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pseae-PA1510

Pseudomonas aeruginosa hypothetical protein pa1510 Tle4

Comment

The type VI lipase effectors Tle1-Tle5 secreted by the bacterial type VI secretion system (T6SS) have recently been identified as antibacterial effectors that hydrolyze membrane phospholipids. The Tle1-4 display phospholipase A1 and A2 (PLA1) (PLA2) activities. Tle1 belongs to Duf_2235 family and here Tle4 belongs to PGAP1. Other strains: Pseudomonas aeruginosa (strains ATCC 15692 \/ PAO1 \/ 1C \/ PRS 101 \/ LMG 12228\; 39016\; LESB58\; UCBPP-PA14\; C3719\; 2192). The structure 5H7Y (Structure of immunity protein TplEi of T6SS from Pseudomonas aeruginosa complexed with L peptide) contains only a small fragment of Tle4

Relationship

Family : PGAP1

Block : X

Position in NCBI Life Tree : Pseudomonas aeruginosa

Molecular evidence

No mutation

No kinetic

No disease

No substrate

No inhibitor

Database

Sequence

Peptide

MSSEPLEPNQ DVIIPRSRDS LGRPVYKAQL TRTDNQSEKV ALIRQTAPLP VIFIPGIMGT NLRNKADKSE VWRPPNGLWP MDDLFASIGA LWTWAWRGPK ARQELLKAEQ VEVDDQGTID VGQSGLSEEA ARLRGWGKVM RSAYNPVMGL MERRLDNIVS RRELQAWWND EALSPPGDQG EEQGKVGPID EEELLRASRY QFDVWCAGYN WLQSNRQSAL DVRDYIENTV LPFYQKECGL DPEQMRRMKV ILVTHSMGGL VARALTQLHG YERVLGVVHG VQPATGSSTI YHHMRCGYEG IAQVVLGRNA GEVTAIVANS AGALELAPSA EYREGRPWLF LCDAQGQVLK DIDGKPRAYP QNQDPYEEIY KNTTWYGLVP EQNSQYLDMS DKKEGLRVGP RDNFEDLIDS IANFHGELSA AGYHSETYAH YGADDSRHSW RDLIWKGDPT PLETPGATLN DDENGTYNSW FRRGLPTIVQ GPLETGNPLD ASGSGGDETV PTDSGQAPAL AGVKASFRHG SKGKGQANTK RGYEHQESYN DARAQWAALY GVIKITQLAD WHPNDKGGT

References

Title : The Pseudomonas aeruginosa Type VI Secretion PGAP1-like Effector Induces Host Autophagy by Activating Endoplasmic Reticulum Stress - Jiang_2016_Cell.Rep_16_1502
Author(s) : Jiang F , Wang X , Wang B , Chen L , Zhao Z , Waterfield NR , Yang G , Jin Q
Ref : Cell Rep , 16 :1502 , 2016
Abstract : Jiang_2016_Cell.Rep_16_1502
ESTHER : Jiang_2016_Cell.Rep_16_1502
PubMedSearch : Jiang_2016_Cell.Rep_16_1502
PubMedID: 27477276
Gene_locus related to this paper: pseae-PA1510

Title : The structural basis of the Tle4-Tli4 complex reveals the self-protection mechanism of H2-T6SS in Pseudomonas aeruginosa - Lu_2014_Acta.Crystallogr.D.Biol.Crystallogr_70_3233
Author(s) : Lu D , Zheng Y , Liao N , Wei L , Xu B , Liu X , Liu J
Ref : Acta Crystallographica D Biol Crystallogr , 70 :3233 , 2014
Abstract : Lu_2014_Acta.Crystallogr.D.Biol.Crystallogr_70_3233
ESTHER : Lu_2014_Acta.Crystallogr.D.Biol.Crystallogr_70_3233
PubMedSearch : Lu_2014_Acta.Crystallogr.D.Biol.Crystallogr_70_3233
PubMedID: 25478841
Gene_locus related to this paper: pseae-PA1510

Title : Genetic characterization indicates that a specific subpopulation of Pseudomonas aeruginosa is associated with keratitis infections - Stewart_2011_J.Clin.Microbiol_49_993
Author(s) : Stewart RM , Wiehlmann L , Ashelford KE , Preston SJ , Frimmersdorf E , Campbell BJ , Neal TJ , Hall N , Tuft S , Kaye SB , Winstanley C
Ref : J Clin Microbiol , 49 :993 , 2011
Abstract : Stewart_2011_J.Clin.Microbiol_49_993
ESTHER : Stewart_2011_J.Clin.Microbiol_49_993
PubMedSearch : Stewart_2011_J.Clin.Microbiol_49_993
PubMedID: 21227987
Gene_locus related to this paper: pseae-a3kt39 , pseae-clipa , pseae-llipa , pseae-PA0201 , pseae-PA0231 , pseae-PA0308 , pseae-PA0368 , pseae-PA0480 , pseae-PA0543 , pseae-PA0599 , pseae-PA1166 , pseae-PA1239 , pseae-PA1304 , pseae-PA1510 , pseae-PA1558 , pseae-PA1597 , pseae-PA2098 , pseae-PA2302 , pseae-PA2425 , pseae-PA2540 , pseae-PA2682 , pseae-PA2927 , pseae-PA2949 , pseae-PA3301 , pseae-PA3327 , pseae-PA3695 , pseae-PA3859 , pseae-PA4968 , pseae-PA5080 , pseae-PCHC , pseae-PCHF , pseae-PHAC2 , pseae-phaD , pseae-Q8G8C7 , pseae-Q8G8T6 , pseae-q9i252

Title : Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen - Stover_2000_Nature_406_959
Author(s) : Stover CK , Pham XQ , Erwin AL , Mizoguchi SD , Warrener P , Hickey MJ , Brinkman FS , Hufnagle WO , Kowalik DJ , Lagrou M , Garber RL , Goltry L , Tolentino E , Westbrock-Wadman S , Yuan Y , Brody LL , Coulter SN , Folger KR , Kas A , Larbig K , Lim R , Smith K , Spencer D , Wong GK , Wu Z , Paulsen IT , Reizer J , Saier MH , Hancock RE , Lory S , Olson MV
Ref : Nature , 406 :959 , 2000
Abstract : Stover_2000_Nature_406_959
ESTHER : Stover_2000_Nature_406_959
PubMedSearch : Stover_2000_Nature_406_959
PubMedID: 10984043
Gene_locus related to this paper: pseae-clipa , pseae-CPO , pseae-metx , pseae-PA0201 , pseae-PA0231 , pseae-PA0308 , pseae-PA0368 , pseae-PA0480 , pseae-PA0502 , pseae-PA0543 , pseae-PA0599 , pseae-PA0829 , pseae-PA1166 , pseae-PA1211 , pseae-PA1239 , pseae-PA1291 , pseae-PA1304 , pseae-PA1510 , pseae-PA1558 , pseae-PA1597 , pseae-PA1621 , pseae-PA1622 , pseae-PA1680 , pseae-PA1771 , pseae-PA1888 , pseae-PA1907 , pseae-PA1990 , pseae-PA2086 , pseae-PA2098 , pseae-PA2168 , pseae-PA2302 , pseae-PA2411 , pseae-PA2425 , pseae-PA2451 , pseae-PA2540 , pseae-PA2682 , pseae-PA2689 , pseae-PA2745 , pseae-PA2764 , pseae-PA2927 , pseae-PA2934 , pseae-PA2949 , pseae-PA3053 , pseae-PA3132 , pseae-PA3226 , pseae-PA3301 , pseae-PA3324 , pseae-PA3327 , pseae-PA3429 , pseae-PA3509 , pseae-PA3586 , pseae-PA3628 , pseae-PA3695 , pseae-PA3734 , pseae-PA3829 , pseae-PA3859 , pseae-PA3994 , pseae-PA4008 , pseae-PA4152 , pseae-PA4440 , pseae-PA4968 , pseae-PA5080 , pseae-PA5384 , pseae-PA5513 , pseae-PCHC , pseae-PCHF , pseae-PHAC1 , pseae-PHAC2 , pseae-phaD , pseae-phag , pseae-PVDD , pseae-q9i4b9 , pseae-q9i538 , pseae-rhla , pseae-Y2218 , pseae-q9hyv3 , pseae-q9i252 , pseae-q9i6m9