(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) > cellular organisms: NE > Bacteria: NE > Terrabacteria group: NE > Firmicutes: NE > Bacilli: NE > Lactobacillales: NE > Streptococcaceae: NE > Streptococcus: NE > Streptococcus agalactiae: NE
Warning: This entry is a compilation of different species or line or strain with more than 90% amino acid identity. You can retrieve all strain data
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) Streptococcus agalactiae COH1: N, E.
Streptococcus agalactiae serogroup III: N, E.
Streptococcus agalactiae serogroup V: N, E.
Streptococcus agalactiae serogroup Ia: N, E.
Streptococcus agalactiae 18RS21: N, E.
Streptococcus agalactiae 515: N, E.
Streptococcus agalactiae CJB111: N, E.
Streptococcus agalactiae H36B: N, E.
Streptococcus agalactiae ATCC 13813: N, E.
Streptococcus agalactiae 2603V/R: N, E.
Streptococcus agalactiae NEM316: N, E.
Streptococcus agalactiae FSL S3-026: N, E.
Streptococcus agalactiae FSL S3-170: N, E.
Streptococcus agalactiae FSL C1-494: N, E.
Streptococcus agalactiae FSL C1-487: N, E.
Streptococcus agalactiae FSL S3-586: N, E.
Streptococcus agalactiae FSL S3-251: N, E.
Streptococcus agalactiae MRI Z1-213: N, E.
Streptococcus agalactiae MRI Z1-214: N, E.
Streptococcus agalactiae MRI Z1-216: N, E.
Streptococcus agalactiae MRI Z1-217: N, E.
LegendThis sequence has been compared to family alignement (MSA) red => minority aminoacid blue => majority aminoacid color intensity => conservation rate title => sequence position(MSA position)aminoacid rate Catalytic site Catalytic site in the MSA MEKLKILQIGEEPWDADLITPDNIEWLYCNGNAIQIFLEKLKSKELEKNN VEYIGKTSTNEVKLWFNAVILTSEVSELQLNLLSDCLEAHTLFYDEDFQL DFCSENGIFKRKVLRPLPFNGSRKEKIIFLSRTLFSEQYGAKLKVSDIDL NPDFKGEIIYEGNSSICFSGDFGEDFQPLFSFRYNLSSTDKAIEIWQEYQ KLQGDNSIMIEVIQYQKGSLDLILNTKYLSENDLADPYILEYDESVGFSS ISIFARGDGVVRFGALHWRYSRKGLGQFLIGGERYSDSKRQEFIYYFNPG DMKPPLNVYFSGFRGAEGFEGFYMMKRLGAPFLLIGDPRIEGGSFYLGTS EYESELENVLQKYLDYLQFDHCQLILSGLSMGSFGALYYGSTFSPHAIVV GKPFTNLGDMVVNLKLRRPDDFETSMDILQNIIGSQNDEAINQFNQKFWN KFKRSNFEKTQFAISYMKHDDYDRDATPRLIDYFSKTNTLLYASGYAGRH NDNSQSINNWFTSQYKTILSDDFGRVFSD
The human and bovine bacterial pathogen Streptococcus agalactiae (Group B Streptococcus, GBS) expresses a thick polysaccharide capsule that constitutes a major virulence factor and vaccine target. GBS can be classified into ten distinct serotypes differing in the chemical composition of their capsular polysaccharide. However, non-typeable strains that do not react with anti-capsular sera are frequently isolated from colonized and infected humans and cattle. To gain a comprehensive insight into the molecular basis for the loss of capsule expression in GBS, a collection of well-characterized non-typeable strains was investigated by genome sequencing. Genome based phylogenetic analysis extended to a wide population of sequenced strains confirmed the recently observed high clonality among GBS lineages mainly containing human strains, and revealed a much higher degree of diversity in the bovine population. Remarkably, non-typeable strains were equally distributed in all lineages. A number of distinct mutations in the cps operon were identified that were apparently responsible for inactivation of capsule synthesis. The most frequent genetic alterations were point mutations leading to stop codons in the cps genes, and the main target was found to be cpsE encoding the portal glycosyl transferase of capsule biosynthesis. Complementation of strains carrying missense mutations in cpsE with a wild-type gene restored capsule expression allowing the identification of amino acid residues essential for enzyme activity.
Streptococcus agalactiae. Uncharacterized protein