Saccharopolyspora erythraea (Streptomyces erythraeus) deoxyerythronolide b synthase III (debs 3) Thioesterase domain
SSALRDGYRQ AGVSGRVRSY LDLLAGLSDF REHFDGSDGF SLDLVDMADG PGEVTVICCA GTAAISGPHE FTRLAGALRG IAPVRAVPQP GYEEGEPLPS SMAAVAAVQA DAVIRTQGDK PFVVAGHSAG ALMAYALATE LLDRGHPPRG VVLIDVYPPG HQDAMNAWLE ELTATLFDRE TVRMDDTRLT ALGAYDRLTG QWRPRETGLP TLLVSAGEPM GPWPDDSWKP TWPFEHDTVA VPGDHFTMVQ EHADAIARHI DAWLGGGNS
Title : Mapping the catalytic conformations of an assembly-line polyketide synthase module - Cogan_2021_Science_374_729 |
Author(s) : Cogan DP , Zhang K , Li X , Li S , Pintilie GD , Roh SH , Craik CS , Chiu W , Khosla C |
Ref : Science , 374 :729 , 2021 |
Abstract : Cogan_2021_Science_374_729 |
ESTHER : Cogan_2021_Science_374_729 |
PubMedSearch : Cogan_2021_Science_374_729 |
PubMedID: 34735239 |
Gene_locus related to this paper: sacer-ery3 |
Title : Discovery and Characterization of a Thioesterase-Specific Monoclonal Antibody That Recognizes the 6-Deoxyerythronolide B Synthase - Li_2018_Biochemistry_57_6201 |
Author(s) : Li X , Sevillano N , La Greca F , Hsu J , Mathews, II , Matsui T , Craik CS , Khosla C |
Ref : Biochemistry , 57 :6201 , 2018 |
Abstract : Li_2018_Biochemistry_57_6201 |
ESTHER : Li_2018_Biochemistry_57_6201 |
PubMedSearch : Li_2018_Biochemistry_57_6201 |
PubMedID: 30289692 |
Gene_locus related to this paper: sacer-ery3 |
Title : Towards a characterization of the structural determinants of specificity in the macrocyclizing thioesterase for deoxyerythronolide B biosynthesis - Argyropoulos_2016_Biochim.Biophys.Acta_1860_486 |
Author(s) : Argyropoulos P , Bergeret F , Pardin C , Reimer JM , Pinto A , Boddy CN , Schmeing TM |
Ref : Biochimica & Biophysica Acta , 1860 :486 , 2016 |
Abstract : Argyropoulos_2016_Biochim.Biophys.Acta_1860_486 |
ESTHER : Argyropoulos_2016_Biochim.Biophys.Acta_1860_486 |
PubMedSearch : Argyropoulos_2016_Biochim.Biophys.Acta_1860_486 |
PubMedID: 26592346 |
Gene_locus related to this paper: sacer-ery3 |
Title : Total synthesis of long DNA sequences: synthesis of a contiguous 32-kb polyketide synthase gene cluster - Kodumal_2004_Proc.Natl.Acad.Sci.U.S.A_101_15573 |
Author(s) : Kodumal SJ , Patel KG , Reid R , Menzella HG , Welch M , Santi DV |
Ref : Proc Natl Acad Sci U S A , 101 :15573 , 2004 |
Abstract : Kodumal_2004_Proc.Natl.Acad.Sci.U.S.A_101_15573 |
ESTHER : Kodumal_2004_Proc.Natl.Acad.Sci.U.S.A_101_15573 |
PubMedSearch : Kodumal_2004_Proc.Natl.Acad.Sci.U.S.A_101_15573 |
PubMedID: 15496466 |
Gene_locus related to this paper: sacer-ery3 |
Title : Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases - Tsai_2002_Biochemistry_41_12598 |
Author(s) : Tsai SC , Lu H , Cane DE , Khosla C , Stroud RM |
Ref : Biochemistry , 41 :12598 , 2002 |
Abstract : Tsai_2002_Biochemistry_41_12598 |
ESTHER : Tsai_2002_Biochemistry_41_12598 |
PubMedSearch : Tsai_2002_Biochemistry_41_12598 |
PubMedID: 12379102 |
Gene_locus related to this paper: sacer-ery3 , strve-PIKAIV |
Title : Crystal structure of the macrocycle-forming thioesterase domain of the erythromycin polyketide synthase: versatility from a unique substrate channel - Tsai_2001_Proc.Natl.Acad.Sci.U.S.A_98_14808 |
Author(s) : Tsai SC , Miercke LJ , Krucinski J , Gokhale R , Chen JC , Foster PG , Cane DE , Khosla C , Stroud RM |
Ref : Proc Natl Acad Sci U S A , 98 :14808 , 2001 |
Abstract : Tsai_2001_Proc.Natl.Acad.Sci.U.S.A_98_14808 |
ESTHER : Tsai_2001_Proc.Natl.Acad.Sci.U.S.A_98_14808 |
PubMedSearch : Tsai_2001_Proc.Natl.Acad.Sci.U.S.A_98_14808 |
PubMedID: 11752428 |
Gene_locus related to this paper: sacer-ery3 |
Title : 6-Deoxyerythronolide-B synthase 2 from Saccharopolyspora erythraea. Cloning of the structural gene, sequence analysis and inferred domain structure of the multifunctional enzyme - Bevitt_1992_Eur.J.Biochem_204_39 |
Author(s) : Bevitt DJ , Cortes J , Haydock SF , Leadlay PF |
Ref : European Journal of Biochemistry , 204 :39 , 1992 |
Abstract : Bevitt_1992_Eur.J.Biochem_204_39 |
ESTHER : Bevitt_1992_Eur.J.Biochem_204_39 |
PubMedSearch : Bevitt_1992_Eur.J.Biochem_204_39 |
PubMedID: 1740151 |
Gene_locus related to this paper: sacer-ery3 |
Title : Identification of DEBS 1, DEBS 2 and DEBS 3, the multienzyme polypeptides of the erythromycin-producing polyketide synthase from Saccharopolyspora erythraea - Caffrey_1992_FEBS.Lett_304_225 |
Author(s) : Caffrey P , Bevitt DJ , Staunton J , Leadlay PF |
Ref : FEBS Letters , 304 :225 , 1992 |
Abstract : Caffrey_1992_FEBS.Lett_304_225 |
ESTHER : Caffrey_1992_FEBS.Lett_304_225 |
PubMedSearch : Caffrey_1992_FEBS.Lett_304_225 |
PubMedID: 1618327 |
Gene_locus related to this paper: sacer-ery3 |
Title : Modular organization of genes required for complex polyketide biosynthesis - Donadio_1991_Science_252_675 |
Author(s) : Donadio S , Staver MJ , McAlpine JB , Swanson SJ , Katz L |
Ref : Science , 252 :675 , 1991 |
Abstract : Donadio_1991_Science_252_675 |
ESTHER : Donadio_1991_Science_252_675 |
PubMedSearch : Donadio_1991_Science_252_675 |
PubMedID: 2024119 |
Gene_locus related to this paper: sacer-ery3 |
Title : An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraea - Cortes_1990_Nature_348_176 |
Author(s) : Cortes J , Haydock SF , Roberts GA , Bevitt DJ , Leadlay PF |
Ref : Nature , 348 :176 , 1990 |
Abstract : Cortes_1990_Nature_348_176 |
ESTHER : Cortes_1990_Nature_348_176 |
PubMedSearch : Cortes_1990_Nature_348_176 |
PubMedID: 2234082 |
Gene_locus related to this paper: sacer-ery3 |