Schistosoma mansoni (Blood fluke, platyhelminth) BC026374 protein SmBChE1 Smbche1-Smp_125350
This enzyme is called SmBChE1 in Tedla et al. 2019<\/A> and is inhibited by dichlorvos A0A3Q0KKW0 replaced G4V715 which was incomplete. This enzyme is peculiar as it has a Q (Gln) instead of H (His) in the catalytic triad
MFLVSPLNFE IFCSCLQLLP VISWADQIVI RTNYGAVSGK QKYIHGKNVF QFLGIPFAKP PTGDLRFRYP EPPDPWSNTL DATKPPNTCM QPLPESQEFL DATTRVWLNT TKMSEDCLYL NIWTRANNNN YSHAIDDRNH MMLESSAIFG PKGGRPVMVW IHGGSLIRGS SSIEMYNGAY LAGKMNVVVV SIQYRLGPLG FLYLGNDEIP GNQGLMDQVA GLQWVRENIA YFGGNPQQIT LFGHSGGVIC VALHLISPIS NHLFQQAILQ SGSPLAWWAV ESSHTALEKT RLLAQLSGCN AVTDSNGQYS KELVKCLQSV DSETLVVNQW HMHLLRNGEN SSRTNQLKKL YRNRASHHLL STAGYYFDLP FKPVVSAPFL PEWPYEVLGS GKLNIRHRIM LGVNKDEGMY HLVQSLRMYF MSPGSWPQIP REFRHGIALM DPLDLLAFYI MDENFLQSVL LQATVFEYQI PSRALGTGSW TSLEVVKALN EVGGDYNIKC PVVEFADFYS RGPNAQVFLY SFEHRTSGLT WPQWTGIMQG YEAEYIFGAP FNQAFTDNYY NFTLEEKRLS EEMMQFWTNF ASTGSPNLNP GEFHTRNKEL YWDRYETYSP HSVAVLSESS SSSSSSSIAI SGVSVSSVLS SSVSSETSSF KTRNDDSRKH MVFTLPRSYI SKNLRRHYCM FWREQLPMLR ERILYNSACK SRQSTTQYEV TNDIHKQPVE SFGTLYPNII KSSEFNTTKR NQASYNLQLK VNYILSLYII YYYHDYYFDY
| Title : Novel cholinesterase paralogs of Schistosoma mansoni have perceived roles in cholinergic signaling and drug detoxification and are essential for parasite survival - Tedla_2019_PLoS.Pathog_15_e1008213 |
| Author(s) : Tedla BA , Sotillo J , Pickering D , Eichenberger RM , Ryan S , Becker L , Loukas A , Pearson MS |
| Ref : PLoS Pathog , 15 :e1008213 , 2019 |
| Abstract : Tedla_2019_PLoS.Pathog_15_e1008213 |
| ESTHER : Tedla_2019_PLoS.Pathog_15_e1008213 |
| PubMedSearch : Tedla_2019_PLoS.Pathog_15_e1008213 |
| PubMedID: 31809524 |
| Gene_locus related to this paper: schma-ACHE1 , schma-ACHE2 , schma-BCHE |