(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) > cellular organisms: NE > Eukaryota: NE > Opisthokonta: NE > Fungi: NE > Dikarya: NE > Basidiomycota: NE > Agaricomycotina: NE > Agaricomycetes: NE > Agaricomycetidae: NE > Agaricales: NE > Schizophyllaceae: NE > Schizophyllum: NE > Schizophyllum commune: NE
LegendThis sequence has been compared to family alignement (MSA) red => minority aminoacid blue => majority aminoacid color intensity => conservation rate title => sequence position(MSA position)aminoacid rate Catalytic site Catalytic site in the MSA MGISWSSASTATTIHYAEKPALIPVREEGDAAQGEGELDLRTLVEKRCPS LHKPFVPAWWLPNGHAQTLYCVLGDFTKSDKMRYRREFIRMKEGGTVALD WAPIDQDSLPADTPIIVVKHGLTGGSYEAYVRSILYTATKPKSEGGLGYR AVVCNFRGCAGTPVTSSQLYSAGYTDDLRQEVMYIRHLYPHAPLLGIGFS LGANVLTRYLAQDGEHSRLVSGCALACPWDLASNSDGLVSTFLGTNVYSK GMARNLLRLVARHREALKKDPNHPAAQLVDQVLALRHPTLEGFDEVITSK IGGPPPEWPFPSARAYYTHCSSHHVVKDIRVPFLAINAADDPVVTRVPMD GGGNGMVVMALTPYGGHLGWFEGVGALPGQTTRWVREPVLEWMRMCGEGV VHEKLTRKERRVYVDEEGWVREEGSEHLGCRRIEGGGIIDGSKQQNVGEE GMLQGL
Much remains to be learned about the biology of mushroom-forming fungi, which are an important source of food, secondary metabolites and industrial enzymes. The wood-degrading fungus Schizophyllum commune is both a genetically tractable model for studying mushroom development and a likely source of enzymes capable of efficient degradation of lignocellulosic biomass. Comparative analyses of its 38.5-megabase genome, which encodes 13,210 predicted genes, reveal the species's unique wood-degrading machinery. One-third of the 471 genes predicted to encode transcription factors are differentially expressed during sexual development of S. commune. Whereas inactivation of one of these, fst4, prevented mushroom formation, inactivation of another, fst3, resulted in more, albeit smaller, mushrooms than in the wild-type fungus. Antisense transcripts may also have a role in the formation of fruiting bodies. Better insight into the mechanisms underlying mushroom formation should affect commercial production of mushrooms and their industrial use for producing enzymes and pharmaceuticals.
