myctu-a85c
Mycobacterium tuberculosis, Mycobacterium bovis Antigen85c H37Rv FBPC fbpC or MPT45 or RV0129C or MTCI5.03C
Comment
Mycobacterium tuberculosis Antigen 85 enzymes (Ag85s) catalyze the transfer of mycolic acid (MA) from trehalose monomycolate to produce the mycolyl arabinogalactan (mAG) or trehalose dimycolate (TDM). These lipids define the protective mycomembrane of Mycobacteria. There are more than 1000 strains. Other Uniprot entries and list of strains can be found with the link: Other strains.
Relationship
Molecular evidence
No mutation
No kinetic
No disease
Database
Sequence
Peptide
MTFFEQVRRL RSAATTLPRR LAIAAMGAVL VYGLVGTFGG PATAGAFSRP GLPVEYLQVP SASMGRDIKV QFQGGGPHAV YLLDGLRAQD DYNGWDINTP AFEEYYQSGL SVIMPVGGQS SFYTDWYQPS QSNGQNYTYK WETFLTREMP AWLQANKGVS PTGNAAVGLS MSGGSALILA AYYPQQFPYA ASLSGFLNPS EGWWPTLIGL AMNDSGGYNA NSMWGPSSDP AWKRNDPMVQ IPRLVANNTR IWVYCGNGTP SDLGGDNIPA KFLEGLTLRT NQTFRDTYAA DGGRNGVFNF PPNGTHSWPY WNEQLVAMKA DIQHVLNGAT PPAAPAAPAA
References
| Title : Total Synthesis of Tetrahydrolipstatin, Its Derivatives, and Evaluation of Their Ability to Potentiate Multiple Antibiotic Classes against Mycobacterium Species - Khan_2021_ACS.Infect.Dis_7_2876 |
| Author(s) : Khan SS , Sudasinghe TD , Landgraf AD , Ronning DR , Sucheck SJ |
| Ref : ACS Infect Dis , 7 :2876 , 2021 |
| Abstract : Khan_2021_ACS.Infect.Dis_7_2876 |
| ESTHER : Khan_2021_ACS.Infect.Dis_7_2876 |
| PubMedSearch : Khan_2021_ACS.Infect.Dis_7_2876 |
| PubMedID: 34478259 |
| Gene_locus related to this paper: myctu-a85c |
| Title : Mycolyltransferase from Mycobacterium tuberculosis in covalent complex with tetrahydrolipstatin provides insights into antigen 85 catalysis - Goins_2018_J.Biol.Chem_293_3651 |
| Author(s) : Goins CM , Dajnowicz S , Smith MD , Parks JM , Ronning DR |
| Ref : Journal of Biological Chemistry , 293 :3651 , 2018 |
| Abstract : Goins_2018_J.Biol.Chem_293_3651 |
| ESTHER : Goins_2018_J.Biol.Chem_293_3651 |
| PubMedSearch : Goins_2018_J.Biol.Chem_293_3651 |
| PubMedID: 29352107 |
| Gene_locus related to this paper: myctu-a85c |
| Title : Cyclipostins and cyclophostin analogs inhibit the antigen 85C from Mycobacterium tuberculosis both in vitro and in vivo - Viljoen_2018_J.Biol.Chem_293_2755 |
| Author(s) : Viljoen A , Richard M , Nguyen PC , Fourquet P , Camoin L , Paudal RR , Gnawali GR , Spilling CD , Cavalier JF , Canaan S , Blaise M , Kremer L |
| Ref : Journal of Biological Chemistry , 293 :2755 , 2018 |
| Abstract : Viljoen_2018_J.Biol.Chem_293_2755 |
| ESTHER : Viljoen_2018_J.Biol.Chem_293_2755 |
| PubMedSearch : Viljoen_2018_J.Biol.Chem_293_2755 |
| PubMedID: 29301937 |
| Gene_locus related to this paper: myctu-a85c |
| Title : Characterization of Tetrahydrolipstatin and Stereoderivatives on the Inhibition of Essential Mycobacterium tuberculosis Lipid Esterases - Goins_2018_Biochemistry_57_2383 |
| Author(s) : Goins CM , Sudasinghe TD , Liu X , Wang Y , O'Doherty GA , Ronning DR |
| Ref : Biochemistry , 57 :2383 , 2018 |
| Abstract : Goins_2018_Biochemistry_57_2383 |
| ESTHER : Goins_2018_Biochemistry_57_2383 |
| PubMedSearch : Goins_2018_Biochemistry_57_2383 |
| PubMedID: 29601187 |
| Gene_locus related to this paper: myctu-a85c , myctu-PKS13 , myctu-Rv3802c |
| Title : Exploring Covalent Allosteric Inhibition of Antigen 85C from Mycobacterium tuberculosis by Ebselen Derivatives - Goins_2017_ACS.Infect.Dis_3_378 |
| Author(s) : Goins CM , Dajnowicz S , Thanna S , Sucheck SJ , Parks JM , Ronning DR |
| Ref : ACS Infect Dis , 3 :378 , 2017 |
| Abstract : Goins_2017_ACS.Infect.Dis_3_378 |
| ESTHER : Goins_2017_ACS.Infect.Dis_3_378 |
| PubMedSearch : Goins_2017_ACS.Infect.Dis_3_378 |
| PubMedID: 28285521 |
| Gene_locus related to this paper: myctu-a85c |
| Title : Cyclipostins and Cyclophostin analogs as promising compounds in the fight against tuberculosis - Nguyen_2017_Sci.Rep_7_11751 |
| Author(s) : Nguyen PC , Delorme V , Benarouche A , Martin BP , Paudel R , Gnawali GR , Madani A , Puppo R , Landry V , Kremer L , Brodin P , Spilling CD , Cavalier JF , Canaan S |
| Ref : Sci Rep , 7 :11751 , 2017 |
| Abstract : Nguyen_2017_Sci.Rep_7_11751 |
| ESTHER : Nguyen_2017_Sci.Rep_7_11751 |
| PubMedSearch : Nguyen_2017_Sci.Rep_7_11751 |
| PubMedID: 28924204 |
| Gene_locus related to this paper: mycle-ML2603 , myctu-a85a , myctu-a85c , myctu-Rv1399c , myctu-Rv2970c , myctu-Rv3569c , myctu-yt28 |
| Title : Inactivation of the Mycobacterium tuberculosis antigen 85 complex by covalent, allosteric inhibitors - Favrot_2014_J.Biol.Chem_289_25031 |
| Author(s) : Favrot L , Lajiness DH , Ronning DR |
| Ref : Journal of Biological Chemistry , 289 :25031 , 2014 |
| Abstract : Favrot_2014_J.Biol.Chem_289_25031 |
| ESTHER : Favrot_2014_J.Biol.Chem_289_25031 |
| PubMedSearch : Favrot_2014_J.Biol.Chem_289_25031 |
| PubMedID: 25028518 |
| Gene_locus related to this paper: myctu-a85c |
| Title : Mechanism of inhibition of Mycobacterium tuberculosis antigen 85 by ebselen - Favrot_2013_Nat.Commun_4_2748 |
| Author(s) : Favrot L , Grzegorzewicz AE , Lajiness DH , Marvin RK , Boucau J , Isailovic D , Jackson M , Ronning DR |
| Ref : Nat Commun , 4 :2748 , 2013 |
| Abstract : Favrot_2013_Nat.Commun_4_2748 |
| ESTHER : Favrot_2013_Nat.Commun_4_2748 |
| PubMedSearch : Favrot_2013_Nat.Commun_4_2748 |
| PubMedID: 24193546 |
| Gene_locus related to this paper: myctu-a85c |
| Title : Single nucleotide polymorphisms in cell wall biosynthesis-associated genes and phylogeny of Mycobacterium tuberculosis lineages - Chuang_2010_Infect.Genet.Evol_10_459 |
| Author(s) : Chuang PC , Chen YM , Chen HY , Jou R |
| Ref : Infect Genet Evol , 10 :459 , 2010 |
| Abstract : Chuang_2010_Infect.Genet.Evol_10_459 |
| ESTHER : Chuang_2010_Infect.Genet.Evol_10_459 |
| PubMedSearch : Chuang_2010_Infect.Genet.Evol_10_459 |
| PubMedID: 20223296 |
| Gene_locus related to this paper: myctu-a85a , myctu-a85c |
| Title : Design, synthesis and biological evaluation of sugar-derived esters, alpha-ketoesters and alpha-ketoamides as inhibitors for Mycobacterium tuberculosis antigen 85C - Sanki_2009_Mol.Biosyst_5_945 |
| Author(s) : Sanki AK , Boucau J , Umesiri FE , Ronning DR , Sucheck SJ |
| Ref : Mol Biosyst , 5 :945 , 2009 |
| Abstract : Sanki_2009_Mol.Biosyst_5_945 |
| ESTHER : Sanki_2009_Mol.Biosyst_5_945 |
| PubMedSearch : Sanki_2009_Mol.Biosyst_5_945 |
| PubMedID: 19668859 |
| Gene_locus related to this paper: myctu-a85c |
| Title : targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis - Raman_2008_BMC.Syst.Biol_2_109 |
| Author(s) : Raman K , Yeturu K , Chandra N |
| Ref : BMC Syst Biol , 2 :109 , 2008 |
| Abstract : Raman_2008_BMC.Syst.Biol_2_109 |
| ESTHER : Raman_2008_BMC.Syst.Biol_2_109 |
| PubMedSearch : Raman_2008_BMC.Syst.Biol_2_109 |
| PubMedID: 19099550 |
| Gene_locus related to this paper: myctu-a85a , myctu-a85b , myctu-a85c , myctu-RV2296 , myctu-YR15 |
| Title : Mycobacterium tuberculosis antigen 85A and 85C structures confirm binding orientation and conserved substrate specificity - Ronning_2004_J.Biol.Chem_279_36771 |
| Author(s) : Ronning DR , Vissa V , Besra GS , Belisle JT , Sacchettini JC |
| Ref : Journal of Biological Chemistry , 279 :36771 , 2004 |
| Abstract : Ronning_2004_J.Biol.Chem_279_36771 |
| ESTHER : Ronning_2004_J.Biol.Chem_279_36771 |
| PubMedSearch : Ronning_2004_J.Biol.Chem_279_36771 |
| PubMedID: 15192106 |
| Gene_locus related to this paper: myctu-a85a , myctu-a85c |
| Title : Crystal structure of the secreted form of antigen 85C reveals potential targets for mycobacterial drugs and vaccines - Ronning_2000_Nat.Struct.Biol_7_141 |
| Author(s) : Ronning DR , Klabunde T , Besra GS , Vissa VD , Belisle JT , Sacchettini JC |
| Ref : Nat Struct Biol , 7 :141 , 2000 |
| Abstract : Ronning_2000_Nat.Struct.Biol_7_141 |
| ESTHER : Ronning_2000_Nat.Struct.Biol_7_141 |
| PubMedSearch : Ronning_2000_Nat.Struct.Biol_7_141 |
| PubMedID: 10655617 |
| Gene_locus related to this paper: myctu-a85c |
| Title : Inactivation of the antigen 85C gene profoundly affects the mycolate content and alters the permeability of the Mycobacterium tuberculosis cell envelope - Jackson_1999_Mol.Microbiol_31_1573 |
| Author(s) : Jackson M , Raynaud C , Laneelle MA , Guilhot C , Laurent-Winter C , Ensergueix D , Gicquel B , Daffe M |
| Ref : Molecular Microbiology , 31 :1573 , 1999 |
| Abstract : Jackson_1999_Mol.Microbiol_31_1573 |
| ESTHER : Jackson_1999_Mol.Microbiol_31_1573 |
| PubMedSearch : Jackson_1999_Mol.Microbiol_31_1573 |
| PubMedID: 10200974 |
| Gene_locus related to this paper: myctu-a85c |
| Title : Role of the major antigen of Mycobacterium tuberculosis in cell wall biogenesis - Belisle_1997_Science_276_1420 |
| Author(s) : Belisle JT , Vissa VD , Sievert T , Takayama K , Brennan PJ , Besra GS |
| Ref : Science , 276 :1420 , 1997 |
| Abstract : Belisle_1997_Science_276_1420 |
| ESTHER : Belisle_1997_Science_276_1420 |
| PubMedSearch : Belisle_1997_Science_276_1420 |
| PubMedID: 9162010 |
| Gene_locus related to this paper: myctu-a85a , myctu-a85b , myctu-a85c |
| Title : A family of cross-reacting proteins secreted by Mycobacterium tuberculosis - Wiker_1992_Scand.J.Immunol_36_307 |
| Author(s) : Wiker HG , Nagai S , Harboe M , Ljungqvist L |
| Ref : Scand J Immunol , 36 :307 , 1992 |
| Abstract : Wiker_1992_Scand.J.Immunol_36_307 |
| ESTHER : Wiker_1992_Scand.J.Immunol_36_307 |
| PubMedSearch : Wiker_1992_Scand.J.Immunol_36_307 |
| PubMedID: 1502498 |
| Gene_locus related to this paper: myctu-a85b , myctu-a85c , myctu-mpt51 |
| Title : The genes coding for the antigen 85 complexes of Mycobacterium tuberculosis and Mycobacterium bovis BCG are members of a gene family: cloning, sequence determination, and genomic organization of the gene coding for antigen 85-C of M. tuberculosis - Content_1991_Infect.Immun_59_3205 |
| Author(s) : Content J , de la Cuvellerie A , De Wit L , Vincent-Levy-Frebault V , Ooms J , De Bruyn J |
| Ref : Infect Immun , 59 :3205 , 1991 |
| Abstract : Content_1991_Infect.Immun_59_3205 |
| ESTHER : Content_1991_Infect.Immun_59_3205 |
| PubMedSearch : Content_1991_Infect.Immun_59_3205 |
| PubMedID: 1715324 |
| Gene_locus related to this paper: myctu-a85c |
| Title : Characterization of fibronectin-binding antigens released by Mycobacterium tuberculosis and Mycobacterium bovis BCG - Abou-Zeid_1988_Infect.Immun_56_3046 |
| Author(s) : Abou-Zeid C , Ratliff TL , Wiker HG , Harboe M , Bennedsen J , Rook GA |
| Ref : Infect Immun , 56 :3046 , 1988 |
| Abstract : Abou-Zeid_1988_Infect.Immun_56_3046 |
| ESTHER : Abou-Zeid_1988_Infect.Immun_56_3046 |
| PubMedSearch : Abou-Zeid_1988_Infect.Immun_56_3046 |
| PubMedID: 3141278 |
| Gene_locus related to this paper: myctu-a85a , myctu-a85b , myctu-a85c |