Gene_locus Report for: phyit-d0mxu5 Phytophthora infestans (strain T30-4) (Potato late blight fungus) Cleavage induced serine protease family S33, putative
Relationship
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) cellular organisms: N E > Eukaryota: N E > Stramenopiles: N E > Oomycetes: N E > Peronosporales: N E > Phytophthora: N E > Phytophthora infestans: N E 6_AlphaBeta_hydrolase :
phyit-d0ns26 Phytophthora infestans (strain T30-4) (Potato late blight fungus) Putative uncharacterized protein .
A85-EsteraseD-FGH :
phyit-d0n6q1 Phytophthora infestans (strain T30-4) (Potato late blight fungus) S-formylglutathione hydrolase, putative .
A85-Feruloyl-Esterase :
phyit-d0ng53 Phytophthora infestans (strain T30-4) (Potato late blight fungus) Putative uncharacterized protein .
ABHD6-Lip :
phyit-d0mqp1 Phytophthora infestans (strain T30-4) (Potato late blight fungus) Putative uncharacterized protein ,
phyit-d0mqp2 Phytophthora infestans (strain T30-4) (Potato late blight fungus) Serine protease family S33, putative .
ABHD13-BEM46 :
phyit-d0n5g6 Phytophthora infestans (strain T30-4) (Potato late blight fungus). protein bem46-like, putative .
ABHD18 :
phyit-d0n4i8 Phytophthora infestans (strain T30-4) (Potato late blight fungus). Putative uncharacterized protein .
abh_upf0017 :
phyit-d0ni28 Phytophthora infestans (strain T30-4) (Potato late blight fungus) Serine protease family S33, putative ,
phyit-d0nrk9 Phytophthora infestans (strain T30-4) (Potato late blight fungus) Serine protease family S33, putative ,
phyit-d0nrl4 Phytophthora infestans (strain T30-4) (Potato late blight fungus) Serine protease family S33, putative .
Acidic_Lipase :
phyit-d0mt75 Phytophthora infestans (strain T30-4) (Potato late blight fungus) Lipase ,
phyit-d0muv1 Phytophthora infestans (strain T30-4) (Potato late blight fungus) Lipase, putative ,
phyit-d0mv34 Phytophthora infestans (strain T30-4) (Potato late blight fungus) Lipase ,
phyit-d0mv35 Phytophthora infestans (strain T30-4) (Potato late blight fungus) Lipase .
Carboxypeptidase_S10 :
phyit-kex1 Phytophthora infestans (strain T30-4) (Potato late blight fungus) Carboxypeptidase D .
CGI-58_ABHD5_ABHD4 :
phyit-d0nj53 Phytophthora infestans (strain T30-4) (Potato late blight fungus) Serine protease family S33, putative ,
phyit-d0nj54 Phytophthora infestans (strain T30-4) (Potato late blight fungus) Serine protease family S33, putative .
Cutinase :
phyin-q2m440 Phytophthora infestans (Potato late blight fungus) cutinase ,
phyin-q58g92 Phytophthora infestans (Potato late blight fungus) cutinase (EC 3.1.1.-) .
Dienelactone_hydrolase :
phyin-ENDO2 Phytophthora infestans (Potato late blight fungus) putative endo-1,3,1,4-beta-glucanase .
DPP4N_Peptidase_S9 :
phyit-d0nfs3 Phytophthora infestans (strain T30-4) (Potato late blight fungus) Dipeptidyl peptidase, putative .
Duf_900 :
phyit-d0n935 Phytophthora infestans (strain T30-4) (Potato late blight fungus) Putative uncharacterized protein .
Duf_1057 :
phyit-d0n4x0 Phytophthora infestans (strain T30-4) (Potato late blight fungus) Serine protease family S33, putative ,
phyit-d0n4x1 Phytophthora infestans (strain T30-4) (Potato late blight fungus) Serine protease family S33, putative ,
phyit-d0n4x3 Phytophthora infestans (strain T30-4) (Potato late blight fungus) Putative uncharacterized protein .
Epoxide_hydrolase :
phyit-d0nhj2 Phytophthora infestans (strain T30-4) (Potato late blight fungus) Epoxide hydrolase, putative ,
phyit-d0nhj4 Phytophthora infestans (strain T30-4) (Potato late blight fungus) Epoxide hydrolase, putative ,
phyit-d0nhj8 Phytophthora infestans (strain T30-4) (Potato late blight fungus) Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, putative ,
phyit-d0ns42 Phytophthora infestans (strain T30-4) (Potato late blight fungus) Epoxide hydrolase, putative ,
phyit-d0ns43 Phytophthora infestans (strain T30-4) (Potato late blight fungus) Epoxide hydrolase, putative .
Kynurenine-formamidase :
phyit-d0mqf7 Phytophthora infestans (strain T30-4) (Potato late blight fungus). N-formylkynurenine formamidase .
Maspardin-ACP33-SPG21_like :
phyit-d0mwf9 Phytophthora infestans (strain T30-4) (Potato late blight fungus) Maspardin-like protein .
Monoglyceridelipase_lysophospholip :
phyit-d0nr53 Phytophthora infestans (strain T30-4) (Potato late blight fungus) Serine protease family S33, putative ,
phyit-d0nrb1 Phytophthora infestans (strain T30-4) (Potato late blight fungus) Serine protease family S33, putative ,
phyit-d0nvt3 Phytophthora infestans (strain T30-4) (Potato late blight fungus) Lipase, putative ,
phyit-d0nwb6 Phytophthora infestans (strain T30-4) (Potato late blight fungus) Serine protease family S33, putative ,
phyit-d0nzc0 Phytophthora infestans (strain T30-4) (Potato late blight fungus) Serine protease family S33, putative ,
phyit-d0nzc1 Phytophthora infestans (strain T30-4) (Potato late blight fungus) Serine protease family S33, putative .
PPase_methylesterase_euk :
phyit-d0p3z2 Phytophthora infestans (strain T30-4) (Potato late blight fungus) Protein phosphatase methylesterase 1 .
Proline_iminopeptidase :
phyit-d0n6q6 Phytophthora infestans (strain T30-4) (Potato late blight fungus). Proline iminopeptidase .
Prolylcarboxypeptidase :
phyit-d0nax9 Phytophthora infestans (strain T30-4) (Potato late blight fungus) Serine protease family S28, putative ,
phyit-d0njf2 Phytophthora infestans (strain T30-4) (Potato late blight fungus) Lysosomal Pro-X carboxypeptidase, putative ,
phyit-d0nkm4 Phytophthora infestans (strain T30-4) (Potato late blight fungus) Serine protease family S28, putative ,
phyit-d0nsr8 Phytophthora infestans (strain T30-4) (Potato late blight fungus) Lysosomal Pro-X carboxypeptidase, putative ,
phyit-d0nu41 Phytophthora infestans (strain T30-4) (Potato late blight fungus) Lysosomal Pro-X carboxypeptidase, putative .
S9N_PREPL_Peptidase_S9 :
phyit-d0nj14 Phytophthora infestans (strain T30-4) (Potato late blight fungus) Serine protease family S09A, putative ,
phyit-d0nwm8 Phytophthora infestans (strain T30-4) (Potato late blight fungus) Serine protease family S09A, putative .
Valacyclovir-hydrolase :
phyit-d0p0z1 Phytophthora infestans (strain T30-4) (Potato late blight fungus) Putative uncharacterized protein Molecular evidence
Database
No mutation No structure No kinetic No Substrate No inhibitor
Sequence
Graphical view for this peptide sequence: phyit-d0mxu5 Colored MSA for CGI-58_ABHD5_ABHD4 (raw)
MLRMLRPIAATTAVLLAAGVATEGRLWQWVPARYSKLEEAERKIFTRAIS
TPFEMKKVAQLGTVVVPCSDEKKRESAKNLVLVHGFAGGNAVWAMNLEKL
SKHFNVYAVEWIGVGRSDRPDFNFNDVRHLYESADDFIVGSFEKWQKEIK
LENFDLVGHSMGAIFASSYALKHPDQVNHLVLASPAGVPHPPPPPDPTTE
EGRAASRSWLRRMVFSAWENGVTPMSLARFVGPYGPKLVQNVVHRRTSFM
SEGSAMRDGRVDLNEMAEYMYHNWALKPSGERVMTTHLAPGAHAVRPLVS
SLLPESVKMPLTFIYGEYDWMDYRNGLSIVDSFKQKGRSADLFRVPNGGH
QMFMENPDEFSRILIDRLARQILVQH
Legend
This sequence has been compared to family alignement (MSA) red => minority aminoacid blue => majority aminoacid color intensity => conservation rate title => sequence position(MSA position)aminoacid rate Catalytic site Catalytic site in the MSA
M L R M L R P I A A T T A V L L A A G V A T E G R L W Q W V P A R Y S K L E E A E R K I F T R A I S T P F E M K K V A Q L G T V V V P C S D E K K R E S A K N L V L V H G F A G G N A V W A M N L E K L S K H F N V Y A V E W I G V G R S D R P D F N F N D V R H L Y E S A D D F I V G S F E K W Q K E I K L E N F D L V G H S M G A I F A S S Y A L K H P D Q V N H L V L A S P A G V P H P P P P P D P T T E E G R A A S R S W L R R M V F S A W E N G V T P M S L A R F V G P Y G P K L V Q N V V H R R T S F M S E G S A M R D G R V D L N E M A E Y M Y H N W A L K P S G E R V M T T H L A P G A H A V R P L V S S L L P E S V K M P L T F I Y G E Y D W M D Y R N G L S I V D S F K Q K G R S A D L F R V P N G G H Q M F M E N P D E F S R I L I D R L A R Q I L V Q H
Reference
Title: Genome sequence and analysis of the Irish potato famine pathogen Phytophthora infestansHaas BJ , Kamoun S , Zody MC , Jiang RH , Handsaker RE , Cano LM , Grabherr M , Kodira CD , Raffaele S and Nusbaum C <86 more author(s)> Haas BJ , Kamoun S , Zody MC , Jiang RH , Handsaker RE , Cano LM , Grabherr M , Kodira CD , Raffaele S , Torto-Alalibo T , Bozkurt TO , Ah-Fong AM , Alvarado L , Anderson VL , Armstrong MR , Avrova A , Baxter L , Beynon J , Boevink PC , Bollmann SR , Bos JI , Bulone V , Cai G , Cakir C , Carrington JC , Chawner M , Conti L , Costanzo S , Ewan R , Fahlgren N , Fischbach MA , Fugelstad J , Gilroy EM , Gnerre S , Green PJ , Grenville-Briggs LJ , Griffith J , Grunwald NJ , Horn K , Horner NR , Hu CH , Huitema E , Jeong DH , Jones AM , Jones JD , Jones RW , Karlsson EK , Kunjeti SG , Lamour K , Liu Z , Ma L , Maclean D , Chibucos MC , McDonald H , McWalters J , Meijer HJ , Morgan W , Morris PF , Munro CA , O'Neill K , Ospina-Giraldo M , Pinzon A , Pritchard L , Ramsahoye B , Ren Q , Restrepo S , Roy S , Sadanandom A , Savidor A , Schornack S , Schwartz DC , Schumann UD , Schwessinger B , Seyer L , Sharpe T , Silvar C , Song J , Studholme DJ , Sykes S , Thines M , van de Vondervoort PJ , Phuntumart V , Wawra S , Weide R , Win J , Young C , Zhou S , Fry W , Meyers BC , van West P , Ristaino J , Govers F , Birch PR , Whisson SC , Judelson HS , Nusbaum C (- 86) Ref: Nature, 461 :393, 2009 : PubMed Abstract ESTHER: Haas_2009_Nature_461_393 PubMedSearch: Haas 2009 Nature 461 393 PubMedID: 19741609 Gene_locus related to this paper: phyin-ENDO2 ,
phyin-q2m440 ,
phyin-q58g92 ,
phyit-d0mqp1 ,
phyit-d0mqp2 ,
phyit-d0mt75 ,
phyit-d0muv1 ,
phyit-d0mv34 ,
phyit-d0mv35 ,
phyit-d0mwf9 ,
phyit-d0mxu5 ,
phyit-d0n935 ,
phyit-d0nax9 ,
phyit-d0nfs3 ,
phyit-d0nhj2 ,
phyit-d0nhj4 ,
phyit-d0nhj8 ,
phyit-d0ni28 ,
phyit-d0nj14 ,
phyit-d0nj53 ,
phyit-d0nj54 ,
phyit-d0njf2 ,
phyit-d0nkm4 ,
phyit-d0nr53 ,
phyit-d0nrb1 ,
phyit-d0nrk9 ,
phyit-d0nrl4 ,
phyit-d0ns26 ,
phyit-d0ns42 ,
phyit-d0ns43 ,
phyit-d0nsr8 ,
phyit-d0nu41 ,
phyit-d0nvt3 ,
phyit-d0nwb6 ,
phyit-d0nwm8 ,
phyit-d0nzc0 ,
phyit-d0nzc1 ,
phyit-d0p0z1 ,
phyit-d0p3z2 ,
phyit-kex1 ,
phyit-d0n6q6 ,
phyit-d0n4i8 ,
phyit-d0mqf7 ,
phyit-d0n5g6 Abstract
Phytophthora infestans is the most destructive pathogen of potato and a model organism for the oomycetes, a distinct lineage of fungus-like eukaryotes that are related to organisms such as brown algae and diatoms. As the agent of the Irish potato famine in the mid-nineteenth century, P. infestans has had a tremendous effect on human history, resulting in famine and population displacement. To this day, it affects world agriculture by causing the most destructive disease of potato, the fourth largest food crop and a critical alternative to the major cereal crops for feeding the world's population. Current annual worldwide potato crop losses due to late blight are conservatively estimated at $$6.7 billion. Management of this devastating pathogen is challenged by its remarkable speed of adaptation to control strategies such as genetically resistant cultivars. Here we report the sequence of the P. infestans genome, which at approximately 240 megabases (Mb) is by far the largest and most complex genome sequenced so far in the chromalveolates. Its expansion results from a proliferation of repetitive DNA accounting for approximately 74% of the genome. Comparison with two other Phytophthora genomes showed rapid turnover and extensive expansion of specific families of secreted disease effector proteins, including many genes that are induced during infection or are predicted to have activities that alter host physiology. These fast-evolving effector genes are localized to highly dynamic and expanded regions of the P. infestans genome. This probably plays a crucial part in the rapid adaptability of the pathogen to host plants and underpins its evolutionary potential.
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