Gene_Locus Report

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Gene_locus Report for: picpa-KEX1

Pichia pastoris (Yeast) Komagataella pastoris, carboxypeptidase kex1 precursor

Comment
Other strains; Komagataella pastoris (strains ATCC 76273 / CBS 7435 / CECT 11047 / NRRL Y-11430 / Wegner 21-1; GS115 / ATCC 20864) (Yeast) (Pichia pastoris)


Relationship
Family|Carboxypeptidase_S10
Block| X
Position in NCBI Life Tree|Pichia pastoris
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms: N E > Eukaryota: N E > Opisthokonta: N E > Fungi: N E > Dikarya: N E > Ascomycota: N E > saccharomyceta: N E > Saccharomycotina: N E > Saccharomycetes: N E > Saccharomycetales: N E > Phaffomycetaceae: N E > Komagataella: N E > Komagataella pastoris: N E
Warning: This entry is a compilation of different species or line or strain with more than 90% amino acide identity. You can retrieve all strain data


Molecular evidence
Database
No mutation
No structure
No kinetic





No Substrate
No inhibitor
1 Genbank : AF095574
3 UniProt : F2QTT4, C4QZV7, O74702
3 UniProt : O74702, F2QTT4, C4QZV7
3 Interpro : O74702, F2QTT4, C4QZV7
3 Pfam : O74702, F2QTT4, C4QZV7
3 PIRSF : O74702, F2QTT4, C4QZV7
3 SUPERFAM : O74702, F2QTT4, C4QZV7
Sequence
Graphical view for this peptide sequence: picpa-KEX1
Colored MSA for Carboxypeptidase_S10 (raw)
MLKLLCLLLPLVAVSASPIDLGSQKDYLVLDLPGLSHLSETQRPTMHAGL
LPLNLSFVADDDTEYFFWRFSKQDVDRADIVFWLNGGPGCSSMDGALMEL
GPFVINPKQEVEYNEGTWVEAADVVFVDQPGGTGFSSTTNYLTELTEVAD
GFVTFLARYFHLFPADVYKKFTLGGESYAGQYVPYILKAIMDDLKSDSGQ
LPKELYLKGALIGNGWIDPNEQSLSYLEFFIKKELIDIHGSYMPGLLQQQ
EKCQNLINHSSGEASESQISYSACEKILNDALRFTRDKKAPLDQQCINMY
DYTLRDTYPSCGMSWPPYLPDVTAFLQKKSVLEALHLDSSASWSECSARV
GSHLKNKISVPSVDILPDLLQEIPIILFNGDHDIICNCIGTERMIDKLEF
NGDQGFTEGTEYIPWFYNEVNVGKVISERNLTYVRVYNSSHMVPFDNTPV
SRGLLDIYFDNFEDVEYNNVSGIAT
Legend This sequence has been compared to family alignement (MSA)
red => minority aminoacid
blue => majority aminoacid
color intensity => conservation rate
title => sequence position(MSA position)aminoacid rate
Catalytic site
Catalytic site in the MSA

MLKLLCLLLPLVAVSASPIDLGSQKDYLVLDLPGLSHLSETQRPTMHAGL
LPLNLSFVADDDTEYFFWRFSKQDVDRADIVFWLNGGPGCSSMDGALMEL
GPFVINPKQEVEYNEGTWVEAADVVFVDQPGGTGFSSTTNYLTELTEVAD
GFVTFLARYFHLFPADVYKKFTLGGESYAGQYVPYILKAIMDDLKSDSGQ
LPKELYLKGALIGNGWIDPNEQSLSYLEFFIKKELIDIHGSYMPGLLQQQ
EKCQNLINHSSGEASESQISYSACEKILNDALRFTRDKKAPLDQQCINMY
DYTLRDTYPSCGMSWPPYLPDVTAFLQKKSVLEALHLDSSASWSECSARV
GSHLKNKISVPSVDILPDLLQEIPIILFNGDHDIICNCIGTERMIDKLEF
NGDQGFTEGTEYIPWFYNEVNVGKVISERNLTYVRVYNSSHMVPFDNTPV
SRGLLDIYFDNFEDVEYNNVSGIAT


References
    Title: High-quality genome sequence of Pichia pastoris CBS7435
    Kuberl A, Schneider J, Thallinger GG, Anderl I, Wibberg D, Hajek T, Jaenicke S, Brinkrolf K, Goesmann A and Pichler H <4 more author(s)>
    Ref: J Biotechnol, 154:312, 2011 : PubMed

            

    Title: Genome sequence of the recombinant protein production host Pichia pastoris
    De Schutter K, Lin YC, Tiels P, Van Hecke A, Glinka S, Weber-Lehmann J, Rouze P, Van de Peer Y, Callewaert N
    Ref: Nat Biotechnol, 27:561, 2009 : PubMed

            

    Title: Disruption of the KEX1 gene in Pichia pastoris allows expression of full-length murine and human endostatin
    Boehm T, Pirie-Shepherd S, Trinh LB, Shiloach J, Folkman J
    Ref: Yeast, 15:563, 1999 : PubMed

            


Other Papers


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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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