Gene_Locus Report

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Gene_locus Report for: rabit-1hlip

Oryctolagus cuniculus (Rabbit) Hepatic triacylglycerol lipase LIPH_RABI LIPC (hl)

Relationship
Family|Hepatic_Lipase
Block| L
Position in NCBI Life Tree|Oryctolagus cuniculus
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms: N E > Eukaryota: N E > Opisthokonta: N E > Metazoa: N E > Eumetazoa: N E > Bilateria: N E > Deuterostomia: N E > Chordata: N E > Craniata: N E > Vertebrata: N E > Gnathostomata: N E > Teleostomi: N E > Euteleostomi: N E > Sarcopterygii: N E > Dipnotetrapodomorpha: N E > Tetrapoda: N E > Amniota: N E > Mammalia: N E > Theria: N E > Eutheria: N E > Boreoeutheria: N E > Euarchontoglires: N E > Glires: N E > Lagomorpha: N E > Leporidae: N E > Oryctolagus: N E > Oryctolagus cuniculus: N E


Molecular evidence
Database
No mutation
No structure
No kinetic





No Substrate
No inhibitor
>3 Genbank links 2 more: AF041202, AAGW02024969, AAGW02024970
2 UniProt : O46559, G1SFU2
1 Ncbi-nid : 2773389
1 Ncbi-pid : 2773390
2 UniProt : O46559, G1SFU2
2 Interpro : O46559, G1SFU2
2 Prodom : O46559, G1SFU2
2 Pfam : O46559, G1SFU2
2 PIRSF : O46559, G1SFU2
2 SUPERFAM : O46559, G1SFU2
Sequence
Graphical view for this peptide sequence: rabit-1hlip
Colored MSA for Hepatic_Lipase (raw)
MGSPLCVPIFLAVCILIQSSTHGQSLRPEPFGRRARVTATKKTLLETETR
FLLFKDKANKGCQIRLHHADTLQECGFNSSLPLVMIVHGWSVDGLLESWI
WQMVAALKSQPARPVNVGLVDWISLAHSHYAVAVRNARLVGQEVAALLQW
LEESAPFSRSNVHLIGYSLGAHVAGFAGSYISGKHKIGRITGLDAAGPLF
EGTSASDRLSPDDATFVDAIHTFTREHMGLSVGIKQPVGHYDFYPNGGSF
QPGCHFLELYKHIAQHGLNALSQTIKCAHERSVHLFIDSLLHPSMQSTAY
QCSDMDSFSQGLCLGCTKGRCNTLGYHIRQEPLSKGKRLFLVTQAQSPFR
VYHYQFKIQFINQIEKPLEPTFTMSLLGTKEEMQKIPITLGEGITSNKTY
SFLITLNLDIGELMVIKFKWENSAVWANVWNTVQTIIPWGIKPRNSGLIL
KTIRVKAGETQQRMTFCSENMDDLQLHPTQEKNFVRCEVNPKKLKLKIK
Legend This sequence has been compared to family alignement (MSA)
red => minority aminoacid
blue => majority aminoacid
color intensity => conservation rate
title => sequence position(MSA position)aminoacid rate
Catalytic site
Catalytic site in the MSA

MGSPLCVPIFLAVCILIQSSTHGQSLRPEPFGRRARVTATKKTLLETETR
FLLFKDKANKGCQIRLHHADTLQECGFNSSLPLVMIVHGWSVDGLLESWI
WQMVAALKSQPARPVNVGLVDWISLAHSHYAVAVRNARLVGQEVAALLQW
LEESAPFSRSNVHLIGYSLGAHVAGFAGSYISGKHKIGRITGLDAAGPLF
EGTSASDRLSPDDATFVDAIHTFTREHMGLSVGIKQPVGHYDFYPNGGSF
QPGCHFLELYKHIAQHGLNALSQTIKCAHERSVHLFIDSLLHPSMQSTAY
QCSDMDSFSQGLCLGCTKGRCNTLGYHIRQEPLSKGKRLFLVTQAQSPFR
VYHYQFKIQFINQIEKPLEPTFTMSLLGTKEEMQKIPITLGEGITSNKTY
SFLITLNLDIGELMVIKFKWENSAVWANVWNTVQTIIPWGIKPRNSGLIL
KTIRVKAGETQQRMTFCSENMDDLQLHPTQEKNFVRCEVNPKKLKLKIK


References
    Title: A high-resolution map of human evolutionary constraint using 29 mammals
    Lindblad-Toh K, Garber M, Zuk O, Lin MF, Parker BJ, Washietl S, Kheradpour P, Ernst J, Jordan G and Kellis M <76 more author(s)>
    Ref: Nature, 478:476, 2011 : PubMed

            

    Title: Rabbit hepatic lipase cDNA sequence: low activity is associated with low messenger RNA levels
    Warren RJ, Ebert DL, Mitchell A, Barter PJ
    Ref: J Lipid Res, 32:1333, 1991 : PubMed

            


Other Papers


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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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