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Gene_locus Report for: ratno-hyep

Rattus norvegicus (Rat) Epoxide hydrolase 1, Epoxide hydratase

Relationship
Family|Epoxide_hydrolase
Block| X
Position in NCBI Life Tree|Rattus norvegicus
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms: N E > Eukaryota: N E > Opisthokonta: N E > Metazoa: N E > Eumetazoa: N E > Bilateria: N E > Deuterostomia: N E > Chordata: N E > Craniata: N E > Vertebrata: N E > Gnathostomata: N E > Teleostomi: N E > Euteleostomi: N E > Sarcopterygii: N E > Dipnotetrapodomorpha: N E > Tetrapoda: N E > Amniota: N E > Mammalia: N E > Theria: N E > Eutheria: N E > Boreoeutheria: N E > Euarchontoglires: N E > Glires: N E > Rodentia: N E > Myomorpha: N E > Muroidea: N E > Muridae: N E > Murinae: N E > Rattus: N E > Rattus norvegicus: N E


Molecular evidence
Database
No mutation
No structure
No kinetic





1 substrate:
Cis-stilbene-oxide
No inhibitor
>3 Genbank links 5 more: M15345, M15339, M15340
2 UniProt : P07687, F1LTS8
2 UniProt : F1LTS8, P07687
2 Interpro : F1LTS8, P07687
2 Prodom : F1LTS8, P07687
2 Pfam : F1LTS8, P07687
2 PIRSF : F1LTS8, P07687
2 SUPERFAM : F1LTS8, P07687
Sequence
Graphical view for this peptide sequence: ratno-hyep
Colored MSA for Epoxide_hydrolase (raw)
MWLELVLASLLGFVIYWFVSRDKEETLPLGDGWWGPGSKPSAKEDESIRP
FKVETSDEEIKDLHQRIDRFRASPPLEGSRFHYGFNSNYMKKVVSYWRNE
FDWRKQVEILNQYPHFKTKIEGLDIHFIHVKPPQLPSGRTPKPLLMVHGW
PGSFYEFYKIIPLLTDPKSHGLSDEHVFEVICPSIPGYGYSEASSKKGLN
SVATARIFYKLMTRLGFQKFYIQGGDWGSLICTNMAQMVPNHVKGLHLNM
AFISRSFYTMTPLLGQRFGRFLGYTEKDIELLYPYKEKVFYSIMRESGYL
HIQATKPDTVGCALNDSPVGLAAYILEKFSTWTKSEYRELEDGGLERKFS
LDDLLVNIMIYWTTGTIVSSQRYYKENLGQGIMVHKHEGMKVFVPTGFSA
FPSELLHAPEKWVKVKYPKLISYSYMERGGHFAAFEEPKLLAQDIRKFVS
LAELQ
Legend This sequence has been compared to family alignement (MSA)
red => minority aminoacid
blue => majority aminoacid
color intensity => conservation rate
title => sequence position(MSA position)aminoacid rate
Catalytic site
Catalytic site in the MSA

MWLELVLASLLGFVIYWFVSRDKEETLPLGDGWWGPGSKPSAKEDESIRP
FKVETSDEEIKDLHQRIDRFRASPPLEGSRFHYGFNSNYMKKVVSYWRNE
FDWRKQVEILNQYPHFKTKIEGLDIHFIHVKPPQLPSGRTPKPLLMVHGW
PGSFYEFYKIIPLLTDPKSHGLSDEHVFEVICPSIPGYGYSEASSKKGLN
SVATARIFYKLMTRLGFQKFYIQGGDWGSLICTNMAQMVPNHVKGLHLNM
AFISRSFYTMTPLLGQRFGRFLGYTEKDIELLYPYKEKVFYSIMRESGYL
HIQATKPDTVGCALNDSPVGLAAYILEKFSTWTKSEYRELEDGGLERKFS
LDDLLVNIMIYWTTGTIVSSQRYYKENLGQGIMVHKHEGMKVFVPTGFSA
FPSELLHAPEKWVKVKYPKLISYSYMERGGHFAAFEEPKLLAQDIRKFVS
LAELQ


References
2 more
    Title: Genome sequence of the Brown Norway rat yields insights into mammalian evolution
    Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC and Collins F <218 more author(s)>
    Ref: Nature, 428:493, 2004 : PubMed

            

    Title: Structure and organization of the microsomal xenobiotic epoxide hydrolase gene
    Falany CN, McQuiddy P, Kasper CB
    Ref: Journal of Biological Chemistry, 262:5924, 1987 : PubMed

            

    Title: Complementary DNA and amino acid sequence of rat liver microsomal, xenobiotic epoxide hydrolase
    Porter TD, Beck TW, Kasper CB
    Ref: Archives of Biochemistry & Biophysics, 248:121, 1986 : PubMed

            


Other Papers


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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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