myctu-ephd

 
Mycobacterium tuberculosis, Mycobacterium bovis, (Rv2214c, MT2270, MTCY190.25c) Probable oxidoreductase ephd gene Short-chain type dehydrogenase

Comment
N-terminus corresponds to several epoxide hydrolases of plants and M. tuberculosis e.g. MTCY9F925. PfamA Abhydrolase_1 56 296. only n-term Pfam A Abhydrolase_6 32 293. There are more than 1000 strains. Other Uniprot entries and list of strains can be found with the link: Other strains CDC 1551 / Oshkosh


Relationship
Block X
Mycobacterium tuberculosis position in NCBI Life Tree :
N link to NCBI taxonomic web page and E link to ESTHER gene locus found in this strain.
> cellular organisms: N E > Bacteria: N E > Terrabacteria group: N E > Actinobacteria [phylum]: N E > Actinobacteria [class]: N E > Corynebacteriales: N E > Mycobacteriaceae: N E > Mycobacterium: N E > Mycobacterium tuberculosis complex: N E > Mycobacterium tuberculosis: N E
Warning: This entry is a compilation of different species or line or strain with more than 90% amino acide identity. You can retrieve all strain data


Molecular evidence
Database
No mutation
No structure
No kinetic

Substrate: Epoxyoleic-acid ,

>3 Genbank links 37 more: Z70283, CP000611, CP001658
>3 UniProt links 1 more: P66778, A5U4P2, P9WGS2
1 Ncbi-nid : 3261561
1 Ncbi-pid : 3261563
>3 UniProtTrembl links 1 more: P66778, A5U4P2, P9WGS2
>3 Interpro links 1 more: P66778, A5U4P2, P9WGS2
>3 Prodom links 1 more: P66778, A5U4P2, P9WGS2
>3 Pfam links 1 more: P66778, A5U4P2, P9WGS2
>3 PIRSF links 1 more: P66778, A5U4P2, P9WGS2
>3 SUPERFAM links 1 more: P66778, A5U4P2, P9WGS2
>3 QuickSwissBlast links 1 more: P66778, A5U4P2, P9WGS2
 
Sequence
Graphical view for this peptide sequence: myctu-ephd
Colored MSA for Epoxide_hydrolase (raw)
MPATQQMSRLVDSPDGVRIAVYHEGNPDGPTVVLVHGFPDSHVLWDGVVP
LLAERFRIVRYDNRGVGRSSVPKPISAYTMAHFADDFDAVIGELSPGEPV
HVLAHDWGSVGVWEYLRRPGASDRVASFTSVSGPSQDHLVNYVYGGLRRP
WRPRTFLRAISQTLRLSYMALFSVPVVAPLLLRVALSSAAVRRNMVGDIP
VDQIHHSETLARDAAHSVKTYPANYFRSFSSSRRGRAIPIVDVPVQLIVN
SQDPYVRPYGYDQTARWVPRLWRRDIKAGHFSPMSHPQVMAAAVHDFADL
ADGK
Legend This sequence has been compared to family alignement (MSA)
red => minority aminoacid
blue => majority aminoacid
color intensity => conservation rate
title => sequence position(MSA position)aminoacid rate
Catalytic site
Catalytic site in the MSA

MPATQQMSRLVDSPDGVRIAVYHEGNPDGPTVVLVHGFPDSHVLWDGVVP
LLAERFRIVRYDNRGVGRSSVPKPISAYTMAHFADDFDAVIGELSPGEPV
HVLAHDWGSVGVWEYLRRPGASDRVASFTSVSGPSQDHLVNYVYGGLRRP
WRPRTFLRAISQTLRLSYMALFSVPVVAPLLLRVALSSAAVRRNMVGDIP
VDQIHHSETLARDAAHSVKTYPANYFRSFSSSRRGRAIPIVDVPVQLIVN
SQDPYVRPYGYDQTARWVPRLWRRDIKAGHFSPMSHPQVMAAAVHDFADL
ADGK

Graphical view for this nucleotide DNA sequence (1827 bp): myctu-ephd



References
4 more
    Title: Whole genome sequence analysis of Mycobacterium bovis bacillus Calmette-Guerin (BCG) Tokyo 172: a comparative study of BCG vaccine substrains
    Seki M, Honda I, Fujita I, Yano I, Yamamoto S, Koyama A
    Ref: Vaccine, 27:1710, 2009 : PubMed

            

    Title: Genome plasticity of BCG and impact on vaccine efficacy
    Brosch R, Gordon SV, Garnier T, Eiglmeier K, Frigui W, Valenti P, Dos Santos S, Duthoy S, Lacroix C and Cole ST <10 more author(s)>
    Ref: Proc Natl Acad Sci U S A, 104:5596, 2007 : PubMed

            

    Title: Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence
    Cole ST, Brosch R, Parkhill J, Garnier T, Churcher C, Harris D, Gordon SV, Eiglmeier K, Gas S and Barrell BG <32 more author(s)>
    Ref: Nature, 393:537, 1998 : PubMed

            


Other Papers


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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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