Gene_locus Report for: staau-d2feb3Staphylococcus aureus Putative uncharacterized protein Bontoxilysin Comment Other strains: Staphylococcus aureus (strains C427; 68-397; M876; M899; E1410; WBG10049; C101; M809; 65-1322; A017934/97; C160; 55/2053; WW2703/97; Btn1260; 58-424; TCH60; M1015; MRSA252; JKD6159; EMRSA16; MN8; D139; H19; ED133); Staphylococcus schleiferi Relationship
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) There are 35 a/b hydrolases in Staphylococcus aureus view in a: Table
6_AlphaBeta_hydrolase : staau-SA0569Staphylococcus aureus Alpha/beta hydrolase fold-containing protein, staau-SA0572Staphylococcus aureus Alpha/beta hydrolase fold family hydrolase, staau-SA2367Staphylococcus aureus putative hydrolase FphE, staau-SAV0321  Staphylococcus aureus, an hypothetical protein sav0321 FI2.A85-EsteraseD-FGH : staau-SA2422 Staphylococcus aureus sa2422 promiscuous esterase EstA FphF.A85-IroE-IroD-Fes-Yiel : staau-SAV1014Staphylococcus aureus Acetyl esterase. ACPH_Peptidase_S9 : staau-SAV1793Staphylococcus aureus YtmA S9C family unassigned peptidase, an hypothetical protein sav1793 FphG. AlphaBeta_hydrolase : staau-SAV0446Staphylococcus aureus Putative uncharacterized protein. Asp2 : staa8-asp2Staphylococcus aureus ; Staphylococcus aureus subsp. aureus; Staphylococcus sp.. Accessory secretory protein Asp2, staau-a0a077ujj5Staphylococcus aureus. Accessory Sec system asp2, staau-a0a0u1msw0Staphylococcus aureus; Staphylococcus argenteus. Accessory Sec system protein Asp2. Bacterial_lip_FamI.6 : staau-LIPStaphylococcus aureus (lipase) (triglyceride lipase)(EC 3.1.1.3) (tributyrase) SAL-1 sal1 geh, staau-lipas Staphylococcus aureus gene for lipase lip2, lipase 2, geh lipase. Glycerol ester hydrolase 2 gehB Staphylococcus simulans.CarbLipBact_1 : staau-MW0741 Staphylococcus aureus Probable carboxylesterase mw0741 SA0734 protein FphH, staau-SAV0457Staphylococcus aureus Lipase/esterase Est, an hypothetical protein sav0457 FphI.Carb_B_Bacteria : staau-SA2240Staphylococcus aureus SA2240 gene similar to bacsu-pnbae para-nitrobenzyl esterase FphA, staau-a0a077ukm7Staphylococcus aureus. Putative carboxylesterase, staau-a0a0h2hy10Staphylococcus aureus; Streptococcus pneumoniae; Mycobacterium abscessus subsp.. Carboxylic ester hydrolase. Chlorophyllase : staau-a0a0h2hx43Staphylococcus aureus. Chlorophyllase. Cocaine_esterase : staau-SAV2594 Staphylococcus aureus COCE/NOND family hydrolase, S15 family peptidase.Duf_915 : staau-SAV2188Staphylococcus aureus Cell surface hydrolase FphD. Homoserine_transacetylase : staau-SA0011 Staphylococcus aureus homoserine o-acetyltransferase (EC 2.3.1.31).Hormone-sensitive_lipase_like : staau-MW2456Staphylococcus aureus Alpha/beta hydrolase fold-3 domain-containing protein virulence factor Q2FV90 FphB, staau-SAV0655Staphylococcus aureus SAV0655 Lipase/esterase LipA HH9, staau-SAV2350 Staphylococcus aureus Esterase.Hydrolase_RBBP9_YdeN : staau-q6gfm6Staphylococcus aureus, Putative uncharacterized protein. Lipase_3 : staau-d2uin3Staphylococcus aureus Putative uncharacterized protein (strains H19; ATCC51811; C427; C160; D139; MSSA476; MW2), staau-SAV2484Staphylococcus aureus hypothetical protein sav2484. LYsophospholipase_carboxylesterase : staau-SA2306Staphylococcus aureus Putative Phospholipase/carboxylesterase family protein FphI. MenH_SHCHC : staau-SA0897 Staphylococcus aureus Alpha/beta hydrolase fold protein.Monoglyceridelipase_lysophospholip : staa3-q2fkj0Staphylococcus aureus putative lysophospholipase HZ1, staau-SA1143Staphylococcus aureus Alpha/beta hydrolase fold protein Lysophospholipase sa1143 protein FphC, staau-SAV1765Staphylococcus aureus protein lysophospholipase homolog. YcjY-like : staau-c8mfq3Staphylococcus aureus Dienelactone hydrolase Warning: This entry is a compilation of different species or line or strain with more than 90% amino acid identity. You can retrieve all strain data
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) Staphylococcus aureus subsp. aureus C427: N, E. Staphylococcus aureus subsp. aureus ED133: N, E. Staphylococcus aureus subsp. aureus H19: N, E. Staphylococcus aureus subsp. aureus D139: N, E. Staphylococcus aureus subsp. aureus MN8: N, E. Staphylococcus aureus subsp. aureus EMRSA16: N, E. Staphylococcus aureus subsp. aureus JKD6159: N, E. Staphylococcus aureus subsp. aureus MRSA252: N, E. Staphylococcus aureus subsp. aureus M1015: N, E. Staphylococcus aureus subsp. aureus TCH60: N, E. Staphylococcus aureus subsp. aureus 58-424: N, E. Staphylococcus aureus subsp. aureus Btn1260: N, E. Staphylococcus aureus subsp. aureus WW2703/97: N, E. Staphylococcus aureus subsp. aureus 55/2053: N, E. Staphylococcus aureus subsp. aureus C160: N, E. Staphylococcus aureus subsp. aureus C101: N, E. Staphylococcus aureus subsp. aureus A017934/97: N, E. Staphylococcus aureus subsp. aureus 65-1322: N, E. Staphylococcus aureus subsp. aureus M809: N, E. Staphylococcus aureus subsp. aureus WBG10049: N, E. Staphylococcus aureus subsp. aureus E1410: N, E. Staphylococcus aureus subsp. aureus 68-397: N, E. Staphylococcus aureus subsp. aureus M876: N, E. Staphylococcus aureus subsp. aureus M899: N, E. Staphylococcus aureus C0673: N, E. Staphylococcus aureus subsp. aureus MW2: N, E. Staphylococcus aureus subsp. aureus MSSA476: N, E. Staphylococcus aureus subsp. aureus ATCC 51811: N, E. Staphylococcus aureus subsp. aureus TCH130: N, E. Staphylococcus aureus subsp. aureus ST398: N, E. Staphylococcus aureus subsp. aureus USA300_TCH959: N, E. Staphylococcus aureus A9635: N, E. Staphylococcus aureus A9754: N, E. Staphylococcus aureus D30: N, E. Staphylococcus aureus A9765: N, E. Staphylococcus aureus subsp. aureus str. JKD6008: N, E. Staphylococcus aureus subsp. aureus ATCC BAA-39: N, E. Staphylococcus aureus A5948: N, E. Staphylococcus aureus subsp. aureus COL: N, E. Staphylococcus aureus subsp. aureus USA300: N, E. Staphylococcus aureus subsp. aureus NCTC 8325: N, E. Staphylococcus aureus subsp. aureus str. Newman: N, E. Staphylococcus aureus subsp. aureus TW20: N, E. Staphylococcus aureus subsp. aureus USA300_TCH1516: N, E. Staphylococcus aureus subsp. aureus N315: N, E. Staphylococcus aureus subsp. aureus Mu3: N, E. Staphylococcus aureus subsp. aureus Mu50: N, E. Staphylococcus aureus A6224: N, E. Staphylococcus aureus 04-02981: N, E. Staphylococcus aureus A8819: N, E. Staphylococcus aureus A10102: N, E. Staphylococcus aureus A9763: N, E. Staphylococcus aureus A9719: N, E. Staphylococcus aureus A8796: N, E. Staphylococcus aureus A5937: N, E. Staphylococcus aureus A6300: N, E. Staphylococcus aureus A8117: N, E. Staphylococcus aureus A8115: N, E. Staphylococcus aureus A9299: N, E. Staphylococcus aureus A9781: N, E. Staphylococcus aureus subsp. aureus ED98: N, E. Staphylococcus aureus 930918-3: N, E. Staphylococcus aureus RF122: N, E. Staphylococcus aureus subsp. aureus MRSA177: N, E. Staphylococcus aureus subsp. aureus MRSA131: N, E. Staphylococcus aureus subsp. aureus TCH70: N, E. Staphylococcus aureus subsp. aureus ECT-R 2: N, E. Staphylococcus aureus subsp. aureus CGS00: N, E. Staphylococcus aureus subsp. aureus CGS01: N, E. Staphylococcus aureus subsp. aureus CGS03: N, E. Staphylococcus aureus subsp. aureus JH9: N, E. Staphylococcus aureus subsp. aureus JH1: N, E. Staphylococcus aureus M0562: N, E. Staphylococcus aureus M1: N, E. Staphylococcus aureus M0329: N, E. Staphylococcus aureus subsp. aureus CIG1114: N, E. Staphylococcus aureus subsp. aureus SA957: N, E. Staphylococcus aureus M1394: N, E. Staphylococcus aureus M1450: N, E. Staphylococcus aureus M0066: N, E. Staphylococcus aureus M0633: N, E. Staphylococcus aureus subsp. aureus 21264: N, E. Staphylococcus aureus M0216: N, E. Staphylococcus aureus subsp. aureus VRS1: N, E. Staphylococcus aureus M0998: N, E. Staphylococcus aureus M0547: N, E. Staphylococcus aureus M0450: N, E. Staphylococcus aureus M1044: N, E. Staphylococcus aureus subsp. aureus CIGC348: N, E. Staphylococcus aureus HI010: N, E. Staphylococcus aureus M1533: N, E. Staphylococcus aureus subsp. aureus VCU006: N, E. Staphylococcus aureus M0934: N, E. Staphylococcus aureus subsp. aureus 21345: N, E. Staphylococcus aureus M0213: N, E. Staphylococcus aureus M0468: N, E. Staphylococcus aureus HI111: N, E. Staphylococcus aureus M0438: N, E. Staphylococcus aureus subsp. aureus DR10: N, E. Staphylococcus aureus M0769: N, E. Staphylococcus aureus subsp. aureus 21232: N, E. Staphylococcus aureus M0571: N, E. Staphylococcus aureus subsp. aureus IS-125: N, E. Staphylococcus aureus M0077: N, E. Staphylococcus aureus subsp. aureus CIG1770: N, E. Staphylococcus aureus subsp. aureus CIG1524: N, E. Staphylococcus aureus M0770: N, E. Staphylococcus aureus M1244: N, E. Staphylococcus aureus M0173: N, E. Staphylococcus aureus M1463: N, E. Staphylococcus aureus M0330: N, E. Staphylococcus aureus M0964: N, E. Staphylococcus aureus M0478: N, E. Staphylococcus aureus KT/Y21: N, E. Staphylococcus aureus M1373: N, E. Staphylococcus aureus subsp. aureus IS-99: N, E. Staphylococcus aureus M0035: N, E. Staphylococcus aureus HI049B: N, E. Staphylococcus aureus SA16: N, E. Staphylococcus aureus M0363: N, E. Staphylococcus aureus KT/314250: N, E. Staphylococcus aureus M0460: N, E. Staphylococcus aureus subsp. aureus VRS11a: N, E. Staphylococcus aureus M0877: N, E. Staphylococcus aureus M0822: N, E. Staphylococcus aureus subsp. aureus 21196: N, E. Staphylococcus aureus subsp. aureus CIG1233: N, E. Staphylococcus aureus M1007: N, E. Staphylococcus aureus M1170: N, E. Staphylococcus aureus M1092: N, E. Staphylococcus aureus M0237: N, E. Staphylococcus aureus subsp. aureus LGA251: N, E. Staphylococcus aureus SA_ST125_MupR: N, E. Staphylococcus aureus M0351: N, E. Staphylococcus aureus M1228: N, E. Staphylococcus aureus M0060: N, E. Staphylococcus aureus subsp. aureus 112808A: N, E. Staphylococcus aureus subsp. aureus IS-91: N, E. Staphylococcus aureus M0529: N, E. Staphylococcus aureus subsp. aureus 21172: N, E. Staphylococcus aureus M1010: N, E. Staphylococcus aureus subsp. aureus CO-08: N, E. Staphylococcus aureus M1076: N, E. Staphylococcus aureus subsp. aureus CIGC340D: N, E. Staphylococcus aureus M0489: N, E. Staphylococcus aureus subsp. aureus CIG1150: N, E. Staphylococcus aureus subsp. aureus IS-111: N, E. Staphylococcus aureus M1078: N, E. Staphylococcus aureus subsp. aureus CIG547: N, E. Staphylococcus aureus subsp. aureus 21193: N, E. Staphylococcus aureus M0312: N, E. Staphylococcus aureus subsp. aureus CIG1835: N, E. Staphylococcus aureus subsp. aureus 21269: N, E. Staphylococcus aureus M0364: N, E. Staphylococcus aureus subsp. aureus DSM 20231: N, E. Staphylococcus aureus subsp. aureus CIG1612: N, E. Staphylococcus aureus subsp. aureus CO-23: N, E. Staphylococcus aureus M1142: N, E. Staphylococcus aureus M0055: N, E. Staphylococcus aureus M1466: N, E. Staphylococcus aureus M0029: N, E. Staphylococcus aureus M0493: N, E. Staphylococcus aureus subsp. aureus 122051: N, E. Staphylococcus aureus M1321: N, E. Staphylococcus aureus M0347: N, E. Staphylococcus aureus M0676: N, E. Staphylococcus aureus M0719: N, E. Staphylococcus aureus M1578: N, E. Staphylococcus aureus M0580: N, E. Staphylococcus aureus M1255: N, E. Staphylococcus aureus M0375: N, E. Staphylococcus aureus M0280: N, E. Staphylococcus aureus M0326: N, E. Staphylococcus aureus S100: N, E. Staphylococcus aureus M0628: N, E. Staphylococcus aureus M0871: N, E. Staphylococcus aureus M1481: N, E. Staphylococcus aureus subsp. aureus 21252: N, E. Staphylococcus aureus M0171: N, E. Staphylococcus aureus M1556: N, E. Staphylococcus aureus M0494: N, E. Staphylococcus aureus M1193: N, E. Staphylococcus aureus M0001: N, E. Staphylococcus aureus subsp. aureus CIG1214: N, E. Staphylococcus aureus M0823: N, E. Staphylococcus aureus subsp. aureus CIGC93: N, E. Staphylococcus aureus subsp. aureus CIG1213: N, E. Staphylococcus aureus M1248: N, E. Staphylococcus aureus subsp. aureus CIG1605: N, E. Staphylococcus aureus M0240: N, E. Staphylococcus aureus M1037: N, E. Staphylococcus aureus subsp. aureus 21189: N, E. Staphylococcus aureus M0294: N, E. Staphylococcus aureus Bmb9393: N, E. Staphylococcus aureus B40950: N, E. Staphylococcus aureus 08BA02176: N, E. Staphylococcus aureus subsp. aureus 21272: N, E. Staphylococcus aureus M0252: N, E. Staphylococcus aureus M1188: N, E. Staphylococcus aureus M0328: N, E. Staphylococcus aureus M0350: N, E. Staphylococcus aureus M1563: N, E. Staphylococcus aureus M1253: N, E. Staphylococcus aureus subsp. aureus CM05: N, E. Staphylococcus aureus M0531: N, E. Staphylococcus aureus subsp. aureus CBD-635: N, E. Staphylococcus aureus subsp. aureus IS-157: N, E. Staphylococcus aureus M1083: N, E. Staphylococcus aureus subsp. aureus str. Newbould 305: N, E. Staphylococcus aureus M0687: N, E. Staphylococcus aureus subsp. aureus 21283: N, E. Staphylococcus aureus M0944: N, E. Staphylococcus aureus subsp. aureus VRS3a: N, E. Staphylococcus aureus HI013: N, E. Staphylococcus aureus CN79: N, E. Staphylococcus aureus subsp. aureus 21262: N, E. Staphylococcus aureus M1199: N, E. Staphylococcus aureus subsp. aureus PSP1996: N, E. Staphylococcus aureus M1275: N, E. Staphylococcus aureus subsp. aureus Z172: N, E. Staphylococcus aureus subsp. aureus CIG1267: N, E. Staphylococcus aureus subsp. aureus IS-189: N, E. Staphylococcus aureus subsp. aureus SA40: N, E. Staphylococcus aureus M0103: N, E. Staphylococcus aureus M0334: N, E. Staphylococcus aureus M1068: N, E. Staphylococcus aureus M1167: N, E. Staphylococcus aureus M0200: N, E. Staphylococcus aureus M0404: N, E. Staphylococcus aureus M1521: N, E. Staphylococcus aureus subsp. aureus IS-M: N, E. Staphylococcus aureus subsp. aureus IS-3: N, E. Staphylococcus aureus CA-347: N, E. Staphylococcus aureus M0045: N, E. Staphylococcus aureus M0197: N, E. Staphylococcus aureus M0396: N, E. Staphylococcus aureus M0279: N, E. Staphylococcus aureus subsp. aureus VC40: N, E. Staphylococcus aureus M0622: N, E. Staphylococcus aureus KLT6: N, E. Staphylococcus aureus M0235: N, E. Staphylococcus aureus subsp. aureus 11819-97: N, E. Staphylococcus aureus M0374: N, E. Staphylococcus aureus M0424: N, E. Staphylococcus aureus subsp. aureus 21201: N, E. Staphylococcus aureus subsp. aureus 21282: N, E. Staphylococcus aureus M1062: N, E. Staphylococcus aureus M1109: N, E. Staphylococcus aureus HI022: N, E. Staphylococcus aureus M0900: N, E. Staphylococcus aureus M0831: N, E. Staphylococcus aureus subsp. aureus T0131: N, E. Staphylococcus aureus subsp. aureus VRS8: N, E. Staphylococcus aureus M1103: N, E. Staphylococcus aureus M0510: N, E. Staphylococcus aureus M0648: N, E. Staphylococcus aureus M0646: N, E. Staphylococcus aureus S123: N, E. Staphylococcus aureus subsp. aureus VRS7: N, E. Staphylococcus aureus M1451: N, E. Staphylococcus aureus B147830: N, E. Staphylococcus aureus M0892: N, E. Staphylococcus aureus M0660: N, E. Staphylococcus aureus M1095: N, E. Staphylococcus aureus subsp. aureus CIG1176: N, E. Staphylococcus aureus subsp. aureus VRS2: N, E. Staphylococcus aureus subsp. aureus 6850: N, E. Staphylococcus aureus M0391: N, E. Staphylococcus aureus subsp. aureus CIG290: N, E. Staphylococcus aureus M0539: N, E. Staphylococcus aureus M0978: N, E. Staphylococcus aureus M1531: N, E. Staphylococcus aureus subsp. aureus 21318: N, E. Staphylococcus aureus M0799: N, E. Staphylococcus aureus M1016: N, E. Staphylococcus aureus subsp. aureus IS-160: N, E. Staphylococcus aureus M1286: N, E. Staphylococcus aureus M1544: N, E. Staphylococcus aureus subsp. aureus 21310: N, E. Staphylococcus aureus subsp. aureus ST228: N, E. Staphylococcus aureus M1367: N, E. Staphylococcus aureus subsp. aureus VRS9: N, E. Staphylococcus aureus subsp. aureus 21202: N, E. Staphylococcus aureus M0075: N, E. Staphylococcus aureus M1359: N, E. Staphylococcus aureus M1063: N, E. Staphylococcus aureus M1229: N, E. Staphylococcus aureus M0340: N, E. Staphylococcus aureus M0427: N, E. Staphylococcus aureus M0586: N, E. Staphylococcus aureus subsp. aureus CIG2018: N, E. Staphylococcus aureus M1462: N, E. Staphylococcus aureus M0250: N, E. Staphylococcus aureus subsp. aureus IS-88: N, E. Staphylococcus aureus M0536: N, E. Staphylococcus aureus M0528: N, E. Staphylococcus aureus HI049: N, E. Staphylococcus aureus M1223: N, E. Staphylococcus aureus subsp. aureus 21305: N, E. Staphylococcus aureus M0104: N, E. Staphylococcus aureus M1291: N, E. Staphylococcus aureus HI010B: N, E. Staphylococcus aureus S130: N, E. Staphylococcus aureus M1093: N, E. Staphylococcus aureus M0177: N, E. Staphylococcus aureus subsp. aureus 21331: N, E. Staphylococcus aureus M1015: N, E. Staphylococcus aureus M0927: N, E. Staphylococcus aureus subsp. aureus 21343: N, E. Staphylococcus aureus subsp. aureus 21340: N, E. Staphylococcus aureus M0844: N, E. Staphylococcus aureus subsp. aureus IS-24: N, E. Staphylococcus aureus M1520: N, E. Staphylococcus aureus subsp. aureus 21259: N, E. Staphylococcus aureus M1061: N, E. Staphylococcus aureus subsp. aureus CIGC341D: N, E. Staphylococcus aureus S1: N, E. Staphylococcus aureus B40723: N, E. Staphylococcus aureus M1320: N, E. Staphylococcus aureus M1119: N, E. Staphylococcus aureus M0367: N, E. Staphylococcus aureus M0408: N, E. Staphylococcus aureus M0239: N, E. Staphylococcus aureus subsp. aureus CIG1750: N, E. Staphylococcus aureus M1322: N, E. Staphylococcus aureus subsp. aureus 21333: N, E. Staphylococcus aureus M0602: N, E. Staphylococcus aureus M1407: N, E. Staphylococcus aureus subsp. aureus CIGC128: N, E. Staphylococcus aureus M0108: N, E. Staphylococcus aureus subsp. aureus 103564: N, E. Staphylococcus aureus subsp. aureus VRS5: N, E. Staphylococcus aureus M0212: N, E. Staphylococcus aureus S94: N, E. Staphylococcus aureus M0663: N, E. Staphylococcus aureus subsp. aureus VRS10: N, E. Staphylococcus aureus M1224: N, E. Staphylococcus aureus subsp. aureus 21235: N, E. Staphylococcus aureus M0415: N, E. Staphylococcus aureus B53639: N, E. Staphylococcus aureus subsp. aureus CIG1096: N, E. Staphylococcus aureus subsp. aureus VRS11b: N, E. Staphylococcus aureus subsp. aureus 21236: N, E. Staphylococcus aureus M0943: N, E. Staphylococcus aureus M0150: N, E. Staphylococcus aureus subsp. aureus 21178: N, E. Staphylococcus aureus M0154: N, E. Staphylococcus aureus M0565: N, E. Staphylococcus aureus subsp. aureus IS-105: N, E. Staphylococcus aureus M1311: N, E. Staphylococcus aureus subsp. aureus 21342: N, E. Staphylococcus aureus M1374: N, E. Staphylococcus aureus subsp. aureus IS-122: N, E. Staphylococcus aureus M0306: N, E. Staphylococcus aureus M0192: N, E. Staphylococcus aureus M1405: N, E. Staphylococcus aureus M1565: N, E. Staphylococcus aureus O46: N, E. Staphylococcus aureus M0946: N, E. Staphylococcus aureus subsp. aureus CIGC345D: N, E. Staphylococcus aureus M0210: N, E. Staphylococcus aureus M1198: N, E. Staphylococcus aureus subsp. aureus VRS4: N, E. Staphylococcus aureus M0221: N, E. Staphylococcus aureus M1256: N, E. Staphylococcus aureus subsp. aureus 21209: N, E. Staphylococcus aureus HI049C: N, E. Staphylococcus aureus subsp. aureus MRGR3: N, E. Staphylococcus aureus HIF003_B2N-C: N, E. Staphylococcus aureus M0584: N, E. Staphylococcus aureus subsp. aureus VRS6: N, E. Staphylococcus aureus subsp. aureus 71193: N, E. Staphylococcus aureus subsp. aureus 21334: N, E. Staphylococcus aureus M0780: N, E. Staphylococcus aureus M1034: N, E. Staphylococcus aureus M0288: N, E. Staphylococcus aureus M1036: N, E. Staphylococcus aureus subsp. aureus CIG1769: N, E. Staphylococcus aureus M0270: N, E. Staphylococcus aureus M1277: N, E. Staphylococcus aureus subsp. aureus CIG149: N, E. Staphylococcus aureus subsp. aureus IS-55: N, E. Staphylococcus aureus M1510: N, E. Staphylococcus aureus subsp. aureus CN1: N, E. Staphylococcus aureus M1215: N, E. Staphylococcus aureus M1060: N, E. Staphylococcus aureus M1216: N, E. Staphylococcus aureus M0102: N, E. Staphylococcus aureus M0273: N, E. Staphylococcus aureus M0695: N, E. Staphylococcus aureus M0006: N, E. Staphylococcus aureus M0953: N, E. Staphylococcus aureus M0513: N, E. Staphylococcus aureus M0455: N, E. Staphylococcus aureus subsp. aureus 091751: N, E. Staphylococcus aureus M0692: N, E. Staphylococcus aureus M0792: N, E. Staphylococcus aureus subsp. aureus HO 5096 0412: N, E. Staphylococcus aureus subsp. aureus CIG1165: N, E. Staphylococcus aureus M0999: N, E. Staphylococcus aureus subsp. aureus 21194: N, E. Staphylococcus aureus subsp. aureus 21200: N, E. Staphylococcus aureus M1309: N, E. Staphylococcus aureus M0673: N, E. Staphylococcus aureus M1126: N, E. Staphylococcus aureus M1257: N, E. Staphylococcus aureus HI168: N, E. Staphylococcus aureus subsp. aureus M013: N, E. Staphylococcus aureus subsp. aureus 21195: N, E. Staphylococcus aureus M0467: N, E. Staphylococcus aureus subsp. aureus CIG1500: N, E. Staphylococcus aureus subsp. aureus 21266: N, E. Staphylococcus aureus M0994: N, E. Staphylococcus aureus O11: N, E. Staphylococcus aureus M0144: N, E. Staphylococcus aureus M1064: N, E. Staphylococcus aureus subsp. aureus CIG1242: N, E. Staphylococcus aureus subsp. aureus CIG1057: N, E. Staphylococcus aureus subsp. aureus CO-98: N, E. Staphylococcus aureus M1057: N, E. Staphylococcus aureus subsp. aureus: N, E. Staphylococcus aureus subsp. aureus ST772-MRSA-V: N, E. Staphylococcus aureus subsp. anaerobius: N, E. Staphylococcus schleiferi: N, E. Sequence
References
Chua K, Seemann T, Harrison PF, Davies JK, Coutts SJ, Chen H, Haring V, Moore R, Howden BP, Stinear TP Ref: Journal of Bacteriology, 192:5556, 2010 : PubMed ESTHER: Chua_2010_J.Bacteriol_192_5556 PubMedSearch: Chua 2010 J.Bacteriol 192 5556 PubMedID: 20729356 Gene_locus related to this paper: staau-c8mfq3, staau-d2feb3, staau-LIP, staau-lipas, staau-MW0741, staau-MW2456, staau-q6gfm6, staau-SA0011, staau-SA0569, staau-SA0572, staau-SA0897, staau-SA1143, staau-SA2240, staau-SA2306, staau-SA2422, staau-SAV0321, staau-SAV0457, staau-SAV0655, staau-SAV1014, staau-SAV1765, staau-SAV1793, staau-SAV2188, staau-SAV2350, staau-SAV2484, staau-SAV2594 Abstract Community methicillin-resistant Staphylococcus aureus (cMRSA) is an emerging issue that has resulted in multiple worldwide epidemics. We report the first complete genome sequence of an ST93-MRSA-IV clinical isolate that caused severe invasive infection and a familial outbreak of skin infection. This isolate is a representative of the most common Australian clone of cMRSA that is more distantly related to the previously sequenced genomes of S. aureus. Title: Evolutionary genomics of Staphylococcus aureus reveals insights into the origin and molecular basis of ruminant host adaptation Guinane CM, Ben Zakour NL, Tormo-Mas MA, Weinert LA, Lowder BV, Cartwright RA, Smyth DS, Smyth CJ, Lindsay JA and Fitzgerald JR <6 more author(s)> Guinane CM, Ben Zakour NL, Tormo-Mas MA, Weinert LA, Lowder BV, Cartwright RA, Smyth DS, Smyth CJ, Lindsay JA, Gould KA, Witney A, Hinds J, Bollback JP, Rambaut A, Penades JR, Fitzgerald JR (- 6) Ref: Genome Biol Evol, 2:454, 2010 : PubMed ESTHER: Guinane_2010_Genome.Biol.Evol_2_454 PubMedSearch: Guinane 2010 Genome.Biol.Evol 2 454 PubMedID: 20624747 Gene_locus related to this paper: staau-d2feb3, staau-LIP, staau-lipas, staau-MW0741, staau-MW2456, staau-q6gfm6, staau-SA0011, staau-SA0569, staau-SA0572, staau-SA0897, staau-SA1143, staau-SA2240, staau-SA2306, staau-SA2367, staau-SA2422, staau-SAV0321, staau-SAV0457, staau-SAV0655, staau-SAV1014, staau-SAV1765, staau-SAV1793, staau-SAV2188, staau-SAV2350, staau-SAV2594 Abstract Phenotypic biotyping has traditionally been used to differentiate bacteria occupying distinct ecological niches such as host species. For example, the capacity of Staphylococcus aureus from sheep to coagulate ruminant plasma, reported over 60 years ago, led to the description of small ruminant and bovine S. aureus ecovars. The great majority of small ruminant isolates are represented by a single, widespread clonal complex (CC133) of S. aureus, but its evolutionary origin and the molecular basis for its host tropism remain unknown. Here, we provide evidence that the CC133 clone evolved as the result of a human to ruminant host jump followed by adaptive genome diversification. Comparative whole-genome sequencing revealed molecular evidence for host adaptation including gene decay and diversification of proteins involved in host-pathogen interactions. Importantly, several novel mobile genetic elements encoding virulence proteins with attenuated or enhanced activity in ruminants were widely distributed in CC133 isolates, suggesting a key role in its host-specific interactions. To investigate this further, we examined the activity of a novel staphylococcal pathogenicity island (SaPIov2) found in the great majority of CC133 isolates which encodes a variant of the chromosomally encoded von Willebrand-binding protein (vWbp(Sov2)), previously demonstrated to have coagulase activity for human plasma. Remarkably, we discovered that SaPIov2 confers the ability to coagulate ruminant plasma suggesting an important role in ruminant disease pathogenesis and revealing the origin of a defining phenotype of the classical S. aureus biotyping scheme. Taken together, these data provide broad new insights into the origin and molecular basis of S. aureus ruminant host specificity. Title: Complete genomes of two clinical Staphylococcus aureus strains: evidence for the rapid evolution of virulence and drug resistance Holden MT, Feil EJ, Lindsay JA, Peacock SJ, Day NP, Enright MC, Foster TJ, Moore CE, Hurst L and Parkhill J <35 more author(s)> Holden MT, Feil EJ, Lindsay JA, Peacock SJ, Day NP, Enright MC, Foster TJ, Moore CE, Hurst L, Atkin R, Barron A, Bason N, Bentley SD, Chillingworth C, Chillingworth T, Churcher C, Clark L, Corton C, Cronin A, Doggett J, Dowd L, Feltwell T, Hance Z, Harris B, Hauser H, Holroyd S, Jagels K, James KD, Lennard N, Line A, Mayes R, Moule S, Mungall K, Ormond D, Quail MA, Rabbinowitsch E, Rutherford K, Sanders M, Sharp S, Simmonds M, Stevens K, Whitehead S, Barrell BG, Spratt BG, Parkhill J (- 35) Ref: Proc Natl Acad Sci U S A, 101:9786, 2004 : PubMed ESTHER: Holden_2004_Proc.Natl.Acad.Sci.U.S.A_101_9786 PubMedSearch: Holden 2004 Proc.Natl.Acad.Sci.U.S.A 101 9786 PubMedID: 15213324 Gene_locus related to this paper: staau-d2feb3, staau-d2uin3, staau-LIP, staau-lipas, staau-MW0741, staau-MW2456, staau-q6gfm6, staau-SA0011, staau-SA0569, staau-SA0572, staau-SA0897, staau-SA1143, staau-SA2240, staau-SA2306, staau-SA2367, staau-SA2422, staau-SAV0321, staau-SAV0446, staau-SAV0457, staau-SAV0655, staau-SAV1014, staau-SAV1765, staau-SAV1793, staau-SAV2188, staau-SAV2350, staau-SAV2594 Abstract Staphylococcus aureus is an important nosocomial and community-acquired pathogen. Its genetic plasticity has facilitated the evolution of many virulent and drug-resistant strains, presenting a major and constantly changing clinical challenge. We sequenced the approximately 2.8-Mbp genomes of two disease-causing S. aureus strains isolated from distinct clinical settings: a recent hospital-acquired representative of the epidemic methicillin-resistant S. aureus EMRSA-16 clone (MRSA252), a clinically important and globally prevalent lineage; and a representative of an invasive community-acquired methicillin-susceptible S. aureus clone (MSSA476). A comparative-genomics approach was used to explore the mechanisms of evolution of clinically important S. aureus genomes and to identify regions affecting virulence and drug resistance. The genome sequences of MRSA252 and MSSA476 have a well conserved core region but differ markedly in their accessory genetic elements. MRSA252 is the most genetically diverse S. aureus strain sequenced to date: approximately 6% of the genome is novel compared with other published genomes, and it contains several unique genetic elements. MSSA476 is methicillin-susceptible, but it contains a novel Staphylococcal chromosomal cassette (SCC) mec-like element (designated SCC(476)), which is integrated at the same site on the chromosome as SCCmec elements in MRSA strains but encodes a putative fusidic acid resistance protein. The crucial role that accessory elements play in the rapid evolution of S. aureus is clearly illustrated by comparing the MSSA476 genome with that of an extremely closely related MRSA community-acquired strain; the differential distribution of large mobile elements carrying virulence and drug-resistance determinants may be responsible for the clinically important phenotypic differences in these strains. Other Papers | ||||||||||||||||||||||||||
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