Gene_Locus Report

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Gene_locus Report for: shifl-PTRB

Other Species: Shigella sonnei, Shigella flexneri, Shigella dysenteriae protease II

Comment
Other Species: Shigella flexneri (and serotype X (strain 2002017)serotype 5b (strain 8401)) and Shigella sonnei (strain Ss046) Shigella dysenteriae serotype 1 (strain Sd197)(1012)


Relationship
Family|S9N_PREPL_Peptidase_S9
Block| X
Position in NCBI Life Tree|Shigella flexneri
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms: N E > Bacteria: N E > Proteobacteria: N E > Gammaproteobacteria: N E > Enterobacterales: N E > Enterobacteriaceae: N E > Shigella: N E > Shigella flexneri: N E
Warning: This entry is a compilation of different species or line or strain with more than 90% amino acide identity. You can retrieve all strain data


Molecular evidence
Database
No mutation
No structure
No kinetic





No Substrate
No inhibitor
>3 Genbank links 5 more: CP001383, CP000266, AAMJ02000022
>3 UniProt links 3 more: Q83R69, Q3Z2J6, D2AHA3
>3 UniProt links 3 more: Q83R69, Q3Z2J6, D2AHA3
>3 Interpro links 3 more: Q83R69, Q3Z2J6, D2AHA3
>3 Prodom links 3 more: Q83R69, Q3Z2J6, D2AHA3
>3 Pfam links 3 more: Q83R69, Q3Z2J6, D2AHA3
>3 PIRSF links 3 more: Q83R69, Q3Z2J6, D2AHA3
>3 SUPERFAM links 3 more: Q83R69, Q3Z2J6, D2AHA3
Sequence
Graphical view for this peptide sequence: shifl-PTRB
Colored MSA for S9N_PREPL_Peptidase_S9 (raw)
MLPKAARIPHAMTLHGDTRIDNYYWLRDDTRSQPKVLDYLQQENSYGHRV
MASQQALQDRILKEIIDRIPQREVSAPYIKNGYRYRHIYEPGCEYAIYQR
QSAFSEEWDEWETLLDANKRAAHSEFYSMGGMAITPDNTIMALAEDFLSR
RQYGIRFRNLETGNWYPELLDNVEPSFVWANDSWTFYYVRKHPVTLLPYQ
VWRHAIGTPASQDTLIYEEKDDTYYVSLHKTTSKHYVVIHLASATTSEVR
LLDAEMADAEPFVFLPRRKDHEYSLDHYQHRFYLRSNRHGKNFGLYRTRM
RDEQQWEELIPPRENIMLEGFTLFTDWLVVEERQRGLTSLRQINRKTREV
IGIAFDDPAYVTWIAYNPEPETARLRYGYSSMTTPDTLFELDMDTGERRV
LKQTEVPGFDAANYRSEHLWIVARDGVEVPVSLVYHRKHFRKGHNPLLVY
GYGSYGASIDADFSFSRLSLLDRGFVYAIVHVRGGGELGQQWYEDGKFLK
KKNTFNDYLDACDALLKLGYGSPSLCYAMGGSAGGMLMGVAINQRPELFH
GVIAQVPFVDVVTTMLDESIPLTTGEFEEWGNPQDPQYYEYMKSYSPYDN
VTAQAYPHLLVTTGLHDSQVQYWEPAKWVAKLRELKTDDHLLLLCTDMDS
GHGGKSGRFKSYEGVAMEYAFLVALAQGTLPATPAD
Legend This sequence has been compared to family alignement (MSA)
red => minority aminoacid
blue => majority aminoacid
color intensity => conservation rate
title => sequence position(MSA position)aminoacid rate
Catalytic site
Catalytic site in the MSA

MLPKAARIPHAMTLHGDTRIDNYYWLRDDTRSQPKVLDYLQQENSYGHRV
MASQQALQDRILKEIIDRIPQREVSAPYIKNGYRYRHIYEPGCEYAIYQR
QSAFSEEWDEWETLLDANKRAAHSEFYSMGGMAITPDNTIMALAEDFLSR
RQYGIRFRNLETGNWYPELLDNVEPSFVWANDSWTFYYVRKHPVTLLPYQ
VWRHAIGTPASQDTLIYEEKDDTYYVSLHKTTSKHYVVIHLASATTSEVR
LLDAEMADAEPFVFLPRRKDHEYSLDHYQHRFYLRSNRHGKNFGLYRTRM
RDEQQWEELIPPRENIMLEGFTLFTDWLVVEERQRGLTSLRQINRKTREV
IGIAFDDPAYVTWIAYNPEPETARLRYGYSSMTTPDTLFELDMDTGERRV
LKQTEVPGFDAANYRSEHLWIVARDGVEVPVSLVYHRKHFRKGHNPLLVY
GYGSYGASIDADFSFSRLSLLDRGFVYAIVHVRGGGELGQQWYEDGKFLK
KKNTFNDYLDACDALLKLGYGSPSLCYAMGGSAGGMLMGVAINQRPELFH
GVIAQVPFVDVVTTMLDESIPLTTGEFEEWGNPQDPQYYEYMKSYSPYDN
VTAQAYPHLLVTTGLHDSQVQYWEPAKWVAKLRELKTDDHLLLLCTDMDS
GHGGKSGRFKSYEGVAMEYAFLVALAQGTLPATPAD


References
2 more
    Title: Emergence of a new multidrug-resistant serotype X variant in an epidemic clone of Shigella flexneri
    Ye C, Lan R, Xia S, Zhang J, Sun Q, Zhang S, Jing H, Wang L, Li Z and Xu J <11 more author(s)>
    Ref: J Clin Microbiol, 48:419, 2010 : PubMed

            

    Title: Complete genome sequence of Shigella flexneri 5b and comparison with Shigella flexneri 2a
    Nie H, Yang F, Zhang X, Yang J, Chen L, Wang J, Xiong Z, Peng J, Sun L and Jin Q <6 more author(s)>
    Ref: BMC Genomics, 7:173, 2006 : PubMed

            

    Title: Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157
    Jin Q, Yuan Z, Xu J, Wang Y, Shen Y, Lu W, Wang J, Liu H, Yang J and Yu J <23 more author(s)>
    Ref: Nucleic Acids Research, 30:4432, 2002 : PubMed

            


Other Papers


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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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