Gene_Locus Report

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Gene_locus Report for: picpg-c4r272

Pichia pastoris (Yeast) Dipeptidyl aminopeptidase, Golgi integral membrane protein

Comment
Other strains: Pichia pastoris (strains GS115 / ATCC 20864; ATCC 76273 / CBS 7435 / CECT 11047 / NRR Y-11430 / Wegner 21-1) (Yeast)


Relationship
Family|DPP4N_Peptidase_S9
Block| X
Position in NCBI Life Tree|Pichia pastoris
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms: N E > Eukaryota: N E > Opisthokonta: N E > Fungi: N E > Dikarya: N E > Ascomycota: N E > saccharomyceta: N E > Saccharomycotina: N E > Saccharomycetes: N E > Saccharomycetales: N E > Phaffomycetaceae: N E > Komagataella: N E > Komagataella pastoris: N E
Warning: This entry is a compilation of different species or line or strain with more than 90% amino acide identity. You can retrieve all strain data


Molecular evidence
Database
No mutation
No structure
No kinetic





No Substrate
No inhibitor
3 Genbank : FN392320, FR839629, EU921448
3 UniProt : C4R272, F2QRJ6, B9UPG4
3 UniProt : C4R272, F2QRJ6, B9UPG4
3 Interpro : C4R272, F2QRJ6, B9UPG4
3 Pfam : C4R272, F2QRJ6, B9UPG4
3 PIRSF : C4R272, F2QRJ6, B9UPG4
3 SUPERFAM : C4R272, F2QRJ6, B9UPG4
Sequence
Graphical view for this peptide sequence: picpg-c4r272
Colored MSA for DPP4N_Peptidase_S9 (raw)
MTSRTAENPFDIELQENLSPRSSNSSILENINEYARRHRNDSLSQECDNE
DENENLNYTDNLAKFSKSGVSRKSCMLIFGICFVIWLFLFDLIQTATELL
LPPRLIVEPKQTELPESKDSNTDYQKGAKLSLSGWRSGLYNVYPKLISRG
EDDIYYEHSFHRIDEKRITDSQHGRTVFNYEKIEVNGITYTVSFVTISPY
DSAKFLVACDYEKHWRHSTFAKYFIYDKESDQEDSFVPVYDDKALSFVEW
SPSGDHVVFVFENNVYLKQLSTLEVKQVTFDGDESIYNGKPDWIYEEEVL
SSDRAIWWNDDGSYFTFLRLDDSNVPTFNLQHFFEETGSVSKYPVIDRLK
YPKPGFDNPLVSLFSYNVAKQKLEKLNIGAAVSLGEDFVLYSLKWIDNSF
FLSKFTDRTSKKMEVTLVDIEANSASVVRKHDATEYNGWFTGEFSVYPVV
GDTIGYIDVIYYEDYDHLAYYPDCTSDKYIVLTDGSWNVVGPGVLEVLED
RVYFIGTKESSMEHHLYYTSLTGPKVKAVMDIKEPGYFDVNIKGKYALLS
YRGPKLPYQKFIDLSDPSTTSLDDILSSNRGIVEVSLATHSVPVSTYTNV
TLEDGVTLNMIEVLPANFNPSKKYPLLVNIYGGPGSQKLDVQFNIGFEHI
ISSSLDAIVLYIDPRGTGGKSWAFKSYATEKIGYWEPRDITAVVSKWISD
HSFVNPDKTAIWGWSYGGFTTLKTLEYDSGEVFKYGMAVAPVTNWLLYDS
IYTERYMNLPKDNVEGYSEHSVIKKVSNFKNVNRFLVCHGTTDDNVHFQN
TLTLLDQFNINGVVNYDLQVYPDSEHSIAHHNANKVIYERLFKWLERAFN
DRFL
Legend This sequence has been compared to family alignement (MSA)
red => minority aminoacid
blue => majority aminoacid
color intensity => conservation rate
title => sequence position(MSA position)aminoacid rate
Catalytic site
Catalytic site in the MSA

MTSRTAENPFDIELQENLSPRSSNSSILENINEYARRHRNDSLSQECDNE
DENENLNYTDNLAKFSKSGVSRKSCMLIFGICFVIWLFLFDLIQTATELL
LPPRLIVEPKQTELPESKDSNTDYQKGAKLSLSGWRSGLYNVYPKLISRG
EDDIYYEHSFHRIDEKRITDSQHGRTVFNYEKIEVNGITYTVSFVTISPY
DSAKFLVACDYEKHWRHSTFAKYFIYDKESDQEDSFVPVYDDKALSFVEW
SPSGDHVVFVFENNVYLKQLSTLEVKQVTFDGDESIYNGKPDWIYEEEVL
SSDRAIWWNDDGSYFTFLRLDDSNVPTFNLQHFFEETGSVSKYPVIDRLK
YPKPGFDNPLVSLFSYNVAKQKLEKLNIGAAVSLGEDFVLYSLKWIDNSF
FLSKFTDRTSKKMEVTLVDIEANSASVVRKHDATEYNGWFTGEFSVYPVV
GDTIGYIDVIYYEDYDHLAYYPDCTSDKYIVLTDGSWNVVGPGVLEVLED
RVYFIGTKESSMEHHLYYTSLTGPKVKAVMDIKEPGYFDVNIKGKYALLS
YRGPKLPYQKFIDLSDPSTTSLDDILSSNRGIVEVSLATHSVPVSTYTNV
TLEDGVTLNMIEVLPANFNPSKKYPLLVNIYGGPGSQKLDVQFNIGFEHI
ISSSLDAIVLYIDPRGTGGKSWAFKSYATEKIGYWEPRDITAVVSKWISD
HSFVNPDKTAIWGWSYGGFTTLKTLEYDSGEVFKYGMAVAPVTNWLLYDS
IYTERYMNLPKDNVEGYSEHSVIKKVSNFKNVNRFLVCHGTTDDNVHFQN
TLTLLDQFNINGVVNYDLQVYPDSEHSIAHHNANKVIYERLFKWLERAFN
DRFL


References
    Title: High-quality genome sequence of Pichia pastoris CBS7435
    Kuberl A, Schneider J, Thallinger GG, Anderl I, Wibberg D, Hajek T, Jaenicke S, Brinkrolf K, Goesmann A and Pichler H <4 more author(s)>
    Ref: J Biotechnol, 154:312, 2011 : PubMed

            

    Title: Genome sequence of the recombinant protein production host Pichia pastoris
    De Schutter K, Lin YC, Tiels P, Van Hecke A, Glinka S, Weber-Lehmann J, Rouze P, Van de Peer Y, Callewaert N
    Ref: Nat Biotechnol, 27:561, 2009 : PubMed

            

    Title: Identification of the dipeptidyl aminopeptidase responsible for N-terminal clipping of recombinant Exendin-4 precursor expressed in Pichia pastoris
    Prabha L, Govindappa N, Adhikary L, Melarkode R, Sastry K
    Ref: Protein Expr Purif, 64:155, 2009 : PubMed

            


Other Papers


Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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