Streptomyces cinnamonensis monensin cyclase
MonCII from the monensin biosynthetic gene cluster in Streptomyces cinnamonensis, which was previously thought to be an epoxide hydrolase, is a novel thioesterase. It hydrolyse several thioester substrates, including an N-acetylcysteamine thioester derivative of monensin A (strci-MONAIX and strci-MONAX are thioesterases typeII)
MKNLRIPVSQ TVSLNVRYRP ADGPGAPGRP FLLLHGMLSN ARMWDEVAAR LAAAGHPAYA VDHRGHGESD TPPDGYDNAT VVTDLVAAVT ALDLSGALVA GHSWGAHLAL RLAAEHPDLV AGLALIDGGW YEFDGPVMRA FWERTADVVR RAQQGTTSAA DMRAYLRATH PDWSPTSIEA RLADYRVGPD GLLIPRLTST QVMSIVAGLQ REAPADWYPK VTVPVRLLPL IPAIPQLSDQ VRAWVAAAEA ALEQVSVRWY PGSDHDLHAG APDEIAADLL LLARSCEAMP GGKAGVRPA
| Title : Evidence that a novel thioesterase is responsible for polyketide chain release during biosynthesis of the polyether ionophore monensin - Harvey_2006_Chembiochem_7_1435 |
| Author(s) : Harvey BM , Hong H , Jones MA , Hughes-Thomas ZA , Goss RM , Heathcote ML , Bolanos-Garcia VM , Kroutil W , Staunton J , Leadlay PF , Spencer JB |
| Ref : Chembiochem , 7 :1435 , 2006 |
| Abstract : Harvey_2006_Chembiochem_7_1435 |
| ESTHER : Harvey_2006_Chembiochem_7_1435 |
| PubMedSearch : Harvey_2006_Chembiochem_7_1435 |
| PubMedID: 16897798 |
| Gene_locus related to this paper: strci-MONCII |
| Title : Analysis of the biosynthetic gene cluster for the polyether antibiotic monensin in Streptomyces cinnamonensis and evidence for the role of monB and monC genes in oxidative cyclization - Oliynyk_2003_Mol.Microbiol_49_1179 |
| Author(s) : Oliynyk M , Stark CB , Bhatt A , Jones MA , Hughes-Thomas ZA , Wilkinson C , Oliynyk Z , Demydchuk Y , Staunton J , Leadlay PF |
| Ref : Molecular Microbiology , 49 :1179 , 2003 |
| Abstract : Oliynyk_2003_Mol.Microbiol_49_1179 |
| ESTHER : Oliynyk_2003_Mol.Microbiol_49_1179 |
| PubMedSearch : Oliynyk_2003_Mol.Microbiol_49_1179 |
| PubMedID: 12940979 |
| Gene_locus related to this paper: strci-MONAIX , strci-MONAX , strci-MONCII , strci-Q846W0 |