Gene_locus Report for: strag-GBS0107

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms: N E > Bacteria: N E > Terrabacteria group: N E > Firmicutes: N E > Bacilli: N E > Lactobacillales: N E > Streptococcaceae: N E > Streptococcus: N E > Streptococcus agalactiae: N E

6_AlphaBeta_hydrolase : strag-SAG0679Streptococcus agalactiae (serotype V) ( and H36B COH1 CJB111 18RS21 serotype Ia) protein of unknown function, strag-SAG0680Streptococcus agalactiae (serotype V) ( and H36B CJB111 18RS21 serotype Ia) protein of unknown function, strag-SAG0681Streptococcus agalactiae (serotype V) conserved domain protein, strag-SAG2132Streptococcus agalactiae conserved hypothetical protein.
A85-EsteraseD-FGH : strag-ESTAStreptococcus agalactiae (serotype V; serotype III; serotype Ia; H36B; COH1; 515; 18RS21; CJB111) tributyrin esterase.
Acetyl-esterase_deacetylase : strag-GBS0040Streptococcus agalactiae, hypothetical protein.
AlphaBeta_hydrolase : strag-GBS0567Streptococcus agalactiae (serotype III) hypothetical protein, strag-SAG0108Streptococcus agalactiae (serotype V) conserved hypothetical protein, strag-SAG0521Streptococcus agalactiae (serotype V) carboxymethylenebutenolidase-related protein.
Asp2 : strag-a0a076z217 Streptococcus agalactiae. Uncharacterized protein, strag-a0a0h1ywg1Streptococcus agalactiae. Accessory Sec system protein Asp2.
Duf_915 : strag-SAG1562Streptococcus agalactiae (serotype V) H36B COH1 CJB111 515 18RS21 serotype Ia conserved hypothetical protein.
Hormone-sensitive_lipase_like : strag-SAG0383Streptococcus agalactiae, protein of unknown function/lipoprotein, putative, strag-SAG0785Streptococcus agalactiae conserved hypothetical protein.
Lactobacillus_peptidase : strag-pepxStreptococcus agalactiae (serotype III) H36B COH1 CJB111 515 18RS21 serotype Ia peptidase (x-prolyl-dipeptidyl aminopeptidase) (x-pdap) (EC 3.4.14.11).
Lipase_3 : strag-GBS1075Streptococcus agalactiae (serotype III) hypothetical protein, strag-SAG1040Streptococcus agalactiae (serotype V) H36B CJB111 515 18RS21 serotype Ia conserved domain protein.
Mbeg1-like : strag-GBS1828Streptococcus agalactiae (serotype III) (serotype V) (CJB11) (515) (H36B) (serotype Ia) (18RS21) (COH1) hypothetical protein, strag-GBS1967Streptococcus agalactiae (serotype III) hypothetical protein, strag-SAG0246Streptococcus agalactiae (serotype V) (COH1) (18RS21) (H36B)(serotype Ia) (CJB111) hypothetical protein, strag-SAG0912Streptococcus agalactiae (serotype V) (serotype III) (H36B) (CJB111)(serotype Ia) (515) (18RS21) (COH1) conserved hypothetical protein

Title: Genome analysis of multiple pathogenic isolates of Streptococcus agalactiae: implications for the microbial pan-genome
Tettelin H, Masignani V, Cieslewicz MJ, Donati C, Medini D, Ward NL, Angiuoli SV, Crabtree J, Jones AL and Fraser CM <36 more author(s)> Tettelin H, Masignani V, Cieslewicz MJ, Donati C, Medini D, Ward NL, Angiuoli SV, Crabtree J, Jones AL, Durkin AS, DeBoy RT, Davidsen TM, Mora M, Scarselli M, Margarit y Ros I, Peterson JD, Hauser CR, Sundaram JP, Nelson WC, Madupu R, Brinkac LM, Dodson RJ, Rosovitz MJ, Sullivan SA, Daugherty SC, Haft DH, Selengut J, Gwinn ML, Zhou L, Zafar N, Khouri H, Radune D, Dimitrov G, Watkins K, O'Connor KJ, Smith S, Utterback TR, White O, Rubens CE, Grandi G, Madoff LC, Kasper DL, Telford JL, Wessels MR, Rappuoli R, Fraser CM (- 36)
Ref: Proc Natl Acad Sci U S A, 102:13950, 2005 : PubMed
Abstract


ESTHER: Tettelin_2005_Proc.Natl.Acad.Sci.U.S.A_102_13950
PubMedSearch: Tettelin 2005 Proc.Natl.Acad.Sci.U.S.A 102 13950
PubMedID: 16172379
Gene_locus related to this paper: strag-ESTA, strag-GBS0040, strag-GBS0107, strag-GBS1828, strag-pepx, strag-q3dah6, strag-SAG0246, strag-SAG0383, strag-SAG0679, strag-SAG0680, strag-SAG0785, strag-SAG0912, strag-SAG1562, strag-SAG2132

Abstract

The development of efficient and inexpensive genome sequencing methods has revolutionized the study of human bacterial pathogens and improved vaccine design. Unfortunately, the sequence of a single genome does not reflect how genetic variability drives pathogenesis within a bacterial species and also limits genome-wide screens for vaccine candidates or for antimicrobial targets. We have generated the genomic sequence of six strains representing the five major disease-causing serotypes of Streptococcus agalactiae, the main cause of neonatal infection in humans. Analysis of these genomes and those available in databases showed that the S. agalactiae species can be described by a pan-genome consisting of a core genome shared by all isolates, accounting for approximately 80% of any single genome, plus a dispensable genome consisting of partially shared and strain-specific genes. Mathematical extrapolation of the data suggests that the gene reservoir available for inclusion in the S. agalactiae pan-genome is vast and that unique genes will continue to be identified even after sequencing hundreds of genomes.



        

Title: Genome sequence of Streptococcus agalactiae, a pathogen causing invasive neonatal disease
Glaser P, Rusniok C, Buchrieser C, Chevalier F, Frangeul L, Msadek T, Zouine M, Couve E, Lalioui L and Kunst F <2 more author(s)> Glaser P, Rusniok C, Buchrieser C, Chevalier F, Frangeul L, Msadek T, Zouine M, Couve E, Lalioui L, Poyart C, Trieu-Cuot P, Kunst F (- 2)
Ref: Molecular Microbiology, 45:1499, 2002 : PubMed
Abstract


ESTHER: Glaser_2002_Mol.Microbiol_45_1499
PubMedSearch: Glaser 2002 Mol.Microbiol 45 1499
PubMedID: 12354221
Gene_locus related to this paper: strag-ESTA, strag-GBS0040, strag-GBS0107, strag-GBS0567, strag-GBS1075, strag-GBS1828, strag-GBS1967, strag-pepx, strag-SAG0383, strag-SAG0785, strag-SAG0912, strag-SAG1562, strag-SAG2132

Abstract

Streptococcus agalactiae is a commensal bacterium colonizing the intestinal tract of a significant proportion of the human population. However, it is also a pathogen which is the leading cause of invasive infections in neonates and causes septicaemia, meningitis and pneumonia. We sequenced the genome of the serogroup III strain NEM316, responsible for a fatal case of septicaemia. The genome is 2 211 485 base pairs long and contains 2118 protein coding genes. Fifty-five per cent of the predicted genes have an ortholog in the Streptococcus pyogenes genome, representing a conserved backbone between these two streptococci. Among the genes in S. agalactiae that lack an ortholog in S. pyogenes, 50% are clustered within 14 islands. These islands contain known and putative virulence genes, mostly encoding surface proteins as well as a number of genes related to mobile elements. Some of these islands could therefore be considered as pathogenicity islands. Compared with other pathogenic streptococci, S. agalactiae shows the unique feature that pathogenicity islands may have an important role in virulence acquisition and in genetic diversity.