Gene_locus Report for: picgu-a5dn92 Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JC 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii) Putative uncharacterized protein
Relationship
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) cellular organisms: N E > Eukaryota: N E > Opisthokonta: N E > Fungi: N E > Dikarya: N E > Ascomycota: N E > saccharomyceta: N E > Saccharomycotina: N E > Saccharomycetes: N E > Saccharomycetales: N E > Debaryomycetaceae: N E > Meyerozyma: N E > Meyerozyma guilliermondii: N E 6_AlphaBeta_hydrolase :
picgu-a5dqu5 Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JC 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii) Putative uncharacterized protein .
A85-EsteraseD-FGH :
picgu-a5dh90 Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JC 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii) Putative uncharacterized protein .
abh_upf0017 :
picgu-a5dlj5 Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JC 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii) Putative uncharacterized protein ,
picgu-a5dm19 Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JC 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii) Putative uncharacterized protein .
Acidic_Lipase :
picgu-a5dc45 Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JC 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii) Putative uncharacterized protein ,
picgu-a5dkd8 Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JC 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii) Putative uncharacterized protein .
Arb2_domain :
picgu-a5dks8 Meyerozyma guilliermondii (Yeast) (Candida guilliermondii); Meyerozyma sp.. Uncharacterized protein .
Canar_LipB :
picgu-a5d9q3 Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JC 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii) Putative uncharacterized protein .
Carboxypeptidase_S10 :
picgu-kex1 Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii). Carboxypeptidase D .
CGI-58_ABHD5_ABHD4 :
picgu-a5dav0 Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JC 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii) Putative uncharacterized protein ,
picgu-a5dev7 Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JC 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii) Putative uncharacterized protein ,
picgu-a5dhe3 Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JC 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii) Putative uncharacterized protein ,
picgu-a5di38 Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JC 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii) Putative uncharacterized protein .
DPP4N_Peptidase_S9 :
picgu-a5dj06 Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JC 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii) Putative uncharacterized protein ,
picgu-a5dle9 Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JC 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii) Putative uncharacterized protein .
Epoxide_hydrolase :
picgu-a5dr14 Meyerozyma guilliermondii (Yeast) (Candida guilliermondii) Putative uncharacterized protein .
Fusarinine_C_esterase_sidJ :
picgu-a5dbk0 Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JC 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii) Putative uncharacterized protein .
PPase_methylesterase_euk :
picgu-a5dnt6 Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JC 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii) Protein phosphatase methylesterase 1 .
Proline_iminopeptidase :
picgu-a5dag9 Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii). Putative uncharacterized protein Molecular evidence
Database
No mutation No structure No kinetic No Substrate No inhibitor
Sequence
Graphical view for this peptide sequence: picgu-a5dn92 Colored MSA for Fungal-Bact_LIP (raw)
MRCLTALTFFSFIASVFALQIGPSVPSKDDFYKAPDGFESKPNGSILKIR
KTPFPLRSMFLKVNVEDSWQILVRSEDSFGEPNAVVATVIKPYNADSSKL
LSYQTAEDSGSPDCAPSYAFQYLASQKTITTEAEMLLIQPALQEGWYVVS
PDYEGMKATFTAGRQSGQATLNSIRGALKSSNITGVDSDAKVVMWGYSGG
TIATGWAASLQPEYAPELKGQLLGAAMGGWVTNITATAEGVEGTLFAGLT
ASALGGLVNEYPELSTLLGTYTTSEGPKVLQTAQSVCMLDSIIHFMFKRY
FTGPNKVFTNGWGLFDIPLVQSVVANNTLALHKGDPIPDIPIFVYHGEVD
TIVPFKDAQRGYTNWCNWGIKSFEFAVDQTAGHISEVWQGSPAGFAWVKK
MFNGAKPVEGCTRTVRKTNNLYPGAVNSIGDIILTAVTSVLGAQIGPNGE
LLEQNPKVQQLKV
Legend
This sequence has been compared to family alignement (MSA) red => minority aminoacid blue => majority aminoacid color intensity => conservation rate title => sequence position(MSA position)aminoacid rate Catalytic site Catalytic site in the MSA
M R C L T A L T F F S F I A S V F A L Q I G P S V P S K D D F Y K A P D G F E S K P N G S I L K I R K T P F P L R S M F L K V N V E D S W Q I L V R S E D S F G E P N A V V A T V I K P Y N A D S S K L L S Y Q T A E D S G S P D C A P S Y A F Q Y L A S Q K T I T T E A E M L L I Q P A L Q E G W Y V V S P D Y E G M K A T F T A G R Q S G Q A T L N S I R G A L K S S N I T G V D S D A K V V M W G Y S G G T I A T G W A A S L Q P E Y A P E L K G Q L L G A A M G G W V T N I T A T A E G V E G T L F A G L T A S A L G G L V N E Y P E L S T L L G T Y T T S E G P K V L Q T A Q S V C M L D S I I H F M F K R Y F T G P N K V F T N G W G L F D I P L V Q S V V A N N T L A L H K G D P I P D I P I F V Y H G E V D T I V P F K D A Q R G Y T N W C N W G I K S F E F A V D Q T A G H I S E V W Q G S P A G F A W V K K M F N G A K P V E G C T R T V R K T N N L Y P G A V N S I G D I I L T A V T S V L G A Q I G P N G E L L E Q N P K V Q Q L K V
Reference
Title: Evolution of pathogenicity and sexual reproduction in eight Candida genomesButler G , Rasmussen MD , Lin MF , Santos MA , Sakthikumar S , Munro CA , Rheinbay E , Grabherr M , Forche A and Cuomo CA <41 more author(s)> Butler G , Rasmussen MD , Lin MF , Santos MA , Sakthikumar S , Munro CA , Rheinbay E , Grabherr M , Forche A , Reedy JL , Agrafioti I , Arnaud MB , Bates S , Brown AJ , Brunke S , Costanzo MC , Fitzpatrick DA , de Groot PW , Harris D , Hoyer LL , Hube B , Klis FM , Kodira C , Lennard N , Logue ME , Martin R , Neiman AM , Nikolaou E , Quail MA , Quinn J , Santos MC , Schmitzberger FF , Sherlock G , Shah P , Silverstein KA , Skrzypek MS , Soll D , Staggs R , Stansfield I , Stumpf MP , Sudbery PE , Srikantha T , Zeng Q , Berman J , Berriman M , Heitman J , Gow NA , Lorenz MC , Birren BW , Kellis M , Cuomo CA (- 41) Ref: Nature, 459 :657, 2009 : PubMed Abstract ESTHER: Butler_2009_Nature_459_657 PubMedSearch: Butler 2009 Nature 459 657 PubMedID: 19465905 Gene_locus related to this paper: canal-ATG15 ,
canal-bna7 ,
canal-c4yl13 ,
canal-LIP1 ,
canal-LIP2 ,
canal-LIP3 ,
canal-LIP4 ,
canal-LIP5 ,
canal-LIP6 ,
canal-LIP7 ,
canal-LIP8 ,
canal-LIP9 ,
canal-LIP10 ,
canal-ppme1 ,
canal-q5a0c9 ,
canal-q5a2i9 ,
canal-q5a042 ,
canal-q5ad17 ,
canal-q5aeu3 ,
canal-q5afp8 ,
canal-q5ag57 ,
canal-q5ai09 ,
canal-q5ai12 ,
canal-q5ajt3 ,
canal-q5akz5 ,
canal-q5apu4 ,
canal-q59l46 ,
canal-q59m48 ,
canal-q59nw6 ,
canal-q59u61 ,
canal-q59u64 ,
canal-q59vp0 ,
canal-q59y97 ,
canaw-c4ykb1 ,
canaw-c4yrn6 ,
canaw-c4yrn9 ,
canaw-c4yrr3 ,
canaw-c4yrv3 ,
canaw-c4ys26 ,
cantt-c5m3d7 ,
cantt-c5m3y5 ,
cantt-c5m4x0 ,
cantt-c5m5e8 ,
cantt-c5m5w2 ,
cantt-c5m8s7 ,
cantt-c5m9c2 ,
cantt-c5m465 ,
cantt-c5m751 ,
cantt-c5m793 ,
cantt-c5m893 ,
cantt-c5ma78 ,
cantt-c5mag0 ,
cantt-c5mbb8 ,
cantt-c5mc53 ,
cantt-c5md87 ,
cantt-c5mdy3 ,
cantt-c5mey7 ,
cantt-c5mfg0 ,
cantt-c5mfh8 ,
cantt-c5mg56 ,
cantt-c5mgj0 ,
cantt-c5mh75 ,
cantt-c5mh80 ,
cantt-c5mh89 ,
cantt-c5mhh0 ,
cantt-c5mhn5 ,
cantt-c5mij5 ,
cantt-c5min7 ,
clal4-c4xvt8 ,
clal4-c4xwy4 ,
clal4-c4xy03 ,
clal4-c4xyx9 ,
clal4-c4xzz1 ,
clal4-c4y3e1 ,
clal4-c4y4f2 ,
clal4-c4y4w8 ,
clal4-c4y5j4 ,
clal4-c4y5j9 ,
clal4-c4y7z7 ,
clal4-c4y8q1 ,
clal4-c4y035 ,
clal4-c4y481 ,
clal4-c4y538 ,
clal4-c4y898 ,
clal4-c4yas2 ,
clal4-c4yba6 ,
clal4-c4yba7 ,
clal4-c4yc85 ,
lodel-a5drz3 ,
lodel-a5ds97 ,
lodel-a5dsc0 ,
lodel-a5duu4 ,
lodel-a5duy7 ,
lodel-a5dv03 ,
lodel-a5dv46 ,
lodel-a5dw16 ,
lodel-a5dwv7 ,
lodel-a5dww6 ,
lodel-a5dxf3 ,
lodel-a5e0z5 ,
lodel-a5e1c1 ,
lodel-a5e1l4 ,
lodel-a5e1p3 ,
lodel-a5e2s1 ,
lodel-a5e2t8 ,
lodel-a5e2v2 ,
lodel-a5e4u8 ,
lodel-a5e5a9 ,
lodel-a5e5k1 ,
lodel-a5e5z7 ,
lodel-a5e6w1 ,
lodel-a5e028 ,
lodel-atg15 ,
lodel-kex1 ,
picgu-a5d9u2 ,
picgu-a5dav0 ,
picgu-a5dbk0 ,
picgu-a5dc45 ,
picgu-a5dc73 ,
picgu-a5dc74 ,
picgu-a5dc75 ,
picgu-a5ddt8 ,
picgu-a5dev7 ,
picgu-a5dh90 ,
picgu-a5dhe3 ,
picgu-a5di38 ,
picgu-a5dj06 ,
picgu-a5dkd8 ,
picgu-a5dle9 ,
picgu-a5dlj5 ,
picgu-a5dm19 ,
picgu-a5dn92 ,
picgu-a5dnr3 ,
picgu-a5dnt6 ,
picgu-a5dqu5 ,
picgu-a5dr14 ,
picgu-a5drl3 ,
picgu-atg15 ,
picgu-bna7 ,
picgu-a5d9q3 ,
picgu-a5dag9 ,
clal4-c4y5a2 ,
clal4-c4y0l0 ,
cantt-c5mcb1 ,
clal4-c4y8j2 ,
cantt-c5m494 ,
clals-a0a202gac7 ,
canal-hda1 ,
picgu-a5dks8 ,
lodel-a5drs6 ,
canpc-g8bbk1 ,
cantt-kex1 ,
clal4-kex1 ,
picgu-kex1 Abstract
Candida species are the most common cause of opportunistic fungal infection worldwide. Here we report the genome sequences of six Candida species and compare these and related pathogens and non-pathogens. There are significant expansions of cell wall, secreted and transporter gene families in pathogenic species, suggesting adaptations associated with virulence. Large genomic tracts are homozygous in three diploid species, possibly resulting from recent recombination events. Surprisingly, key components of the mating and meiosis pathways are missing from several species. These include major differences at the mating-type loci (MTL); Lodderomyces elongisporus lacks MTL, and components of the a1/2 cell identity determinant were lost in other species, raising questions about how mating and cell types are controlled. Analysis of the CUG leucine-to-serine genetic-code change reveals that 99% of ancestral CUG codons were erased and new ones arose elsewhere. Lastly, we revise the Candida albicans gene catalogue, identifying many new genes.
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