium avium (strain 104) hypothetical protein ,
mycpa-q742z2 Mycobacterium paratuberculosis Mycobacterium avium (strain 104) 2-hydroxy-6-ketonona-2,4-dienedoic acid hydrolase ,
mycpa-q743u3 Mycobacterium paratuberculosis Mycobacterium avium (strain 104) 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase .
Carb_B_Bacteria :
mycpa-lipT Mycobacterium paratuberculosis; Mycobacterium avium; Mycobacterium bouchedurhonense. lipt lppt ,
mycpa-MAP2689c Mycobacterium paratuberculosis, Mycobacterium avium, Mycobacterium avium subsp. hominissuis, subsp. paratuberculosis, Mycobacterium sp Hypothetical protein .
Cocaine_esterase :
mycpa-q73vv9 Mycobacterium paratuberculosis hypothetical protein ,
mycpa-q73wu7 Mycobacterium paratuberculosis hypothetical protein .
Cutinase :
mycav-Q9KK87 Mycobacterium avium Mycobacterium paratuberculosis, Mycobacterium intracellulare, serine esterase cutinase ,
mycpa-q73s39 Mycobacterium paratuberculosis, Mycobacterium avium, hypothetical protein ,
mycpa-q73s40 Mycobacterium paratuberculosis, Mycobacterium avium, hypothetical protein ,
mycpa-q73u73 Mycobacterium paratuberculosis; Mycobacterium intracellulare; Mycobacterium avium subsp. paratuberculosis hypothetical protein ,
mycpa-q73ue0 Mycobacterium paratuberculosis Mycobacterium avium (strain 104) hypothetical protein ,
mycpa-q73xk5 Mycobacterium paratuberculosis, Mycobacterium avium , hypothetical protein ,
mycpa-q73yd6 Mycobacterium paratuberculosis, Mycobacterium avium, hypothetical protein ,
mycpa-q73ze1 Mycobacterium paratuberculosiss, Mycobacterium avium hypothetical protein ,
mycpa-q73zx5 Mycobacterium paratuberculosis, Mycobacterium avium hypothetical protein ,
mycpa-q744k8 Mycobacterium paratuberculosis, Mycobacterium avium, Cutinase ,
mycpa-q745l1 Mycobacterium paratuberculosis, Mycobacterium avium, hypothetical protein .
Dienelactone_hydrolase :
mycpa-q73vz1 Mycobacterium paratuberculosis hypothetical protein ,
mycpa-q73z00 Mycobacterium paratuberculosis hypothetical protein .
Duf_1023 :
mycpa-q73ru8 Mycobacterium paratuberculosis Mycobacterium avium (strain 104), hypothetical protein .
Duf_1100-S :
mycpa-q73tg1 Mycobacterium paratuberculosis hypothetical protein .
Epoxide_hydrolase :
mycpa-q73u18 Mycobacterium paratuberculosis Mycobacterium avium (strain 104) ephf ,
mycpa-q73ut4 Mycobacterium paratuberculosis Mycobacterium avium (strain 104) hypothetical protein ,
mycpa-q73vx6 Mycobacterium paratuberculosis Mycobacterium avium (strain 104) hypothetical protein ,
mycpa-q73w28 Mycobacterium paratuberculosis and Mycobacterium avium (strain 104) hypothetical protein ,
mycpa-q73wj3 Mycobacterium paratuberculosis Mycobacterium avium (strain 104) Epoxide hydrolase EphC ,
mycpa-q73yg7 Mycobacterium paratuberculosis Mycobacterium avium (strain 104) hypothetical protein ,
mycpa-q73yk0 Mycobacterium paratuberculosis Short chain dehydrogenase ephd Mycobacterium avium (strain 104) ,
mycpa-q743z5 Mycobacterium paratuberculosis Mycobacterium avium (strain 104) epha (EC 3.3.2.3) (epoxide hydrolase) ,
mycpa-q744d7 Mycobacterium paratuberculosis Mycobacterium avium (strain 104) ephe .
Fungal-Bact_LIP :
mycpa-q73ry9 Mycobacterium paratuberculosis Mycobacterium parascrofulaceum, Mycobacterium avium, hypothetical protein ,
mycpa-q740q6 Mycobacterium paratuberculosis, Mycobacterium avium, Mycobacterium parascrofulaceum hypothetical protein .
Haloalkane_dehalogenase-HLD1 :
mycav-DHMA Mycobacterium avium Mycobacterium paratuberculosis; Mycobacterium sp.; Mycobacterium tuberculosis haloalkane dehalogenase ,
mycpa-q744j6 Mycobacterium paratuberculosis Mycobacterium avium (strain 104) hypothetical protein .
Haloperoxidase :
mycpa-q73u31 Mycobacterium paratuberculosis Mycobacterium avium (strain 104) bpoc_1 non-haem bromoperoxidase bpo-a2 (EC 1.11.1.-) .
Homoserine_transacetylase :
mycpa-q73ub0 Mycobacterium paratuberculosis Mycobacterium avium (strain 104)Homoserine O-trans-acetylase meta .
Hormone-sensitive_lipase_like :
mycpa-lipI Mycobacterium paratuberculosis lipi ,
mycpa-q73tx3 Mycobacterium paratuberculosis hypothetical protein ,
mycpa-q73vk7 Mycobacterium paratuberculosis lipn ,
mycpa-q73xe5 Mycobacterium paratuberculosis hypothetical protein ,
mycpa-q73xw1 Mycobacterium paratuberculosis lipk ,
mycpa-q73z68 Mycobacterium paratuberculosis hypothetical protein ,
mycpa-q73zz5 Mycobacterium paratuberculosis, Mycobacterium avium,hypothetical protein ,
mycpa-q740a6 Mycobacterium paratuberculosis hypothetical protein ,
mycpa-q740b3 Mycobacterium paratuberculosis liph ,
mycpa-q741r4 Mycobacterium paratuberculosis lipu .
Monoglyceridelipase_lysophospholip :
mycpa-q73tu6 Mycobacterium paratuberculosis Mycobacterium avium (strain 104) hypothetical protein ,
mycpa-q73vt9 Mycobacterium paratuberculosis (strain ATCC BAA-968 / K-10) Putative uncharacterized protein .
PHA_synth_III_C :
mycpa-q740g2 Mycobacterium paratuberculosis Mycobacterium avium (strain 104) hypothetical protein .
Proline_iminopeptidase :
mycpa-q743a1 Mycobacterium paratuberculosis Mycobacterium avium (strain 104) hypothetical protein .
S9N_PPCE_Peptidase_S9 :
mycpa-q73sx2 Mycobacterium paratuberculosis hypothetical protein .
S9N_PREPL_Peptidase_S9 :
mycpa-q743h0 Mycobacterium paratuberculosis ptrba .
Thioesterase :
mycpa-q73th3 Mycobacterium paratuberculosis hypothetical protein ,
mycpa-q73th6 Mycobacterium paratuberculosis hypothetical protein ,
mycpa-q73xy2 Mycobacterium paratuberculosis hypothetical protein ,
mycpa-q73yt6 Mycobacterium paratuberculosis hypothetical protein ,
mycpa-q740d1 Mycobacterium paratuberculosis hypothetical protein ,
mycpa-q745k9 Mycobacterium paratuberculosis pks13 .
Tiancimycin-TnmK-Tripeptidase-HIP :
mycpa-q73yi8 Mycobacterium paratuberculosis Mycobacterium avium (strain 104) hypothetical protein ,
mycpa-q73yi9 Mycobacterium paratuberculosis Mycobacterium avium (strain 104) hypothetical protein .
Xaa-Pro-like_dom :
mycpa-q73z76 Mycobacterium paratuberculosis hypothetical protein Warning: This entry is a compilation of different species or line or strain with more than 90% amino acide identity. You can
retrieve all strain data
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) Mycobacterium avium subsp. paratuberculosis K-10:
N ,
E .
Mycobacterium avium subsp. paratuberculosis:
N ,
E .
Mycobacterium avium subsp. paratuberculosis S397:
N ,
E .
Mycobacterium avium subsp. paratuberculosis MAP4:
N ,
E .
Mycobacterium avium subsp. paratuberculosis S5:
N ,
E .
Mycobacterium avium subsp. paratuberculosis 10-4404:
N ,
E .
Mycobacterium avium subsp. paratuberculosis 10-8425:
N ,
E .
Mycobacterium avium subsp. paratuberculosis 08-8281:
N ,
E .
Mycobacterium avium subsp. paratuberculosis 10-5975:
N ,
E .
Mycobacterium avium subsp. paratuberculosis 10-5864:
N ,
E .
Mycobacterium avium subsp. paratuberculosis 11-1786:
N ,
E .
Mycobacterium avium 104:
N ,
E .
Molecular evidence
Database
No mutation No structure No kinetic No Substrate No inhibitor
Sequence
Graphical view for this peptide sequence: mycpa-q73xs5 Colored MSA for PE-PPE (raw)
MKQLLAGVTALLSVSTAGYFGIGTAAADGGPIGGPPTPGAPGDQTAYALG
GAHVLGIPYDQYIRMEGADWFPGQQRQIVRYPAGQVQGHVLERLFPGIGK
LDESFPGLGMNGPSVGESVAEGIDNLDAAIRTTGRPGTAIGLSEGAFVVD
GEQARLANDPTAPPPNTLNFATFGDPIGRHAFGQSFLTAMFGVGSVVPAL
DYTMPPPYESQYDTNRFVAAYDSIADFPDRPDNMFALANTLMGLATGHTA
VAFTNPSMVPPQNIRTTINSRGAKDTTIMIPEKHLPLVMPLRYIGIDENT
LNKLDAILTPRVNAGYSRNDDPATAPVQVDPVHGFDPAEVTAPANQATFG
GGADPLSQIMAGAMSVLSHGAGEADH
Legend
This sequence has been compared to family alignement (MSA) red => minority aminoacid blue => majority aminoacid color intensity => conservation rate title => sequence position(MSA position)aminoacid rate Catalytic site Catalytic site in the MSA
M K Q L L A G V T A L L S V S T A G Y F G I G T A A A D G G P I G G P P T P G A P G D Q T A Y A L G G A H V L G I P Y D Q Y I R M E G A D W F P G Q Q R Q I V R Y P A G Q V Q G H V L E R L F P G I G K L D E S F P G L G M N G P S V G E S V A E G I D N L D A A I R T T G R P G T A I G L S E G A F V V D G E Q A R L A N D P T A P P P N T L N F A T F G D P I G R H A F G Q S F L T A M F G V G S V V P A L D Y T M P P P Y E S Q Y D T N R F V A A Y D S I A D F P D R P D N M F A L A N T L M G L A T G H T A V A F T N P S M V P P Q N I R T T I N S R G A K D T T I M I P E K H L P L V M P L R Y I G I D E N T L N K L D A I L T P R V N A G Y S R N D D P A T A P V Q V D P V H G F D P A E V T A P A N Q A T F G G G A D P L S Q I M A G A M S V L S H G A G E A D H
Reference
Title: The complete genome sequence of Mycobacterium avium subspecies paratuberculosisLi L , Bannantine JP , Zhang Q , Amonsin A , May BJ , Alt D , Banerji N , Kanjilal S , Kapur V Ref: Proc Natl Acad Sci U S A, 102 :12344, 2005 : PubMed Abstract ESTHER: Li_2005_Proc.Natl.Acad.Sci.U.S.A_102_12344 PubMedSearch: Li 2005 Proc.Natl.Acad.Sci.U.S.A 102 12344 PubMedID: 16116077 Gene_locus related to this paper: mycpa-q73tc9 ,
mycpa-q73vt9 ,
mycpa-q73xs5 ,
mycpa-q741s1 Abstract
We describe here the complete genome sequence of a common clone of Mycobacterium avium subspecies paratuberculosis (Map) strain K-10, the causative agent of Johne's disease in cattle and other ruminants. The K-10 genome is a single circular chromosome of 4,829,781 base pairs and encodes 4,350 predicted ORFs, 45 tRNAs, and one rRNA operon. In silico analysis identified >3,000 genes with homologs to the human pathogen, M. tuberculosis (Mtb), and 161 unique genomic regions that encode 39 previously unknown Map genes. Analysis of nucleotide substitution rates with Mtb homologs suggest overall strong selection for a vast majority of these shared mycobacterial genes, with only 68 ORFs with a synonymous to nonsynonymous substitution ratio of >2. Comparative sequence analysis reveals several noteworthy features of the K-10 genome including: a relative paucity of the PE/PPE family of sequences that are implicated as virulence factors and known to be immunostimulatory during Mtb infection; truncation in the EntE domain of a salicyl-AMP ligase (MbtA), the first gene in the mycobactin biosynthesis gene cluster, providing a possible explanation for mycobactin dependence of Map; and Map-specific sequences that are likely to serve as potential targets for sensitive and specific molecular and immunologic diagnostic tests. Taken together, the availability of the complete genome sequence offers a foundation for the study of the genetic basis for virulence and physiology in Map and enables the development of new generations of diagnostic tests for bovine Johne's disease.
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