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Gene_locus Report for: rat-dpp9

Rattus norvegicus (Rat) Dipeptidyl peptidase 9 DPP9

Relationship
Family|DPP4N_Peptidase_S9
Block| X
Position in NCBI Life Tree|Rattus norvegicus
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms: N E > Eukaryota: N E > Opisthokonta: N E > Metazoa: N E > Eumetazoa: N E > Bilateria: N E > Deuterostomia: N E > Chordata: N E > Craniata: N E > Vertebrata: N E > Gnathostomata: N E > Teleostomi: N E > Euteleostomi: N E > Sarcopterygii: N E > Dipnotetrapodomorpha: N E > Tetrapoda: N E > Amniota: N E > Mammalia: N E > Theria: N E > Eutheria: N E > Boreoeutheria: N E > Euarchontoglires: N E > Glires: N E > Rodentia: N E > Myomorpha: N E > Muroidea: N E > Muridae: N E > Murinae: N E > Rattus: N E > Rattus norvegicus: N E


Molecular evidence
Database
No mutation
1 structure:
7CRW: Cryo-EM structure of rNLRP1rDPP9 complex
No kinetic





No Substrate
No inhibitor
1 Genbank : NP_001292170
1 UniProt : M0R781
1 Structure : 7CRW
1 UniProt : M0R781
1 Interpro : M0R781
1 Prodom : M0R781
1 Pfam : M0R781
1 PIRSF : M0R781
1 SUPERFAM : M0R781
Sequence
Graphical view for this peptide sequence: rat-dpp9
Colored MSA for DPP4N_Peptidase_S9 (raw)
MSGGVSPVEQVAAGDMDDTAARFCVQKHSWDGLRNIIHGSRKSSGLIVSK
APHDFQFVQKPDESGPHSHRLYYLGMPYGSRENSLLYSEIPKKVRKEALL
LLSWKQMLDHFQATPHHGVYSREEELLRERKRLGVFGITSYDFHSESGLF
LFQASNSLFHCRDGGKNGFMVSPMKPLEIKTQCSGPRMDPKICPADPAFF
SFINNNDLWVANIETGEERRLTFCHQGSASVLDNPKSAGVATFVIQEEFD
RFTGCWWCPTASWEGSGGLKTLRILYEEVDESEVEVIHVPSPALEERKTD
SYRYPRTGSKNPKIALKLAELQTDHQGKIVSSCEKELVQPFSSLFPKVEY
IARAGWTRDGRYAWAMFLDRPQQRLQLVLLPPALFIPTLESEAQWQEAAR
AIPKNVQPFIIYEEVTNVWINVHDIFHPFPQAEGQQDFCFLRANECKTGF
CHLYRVTVDLKTNDYDWTEPLSPAEDEFKCPIKEEVALTSGEWEVLSRHG
SKIWVNEQTKLVYFQGTKDTPLEHHLYVVSYESAGEIVRLTTPGFSHSCS
MSQNFDMFVSHYSSVSTPPCVHVYKLSGPDDDPLHKQPRFWASMMEAASC
PPDYVPPEIFHFHTRADVQLYGMIYKPHTLQPGRKHPTVLFVYGGPQVQL
VNNSFKGIKYLRLNTLASLGYAVVVIDGRGSCQRGLHFEGALKNQMGQVE
IEDQVEGLQYVAEKYGFIDLSRVAIHGWSYGGFLSLMGLIHKPQVFKVAI
AGAPVTVWMAYDTGYTERYMDVPENNQQGYEAGSVALHVEKLPNEPNRLL
ILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHSIRCRESGEHY
EVTLLHFLQEHL
Legend This sequence has been compared to family alignement (MSA)
red => minority aminoacid
blue => majority aminoacid
color intensity => conservation rate
title => sequence position(MSA position)aminoacid rate
Catalytic site
Catalytic site in the MSA

MSGGVSPVEQVAAGDMDDTAARFCVQKHSWDGLRNIIHGSRKSSGLIVSK
APHDFQFVQKPDESGPHSHRLYYLGMPYGSRENSLLYSEIPKKVRKEALL
LLSWKQMLDHFQATPHHGVYSREEELLRERKRLGVFGITSYDFHSESGLF
LFQASNSLFHCRDGGKNGFMVSPMKPLEIKTQCSGPRMDPKICPADPAFF
SFINNNDLWVANIETGEERRLTFCHQGSASVLDNPKSAGVATFVIQEEFD
RFTGCWWCPTASWEGSGGLKTLRILYEEVDESEVEVIHVPSPALEERKTD
SYRYPRTGSKNPKIALKLAELQTDHQGKIVSSCEKELVQPFSSLFPKVEY
IARAGWTRDGRYAWAMFLDRPQQRLQLVLLPPALFIPTLESEAQWQEAAR
AIPKNVQPFIIYEEVTNVWINVHDIFHPFPQAEGQQDFCFLRANECKTGF
CHLYRVTVDLKTNDYDWTEPLSPAEDEFKCPIKEEVALTSGEWEVLSRHG
SKIWVNEQTKLVYFQGTKDTPLEHHLYVVSYESAGEIVRLTTPGFSHSCS
MSQNFDMFVSHYSSVSTPPCVHVYKLSGPDDDPLHKQPRFWASMMEAASC
PPDYVPPEIFHFHTRADVQLYGMIYKPHTLQPGRKHPTVLFVYGGPQVQL
VNNSFKGIKYLRLNTLASLGYAVVVIDGRGSCQRGLHFEGALKNQMGQVE
IEDQVEGLQYVAEKYGFIDLSRVAIHGWSYGGFLSLMGLIHKPQVFKVAI
AGAPVTVWMAYDTGYTERYMDVPENNQQGYEAGSVALHVEKLPNEPNRLL
ILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHSIRCRESGEHY
EVTLLHFLQEHL


References
2 more
    Title: Structural and biochemical mechanisms of NLRP1 inhibition by DPP9
    Huang M, Zhang X, Toh GA, Gong Q, Wang J, Han Z, Wu B, Zhong F, Chai J
    Ref: Nature, :, 2021 : PubMed

            

    Title: Gene and alternative splicing annotation with AIR
    Florea L, Di Francesco V, Miller J, Turner R, Yao A, Harris M, Walenz B, Mobarry C, Merkulov GV and Sutton G <5 more author(s)>
    Ref: Genome Res, 15:54, 2005 : PubMed

            

    Title: Genome sequence of the Brown Norway rat yields insights into mammalian evolution
    Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC and Collins F <218 more author(s)>
    Ref: Nature, 428:493, 2004 : PubMed

            


Other Papers


Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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