Gene_locus Report for: myobr-s7nnt6

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms: N E > Eukaryota: N E > Opisthokonta: N E > Metazoa: N E > Eumetazoa: N E > Bilateria: N E > Deuterostomia: N E > Chordata: N E > Craniata: N E > Vertebrata: N E > Gnathostomata: N E > Teleostomi: N E > Euteleostomi: N E > Sarcopterygii: N E > Dipnotetrapodomorpha: N E > Tetrapoda: N E > Amniota: N E > Mammalia: N E > Theria: N E > Eutheria: N E > Boreoeutheria: N E > Laurasiatheria: N E > Chiroptera: N E > Microchiroptera: N E > Vespertilionidae: N E > Myotis: N E > Myotis brandtii: N E

Title: Genome analysis reveals insights into physiology and longevity of the Brandt's bat Myotis brandtii
Seim I, Fang X, Xiong Z, Lobanov AV, Huang Z, Ma S, Feng Y, Turanov AA, Zhu Y and Gladyshev VN <19 more author(s)> Seim I, Fang X, Xiong Z, Lobanov AV, Huang Z, Ma S, Feng Y, Turanov AA, Zhu Y, Lenz TL, Gerashchenko MV, Fan D, Hee Yim S, Yao X, Jordan D, Xiong Y, Ma Y, Lyapunov AN, Chen G, Kulakova OI, Sun Y, Lee SG, Bronson RT, Moskalev AA, Sunyaev SR, Zhang G, Krogh A, Wang J, Gladyshev VN (- 19)
Ref: Nat Commun, 4:2212, 2013 : PubMed
Abstract


ESTHER: Seim_2013_Nat.Commun_4_2212
PubMedSearch: Seim 2013 Nat.Commun 4 2212
PubMedID: 23962925
Gene_locus related to this paper: myobr-s7mf99, myobr-s7n4r2, myobr-s7neb7, myobr-s7ney7, myobr-s7n9l2, myobr-s7nk13, myobr-s7mh20, myobr-s7pbt8, myobr-s7mux2, myobr-s7mjb5, myobr-s7n6x5, myobr-s7nnt6, myobr-s7n728.2, myobr-s7n728.3, myobr-s7n8d2, myobr-s7nqw0, myobr-s7mju4, myolu-g1nth4, myobr-s7mij5, myobr-s7pr94, myolu-g1q4e3, myolu-g1p353

Abstract

Bats account for one-fifth of mammalian species, are the only mammals with powered flight, and are among the few animals that echolocate. The insect-eating Brandt's bat (Myotis brandtii) is the longest-lived bat species known to date (lifespan exceeds 40 years) and, at 4-8 g adult body weight, is the most extreme mammal with regard to disparity between body mass and longevity. Here we report sequencing and analysis of the Brandt's bat genome and transcriptome, which suggest adaptations consistent with echolocation and hibernation, as well as altered metabolism, reproduction and visual function. Unique sequence changes in growth hormone and insulin-like growth factor 1 receptors are also observed. The data suggest that an altered growth hormone/insulin-like growth factor 1 axis, which may be common to other long-lived bat species, together with adaptations such as hibernation and low reproductive rate, contribute to the exceptional lifespan of the Brandt's bat.