Sphingopyxis macrogoltabida FumD Fumonisin B1 esterase
Fumonisins are toxins produced by several species of Fusarium molds, such as Fusarium verticillioides which occur mainly in maize (corn), wheat and other cereals. Fumonisin B1 is hepatotoxic and nephrotoxic. fumonisins are able to inhibit sphingosine-sphinganin-transferases and ceramide synthases and are therefore competitive inhibitors of sphingolipid biosynthesis and metabolism. Fumonisin is hydrolysed by Sphingopyxis macrogoltabida FumD. It is used as enzyme-basedfeed additive intended to degrade fumonisin mycotoxins found as contaminants in feeds for growing pigs: FUMzyme
MKEHQCRGGR ASPAAPATWL ARISVSRGAS AIAWTFMLGA TAIPVAAQTD DPKLVRHTQS GAVEGVEGDV ETFLGIPFAA PPVGDLRWRP PAPPRAWAGT RDGRRFAPDC IGNERLREGS RAAGTSEDCL YLNIWSPKQV GKGGLPVMIW VYGGGFSGGS GAVPYYDGSA LAQKGVVVVT FNYRAGILGF LAHPALSKES PNGVSGNYGL LDMLAAFKWV QNNIREFGGD PNRVTVFGES AGASALGLLL TSPLSESAFN QAILQSPGLA RPLATLSESE ANGLELGADI SALRRADAGE LTKIAQSRIP MSRQFTKPRP MGPILDGYVL RTLDVDAFAK GAFRKIPVLV GGNADEGRAF TDRLPVKTVL EYRAYLTEQF GDEADAWERC YPANSDADVP AAVARLFGDS QFNNGIELLS AAFAKWRTPL WRYRFTGIPG AGRRPATHGD EIPYVFANLG PSSVSMFGSL EGGAGASDIK LATEMSAAWV SFAVHGVPDQ GTKSHWPRFE RRGEIMTFGS QVGSGEGLGV SPSKACQPSK
| Title : Comparison Study of Two Fumonisin-Degrading Enzymes for Detoxification in Piglets - Wang_2024_Toxins.(Basel)_16_3 |
| Author(s) : Wang Z , Lv Z , Czabany T , Nagl V , Krska R , Wang X , Han B , Tao H , Liu J , Wang J |
| Ref : Toxins (Basel) , 16 :3 , 2024 |
| Abstract : Wang_2024_Toxins.(Basel)_16_3 |
| ESTHER : Wang_2024_Toxins.(Basel)_16_3 |
| PubMedSearch : Wang_2024_Toxins.(Basel)_16_3 |
| PubMedID: 38276527 |
| Gene_locus related to this paper: sphmc-FumD , 9sphn-a0a101vlk1 |
| Title : Improved Production of Recombinant Carboxylesterase FumDM by Co-Expressing Molecular Chaperones in Pichia pastoris - Jiang_2023_Toxins.(Basel)_15_ |
| Author(s) : Jiang L , Guan X , Liu H , Chang X , Sun J , Sun C , Zhao C |
| Ref : Toxins (Basel) , 15 : , 2023 |
| Abstract : Jiang_2023_Toxins.(Basel)_15_ |
| ESTHER : Jiang_2023_Toxins.(Basel)_15_ |
| PubMedSearch : Jiang_2023_Toxins.(Basel)_15_ |
| PubMedID: 36828470 |
| Gene_locus related to this paper: sphmc-FumD |
| Title : Biodegradation of Fumonisins by the Consecutive Action of a Fusion Enzyme - Li_2022_Toxins.(Basel)_14_ |
| Author(s) : Li K , Yu S , Yu D , Lin H , Liu N , Wu A |
| Ref : Toxins (Basel) , 14 : , 2022 |
| Abstract : Li_2022_Toxins.(Basel)_14_ |
| ESTHER : Li_2022_Toxins.(Basel)_14_ |
| PubMedSearch : Li_2022_Toxins.(Basel)_14_ |
| PubMedID: 35448875 |
| Gene_locus related to this paper: sphmc-FumD |
| Title : FumDSB can alleviate the inflammatory response induced by fumonisin B(1) in growing pigs - Liu_2022_Food.Addit.Contam.Part.A.Chem.Anal.Control.Expo.Risk.Assess__ |
| Author(s) : Liu Q , Huang L , Cui Z , Qiao B , Li F , Wang C |
| Ref : Food Additives & Contaminants Part A Chem Anal Control Expo Risk Assess , :1 , 2022 |
| Abstract : Liu_2022_Food.Addit.Contam.Part.A.Chem.Anal.Control.Expo.Risk.Assess__ |
| ESTHER : Liu_2022_Food.Addit.Contam.Part.A.Chem.Anal.Control.Expo.Risk.Assess__ |
| PubMedSearch : Liu_2022_Food.Addit.Contam.Part.A.Chem.Anal.Control.Expo.Risk.Assess__ |
| PubMedID: 35858108 |
| Gene_locus related to this paper: sphmc-FumD , 9sphn-a0a101vlk1 |
| Title : Detoxification of the Fumonisin Mycotoxins in Maize: An Enzymatic Approach - Alberts_2019_Toxins.(Basel)_11_523 |
| Author(s) : Alberts J , Schatzmayr G , Moll WD , Davids I , Rheeder J , Burger HM , Shephard G , Gelderblom W |
| Ref : Toxins (Basel) , 11 : , 2019 |
| Abstract : Alberts_2019_Toxins.(Basel)_11_523 |
| ESTHER : Alberts_2019_Toxins.(Basel)_11_523 |
| PubMedSearch : Alberts_2019_Toxins.(Basel)_11_523 |
| PubMedID: 31510008 |
| Gene_locus related to this paper: sphmc-FumD |
| Title : Gastrointestinal Degradation of Fumonisin B(1) by Carboxylesterase FumD Prevents Fumonisin Induced Alteration of Sphingolipid Metabolism in Turkey and Swine - Masching_2016_Toxins.(Basel)_8_ |
| Author(s) : Masching S , Naehrer K , Schwartz-Zimmermann HE , Sarandan M , Schaumberger S , Dohnal I , Nagl V , Schatzmayr D |
| Ref : Toxins (Basel) , 8 : , 2016 |
| Abstract : Masching_2016_Toxins.(Basel)_8_ |
| ESTHER : Masching_2016_Toxins.(Basel)_8_ |
| PubMedSearch : Masching_2016_Toxins.(Basel)_8_ |
| PubMedID: 27007395 |
| Gene_locus related to this paper: sphmc-FumD |
| Title : Degradation of fumonisin B1 by the consecutive action of two bacterial enzymes - Heinl_2010_J.Biotechnol_145_120 |
| Author(s) : Heinl S , Hartinger D , Thamhesl M , Vekiru E , Krska R , Schatzmayr G , Moll WD , Grabherr R |
| Ref : J Biotechnol , 145 :120 , 2010 |
| Abstract : Heinl_2010_J.Biotechnol_145_120 |
| ESTHER : Heinl_2010_J.Biotechnol_145_120 |
| PubMedSearch : Heinl_2010_J.Biotechnol_145_120 |
| PubMedID: 19922747 |
| Gene_locus related to this paper: sphmc-FumD |