Gene_locus Report for: sacen-a4fam2 Saccharopolyspora erythraea (strain NRRL 23338) Alpha/beta hydrolase fold
Relationship
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) cellular organisms: N E > Bacteria: N E > Terrabacteria group: N E > Actinobacteria [phylum]: N E > Actinobacteria [class]: N E > Pseudonocardiales: N E > Pseudonocardiaceae: N E > Saccharopolyspora: N E > Saccharopolyspora erythraea: N E 6_AlphaBeta_hydrolase :
sacen-a4f7j9 Saccharopolyspora erythraea (strain NRRL 23338) Alpha/beta hydrolase fold ,
sacen-a4f8m4 Saccharopolyspora erythraea (strain NRRL 23338) Alpha/beta hydrolase fold ,
sacen-a4fc70 Saccharopolyspora erythraea (strain NRRL 23338) Putative hydrolase (Partial match) ,
sacen-a4fd56 Saccharopolyspora erythraea (strain NRRL 23338) Alpha/beta hydrolase fold ,
sacen-a4fdt8 Saccharopolyspora erythraea (strain NRRL 23338) Alpha/beta hydrolase fold ,
sacen-a4fgw0 Saccharopolyspora erythraea (strain NRRL 23338) Alpha/beta hydrolase fold ,
sacen-a4fh60 Saccharopolyspora erythraea (strain NRRL 23338) Alpha/beta hydrolase fold ,
sacen-a4fja4 Saccharopolyspora erythraea (strain NRRL 23338) Putative uncharacterized protein ,
sacen-a4fmr1 Saccharopolyspora erythraea (strain NRRL 23338) Putative uncharacterized protein ,
sacen-a4fmz0 Saccharopolyspora erythraea (strain NRRL 23338) Alpha/beta hydrolase fold ,
sacen-a4fpf4 Saccharopolyspora erythraea (strain NRRL 23338) Alpha/beta hydrolase fold ,
sacen-a4fq24 Saccharopolyspora erythraea (strain NRRL 23338) Putative uncharacterized protein .
A85-Feruloyl-Esterase :
sacen-a4f9g1 Saccharopolyspora erythraea (strain NRRL 23338) Putative esterase .
A85-IroE-IroD-Fes-Yiel :
sacen-a4fgk3 Saccharopolyspora erythraea (strain NRRL 23338) Putative uncharacterized protein .
Aclacinomycin-methylesterase_RdmC :
sacen-a4ffy1 Saccharopolyspora erythraea (strain NRRL 23338) Hydrolase, alpha/beta fold family .
AcoC_BiotinLipoyl-ABH :
sacen-a4fiz9 Saccharopolyspora erythraea (strain NRRL 23338) Acetoin dehydrogenase, dihydrolipoamide acetyltransferase component .
AlphaBeta_hydrolase :
sacen-a4fpp0 Saccharopolyspora erythraea (strain NRRL 23338) Carboxylesterase .
Carboxymethylbutenolide_lactonase :
sacen-a4ffg0 Saccharopolyspora erythraea (strain NRRL 23338) 3-oxoadipate enol-lactone hydrolase .
Carboxypeptidase_S10 :
sacen-a4f815 Saccharopolyspora erythraea (strain NRRL 23338) Peptidase S10, serine carboxypeptidase .
Carb_B_Bacteria :
sacen-a4f9k7 Saccharopolyspora erythraea para-nitrobenzyl esterase (EC 3.1.1.1) ,
sacen-a4fcq9 Saccharopolyspora erythraea; Saccharopolyspora hirsuta, putative para-nitrobenzyl esterase (EC 3.1.1.1) ,
sacen-a4fdp9 Saccharopolyspora erythraea carboxylesterase, type b (EC 3.1.1.1) ,
sacen-a4fdt6 Saccharopolyspora erythraea putative para-nitrobenzyl esterase (EC 3.1.1.1) ,
sacen-a4ffv6 Saccharopolyspora erythraea carboxylesterase ,
sacen-a4ffx1 Saccharopolyspora erythraea (strain NRRL 23338) carboxylesterase, type b .
CFTR-inhibitory-factor_Cif :
sacen-a4fcs3 Saccharopolyspora erythraea (strain NRRL 23338) Hydrolase ,
sacen-a4fjd3 Saccharopolyspora erythraea (strain NRRL 23338) Alpha/beta hydrolase .
DLH-S :
sacen-a4fcc3 Saccharopolyspora erythraea (strain NRRL 23338) Phosphoribosyltransferase ,
sacen-a4fn55 Saccharopolyspora erythraea (strain NRRL 23338) Dienelactone hydrolase .
DPP4N_Peptidase_S9 :
sacen-a4fk92 Saccharopolyspora erythraea (strain NRRL 23338) Peptidase .
Duf_1023 :
sacen-a4f8h3 Saccharopolyspora erythraea (strain NRRL 23338) Uncharacterized protein ,
sacen-a4f824 Saccharopolyspora erythraea (strain NRRL 23338) Uncharacterized protein .
Epoxide_hydrolase :
sacen-a4f8u9 Saccharopolyspora erythraea (strain NRRL 23338) Alpha/beta hydrolase fold ,
sacen-a4faz0 Saccharopolyspora erythraea (strain NRRL 23338) Alpha/beta hydrolase ,
sacen-a4ffk3 Saccharopolyspora erythraea (strain NRRL 23338) Short-chain dehydrogenase/reductase SDR ,
sacen-a4fix9 Saccharopolyspora erythraea (strain NRRL 23338) Oxidoreductase ,
sacen-a4fk07 Saccharopolyspora erythraea (strain NRRL 23338) Oxidoreductase ,
sacen-a4flt0 Saccharopolyspora erythraea (strain NRRL 23338) Haloalkane dehalogenase .
Fungal-Bact_LIP :
sacen-a4fc79 Saccharopolyspora erythraea (strain NRRL 23338) Triacylglycerol lipase .
Haloacetate_dehalogenase :
sacen-a4fbt1 Saccharopolyspora erythraea (strain NRRL 23338) Alpha/beta hydrolase fold ,
sacen-a4fdk1 Saccharopolyspora erythraea (strain NRRL 23338) Probable epoxide alpha/beta hydrolase .
Haloperoxidase :
sacen-a4ff15 Saccharopolyspora erythraea (strain NRRL 23338) Non-heme chloroperoxidase .
HNLyase_Bact :
sacen-a4f6m6 Saccharopolyspora erythraea (strain NRRL 23338) Esterase ,
sacen-a4fdc0 Saccharopolyspora erythraea (strain NRRL 23338) Alpha/beta hydrolase fold ,
sacen-a4feu5 Saccharopolyspora erythraea (strain NRRL 23338) Alpha/beta hydrolase ,
sacen-a4few8 Saccharopolyspora erythraea (strain NRRL 23338) Possible esterase ,
sacen-a4fkg4 Saccharopolyspora erythraea (strain NRRL 23338) Putative uncharacterized protein ,
sacen-a4fpb3 Saccharopolyspora erythraea (strain NRRL 23338) Esterase .
Monoglyceridelipase_lysophospholip :
sacen-a4f7j2 Saccharopolyspora erythraea (strain NRRL 23338) Lipase ,
sacen-a4fbh5 Saccharopolyspora erythraea (strain NRRL 23338) Putative lysophospholipase .
NLS3-Tex30 :
sacen-a4fnh7 Saccharopolyspora erythraea Uncharacterized protein .
Peptidase_S37 :
sacen-a4fkn0 Saccharopolyspora erythraea (strain NRRL 23338) Secreted tripeptidyl aminopeptidase .
Proline_iminopeptidase :
sacen-a4fd61 Saccharopolyspora erythraea (strain NRRL 23338). Proline iminopeptidase ,
sacen-a4ffa2 Saccharopolyspora erythraea (strain NRRL 23338). Alpha/beta hydrolase fold .
Thioesterase :
sacer-ery3 ,
sacer-q5vkr3 Saccharopolyspora erythraea (Streptomyces erythraeus) type I pks ,
sacer-Q9JN61 Saccharopolyspora erythraea (Streptomyces erythraeus) erythomycin a biosynthesis thioesterase (EC 3.1.-.-.) 26.5 kda Ery-ORF5 TEII orf3? Molecular evidence
Database
No mutation No structure No kinetic No Substrate No inhibitor
Sequence
Graphical view for this peptide sequence: sacen-a4fam2 Colored MSA for UCP037442 (raw)
MVVDEPTTLGVIDAGAHQLSVSATEQADRTSPVVILLPAMGVPATYYRPF
IENLRERGLTVVGIDFRGHGQSRPRAARGVRFGYQALVDDVDAVVDLVAE
RYPRAPRFLVGHSLGGQITMLNAAARPDRVHGTAMLASGSVWFRSFPGSR
GIKNLIGTQFIAVVSTLLGYWPGWSFGGRQPTALMRDWARMARTGRWSLT
GSTTDYEKALGELRLPLLTVTFDGDELAPPSSTDHLAGKAPHAVRTRRHY
SLADAGAEKLGHFGWVYRSAELSRWISEWISSCDATAEGPASAVGPHSAG
RGGAASG
Legend
This sequence has been compared to family alignement (MSA) red => minority aminoacid blue => majority aminoacid color intensity => conservation rate title => sequence position(MSA position)aminoacid rate Catalytic site Catalytic site in the MSA
M V V D E P T T L G V I D A G A H Q L S V S A T E Q A D R T S P V V I L L P A M G V P A T Y Y R P F I E N L R E R G L T V V G I D F R G H G Q S R P R A A R G V R F G Y Q A L V D D V D A V V D L V A E R Y P R A P R F L V G H S L G G Q I T M L N A A A R P D R V H G T A M L A S G S V W F R S F P G S R G I K N L I G T Q F I A V V S T L L G Y W P G W S F G G R Q P T A L M R D W A R M A R T G R W S L T G S T T D Y E K A L G E L R L P L L T V T F D G D E L A P P S S T D H L A G K A P H A V R T R R H Y S L A D A G A E K L G H F G W V Y R S A E L S R W I S E W I S S C D A T A E G P A S A V G P H S A G R G G A A S G
Reference
Title: Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338Oliynyk M , Samborskyy M , Lester JB , Mironenko T , Scott N , Dickens S , Haydock SF , Leadlay PF Ref: Nat Biotechnol, 25 :447, 2007 : PubMed Abstract ESTHER: Oliynyk_2007_Nat.Biotechnol_25_447 PubMedSearch: Oliynyk 2007 Nat.Biotechnol 25 447 PubMedID: 17369815 Gene_locus related to this paper: sacen-a4f6m6 ,
sacen-a4f7j2 ,
sacen-a4f7j9 ,
sacen-a4f8h3 ,
sacen-a4f8m4 ,
sacen-a4f8u9 ,
sacen-a4f9g1 ,
sacen-a4f9k7 ,
sacen-a4f815 ,
sacen-a4f824 ,
sacen-a4fam2 ,
sacen-a4faz0 ,
sacen-a4fbh5 ,
sacen-a4fbt1 ,
sacen-a4fc70 ,
sacen-a4fc79 ,
sacen-a4fcc3 ,
sacen-a4fcq9 ,
sacen-a4fcs3 ,
sacen-a4fd56 ,
sacen-a4fdc0 ,
sacen-a4fdk1 ,
sacen-a4fdp9 ,
sacen-a4fdt6 ,
sacen-a4fdt8 ,
sacen-a4feu5 ,
sacen-a4few8 ,
sacen-a4ff15 ,
sacen-a4ffg0 ,
sacen-a4ffk3 ,
sacen-a4ffv6 ,
sacen-a4ffx1 ,
sacen-a4ffy1 ,
sacen-a4fgk3 ,
sacen-a4fgw0 ,
sacen-a4fh60 ,
sacen-a4fix9 ,
sacen-a4fiz9 ,
sacen-a4fja4 ,
sacen-a4fjd3 ,
sacen-a4fk07 ,
sacen-a4fk92 ,
sacen-a4fkg4 ,
sacen-a4fkn0 ,
sacen-a4flt0 ,
sacen-a4fmr1 ,
sacen-a4fmz0 ,
sacen-a4fn55 ,
sacen-a4fpb3 ,
sacen-a4fpf4 ,
sacen-a4fpp0 ,
sacen-a4fq24 ,
sacer-Q9JN61 ,
sacen-a4fnh7 ,
sacen-a4fd61 ,
sacen-a4ffa2 Abstract
Saccharopolyspora erythraea is used for the industrial-scale production of the antibiotic erythromycin A, derivatives of which play a vital role in medicine. The sequenced chromosome of this soil bacterium comprises 8,212,805 base pairs, predicted to encode 7,264 genes. It is circular, like those of the pathogenic actinomycetes Mycobacterium tuberculosis and Corynebacterium diphtheriae, but unlike the linear chromosomes of the model actinomycete Streptomyces coelicolor A3(2) and the closely related Streptomyces avermitilis. The S. erythraea genome contains at least 25 gene clusters for production of known or predicted secondary metabolites, at least 72 genes predicted to confer resistance to a range of common antibiotic classes and many sets of duplicated genes to support its saprophytic lifestyle. The availability of the genome sequence of S. erythraea will improve insight into its biology and facilitate rational development of strains to generate high-titer producers of clinically important antibiotics.
Other Papers
Saccharopolyspora erythraea (Streptomyces erythraeus) deoxyerythronolide b synthase III (debs 3) Thioesterase domain