Gene_locus Report for: neofi-a1da18

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms: N E > Eukaryota: N E > Opisthokonta: N E > Fungi: N E > Dikarya: N E > Ascomycota: N E > saccharomyceta: N E > Pezizomycotina: N E > leotiomyceta: N E > Eurotiomycetes: N E > Eurotiomycetidae: N E > Eurotiales: N E > Aspergillaceae: N E > Aspergillus: N E > Aspergillus fischeri: N E

Title: Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus
Fedorova ND, Khaldi N, Joardar VS, Maiti R, Amedeo P, Anderson MJ, Crabtree J, Silva JC, Badger JH and Nierman WC <29 more author(s)> Fedorova ND, Khaldi N, Joardar VS, Maiti R, Amedeo P, Anderson MJ, Crabtree J, Silva JC, Badger JH, Albarraq A, Angiuoli S, Bussey H, Bowyer P, Cotty PJ, Dyer PS, Egan A, Galens K, Fraser-Liggett CM, Haas BJ, Inman JM, Kent R, Lemieux S, Malavazi I, Orvis J, Roemer T, Ronning CM, Sundaram JP, Sutton G, Turner G, Venter JC, White OR, Whitty BR, Youngman P, Wolfe KH, Goldman GH, Wortman JR, Jiang B, Denning DW, Nierman WC (- 29)
Ref: PLoS Genet, 4:e1000046, 2008 : PubMed
Abstract


ESTHER: Fedorova_2008_PLoS.Genet_4_E1000046
PubMedSearch: Fedorova 2008 PLoS.Genet 4 E1000046
PubMedID: 18404212
Gene_locus related to this paper: aspcl-a1c4m6, aspcl-a1c5a7, aspcl-a1c6w3, aspcl-a1c8p7, aspcl-a1c8q9, aspcl-a1c9k4, aspcl-a1c759, aspcl-a1c786, aspcl-a1c823, aspcl-a1c859, aspcl-a1c881, aspcl-a1c994, aspcl-a1cag4, aspcl-a1caj8, aspcl-a1cas0, aspcl-a1cc86, aspcl-a1ccq2, aspcl-a1cfv7, aspcl-a1chj6, aspcl-a1cif4, aspcl-a1ck14, aspcl-a1cke4, aspcl-a1ckq1, aspcl-a1cli1, aspcl-a1cln8, aspcl-a1cm72, aspcl-a1cns2, aspcl-a1cpk9, aspcl-a1cra8, aspcl-a1crr5, aspcl-a1crs9, aspcl-a1cs04, aspcl-a1cs39, aspcl-a1cu39, aspcl-atg15, aspcl-axe1, aspcl-cuti1, aspcl-cuti3, aspcl-dapb, aspcl-dpp4, aspcl-dpp5, aspcl-faeb, aspcl-faec1, aspcl-faec2, aspfc-b0xp50, aspfc-b0xu40, aspfc-b0xzj6, aspfc-b0y2h6, aspfc-b0y962, aspfc-b0yaj6, aspfc-dpp5, aspfu-DPP4, aspfu-faeb1, aspfu-faec, aspfu-ppme1, aspfu-q4w9r3, aspfu-q4w9t5, aspfu-q4w9z4, aspfu-q4wa57, aspfu-q4wa78, aspfu-q4wag0, aspfu-q4wal3, aspfu-q4wbc5, aspfu-q4wbj7, aspfu-q4wdg2, aspfu-q4wf06, aspfu-q4wf29, aspfu-q4wf56, aspfu-q4wfq9, aspfu-q4wg73, aspfu-q4wgm4, aspfu-q4win2, aspfu-q4wk31, aspfu-q4wk44, aspfu-q4wk90, aspfu-q4wm12, aspfu-q4wm84, aspfu-q4wm86, aspfu-q4wmr0, aspfu-q4wny7, aspfu-q4wp19, aspfu-q4wpb9, aspfu-q4wqj8, aspfu-q4wqv2, aspfu-q4wrr7, aspfu-q4wu51, aspfu-q4wub2, aspfu-q4wui7, aspfu-q4wuk8, aspfu-q4wum3, aspfu-q4wuw0, aspfu-q4wvy1, aspfu-q4ww22, aspfu-q4wx13, aspfu-q4wxd0, aspfu-q4wxe4, aspfu-q4wxr1, aspfu-q4wyq5, aspfu-q4wz16, aspfu-q4wzd5, aspfu-q4wzh6, aspfu-q4x0n6, aspfu-q4x1n0, aspfu-q4x1w9, aspfu-q4x078, neofi-a1cwa6, neofi-a1d4m8, neofi-a1d4p0, neofi-a1d5p2, neofi-a1d104, neofi-a1d380, neofi-a1d512, neofi-a1d654, neofi-a1da18, neofi-a1dal8, neofi-a1df46, neofi-a1dhj0, neofi-a1di44, neofi-a1dk35, neofi-a1dki7, neofi-a1dkt6, neofi-a1dn55, neofi-atg15, neofi-axe1, neofi-faeb1, neofi-faeb2, neofi-faec, aspcl-a1cd34, aspcl-a1cd88, neofi-a1dc66, aspcl-a1ceh5, neofi-a1dfr9, aspfm-a0a084bf80, aspcl-a1cqb5, aspcl-a1cs44, neofi-a1d517, neofi-a1dbz0, neofi-a1cuz0, aspcl-a1c5e8, neofi-a1d0b8, aspcl-a1cdf0, aspcl-a1ccd3, neofi-a1da82, neofi-a1d5e6, aspcl-kex1, aspcl-cbpya

Abstract

We present the genome sequences of a new clinical isolate of the important human pathogen, Aspergillus fumigatus, A1163, and two closely related but rarely pathogenic species, Neosartorya fischeri NRRL181 and Aspergillus clavatus NRRL1. Comparative genomic analysis of A1163 with the recently sequenced A. fumigatus isolate Af293 has identified core, variable and up to 2% unique genes in each genome. While the core genes are 99.8% identical at the nucleotide level, identity for variable genes can be as low 40%. The most divergent loci appear to contain heterokaryon incompatibility (het) genes associated with fungal programmed cell death such as developmental regulator rosA. Cross-species comparison has revealed that 8.5%, 13.5% and 12.6%, respectively, of A. fumigatus, N. fischeri and A. clavatus genes are species-specific. These genes are significantly smaller in size than core genes, contain fewer exons and exhibit a subtelomeric bias. Most of them cluster together in 13 chromosomal islands, which are enriched for pseudogenes, transposons and other repetitive elements. At least 20% of A. fumigatus-specific genes appear to be functional and involved in carbohydrate and chitin catabolism, transport, detoxification, secondary metabolism and other functions that may facilitate the adaptation to heterogeneous environments such as soil or a mammalian host. Contrary to what was suggested previously, their origin cannot be attributed to horizontal gene transfer (HGT), but instead is likely to involve duplication, diversification and differential gene loss (DDL). The role of duplication in the origin of lineage-specific genes is further underlined by the discovery of genomic islands that seem to function as designated "gene dumps" and, perhaps, simultaneously, as "gene factories".