Gene_locus Report for: sarha-g3wl42

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms: N E > Eukaryota: N E > Opisthokonta: N E > Metazoa: N E > Eumetazoa: N E > Bilateria: N E > Deuterostomia: N E > Chordata: N E > Craniata: N E > Vertebrata: N E > Gnathostomata: N E > Teleostomi: N E > Euteleostomi: N E > Sarcopterygii: N E > Dipnotetrapodomorpha: N E > Tetrapoda: N E > Amniota: N E > Mammalia: N E > Theria: N E > Metatheria: N E > Dasyuromorphia: N E > Dasyuridae: N E > Sarcophilus: N E > Sarcophilus harrisii: N E

Title: Genetic diversity and population structure of the endangered marsupial Sarcophilus harrisii (Tasmanian devil)
Miller W, Hayes VM, Ratan A, Petersen DC, Wittekindt NE, Miller J, Walenz B, Knight J, Qi J and Schuster SC <20 more author(s)> Miller W, Hayes VM, Ratan A, Petersen DC, Wittekindt NE, Miller J, Walenz B, Knight J, Qi J, Zhao F, Wang Q, Bedoya-Reina OC, Katiyar N, Tomsho LP, Kasson LM, Hardie RA, Woodbridge P, Tindall EA, Bertelsen MF, Dixon D, Pyecroft S, Helgen KM, Lesk AM, Pringle TH, Patterson N, Zhang Y, Kreiss A, Woods GM, Jones ME, Schuster SC (- 20)
Ref: Proc Natl Acad Sci U S A, 108:12348, 2011 : PubMed
Abstract


ESTHER: Miller_2011_Proc.Natl.Acad.Sci.U.S.A_108_12348
PubMedSearch: Miller 2011 Proc.Natl.Acad.Sci.U.S.A 108 12348
PubMedID: 21709235
Gene_locus related to this paper: sarha-g3vcc9, sarha-g3vfe5, sarha-g3vfr7, sarha-g3vgt0, sarha-g3vix0, sarha-g3vqx7, sarha-g3vrx3, sarha-g3vsl6, sarha-g3vvi8, sarha-g3vyq6, sarha-g3vz51, sarha-g3vze3, sarha-g3vzx8, sarha-g3w1a9, sarha-g3w685, sarha-g3wfj3, sarha-g3wg02, sarha-g3wuz4, sarha-g3x0l1, sarha-g3whf8, sarha-g3w6u4, sarha-g3wrd7, sarha-g3vun8, sarha-g3vyu7, sarha-g3wmk1, sarha-g3w4n0, sarha-g3x182, sarha-g3wyt9, sarha-g3vdz2, sarha-g3vft8, sarha-g3vtk1, sarha-g3w6i3, sarha-g3wy72, sarha-g3vv12, sarha-g3vv13, sarha-g3vl97, sarha-g3wzy4, sarha-g3vcj1, sarha-g3w1u8, sarha-g3vik5, sarha-g3wtu4, sarha-g3wl42, sarha-g3w041, sarha-g3vyg5, sarha-g3w5l6, sarha-g3whf6

Abstract

The Tasmanian devil (Sarcophilus harrisii) is threatened with extinction because of a contagious cancer known as Devil Facial Tumor Disease. The inability to mount an immune response and to reject these tumors might be caused by a lack of genetic diversity within a dwindling population. Here we report a whole-genome analysis of two animals originating from extreme northwest and southeast Tasmania, the maximal geographic spread, together with the genome from a tumor taken from one of them. A 3.3-Gb de novo assembly of the sequence data from two complementary next-generation sequencing platforms was used to identify 1 million polymorphic genomic positions, roughly one-quarter of the number observed between two genetically distant human genomes. Analysis of 14 complete mitochondrial genomes from current and museum specimens, as well as mitochondrial and nuclear SNP markers in 175 animals, suggests that the observed low genetic diversity in today's population preceded the Devil Facial Tumor Disease disease outbreak by at least 100 y. Using a genetically characterized breeding stock based on the genome sequence will enable preservation of the extant genetic diversity in future Tasmanian devil populations.